Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog
Abstract
Abstract —The aim of the present study was to determine whether cardiac nitric oxide (NO) production changes during the progression of pacing-induced heart failure and whether this occurs in association with alterations in myocardial metabolism. Dogs (n=8) were instrumented and the heart paced until left ventricular end-diastolic pressure reached 25 mm Hg and clinical signs of severe failure were evident. Every week, hemodynamic measurements were recorded and blood samples were withdrawn from the aorta and the coronary sinus for measurement of NO metabolites, O 2 content, free fatty acids (FFAs), and lactate and glucose concentrations. Cardiac production of NO metabolites or consumption of O 2 or utilization of substrates was calculated as coronary sinus-arterial difference times coronary flow. In end-stage failure, occurring at 29±1.6 days, left ventricular end-diastolic pressure was 25±1 mm Hg, left ventricular systolic pressure was 92±3 mm Hg, mean arterial pressure was 75±2.5 mm Hg, and dP/dt max was 1219±73 mm Hg/s (all P <0.05). These changes in hemodynamics were associated with a fall of cardiac NO metabolite production from 0.37±0.16 to −0.28±0.13 nmol/beat ( P <0.05). O 2 consumption and lactate uptake did not change significantly from control, while FFA uptake decreased from 0.16±0.03 to 0.05±0.01 μEq/beat and glucose uptake increased from −2.3±7.0 to 41±10 μg/beat ( P <0.05). The cardiac respiratory quotient also increased significantly by 28%. In 14 normal dogs the same measurements were performed at control and 1 hour after we injected 30 mg/kg of nitro- l -arginine, a competitive inhibitor of NO synthase. O 2 consumption increased from 0.05±0.002 mL/beat at control to 0.071±0.003 mL/beat after nitro- l -arginine, while FFA uptake decreased from 0.1±0.01 to 0.06±0.01 μEq/beat, lactate uptake increased from 0.15±0.04 to 0.31±0.03 μmol/beat, glucose uptake increased from 8.2±5.0 to 35.4±9.5 μg/beat, and RQ increased by 23% (all P <0.05). Our results indicate that basal cardiac production of NO falls below normal levels during cardiac decompensation and that there are shifts in substrate utilization. This switch in myocardial substrate utilization also occurs after acute pharmacological blockade of NO production in normal dogs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some canine heart disease models include sudden cardiac death, rapid pacing induced heart failure, repeated microembolization induced chronic heart failure, and gradual aortic constriction induced left-ventricular pressure-overload.
“Some of these models include sudden cardiac death (review: (Billman, 2006)), rapid pacing induced heart failure (Recchia, et al., 1998; Sabbah, et al., 1991), repeated microembolization induced chronic heart failure (Sabbah, et al., 1991), gradual aortic constriction induced left-ventricular pressure-overload (Koide, et al., 1997).”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Recchia, et al., 1998
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1978) · Biochemical Education · doi:10.1016/0307-4412(78)90049-3 · Cited by 5,073 · see citing works
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582 · cited 1× · see citing works
“4 days); (2) the transition to decompensated heart failure is associated with a significant fall of cardiac NO production; (3) there are profound changes in myocardial metabolism at this time; and (4) after acute inhibition of NO production in healthy, conscious dogs there is an alteration in cardiac substrate utiliza…”
BackgroundWaage, A., Halstensen, A. I., & Espevik, T. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91728-4 · Cited by 1,085 · see citing works
Brown, G. C., & Cooper, C. E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01290-3 · Cited by 1,055 · see citing works
Fatty Acid Oxidation Enzyme Gene Expression Is Downregulated in the Failing Heart
Sack, M. N., Rader, T. A., Park, S., Bastin, J., McCune, S. A., & Kelly, D. P. (1996) · Circulation · doi:10.1161/01.cir.94.11.2837 · Cited by 678 · see citing works
Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.
Balligand, J., Kelly, R. A., Marsden, P. A., Smith, T. W., & Michel, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.347 · Cited by 659 · see citing works
Stanley, W. C. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00245-3 · Cited by 606 · see citing works
Endothelial function in chronic congestive heart failure
Drexler, H., Hayoz, D., Münzel, T. F., Hornig, B., Just, H., Brunner, H. R., & ZELIS, R. F. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90710-g · Cited by 549 · see citing works
Méry, P., Pavoine, C., Belhassen, L., Pecker, F., & Fischmeister, R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74313-0 · Cited by 467 · see citing works
Nitric oxide attenuates cardiac myocyte contraction
Brady, A. J., Warren, J. B., Poole-Wilson, P. A., Williams, T. J., & Harding, S. E. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.265.1.h176 · Cited by 408 · see citing works
8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.
Shah, A. M., Spurgeon, H. A., Sollott, S. J., Talo, A., & Lakatta, E. G. (1994) · Circulation Research · doi:10.1161/01.res.74.5.970 · Cited by 377 · see citing works
Paulus, W. J., Vantrimpont, P. J. M. J., & Shah, A. M. (1994) · Circulation · doi:10.1161/01.cir.89.5.2070 · Cited by 367 · see citing works
Nitric oxide synthase activities in human myocardium
de Belder, A., Why, H. J. F., Richardson, P., Bucknall, C. A., Martin, J., Radomski, M. W., Salas, E., & Moncada, S. (1993) · The Lancet · doi:10.1016/0140-6736(93)92559-c · Cited by 353 · see citing works
Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension
Schweizer, M., & Richter, C. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2441 · Cited by 331 · see citing works
Role of nitric oxide in the regulation of oxygen consumption in conscious dogs.
