Cited by 1,081Stroke Rehabilitation and RecoveryAcute Ischemic Stroke ManagementMedical Practices and Rehabilitation

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Effects of Augmented Exercise Therapy Time After Stroke: A Meta-Analysis

Kwakkel, Gert, van Peppen, Roland, Wagenaar, Robert C., Wood Dauphinee, Sharon, Richards, Carol, Ashburn, Ann, Miller, Kimberly, Lincoln, Nadina, Partridge, Cecily, Wellwood, Ian, Langhorne, Peter·2004·Stroke

DOI 10.1161/01.str.0000143153.76460.7d

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Abstract

Background and Purpose— To present a systematic review of studies that addresses the effects of intensity of augmented exercise therapy time (AETT) on activities of daily living (ADL), walking, and dexterity in patients with stroke. Summary of Review— A database of articles published from 1966 to November 2003 was compiled from MEDLINE, CINAHL, Cochrane Central Register of Controlled Trials, PEDro, DARE, and PiCarta using combinations of the following key words: stroke, cerebrovascular disorders, physical therapy, physiotherapy, occupational therapy, exercise therapy, rehabilitation, intensity, dose–response relationship, effectiveness, and randomized controlled trial. References presented in relevant publications were examined as well as abstracts in proceedings. Studies that satisfied the following selection criteria were included: (1) patients had a diagnosis of stroke; (2) effects of intensity of exercise training were investigated; and (3) design of the study was a randomized controlled trial (RCT). For each outcome measure, the estimated effect size (ES) and the summary effect size (SES) expressed in standard deviation units (SDU) were calculated for ADL, walking speed, and dexterity using fixed and random effect models. Correlation coefficients were calculated between observed individual effect sizes on ADL of each study, additional time spent on exercise training, and methodological quality. Cumulative meta-analyses (random effects model) adjusted for the difference in treatment intensity in each study was used for the trials evaluating the effects of AETT provided. Twenty of the 31 candidate studies, involving 2686 stroke patients, were included in the synthesis. The methodological quality ranged from 2 to 10 out of the maximum score of 14 points. The meta-analysis resulted in a small but statistically significant SES with regard to ADL measured at the end of the intervention phase. Further analysis showed a significant homogeneous SES for 17 studies that investigated effects of increased exercise intensity within the first 6 months after stroke. No significant SES was observed for the 3 studies conducted in the chronic phase. Cumulative meta-analysis strongly suggests that at least a 16-hour difference in treatment time between experimental and control groups provided in the first 6 months after stroke is needed to obtain significant differences in ADL. A significant SES supporting a higher intensity was also observed for instrumental ADL and walking speed, whereas no significant SES was found for dexterity. Conclusion— The results of the present research synthesis support the hypothesis that augmented exercise therapy has a small but favorable effect on ADL, particularly if therapy input is augmented at least 16 hours within the first 6 months after stroke. This meta-analysis also suggests that clinically relevant treatment effects may be achieved on instrumental ADL and gait speed.

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Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Book Reviews: Statistical Methods for Meta-Analysis Larry V. Hedges and Ingram Olkin New York: Academic Press, 1985. xxii + 369 pp
Wasserman, S. S., Hedges, L. V., & Olkin, I. (1988) · Journal of Educational Statistics · doi:10.2307/1164953 · Cited by 10,377
The Handbook of Research Synthesis.
Howel, D., Cooper, H., & Hedges, L. V. (1995) · Biometrics · doi:10.2307/2533295 · Cited by 3,657
Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders.
(1989) · Stroke · doi:10.1161/01.str.20.10.1407 · Cited by 1,543
Probability of Regaining Dexterity in the Flaccid Upper Limb
Kwakkel, G., Kollen, B. J., van der Grond, J., & Prevo, A. J. H. (2003) · Stroke · doi:10.1161/01.str.0000087172.16305.cd · Cited by 1,409
Self-citation
A controlled trial
Kennedy, C. O. (1971) · British Homeopathic journal · doi:10.1016/s0007-0785(71)80027-3 · Cited by 976
Intensity of leg and arm training after primary middle-cerebral-artery stroke: a randomised trial
Kwakkel, G., WAGENAAR, R. C., Twisk, J. W. R., Lankhorst, G. J., & Koetsier, J. C. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09477-x · Cited by 931
Self-citation
Task-related circuit training improves performance of locomotor tasks in chronic stroke: A randomized, controlled pilot trial
Dean, C. M., Richards, C. L., & Malouin, F. (2000) · Archives of Physical Medicine and Rehabilitation · doi:10.1053/mr.2000.3839 · Cited by 666
Self-citation
Effects of Intensity of Rehabilitation After Stroke
Kwakkel, G., WAGENAAR, R. C., Koelman, T. W., Lankhorst, G. J., & Koetsier, J. C. (1997) · Stroke · doi:10.1161/01.str.28.8.1550 · Cited by 588
Self-citation

Show all 54 references

Research works printed but not linked: 8

10.1161/str.32.1.268 · DOI
10.1161/str.28.8.1550 · DOI
10.1161/str.30.3.573 · DOI
10.1161/str.29.4.785 · DOI
10.1161/str.20.10.2799873 · DOI
Hedges L Olkin I. Statistical Methods for Meta-analysis. Orlanda Fla: Academic Press; 1985.
Raudenbush S. Random effects model. In: Cooper H Hedges LV eds. The Handbook of Research Synthesis. New York: Russell Sage Foundation; 1994: 301–323.
10.1161/str.16.6.3911506 · DOI

