The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Modulation of Mitochondrial ATP-Dependent K+Channels by Protein Kinase C
Abstract
Abstract—Pharmacological openers of mitochondrial ATP-dependent K+(mitoK ATP) channels mimic ischemic preconditioning, and such cardioprotection can be prevented by mitoK ATP channel blockers. It is also known that protein kinase C (PKC) plays a key role in the induction and maintenance of preconditioning. To look for possible mechanistic links between these 2 sets of observations, we measured mitochondrial matrix redox potential as an index of mitoK ATP channel activity in rabbit ventricular myocytes. The mitoK ATP channel opener diazoxide (100 μmol/L) partially oxidized the matrix redox potential. Exposure to phorbol 12-myristate 13-acetate (PMA, 100 nmol/L) potentiated and accelerated the effect of diazoxide. These effects of PMA were blocked by the mitoK ATP channel blocker 5-hydroxydecanoate, which we verified to be a selective blocker of the mitoK ATP channel in simultaneous recordings of membrane current and flavoprotein fluorescence. The inactive control compound 4α-phorbol (100 nmol/L) did not alter the effects of diazoxide. We conclude that the activity of mitoK ATP channels can be regulated by PKC in intact heart cells. Potentiation of mitoK ATP channel opening by PKC provides a direct mechanistic link between the signal transduction of ischemic preconditioning and pharmacological cardioprotection targeted at ATP-dependent K+channels.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
Murry, C. E., Jennings, R. B., & Reimer, K. A. (1986) · Circulation · doi:10.1161/01.cir.74.5.1124 · Cited by 7,812
Reconstitution of I KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor
Inagaki, N., Gonoi, T., Clement, J. P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., & Bryan, J. (1995) · Science · doi:10.1126/science.270.5239.1166 · Cited by 1,709
Garlid, K. D., Paucek, P., Yarov-Yarovoy, V., Murray, H. N., Darbenzio, R. B., D’Alonzo, A. J., Lodge, N. J., Smith, M. A., & Grover, G. J. (1997) · Circulation Research · doi:10.1161/01.res.81.6.1072 · Cited by 1,019
Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs.
Gross, G. J., & Auchampach, J. A. (1992) · Circulation Research · doi:10.1161/01.res.70.2.223 · Cited by 949
ATP-sensitive K+ channel in the mitochondrial inner membrane
Inoue, I., Nagase, H., Kishi, K., & Higuti, T. (1991) · Nature · doi:10.1038/352244a0 · Cited by 749
Association and Stoichiometry of KATP Channel Subunits
Clement, J. P., Kunjilwar, K., Gonzalez, G., Schwanstecher, M., Panten, U., Aguilar-Bryan, L., & Bryan, J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80321-9 · Cited by 692
Preconditioning protects ischemic rabbit heart by protein kinase C activation
Ytrehus, K., Liu, Y., & Downey, J. M. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.3.h1145 · Cited by 615
Octameric Stoichiometry of the KATP Channel Complex
Shyng, S.-L., & Nichols, C. G. (1997) · The Journal of General Physiology · doi:10.1085/jgp.110.6.655 · Cited by 495
The Mitochondrial K Channel as a Receptor for Potassium Channel Openers
Garlid, K. D., Paucek, P., Yarov-Yarovoy, V., Sun, X., & Schindler, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8796 · Cited by 445
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea‐sensitive but ATP‐insensitive K+ channel.
Yamada, M., Isomoto, S., Matsumoto, S., Kondo, C., Shindo, T., Horio, Y., & Kurachi, Y. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021963 · Cited by 390
Cited by
Preconditioning the myocardium: from cellular physiology to clinical cardiology
YELLON, D. M., & DOWNEY, J. M. (2003) · Physiological Reviews · doi:10.1152/physrev.00009.2003 · Cited by 1,062
Mitochondria as a Pharmacological Target
Szewczyk, A., & Wojtczak, L. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.101 · Cited by 538
Survival kinases in ischemic preconditioning and postconditioning
HAUSENLOY, D., & YELLON, D. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.017 · Cited by 472
Evidence for Mitochondrial K + Channels and Their Role in Cardioprotection
O’Rourke, B. (2004) · Circulation Research · doi:10.1161/01.res.0000117583.66950.43 · Cited by 444
Self-citationBaines, C. P., Zhang, J., Wang, G.-W., Zheng, Y.-T., Xiu, J. X., Cardwell, E. M., Bolli, R., & Ping, P. (2002) · Circulation Research · doi:10.1161/01.res.0000012702.90501.8d · Cited by 429
Metadata
- Authors
- Sato, T., O’Rourke, B., & Marbán, E.
- Venue
- Circulation Research
- Published
- 1998-07-13
- Volume
- 83
- Issue
- 1
- Pages
- 110-114
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2007939778
- Cited by
- 366
- References
- 27
- FWCI
- 28.86
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Modulation of Mitochondrial ATP-Dependent K+Channels by Protein Kinase C. https://app.cochat.ai/papers/10.1161/01.res.83.1.110
- The paper
- Sato, T., O’Rourke, B., & Marbán, E. (1998). Modulation of Mitochondrial ATP-Dependent K+Channels by Protein Kinase C. Circulation Research. https://doi.org/10.1161/01.res.83.1.110
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