Shen, W., Xu, X., Ochoa, M., Zhao, G., Wolin, M. S., & Hintze, T. H. (1994) · Circulation Research · doi:10.1161/01.res.75.6.1086 · Cited by 317 · see citing works
Self-citationFunctional Coupling Between Glycolysis and Sarcoplasmic Reticulum Ca 2+ Transport
Xu, K. Y., Zweier, J. L., & Becker, L. C. (1995) · Circulation Research · doi:10.1161/01.res.77.1.88 · Cited by 308 · see citing works
Nitric oxide as a signal in blood vessels
Knowles, R. G., & Moncada, S. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90008-w · Cited by 283 · see citing works
Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase.
Zhang, J., & Snyder, S. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9382 · Cited by 283 · see citing works
Myocardial Contractile Response to Nitric Oxide and cGMP
Mohan, P., Brutsaert, D. L., Paulus, W. J., & Sys, S. U. (1996) · Circulation · doi:10.1161/01.cir.93.6.1223 · Cited by 281 · see citing works
Reduced Gene Expression of Vascular Endothelial NO Synthase and Cyclooxygenase-1 in Heart Failure
Smith, C. J., Sun, D., Hoegler, C., Roth, B. S., Zhang, X.-P. S., Zhao, G., Xu, X., Kobari, Y., Pritchard, K. A., Sessa, W. C., et al. (1996) · Circulation Research · doi:10.1161/01.res.78.1.58 · Cited by 267 · see citing works
Self-citationIncreased nitric oxide production in heart failure
Ds, W. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91403-6 · Cited by 256 · see citing works
Xie, Y.-W., Shen, W., Zhao, G., Xu, X., Wolin, M. S., & Hintze, T. H. (1996) · Circulation Research · doi:10.1161/01.res.79.3.381 · Cited by 229 · see citing works
Self-citationKatz, S. D., Schwarz, M., Yuen, J., & LeJemtel, T. H. (1993) · Circulation · doi:10.1161/01.cir.88.1.55 · Cited by 227 · see citing works
Evidence of increased nitric oxide production in patients with the sepsis syndrome.
Evans, T. J., Carpenter, A., Kinderman, H., & Cohen, J. (1993) · PubMed · Cited by 222 · see citing works
Hare, J. M., Loh, E., Creager, M. A., & Colucci, W. S. (1995) · Circulation · doi:10.1161/01.cir.92.8.2198 · Cited by 219 · see citing works
The ABC of acid-base chemistry
Davenport, H. F. (1969) · Cited by 207 · see citing works
Zeballos, G. A., Bernstein, R. D., Thompson, C. I., Forfia, P. R., Seyedi, N., Shen, W., Kaminski, P. M., Wolin, M. S., & Hintze, T. H. (1995) · Circulation · doi:10.1161/01.cir.91.12.2982 · Cited by 194 · see citing works
Self-citationBernstein, R. D., Ochoa, F., Xu, X., Forfia, P. R., Shen, W., Thompson, C. I., & Hintze, T. H. (1996) · Circulation Research · doi:10.1161/01.res.79.4.840 · Cited by 192 · see citing works
Self-citationHeart failure depresses endothelium-dependent responses in canine femoral artery
Kaiser, L., Spickard, R. C., & Olivier, N. B. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.256.4.h962 · Cited by 188 · see citing works
ACE Inhibitors Promote Nitric Oxide Accumulation to Modulate Myocardial Oxygen Consumption
Zhang, X., Xie, Y.-W., Nasjletti, A., Xu, X., Wolin, M. S., & Hintze, T. H. (1997) · Circulation · doi:10.1161/01.cir.95.1.176 · Cited by 181 · see citing works
Self-citationTHE CORONARY CIRCULATION IN THE DOG
Eckenhoff, J. E., Hafkenschiel, J. H., & Landmesser, C. M. (1947) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1947.148.3.582 · Cited by 174 · see citing works
Duhm, J. (1971) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00586998 · Cited by 171 · see citing works
Paracrine modulation of heart cell function by endothelial cells
Shah, A. M. (1996) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00025-9 · Cited by 165 · see citing works
Kichuk, M. R., Seyedi, N., Zhang, X., Marboe, C. C., Michler, R. E., Addonizio, L. J., Kaley, G., Nasjletti, A., & Hintze, T. H. (1996) · Circulation · doi:10.1161/01.cir.94.1.44 · Cited by 153 · see citing works
Self-citationPaternostro, G., Camici, P. G., Lammertsma, A. A., Marinho, N. V. S., Baliga, R. R., Kooner, J. S., Radda, G. K., & Ferrannini, E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119015 · Cited by 150 · see citing works
Inhibition of the skeletal muscle ryanodine receptor calcium release channel by nitric oxide
Mészáros, L., Minarovič, I., & Zahradnı́ková, A. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00003-8 · Cited by 148 · see citing works
Defective lipid metabolism in the failing heart
Wittel, B., & Spann, J. F. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105868 · Cited by 145 · see citing works
Defective endothelium-mediated control of coronary circulation in conscious dogs after heart failure
