Cited by 1,081Stroke Rehabilitation and RecoveryAcute Ischemic Stroke ManagementMedical Practices and Rehabilitation

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Effects of Augmented Exercise Therapy Time After Stroke: A Meta-Analysis

Kwakkel, Gert, van Peppen, Roland, Wagenaar, Robert C., Wood Dauphinee, Sharon, Richards, Carol, Ashburn, Ann, Miller, Kimberly, Lincoln, Nadina, Partridge, Cecily, Wellwood, Ian, Langhorne, Peter·2004·Stroke

DOI 10.1161/01.str.0000143153.76460.7d

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Abstract

Background and Purpose— To present a systematic review of studies that addresses the effects of intensity of augmented exercise therapy time (AETT) on activities of daily living (ADL), walking, and dexterity in patients with stroke. Summary of Review— A database of articles published from 1966 to November 2003 was compiled from MEDLINE, CINAHL, Cochrane Central Register of Controlled Trials, PEDro, DARE, and PiCarta using combinations of the following key words: stroke, cerebrovascular disorders, physical therapy, physiotherapy, occupational therapy, exercise therapy, rehabilitation, intensity, dose–response relationship, effectiveness, and randomized controlled trial. References presented in relevant publications were examined as well as abstracts in proceedings. Studies that satisfied the following selection criteria were included: (1) patients had a diagnosis of stroke; (2) effects of intensity of exercise training were investigated; and (3) design of the study was a randomized controlled trial (RCT). For each outcome measure, the estimated effect size (ES) and the summary effect size (SES) expressed in standard deviation units (SDU) were calculated for ADL, walking speed, and dexterity using fixed and random effect models. Correlation coefficients were calculated between observed individual effect sizes on ADL of each study, additional time spent on exercise training, and methodological quality. Cumulative meta-analyses (random effects model) adjusted for the difference in treatment intensity in each study was used for the trials evaluating the effects of AETT provided. Twenty of the 31 candidate studies, involving 2686 stroke patients, were included in the synthesis. The methodological quality ranged from 2 to 10 out of the maximum score of 14 points. The meta-analysis resulted in a small but statistically significant SES with regard to ADL measured at the end of the intervention phase. Further analysis showed a significant homogeneous SES for 17 studies that investigated effects of increased exercise intensity within the first 6 months after stroke. No significant SES was observed for the 3 studies conducted in the chronic phase. Cumulative meta-analysis strongly suggests that at least a 16-hour difference in treatment time between experimental and control groups provided in the first 6 months after stroke is needed to obtain significant differences in ADL. A significant SES supporting a higher intensity was also observed for instrumental ADL and walking speed, whereas no significant SES was found for dexterity. Conclusion— The results of the present research synthesis support the hypothesis that augmented exercise therapy has a small but favorable effect on ADL, particularly if therapy input is augmented at least 16 hours within the first 6 months after stroke. This meta-analysis also suggests that clinically relevant treatment effects may be achieved on instrumental ADL and gait speed.

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Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Book Reviews: Statistical Methods for Meta-Analysis Larry V. Hedges and Ingram Olkin New York: Academic Press, 1985. xxii + 369 pp
Wasserman, S. S., Hedges, L. V., & Olkin, I. (1988) · Journal of Educational Statistics · doi:10.2307/1164953 · Cited by 10,377
The Handbook of Research Synthesis.
Howel, D., Cooper, H., & Hedges, L. V. (1995) · Biometrics · doi:10.2307/2533295 · Cited by 3,657
Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders.
(1989) · Stroke · doi:10.1161/01.str.20.10.1407 · Cited by 1,543
Probability of Regaining Dexterity in the Flaccid Upper Limb
Kwakkel, G., Kollen, B. J., van der Grond, J., & Prevo, A. J. H. (2003) · Stroke · doi:10.1161/01.str.0000087172.16305.cd · Cited by 1,409
Self-citation
A controlled trial
Kennedy, C. O. (1971) · British Homeopathic journal · doi:10.1016/s0007-0785(71)80027-3 · Cited by 976
Intensity of leg and arm training after primary middle-cerebral-artery stroke: a randomised trial
Kwakkel, G., WAGENAAR, R. C., Twisk, J. W. R., Lankhorst, G. J., & Koetsier, J. C. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09477-x · Cited by 931
Self-citation
Task-related circuit training improves performance of locomotor tasks in chronic stroke: A randomized, controlled pilot trial
Dean, C. M., Richards, C. L., & Malouin, F. (2000) · Archives of Physical Medicine and Rehabilitation · doi:10.1053/mr.2000.3839 · Cited by 666
Self-citation
Effects of Intensity of Rehabilitation After Stroke
Kwakkel, G., WAGENAAR, R. C., Koelman, T. W., Lankhorst, G. J., & Koetsier, J. C. (1997) · Stroke · doi:10.1161/01.str.28.8.1550 · Cited by 588
Self-citation

