CoChat
Sign Up
Cited by 317Nitric Oxide and Endothelin EffectsHemoglobin structure and functionCardiovascular and exercise physiology

Role of nitric oxide in the regulation of oxygen consumption in conscious dogs.

Open access
Shen, W, Xu, X, Ochoa, M, Zhao, G, Wolin, M S, Hintze, T H·1994·Circulation Research
DOI 10.1161/01.res.75.6.1086
Open this paper in CoChat — free accountOpen PDF

Abstract

The role of nitric oxide (NO) in the regulation of O2 consumption was studied in chronically instrumented conscious dogs. A specific NO synthesis inhibitor, nitro-L-arginine (NLA, 30 mg/kg i.v.), significantly increased mean arterial pressure from 100 +/- 4 to 134 +/- 5 mm Hg (mean +/- SEM) and total peripheral resistance by 157 +/- 16% and reduced cardiac output by 47 +/- 3% and heart rate by 34 +/- 6% after 120 minutes. Changes in arterial blood gases were not observed. There were significant changes in PO2 (-14 +/- 2 mm Hg), O2 saturation (-21 +/- 2%), the percentage of hemoglobin as oxyhemoglobin (-21 +/- 2%), and O2 content (-3.0 +/- 0.9 vol%) and a significant increase in percent reduced hemoglobin (21 +/- 1%) in mixed venous blood, associated with an increase in O2 extraction (5.1 +/- 0.2 vol%) (all P < .01). O2 consumption was increased from 124 +/- 6 to 155 +/- 9 mL/min (P < .05). Methoxamine, titrated to have hemodynamic effects similar to those of NLA (eg, mean arterial pressure increased from 97 +/- 4 to 131 +/- 5 mm Hg), had much smaller effects on venous blood gases, hemoglobin, and O2 extraction (2.3 +/- 0.7 vol%) and no significant effect on O2 consumption. NLA also caused an increase in O2 consumption of 37 +/- 8% (P < .01) in quietly resting conscious dogs that had undergone pretreatment with hexamethonium and atropine, but no significant change in O2 consumption in dogs anesthetized with barbiturate.(ABSTRACT TRUNCATED AT 250 WORDS)

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/01.res.75.6.1086

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In vivo, NOS inhibition increases oxygen consumption in dogs and rats.

    “In vivo, NOS inhibition, which would reduce endogenous NO production, increases oxygen consumption () in dogs [20] and rats [21]”

    From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [20]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 34 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

  1. Drapier SR, Hibbs JB. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. J Clin Invest. 1986;78:790-797.
  2. Geng YJ, Hansson GK, Holme E. Interferon-y and tumor necrosis factor synergize to induce nitric oxide production and inhibit mito- chondrial respiration in vascular smooth muscle cells. Circ Res. 1992;71:1268-1276.
  3. Shen W, Wang J, Xu X, Hintze TH. EDRF-mediated coronary dilation following carotid chemoreflex stimulation in conscious dogs. FASEB J. 1993;7:A213. Abstract.
  4. Hintze TH, Shen W, Wang J, Lundborg M. Role of EDRF/shear rate in the control of blood flow during exercise. JAm Coll Cardiol. 1993;21:432A. Abstract.
  5. Sakuma I, Togashi H, Yoshioka M, Saito H, Yanagida M, Tamura M, Kobayashi T, Yasuda H, Gross SS, Levi R. N0-methyl-L- arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo: a role for nitric oxide in the central regulation of sympathetic tone? Circ Res. 1992;70:607-61 1.
  6. Buxton IL, Cheek DL, Eckman D, Westfall DP, Sanders KM, Keef KD. N-Nitro-L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ Res. 1993;72: 387-395. Downloaded from http://ahajournals.org by on March 9, 2024

Cited by

Sorted by citations

Related

Authors
Shen, W., Xu, X., Ochoa, M., Zhao, G., Wolin, M. S., & Hintze, T. H.
Affiliations
New York Medical College (US)
ORCID
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1994-12
Volume
75
Issue
6
Pages
1086-1095
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/01.res.75.6.1086
OpenAlex
W2059418292
Cited by
317
References
34
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 8 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 5
FWCI
9.29
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • National Heart, Lung, and Blood Institute (HL50142, P01HL043023, P01 HL 43023, HL 43023, R01HL050142, HL-31068)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
nitric oxide, oxygen consumption, nitric oxide synthase inhibition, nitro-L-arginine, methoxamine, oxygen extraction, hemodynamics, arterial blood gases, hemoglobin decrease, conscious dogs
MeSH terms
Amino Acid Oxidoreductases, Animals, Arginine, Cardiac Output, Consciousness, Dogs, Hemodynamics, Methoxamine, Nitric Oxide, Oxygen Consumption, Time Factors, Nitric Oxide Synthase, Nitroarginine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review