Wang, J., Seyedi, N., Xu, X. B., Wolin, M. S., & Hintze, T. H. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.2.h670 · Cited by 143 · see citing works
Self-citationBasal Release of Nitric Oxide Augments the Frank-Starling Response in the Isolated Heart
Prendergast, B., Sagach, V. F., & Shah, A. M. (1997) · Circulation · doi:10.1161/01.cir.96.4.1320 · Cited by 142 · see citing works
Weyrich, A. S., L, X., Buerke, M., Murohara, T., Armstead, V. E., Lefer, A. M., Nicolás, J. M., Thomas, A. P., Lefer, D. J., & Vinten‐Johansen, J. (1994) · Circulation Research · doi:10.1161/01.res.75.4.692 · Cited by 140 · see citing works
Baron, A. D. (1996) · Diabetes · doi:10.2337/diab.45.1.s105 · Cited by 132 · see citing works
Shih-Ann, C., Chiang, C., Ching-Tai, T., Chen-Chuen, C., Chuen-Wang, C., Lee, S., Ueng, K.-C., Zu-Chi, W., & Chang, M.-S. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)89132-1 · Cited by 125 · see citing works
Shannon, R. P., Komamura, K., Shen, Y. T., Bishop, S. P., & Vatner, S. F. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.265.3.h801 · Cited by 102 · see citing works
Myocardial metabolism in congestive heart failure
Olson, R. E. (1959) · Journal of Chronic Diseases · doi:10.1016/0021-9681(59)90172-9 · Cited by 97 · see citing works
Autocrine control of wound repair by insulin-like growth factor I in cultured endothelial cells
Taylor, W. R., & Alexander, R. W. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.3.c801 · Cited by 96 · see citing works
Wolff, M. R., de Tombe, P. P., Harasawa, Y., Burkhoff, D., Bier, S., Hunter, W. C., Gerstenblith, G., & Kass, D. A. (1992) · Circulation Research · doi:10.1161/01.res.70.3.516 · Cited by 85 · see citing works
Packer, M. (1996) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00301-4 · Cited by 82 · see citing works
Mohri, M., Egashira, K., Tagawa, T., Kuga, T., Tagawa, H., Harasawa, Y., Shimokawa, H., & Takeshita, A. (1997) · Hypertension · doi:10.1161/01.hyp.30.1.50 · Cited by 76 · see citing works
Some effects of low pH on chloride exchange in human red blood cells.
Gunn, R. B., Wieth, J. O., & Tosteson, D. C. (1975) · The Journal of General Physiology · doi:10.1085/jgp.65.6.731 · Cited by 59 · see citing works
Eisner, D., Müntze, A., Kromer, E. P., & Riegger, G. A. J. (1991) · Cardiovascular Research · doi:10.1093/cvr/25.5.438 · Cited by 55 · see citing works
Nitrates in the treatment of congestive heart failure
Elkayam, U. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00188-9 · Cited by 53 · see citing works
Forfia, P. R., Zhang, X., Ochoa, F., Ochoa, M., Xu, X., Bernstein, R. D., Sehgal, P. B., Ferreri, N. R., & Hintze, T. H. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.1.h193 · Cited by 39 · see citing works
Self-citationAlteration in Energetics in Patients With Left Ventricular Dysfunction After Myocardial Infarction
Hayashi, Y., Takeuchi, M., Takaoka, H., Hata, K., Mori, M., & Yokoyama, M. (1996) · Circulation · doi:10.1161/01.cir.93.5.932 · Cited by 38 · see citing works
L-Carnitine Treatment for Congestive Heart Failure. Experimental and clinical study.
Kobayashi, A., Masumura, Y., & Yamazaki, N. (1992) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.56.86 · Cited by 36 · see citing works
Effect of nicotinic acid on exogenous myocardial glucose utilization.
Stone, C. K., Holden, J. E., Stanley, W. C., & Perlman, S. B. (1995) · PubMed · Cited by 34 · see citing works
Myocardial lipid turnover in dilated cardiomyopathy: A dual in vivo tracer approach
Feinendegen, L. E., Henrich, M. M., Kuikka, J. T., Thompson, K., Vester, E. G., & Strauer, B. E. (1995) · Journal of Nuclear Cardiology · doi:10.1016/s1071-3581(05)80007-8 · Cited by 23 · see citing works
Estimation of total rate of formation of nitric oxide in the rat
Sakinis, A., & Wennmalm, Å. (1998) · Biochemical Journal · doi:10.1042/bj3300527 · Cited by 23 · see citing works
Mechanisms of Nitrate Accumulation in Plasma during Pacing-Induced Heart Failure in Conscious Dogs
Bernstein, R. D., Zhang, X., Zhao, G., Forfia, P. R., Tuzman, J., Ochoa, F., Ochoa, M., Vogel, T. R., & Hintze, T. H. (1997) · Nitric Oxide · doi:10.1006/niox.1997.0150 · Cited by 16 · see citing works
Self-citationThe failing human heart does not release nitrogen oxides
Kaye, D. M., Chin-Dusting, J. P. F., Esler, M., & Jennings, G. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00005-8 · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 8
- De Belder AJ, Radomski MW, Why HJF, Richardson PJ, Bucknall CA, Salas E, Martin JF, Moncada S. Nitric oxide activities in human myo- cardium. Lancet. 1993;341:84 -85.