Show all 54 references

Research works printed but not linked: 8

10.1161/str.32.1.268 · DOI
10.1161/str.28.8.1550 · DOI
10.1161/str.30.3.573 · DOI
10.1161/str.29.4.785 · DOI
10.1161/str.20.10.2799873 · DOI
Hedges L Olkin I. Statistical Methods for Meta-analysis. Orlanda Fla: Academic Press; 1985.
Raudenbush S. Random effects model. In: Cooper H Hedges LV eds. The Handbook of Research Synthesis. New York: Russell Sage Foundation; 1994: 301–323.
10.1161/str.16.6.3911506 · DOI

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van der Kooij, H., Veneman, J. F., & Ekkelenkamp, R. (2006) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2006.259397 · Cited by 37
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Wirz, M., Mach, O., Maier, D. D., Benito-Penalva, J., Taylor, J., Esclarín, A., Dietz, V., & the EMSCI Network (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4643 · Cited by 36
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Tyson, S. F., Wilkinson, J., Thomas, N., Selles, R. W., McCabe, C., Tyrrell, P. J., & Vail, A. (2015) · Neurorehabilitation and neural repair · doi:10.1177/1545968314565513 · Cited by 36
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Ramas, J., Courbon, A., Roche, F., Béthoux, F., & Calmels, P. (2007) · Annales de Réadaptation et de Médecine Physique · doi:10.1016/j.annrmp.2007.04.006 · Cited by 36
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Yeong, C. F., Melendez-Calderon, A., Gassert, R., & Burdet, E. (2009) · IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) · doi:10.1109/iros.2009.5354837 · Cited by 36
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Clinical Practice Guideline for Stroke Rehabilitation in Korea
Kim, Y., Han, T. R., Jung, H. Y., Chun, M. H., Lee, J., Kim, D. Y., Paik, N., Park, S.-W., Kim, M.-W., Pyun, S., et al. (2009) · Brain & Neurorehabilitation · doi:10.12786/bn.2009.2.1.1 · Cited by 35
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Standen, P., Brown, D. J., Battersby, S., Walker, M. F., Connell, L., Richardson, A., Platts, F., Threapleton, K., & Burton, A. (2011) · International Journal on Disability and Human Development · doi:10.1515/ijdhd.2011.063 · Cited by 35
Principles of neuroplasticity and behavior
Kolb, B. E., & Gibb, R. L. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9781316529898.003 · Cited by 35
Designing inclusive interactions
Langdon, P., Clarkson, P. J., & Robinson, P. (2013) · Universal Access in the Information Society · doi:10.1007/s10209-013-0289-0 · Cited by 35
Interventions to Improve Movement and Functional Outcomes in Adult Stroke Rehabilitation: Review and Evidence Summary
Lin, S. H., & Dionne, T. P. (2018) · Journal of Participatory Medicine · doi:10.2196/jopm.8929 · Cited by 34
Spatiotemporal gait characteristic changes with gait training using the hybrid assistive limb for chronic stroke patients
Tanaka, H., Nankaku, M., Nishikawa, T., Hosoe, T., Yonezawa, H., Mori, H., Kikuchi, T., Nishi, H., Takagi, Y., Miyamoto, S., et al. (2019) · Gait & Posture · doi:10.1016/j.gaitpost.2019.05.003 · Cited by 34
Additional, Mechanized Upper Limb Self-Rehabilitation in Patients With Subacute Stroke: The REM-AVC Randomized Trial
Rémy‐Néris, O., Jeannic, A. L., Dion, A., Médée, B., Nowak, E., Poiroux, É., Durand‐Zaleski, I., Beis, J.-M., Bensmaïl, D., Benaïm, C., et al. (2021) · Stroke · doi:10.1161/strokeaha.120.032545 · Cited by 34
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Dutta, D., Aruchamy, S., Mandal, S., & Sen, S. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3110432 · Cited by 34
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Luque-Moreno, C., Kiper, P., Marcos, I. S., Agostini, M., Polli, A., Turolla, A., & Oliva‐Pascual‐Vaca, Á. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111210 · Cited by 34
