The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Carotid Plaque Area: A Tool for Targeting and Evaluating Vascular Preventive Therapy
Abstract
Background and Purpose— Carotid plaque area measured by ultrasound (cross-sectional area of longitudinal views of all plaques seen) was studied as a way of identifying patients at increased risk of stroke, myocardial infarction, and vascular death. Methods— Patients from an atherosclerosis prevention clinic were followed up annually for up to 5 years (mean, 2.5±1.3 years) with baseline and follow-up measurements recorded. Plaque area progression (or regression) was defined as an increase (or decrease) of ≥0.05 cm 2 from baseline. Results— Carotid plaque areas from 1686 patients were categorized into 4 quartile ranges: 0.00 to 0.11 cm 2 (n=422), 0.12 to 0.45 cm 2 (n=424), 0.46 to 1.18 cm 2 (n=421), and 1.19 to 6.73 cm 2 (n=419). The combined 5-year risk of stroke, myocardial infarction, and vascular death increased by quartile of plaque area: 5.6%, 10.7%, 13.9%, and 19.5%, respectively ( P <0.001) after adjustment for all baseline patient characteristics. A total of 1085 patients had ≥1 annual carotid plaque area measurements: 685 (63.1%) had carotid plaque progression, 306 (28.2%) had plaque regression, and 176 (16.2%) had no change in carotid plaque area over the period of follow-up. The 5-year adjusted risk of combined outcome was 9.4%, 7.6%, and 15.7% for patients with carotid plaque area regression, no change, and progression, respectively ( P =0.003). Conclusions— Carotid plaque area and progression of plaque identified high-risk patients. Plaque measurement may be useful for targeting preventive therapy and evaluating new treatments and response to therapy and may improve cost-effectiveness of secondary preventive treatment.
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Cites
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
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An Assessment of Clinically Useful Measures of the Consequences of Treatment
Laupacis, A., Sackett, D. L., & Roberts, R. S. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806303182605 · Cited by 1,681
Regression Analysis of Grouped Survival Data with Application to Breast Cancer Data
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Three-dimensional ultrasound imaging
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Psychological stress and the progression of carotid artery disease
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Self-citationPassive smoking as well as active smoking increases the risk of acute stroke
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Cited by
Baber, U., Mehran, R., Sartori, S., Schoos, M. M., Sillesen, H., Muntendam, P., Garcia, M. J., Gregson, J., Pocock, S., Falk, E., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.01.017 · Cited by 461
Chan, S. Y., Mancini, G. B. J., Kuramoto, L., Schulzer, M., Frohlich, J., & Ignaszewski, A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00927-6 · Cited by 326
Sillesen, H., Sartori, S., Sandholt, B., Baber, U., Mehran, R., & Fuster, V. (2018) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jex239 · Cited by 204
Egg yolk consumption and carotid plaque
Spence, J. D., Jenkins, D. J. A., & Davignon, J. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.07.032 · Cited by 85
Self-citationZhan, C., Shi, M., Yang, Y., Pang, H., Fei, S., Bai, L., Liu, B., Tu, J., Huo, Y., Ning, X., et al. (2016) · Scientific Reports · doi:10.1038/srep23870 · Cited by 41
Metadata
- Authors
- Spence, J. D., Eliasziw, M., DiCicco, M., Hackam, D. G., Galil, R., & Lohmann, T.
- Venue
- Stroke
- Published
- 2002-12
- Volume
- 33
- Issue
- 12
- Pages
- 2916-2922
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2125096763
- Cited by
- 587
- References
- 24
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- closed
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