- Oser BL. Hawks Physiological Chemistry. 14th ed. New York, NY: McGraw-Hill Publishing Co; 1965:900 -905.
- Rose CP, Goresky CA. Interactions between capillary exchange, cellular entry, and metabolic sequestration processes in the heart. In: Renkin EM, Michel CC, eds. Handbook of Physiology: The Cardiovascular System, Microcirculation. Bethesda, Md: American Physiological Society; 1984: 781-798.
- Paulus WJ, Vantrimpont PJ, Shah AM. Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in man. Circulation. 1994;89:2070 -2078.
- Mery PF, Pavoine C, Belhassen L, Pecker F, Fischmeister R. Nitric oxide regulates cardiac Ca 2ϩ current. J Biol Chem. 1993;268:26286 -26295.
- Stanley WC, Lopaschuk GD, Hall JL, McCormack JG. Regulation of myocardial carbohydrate metabolism under normal and ischaemic con- ditions. Cardiovasc Res. 1997;33:243-257.
- Stone CK, Holden J, Stanley WC, Perlman SB. Effect of substrate availability upon cardiac glucose uptake. J Nucl Med. 1995;36:996 -1002.
- Paternostro G, Camici PG, Lammerstma AA, Marinho N, Baliga RR, Kooner JS, Radda GK, Ferrannini E. Cardiac and skeletal muscle insulin resistance in patients with coronary heart disease. J Clin Invest. 1996;98: 2094 -2099.
Cited by
Sorted by citations
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,180 · see citing works
Myocardial Substrate Metabolism in the Normal and Failing Heart
Stanley, W. C., Recchia, F. A., & Lopaschuk, G. D. (2005) · Physiological Reviews · doi:10.1152/physrev.00006.2004 · Cited by 2,042 · see citing works
Self-citationCardiac Energy Metabolism in Heart Failure
Lopaschuk, G. D., Karwi, Q. G., Tian, R., Wende, A. R., & Abel, E. D. (2021) · Circulation Research · doi:10.1161/circresaha.121.318241 · Cited by 1,420 · see citing works
Nelson, G. S., Berger, R. D., Fetics, B. J., Talbot, M. W., Spinelli, J., Hare, J. M., & Kass, D. A. (2000) · Circulation · doi:10.1161/01.cir.102.25.3053 · Cited by 759 · see citing works
Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697 · see citing works
Nitric Oxide and Cardiac Function
Massion, P. B., Féron, O., Dessy, C., & Balligand, J. (2003) · Circulation Research · doi:10.1161/01.res.0000088351.58510.21 · Cited by 566 · see citing works
Mitochondrial energy metabolism in heart failure: a question of balance
Huss, J. M., & Kelly, D. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24405 · Cited by 533 · see citing works
Metabolic Mechanisms in Heart Failure
Ashrafian, H., Frenneaux, M. P., & Opie, L. H. (2007) · Circulation · doi:10.1161/circulationaha.107.702795 · Cited by 517 · see citing works
Small and large animal models in cardiac contraction research: advantages and disadvantages
Milani-Nejad, N., & Janssen, P. M. L. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.007 · Cited by 484 · see citing works
Nuclear Receptor Signaling and Cardiac Energetics
Huss, J. M., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000141774.29937.e3 · Cited by 472 · see citing works
Loss of Metabolic Flexibility in the Failing Heart
Karwi, Q. G., Uddin, G. M., Ho, K. L., & Lopaschuk, G. D. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00068 · Cited by 441 · see citing works
Czubryt, M. P., McAnally, J., Fishman, G. I., & Olson, E. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337639100 · Cited by 418 · see citing works
Arrhythmia-Induced Cardiomyopathies
Gopinathannair, R., Etheridge, S. P., Marchlinski, F. E., Spinale, F. G., Lakkireddy, D., & Olshansky, B. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.08.038 · Cited by 388 · see citing works
Guazzi, M., Vicenzi, M., Arena, R. A., & Guazzi, M. D. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.944694 · Cited by 382 · see citing works
Osorio, J. C., Stanley, W. C., Linke, A., Castellari, M., Diep, Q. N., Panchal, A. R., Hintze, T. H., Lopaschuk, G. D., & Recchia, F. A. (2002) · Circulation · doi:10.1161/01.cir.0000023531.22727.c1 · Cited by 333 · see citing works
Self-citationEmerging Roles of Vascular Endothelium in Metabolic Homeostasis
Pi, X., Xie, L., & Patterson, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.313237 · Cited by 299 · see citing works
Paracrine and autocrine effects of nitric oxide on myocardial function
Shah, A. M. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00072-8 · Cited by 293 · see citing works
Metformin Prevents Progression of Heart Failure in Dogs
Sasaki, H., Asanuma, H., Fujita, M., Takahama, H., Wakeno, M., Ito, S., Ogai, A., Asakura, M., Kim, J., Minamino, T., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.798561 · Cited by 287 · see citing works
Energy Metabolism in the Normal and Failing Heart: Potential for Therapeutic Interventions
Stanley, W. C., & Chandler, M. P. (2002) · Heart Failure Reviews · doi:10.1023/a:1015320423577 · Cited by 271 · see citing works
Mitochondrial pyruvate transport: a historical perspective and future research directions
McCommis, K. S., & Finck, B. N. (2015) · Biochemical Journal · doi:10.1042/bj20141171 · Cited by 269 · see citing works
β-Adrenergic Blockade in Developing Heart Failure
Prabhu, S. D., Chandrasekar, B., Murray, D. R. P., & Freeman, G. L. (2000) · Circulation · doi:10.1161/01.cir.101.17.2103 · Cited by 265 · see citing works
Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?
