Thyroid hormone and blood pressure regulation

Danzi, Sara; Klein, Irwin

doi:10.1007/s11906-003-0060-7

Cited by 261Thyroid Disorders and TreatmentsBlood Pressure and Hypertension StudiesHormonal Regulation and Hypertension

Thyroid hormone and blood pressure regulation

Danzi, Sara, Klein, Irwin·2003·Current Hypertension Reports

DOI 10.1007/s11906-003-0060-7

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Abstract

Thyroid hormone has well-recognized effects on the cardiovascular system and blood pressure regulation. Blood pressure is altered across the entire spectrum of thyroid disease. The effects of hyperthyroidism include increased cardiac output, contractility, tachycardia, widened pulse pressure, decreased systemic vascular resistance, and increased basal metabolic rate. The manifestations of hypothyroidism are in marked contrast to those of hyperthyroidism and include decreased cardiac output, narrow pulse pressure, increased systemic vascular resistance, and decreased metabolic rate. Although thyroid hormone affects almost all tissues of the body and mediates changes in homeostasis, adaptations of the cardiovascular system can result in changes in blood pressure to accommodate the new demands on the system. In this paper, we review the direct and indirect thyroid hormone-mediated effects on blood pressure.

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Increased arterial stiffness and a low renin state contribute to blood pressure and vascular dysregulation due to the lack of normal vasodilatory effects of triiodothyronine.
“In addition, increased arterial stiffness and a low renin state are contributory factors leading to blood pressure and vascular dysregulation due to the lack of the normal vasodilatory effects of T 3 (4,43)”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [43]

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Authors: Danzi, S., & Klein, I.
Affiliations: North Shore University Hospital (US)
Venue: Current Hypertension Reports
Publisher: Springer Science and Business Media LLC
Published: 2003-12
Volume: 5
Issue: 6
Pages: 513-520
ISSN: 1522-6417 (ISSN-L)
1534-3111
DOI: 10.1007/s11906-003-0060-7
OpenAlex: W1964706390
Cited by: 261
References: 85
Citations by year: 2026: 3 · 2025: 10 · 2024: 12 · 2023: 12 · 2022: 27 · 2021: 14 · 2020: 13 · 2019: 13 · 2018: 13 · 2017: 10 · 2016: 10 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 9
FWCI: 1.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Hypertension Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: thyroid hormones, blood pressure regulation, hyperthyroidism, hypothyroidism, thyroid dysfunction, cardiovascular effects, cardiac output, systemic vascular resistance, pulse pressure, basal metabolic rate, tachycardia
MeSH terms: Blood Pressure, Blood Volume, Cardiovascular System, Catecholamines, Humans, Hypertension, Renin-Angiotensin System, Thyroid Diseases, Thyroid Hormones, Endothelins, Natriuretic Peptides

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Thyroid hormone and blood pressure regulation

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