The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Mice With Disrupted BK Channel β1 Subunit Gene Feature Abnormal Ca 2+ Spark/STOC Coupling and Elevated Blood Pressure
Abstract
Abstract —Large-conductance potassium (BK) channels in vascular smooth muscle cells (VSMCs) sense both changes in membrane potential and in intracellular Ca 2+ concentration. BK channels may serve as negative feedback regulators of vascular tone by linking membrane depolarization and local increases in intracellular Ca 2+ concentration (Ca 2+ sparks) to repolarizing spontaneous transient outward K + currents (STOCs). BK channels are composed of channel-forming BKα and auxiliary BKβ1 subunits, which confer to BK channels an increased sensitivity for changes in membrane potential and Ca 2+ . To assess the in vivo functions of this β subunit, mice with a disrupted BKβ1 gene were generated. Cerebral artery VSMCs from BKβ1 −/− mice generated Ca 2+ sparks of normal amplitude and frequency, but STOC frequencies were largely reduced at physiological membrane potentials. Our results indicate that BKβ1 −/− mice have an abnormal Ca 2+ spark/STOC coupling that is shifted to more depolarized potentials. Thoracic aortic rings from BKβ1 −/− mice responded to agonist and elevated KCl with an increased contractility. BKβ1 −/− mice had higher systemic blood pressure than BKβ1 +/+ mice but responded normally to α 1 -adrenergic vasoconstriction and nitric oxide–mediated vasodilation. We propose that the elevated blood pressure in BKβ1 −/− mice serves to normalize Ca 2+ spark/STOC coupling for regulating myogenic tone. The full text of this article is available at http://www.circresaha.org.
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Cites
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Metadata
- Authors
- Plüger, S., Faulhaber, J., Fürstenau, M., Löhn, M., Waldschütz, R., Gollasch, M., Haller, H., Luft, F. C., Ehmke, H., & Pongs, O.
- Venue
- Circulation Research
- Published
- 2000-11-24
- Volume
- 87
- Issue
- 11
- Pages
- E53-60
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2164566530
- Cited by
- 342
- References
- 33
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Plüger, S., Faulhaber, J., Fürstenau, M., Löhn, M., Waldschütz, R., Gollasch, M., Haller, H., Luft, F. C., Ehmke, H., & Pongs, O. (2000). Mice With Disrupted BK Channel β1 Subunit Gene Feature Abnormal Ca 2+ Spark/STOC Coupling and Elevated Blood Pressure. Circulation Research. https://doi.org/10.1161/01.res.87.11.e53
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