VANBILSEN, M., Smeets, P. J. H., Gilde, A. J., & Vandervusse, G. J. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.11.014 · Cited by 261 · see citing works
Ritterhoff, J., & Tian, R. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00887-x · Cited by 264 · see citing works
Mechanisms for Increased Glycolysis in the Hypertrophied Rat Heart
Nascimben, L., Ingwall, J. S., Lorell, B. H., Pinz, I. M., Schultz, V., Tornheim, K., & Tian, R. (2004) · Hypertension · doi:10.1161/01.hyp.0000144292.69599.0c · Cited by 242 · see citing works
Vascular Pathophysiology in Response to Increased Heart Rate
Custodis, F., Schirmer, S. H., Baumhäkel, M., Heusch, G., Böhm, M., & Laufs, U. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.014 · Cited by 242 · see citing works
Rosca, M. G., & Hoppel, C. L. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq240 · Cited by 237 · see citing works
Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice
Jones, S. P., Greer, J. J. M., van Haperen, R., Duncker, D. J., de Crom, R., & Lefer, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0837428100 · Cited by 229 · see citing works
AMP‐activated protein kinase: role in metabolism and therapeutic implications
Schimmack, G., DeFronzo, R. A., & Musi, N. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00561.x · Cited by 229 · see citing works
Nitric oxide and cardiac function
Rastaldo, R., Pagliaro, P., Cappello, S., Penna, C. R. R., Mancardi, D., Westerhof, N., & Losano, G. A. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.07.019 · Cited by 224 · see citing works
Cardioprotection: A radical view
Penna, C. R. R., Mancardi, D., Rastaldo, R., & Pagliaro, P. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.02.008 · Cited by 219 · see citing works
Neglia, D., Caterina, A. D., Marraccini, P., Natali, A., Ciardetti, M., Vecoli, C., Gastaldelli, A., Ciociaro, D., Pellegrini, P., Testa, R., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00887.2007 · Cited by 215 · see citing works
Self-citationUngvari, Z. I., Gupte, S. A., Recchia, F. A., Bátkai, S., & Pacher, P. (2005) · Current Vascular Pharmacology · doi:10.2174/1570161054368607 · Cited by 205 · see citing works
Self-citationKanno, S., Lee, P. C., Zhang, Y., Ho, C., Griffith, B. P., Shears, L. L., & Billiar, T. R. (2000) · Circulation · doi:10.1161/01.cir.101.23.2742 · Cited by 199 · see citing works
Li, J., Hu, X., Selvakumar, P., Russell, R. R., Cushman, S. W., Holman, G. D., & Young, L. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00234.2004 · Cited by 197 · see citing works
Saavedra, W. F., Paolocci, N., John, M. E. S., Skaf, M. W., Stewart, G. C., Xie, J.-S., Harrison, R. W., Zeichner, J., Mudrick, D. W., Marbán, E., et al. (2002) · Circulation Research · doi:10.1161/hh0302.104531 · Cited by 196 · see citing works
Metabolic remodelling of the failing heart: beneficial or detrimental?