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Functional strength training and movement performance therapy produce analogous improvement in sit-to-stand early after stroke: early-phase randomised controlled trial
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Strømmen, A. M., Christensen, T., & Jensen, K. (2014) · Stroke · doi:10.1161/strokeaha.114.006496 · Cited by 33
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Kamo, T., Momosaki, R., Suzuki, K., Asahi, R., Azami, M., Ogihara, H., & Nishida, Y. (2019) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2019.06.007 · Cited by 36
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Colombo, R., Raglio, A., Panigazzi, M., Mazzone, A., Bazzini, G., Imarisio, C., Molteni, D., Caltagirone, C., & Imbriani, M. (2019) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2019.2905076 · Cited by 33
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Ringleb, P. A., Schellinger, P. D., & Hacke, W. (2008) · Der Nervenarzt · doi:10.1007/s00115-008-2531-1 · Cited by 34
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Walker, M. F. (2007) · Acta Dermato Venereologica · doi:10.2340/16501977-0063 · Cited by 29
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New, P. W., & Poulos, C. J. (2008) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2008.tb02058.x · Cited by 29
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Signal, N., McLaren, R., Rashid, U., Vandal, A. C., King, M., Almesfer, F., Henderson, J., & Taylor, D. (2020) · JMIR mhealth and uhealth · doi:10.2196/17036 · Cited by 28
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Authors: Kwakkel, G., van Peppen, R., Wagenaar, R. C., Wood Dauphinee, S., Richards, C., Ashburn, A., Miller, K., Lincoln, N., Partridge, C., Wellwood, I., & Langhorne, P.
Affiliations: Boston University (US)
From the Department of Physical Therapy and Research Institute for Fundamental and Clinical Human Movement Sciences (G.K., R.v.P.), VU University Medical Center, Amsterdam, the Netherlands; the Center of Excellence for Rehabilitation Medicine “De Hoogstraat” (G.K.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; the Department of Rehabilitation Sciences and Center for Neurorehabilitation (R.C.W.), Sargent College of Health and Rehabilitation Sciences,...
ORCID: Kwakkel, Gert
Wagenaar, Robert C.
Richards, Carol
Ashburn, Ann
Miller, Kimberly
Lincoln, Nadina
Wellwood, Ian
Langhorne, Peter
Venue: Stroke
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-11
Volume: 35
Issue: 11
Pages: 2529-2539
ISSN: 0039-2499 (ISSN-L)
1524-4628
DOI: 10.1161/01.str.0000143153.76460.7d
OpenAlex: W2141635852
Cited by: 1,081
References: 54
Citations by year: 2026: 30 · 2025: 39 · 2024: 30 · 2023: 32 · 2022: 53 · 2021: 59 · 2020: 52 · 2019: 56 · 2018: 57 · 2017: 47 · 2016: 56 · 2015: 73 · 2014: 70 · 2013: 51 · 2012: 55
FWCI: 4.83
Type: journal article
Language: en
Open access: closed
Locations: Stroke (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Kent Academic Repository (University of Kent) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: ZonMw
Koninklijk Nederlands Genootschap voor Fysiotherapie
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
Keywords: stroke rehabilitation, exercise therapy, treatment intensity, dose-response relationship, activities of daily living, walking speed, dexterity, instrumental activities of daily living, early rehabilitation, chronic stroke, treatment duration, walking training, upper limb training, gait training, balance training, stroke mortality, stroke recurrence, stroke complications, stroke risk factors
MeSH terms: Stroke Rehabilitation, Activities of Daily Living, Exercise Therapy, Humans

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Effects of Augmented Exercise Therapy Time After Stroke: A Meta-Analysis

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