van Bilsen, M., van Nieuwenhoven, F. A., & Vusse, G. J. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn282 · Cited by 191 · see citing works
McNulty, P. H., King, N. C., Scott, S., Hartman, G., McCann, J., Kozak, M., Chambers, C. E., Demers, L. M., & Sinoway, L. I. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00625.2004 · Cited by 180 · see citing works
Nitric oxide and excitation–contraction coupling
Hare, J. M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00143-3 · Cited by 179 · see citing works
Serpillon, S., Floyd, B. C., Gupte, R. S., George, S., Kozicky, M., Neito, V., Recchia, F. A., Stanley, W. C., Wolin, M. S., & Gupte, S. A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01142.2008 · Cited by 179 · see citing works
Self-citationNitric Oxide Regulation of Myocardial Contractility and Calcium Cycling
Khan, S. A., Skaf, M. W., Harrison, R. W., Lee, K. H., Minhas, K. M., Kumar, A., Fradley, M., Shoukas, A. A., Berkowitz, D. E., & Hare, J. M. (2003) · Circulation Research · doi:10.1161/01.res.0000078171.52542.9e · Cited by 178 · see citing works
Lei, B., Lionetti, V., Young, M. E., Chandler, M. P., Agostino, C. D., Kang, E. Y., Altarejos, M., Matsuo, K., Hintze, T. H., & Stanley, W. C. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.02.004 · Cited by 172 · see citing works
Self-citationPalmitate-mediated Alterations in the Fatty Acid Metabolism of Rat Neonatal Cardiac Myocytes
Hickson-Bick, D. L. M., Buja, L. M., & McMillin, J. B. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1999.1098 · Cited by 170 · see citing works
Role of Endothelium-Derived Nitric Oxide in the Regulation of Cardiac Oxygen Metabolism
Trochu, J., Bouhour, J.-B., Kaley, G., & Hintze, T. H. (2000) · Circulation Research · doi:10.1161/01.res.87.12.1108 · Cited by 163 · see citing works
Self-citationTurer, A. T., Stevens, R. D., Bain, J. R., Muehlbauer, M. J., van der Westhuizen, J., Mathew, J. P., Schwinn, D. A., Glower, D. D., Newgard, C. B., & Podgoreanu, M. V. (2009) · Circulation · doi:10.1161/circulationaha.108.816116 · Cited by 162 · see citing works
Schroeder, M., Lau, A. Z., Chen, A. P., Gu, Y., Nagendran, J., Barry, J., Hu, X., Dyck, J. R. B., Tyler, D. J., Clarke, K., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs192 · Cited by 159 · see citing works
Endomyocardial Nitric Oxide Synthase and Left Ventricular Preload Reserve in Dilated Cardiomyopathy
Heymes, C., Vanderheyden, M., Bronzwaer, J. G. F., Shah, A. M., & Paulus, W. J. (1999) · Circulation · doi:10.1161/01.cir.99.23.3009 · Cited by 157 · see citing works
Lim, S. L., Lam, C. S. P., Segers, V. F. M., Brutsaert, D. L., & Keulenaer, G. W. D. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv132 · Cited by 149 · see citing works
Jong, K. A. D., & Lopaschuk, G. D. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.03.009 · Cited by 148 · see citing works
Coronary blood flow in heart failure: cause, consequence and bystander
Heusch, G. (2022) · Basic Research in Cardiology · doi:10.1007/s00395-022-00909-8 · Cited by 145 · see citing works
Sabbah, H. N., Chandler, M. P., Mishima, T., Suzuki, G., Chaudhry, P. A., Nass, O., Biesiadecki, B. J., Blackburn, B. K., Wolff, A. A., & Stanley, W. C. (2002) · Journal of Cardiac Failure · doi:10.1054/jcaf.2002.129232 · Cited by 142 · see citing works
Scheubel, R. J., Tostlebe, M., Simm, A., Rohrbach, S., Prondzinsky, R., Gellerich, F. N., Silber, R.-E., & Holtz, J. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02600-1 · Cited by 137 · see citing works
Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation
Chandler, M. P., Kerner, J., Huang, H., Vazquez, E. J., Reszko, A. E., Martini, W. Z., Hoppel, C. L., Imai, M., Rastogi, S., Sabbah, H. N., et al. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00281.2004 · Cited by 133 · see citing works
NO and cardiac diastolic function
Paulus, W. J. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00151-0 · Cited by 129 · see citing works
Lionetti, V., Linke, A., CHANDLER, M., Young, M. A., Penn, M. S., Gupte, S. A., d’Agostino, C., Hintze, T. H., Stanley, W. C., & Recchia, F. A. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.004 · Cited by 122 · see citing works
Self-citationFraccarollo, D., Widder, J. D., Galuppo, P., Thum, T., Tsikas, D., Hoffmann, M., Ruetten, H., Ertl, G., & Bauersachs, J. K. (2008) · Circulation · doi:10.1161/circulationaha.107.717702 · Cited by 120 · see citing works
Contrasting Inotropic Effects of Endogenous Endothelin in the Normal and Failing Human Heart
MacCarthy, P. A., Grocott-Mason, R. M., Prendergast, B., & Shah, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.2.142 · Cited by 119 · see citing works
Metabolic aspects of programmed cell survival and cell death in the heart
Depre, C. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00266-7 · Cited by 116 · see citing works
Hare, J. M., Lofthouse, R. A., Juang, G., Colman, L., Ricker, K. M., Kim, B. B., Senzaki, H., Cao, S., Tunin, R. S., & Kass, D. A. (2000) · Circulation Research · doi:10.1161/01.res.86.10.1085 · Cited by 115 · see citing works
Nitric Oxide Modulates Mitochondrial Respiration in Failing Human Heart
Loke, K. E., Laycock, S. K., Mital, S. R., Wolin, M. S., Bernstein, R. D., Oz, M. C., Addonizio, L. J., Kaley, G., & Hintze, T. H. (1999) · Circulation · doi:10.1161/01.cir.100.12.1291 · Cited by 107 · see citing works
Self-citationEfrati, S., Dishy, V., Averbukh, M., Blatt, A., Krakover, R., Weissgarten, J., Morrow, J. D., Stein, M. C., & Golik, A. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00322.x · Cited by 107 · see citing works
Therapeutic Manipulation of Myocardial Metabolism
Honka, H., Solis‐Herrera, C., Triplitt, C. L., Norton, L., Butler, J., & DeFronzo, R. A. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.02.057 · Cited by 98 · see citing works
Cotton, J. M., Kearney, M. T., MacCarthy, P. A., Grocott-Mason, R. M., McClean, D. R., Heymes, C., Richardson, P. J., & Shah, A. M. (2001) · Circulation · doi:10.1161/hc4401.098515 · Cited by 103 · see citing works
Deranged Myocardial Fatty Acid Metabolism in Heart Failure
Yamamoto, T., & Sano, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020996 · Cited by 102 · see citing works
Lee, D. I., Vahebi, S., Tocchetti, C. G., Barouch, L. A., Solaro, R. J., Takimoto, E., & Kass, D. A. (2010) · Basic Research in Cardiology · doi:10.1007/s00395-010-0084-5 · Cited by 101 · see citing works
Nitric Oxide Synthases in the Failing Human Heart
Drexler, H. (1999) · Circulation · doi:10.1161/01.cir.99.23.2972 · Cited by 101 · see citing works
Adler, A., Messina, E. J., Sherman, B., Wang, Z., Huang, H., Linke, A., & Hintze, T. H. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01047.2002 · Cited by 100 · see citing works
Self-citationWink, D. A., Miranda, K. M., Katori, T., Mancardi, D., Thomas, D. D., Ridnour, L. A., Espey, M. G., Feelisch, M., Colton, C. A., Fukuto, J. M., et al. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00531.2003 · Cited by 98 · see citing works
Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs
Mital, S. R., Zhang, X., Zhao, G., Bernstein, R. D., Smith, C. J., Fulton, D. J., Sessa, W. C., Liao, J. K., & Hintze, T. H. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.6.h2649 · Cited by 98 · see citing works
Self-citationCicoira, M., Zanolla, L., Rossi, A., Golia, G., Franceschini, L., Brighetti, G., Zeni, P., & Zardini, P. (2002) · American Heart Journal · doi:10.1067/mhj.2002.122122 · Cited by 97 · see citing works
Pepe, M., Mamdani, M., Zentilin, L., Csiszar, A., Qanud, K., Zacchigna, S., Ungvari, Z., Puligadda, U., Moimas, S., Xu, X., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.220855 · Cited by 93 · see citing works
Self-citationProteomic and metabolomic analysis of atrial profibrillatory remodelling in congestive heart failure
Souza, A. I. D., Cardin, S., Wait, R., Chung, Y., Vijayakumar, M., Maguy, A., Camm, A. J., & Nattel, S. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.07.008 · Cited by 89 · see citing works
Metabolic remodelling in human heart failure
Tuunanen, H., & Knuuti, J. M. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr052 · Cited by 88 · see citing works
Metabolic remodeling in hypertrophied and failing myocardium: a review
Peterzan, M. A., Lygate, C. A., Neubauer, S., & Rider, O. J. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00731.2016 · Cited by 88 · see citing works
Adrenoreceptors and nitric oxide in the cardiovascular system
Conti, V., Russomanno, G., Corbi, G., Izzo, V., Vecchione, C., & Filippelli, A. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00321 · Cited by 87 · see citing works
Animal Models of Dilated Cardiomyopathy for Translational Research
Recchia, F. A., & Lionetti, V. (2007) · Veterinary Research Communications · doi:10.1007/s11259-007-0005-8 · Cited by 85 · see citing works
Self-citationPremature death and age-related cardiac dysfunction in male eNOS-knockout mice
Li, W., Mital, S. R., Ojaimi, C., Csiszár, A., Kaley, G., & Hintze, T. H. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.05.005 · Cited by 84 · see citing works
Self-citationTada, H., Thompson, C. I., Recchia, F. A., Loke, K. E., Ochoa, M., Smith, C. J., Shesely, E. G., Kaley, G., & Hintze, T. H. (2000) · Circulation Research · doi:10.1161/01.res.86.3.270 · Cited by 84 · see citing works
Self-citationNitric oxide's role in the heart: control of beating or breathing?
Paulus, W. J., & Bronzwaer, J. G. F. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01147.2003 · Cited by 82 · see citing works
Arimoto, T., Takeishi, Y., Shiga, R., Fukui, A., Tachibana, H., Nozaki, N., Hirono, O., Nitobe, J., Miyamoto, T., Hoit, B. D., et al. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2004.03.005 · Cited by 81 · see citing works
Preservation of NO production by statins in the treatment of heart failure
Trochu, J. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.08.003 · Cited by 80 · see citing works
Kakinuma, Y., Miyauchi, T., Yuki, K., Murakoshi, N., Goto, K., & Yamaguchi, I. (2001) · Circulation · doi:10.1161/01.cir.103.19.2387 · Cited by 80 · see citing works
Suematsu, N., Ojaimi, C., Kinugawa, S., Wang, Z., Xu, X., Koller, Á., Recchia, F. A., & Hintze, T. H. (2007) · Circulation · doi:10.1161/circulationaha.106.652693 · Cited by 74 · see citing works
Self-citationNitric oxide controls cardiac substrate utilization in the conscious dog
Recchia, F. A. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00245-x · Cited by 73 · see citing works
Self-citationSaitoh, M., Osanai, T., Kamada, T., Matsunaga, T., Ishizaka, H., Hanada, H., & Okumura, K. (2003) · Heart and Vessels · doi:10.1007/s00380-003-0715-y · Cited by 70 · see citing works
Impact of the renin–angiotensin system on cardiac energy metabolism in heart failure
Mori, J., Zhang, L., Oudit, G. Y., & Lopaschuk, G. D. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.07.010 · Cited by 65 · see citing works
Intracoronary Cytoprotective Gene Therapy
Woitek, F. J., Zentilin, L., Hoffman, N. E., Powers, J., Ottiger, I., Parikh, S., Kulczycki, A. M., Hurst, M., Ring, N., Wang, T., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.04.071 · Cited by 65 · see citing works
Self-citationHeart Failure and Loss of Metabolic Control
Wang, Z. V., Li, D. ‘., & Hill, J. A. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000054 · Cited by 62 · see citing works
MacCarthy, P. A., & Shah, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.15.1854 · Cited by 62 · see citing works
Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts
Chen, Y., Li, Y., Zhang, P., Traverse, J. H., Hou, M., Xu, X. Y., Kimoto, M., & Bache, R. J. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00224.2005 · Cited by 62 · see citing works
Self-citationVarga, E., Bodi, A., Ferdinándy, P., Droy‐Lefaix, M., Blasig, I. E., & Tósaki, Á. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199911000-00013 · Cited by 62 · see citing works
Nitric Oxide Protects Against Pathological Ventricular Remodeling
Prabhu, S. D. (2004) · Circulation Research · doi:10.1161/01.res.0000129569.07667.89 · Cited by 62 · see citing works
Lionetti, V., Guiducci, L., Simioniuc, A., Aquaro, G. D., Simi, C., Marchi, D. D., Burchielli, S., Pratali, L., Piacenti, M., Lombardi, M., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00592.2007 · Cited by 61 · see citing works
Self-citationSeki, M., Powers, J. C., Maruyama, S., Zuriaga, M. A., Wu, C.-L., Kurishima, C., Kim, L., Johnson, J., Poidomani, A., Wang, T., et al. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004486 · Cited by 59 · see citing works
Self-citationHankins, J. S., McCarville, M. B., Hillenbrand, C. M., Loeffler, R. B., Ware, R. E., Song, R., Smeltzer, M. P., & Joshi, V. M. (2010) · Pediatric Blood & Cancer · doi:10.1002/pbc.22587 · Cited by 59 · see citing works
Rottman, J. N., Bracy, D. P., Malabanan, C. M., Yue, Z., Clanton, J., & Wasserman, D. H. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00545.2001 · Cited by 58 · see citing works
Recchia, F. A., Osorio, J. C., Chandler, M. P., Xu, X., Panchal, A. R., Lopaschuk, G. D., Hintze, T. H., & Stanley, W. C. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e197 · Cited by 58 · see citing works
Self-citationZhang, H., Zang, Y.-M., Huo, J., Liang, S.-J., Zhang, H., Wang, Y.-M., Fan, Q., Guo, W., Wang, H., & Gao, F. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000249873.73197.c3 · Cited by 57 · see citing works
The Role of Nitric Oxide in the Failing Heart
Paulus, W. J. (2001) · Heart Failure Reviews · doi:10.1023/a:1011453809750 · Cited by 57 · see citing works
Andreou, I., Tousoulis, D., Tentolouris, C. A., Antoniades, C. A., & Stefanadis, C. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.06.021 · Cited by 56 · see citing works
Lei, B., Matsuo, K., Labinskyy, V., Sharma, N., Chandler, M. P., Ahn, A. N., Hintze, T. H., Stanley, W. C., & Recchia, F. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500768102 · Cited by 55 · see citing works
Self-citation
- Authors
- Recchia, F. A., McConnell, P. I., Bernstein, R. D., Vogel, T. R., Xu, X., & Hintze, T. H.
- Affiliations
- New York Medical College (US)
- Venue
- Circulation Research
- Published
- 1998-11-16
- Volume
- 83
- Issue
- 10
- Pages
- 969-979
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2033767220
- Cited by
- 302
- References
- 59
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 4 · 2015: 10 · 2014: 5 · 2013: 10 · 2012: 6
- FWCI
- 12.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Funders
- Sarnoff Cardiovascular Research Foundation
- National Heart, Lung, and Blood Institute (R01 HL 50142, P01 HL 43023)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- nitric oxide production, pacing-induced heart failure, myocardial metabolism, oxygen consumption, free fatty acid uptake, glucose uptake, lactate utilization, respiratory quotient, nitro-L-arginine, nitric oxide synthase inhibition, left ventricular end-diastolic pressure, coronary sinus blood flow, conscious dogs, heart failure decompensation, substrate utilization
- MeSH terms
- Animals, Blood Pressure, Carbon Dioxide, Consciousness, Diastole, Dogs, Fatty Acids, Nonesterified, Glucose, Heart Failure, Male, Myocardium, Nitric Oxide, Oxygen Consumption, Pacemaker, Artificial, Respiration, Systole, Muscle Fibers, Skeletal, Ventricular Dysfunction, Left, Nitric Oxide Synthase, Nitroarginine, Lactic Acid, Nitric Oxide Synthase Type II
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