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Ji, S.-G., Nam, G.-W., Kim, M.-K., & Cha, H.-K. (2011) · Journal of the Korean Society of Physical Medicine · Cited by 8
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Ng, L., Reid, I., Gorelik, A., Galea, M. P., & Khan, F. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011879 · Cited by 8
Health-Related Quality of Life Trajectories over the First Year after Stroke in Colombia, South America
Paredes, A. M., Landa, L. O., Chagualá, A. C., Peralta, H. C., Torres, G. P. V., Perrin, P. B., & Arango‐Lasprilla, J. C. (2016) · Topics in Stroke Rehabilitation · doi:10.1080/10749357.2016.1143694 · Cited by 8
A proof of concept study investigating the feasibility of combining iPAM robot assisted rehabilitation with functional electrical stimulation to deliver whole arm exercise in stroke survivors
O’Connor, R. J., Jackson, A., Makower, S., Cozens, A., & Levesley, M. C. (2015) · Journal of Medical Engineering & Technology · doi:10.3109/03091902.2015.1088094 · Cited by 8
Difference in independent mobility improvement from admission to discharge between subacute stroke patients using knee-ankle-foot and those using ankle-foot orthoses
Ota, T., Hashidate, H., Shimizu, N., & Saito, A. (2018) · Journal of Physical Therapy Science · doi:10.1589/jpts.30.1003 · Cited by 8
Interventions to Improve Recovery after Stroke
Cramer, S. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-29544-4.00059-1 · Cited by 10
Keyboard Playing as a Hand Exercise for Patients with Subacute Stroke
Chong, H. J., Han, S. J., & Kim, S. J. (2016) · Music Therapy Perspectives · doi:10.1093/mtp/miw023 · Cited by 8
Displacement Analysis and Design of a (2–RRU)–URR Parallel Mechanism Performing 2R1T Output Motion for Thumb Rehabilitation
Choi, W.-H., & Takeda, Y. (2020) · Robotics · doi:10.3390/robotics9030067 · Cited by 8
Stable and User-Controlled Assistance of Human Motor Function
Vallery, H. (2009) · Cited by 8
Home-Based Nonimmersive Virtual Reality Training After Discharge From Inpatient or Outpatient Stroke Rehabilitation: Parallel Feasibility Randomized Controlled Trial
Sheehy, L., Taillon‐Hobson, A., Sveistrup, H., Bilodeau, M., Yang, C. P., Welch, V. A., & Finestone, H. M. (2025) · JMIR Rehabilitation and Assistive Technologies · doi:10.2196/64729 · Cited by 7
Serious Gaming for Upper Limbs Rehabilitation—Game Controllers Features: A Scoping Review
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Effects of different rehabilitation provision systems on functional recovery in patients with subacute stroke
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Effort-based decision making and motivational deficits in stroke patients
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Liftacube
Vandermaesen, M., Weyer, T. D., Coninx, K., Luyten, K., & Geers, R. P. J. (2013) · International Conference on PErvasive Technologies Related to Assistive Environments (PETRA) · doi:10.1145/2504335.2504354 · Cited by 7
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Knippenberg, E., Hout, L. V., Smeets, W., Palmaers, S., Timmermans, A. A. A., & Spooren, A. I. F. (2019) · Technology and Health Care · doi:10.3233/thc-191854 · Cited by 7
Basis and Clinical Evidence of Virtual Reality-Based Rehabilitation of Sensorimotor Impairments After Stroke
Fluet, G. G., Roy, D., Lloréns, R., Badia, S. B. I., & Deutsch, J. E. (2022) · Springer eBooks · doi:10.1007/978-3-031-08995-4_20 · Cited by 7
A variational Bayesian approach for the robust analysis of the cortical silent period from EMG recordings of brain stroke patients
Olier, I., Amengual, J. L., & Vellido, A. (2011) · Neurocomputing · doi:10.1016/j.neucom.2010.12.006 · Cited by 7
Amount and Content of Sensorimotor Therapy Delivered in Three Stroke Rehabilitation Units in Quebec, Canada
Richards, C. L., Malouin, F., Nadeau, S. M., Fung, J., D’Amours, L., Pérez, C., & Durand, A. (2017) · Physiotherapy Canada · doi:10.3138/ptc.2016-66 · Cited by 7
Self-citation
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Kostenko, E. V., Петрова, Л. В., Rylsky, A. V., & Ахматовна, Э. М. (2019) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201911901123 · Cited by 7
Factors affecting the performance of activities of daily living in patients with advanced cancer undergoing inpatient rehabilitation: results from a retrospective observational study
Shimoda, K., Imai, H., Tsuji, T., Tsuchiya, K., Tajima, H., Kanemaki, H., & Tozato, F. (2019) · Journal of Physical Therapy Science · doi:10.1589/jpts.31.795 · Cited by 8
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Ogasawara, T., Mukaino, M., Otaka, Y., Matsuura, H., Aoshima, Y., Suzuki, T., Togo, H., Nakashima, H., Yamaguchi, M., Tsukada, S., et al. (2021) · Journal of Medical and Biological Engineering · doi:10.1007/s40846-021-00622-2 · Cited by 7
The effects of increased therapy time on cognition and mood in frail patients with a stroke who rehabilitate on rehabilitation units of nursing homes in the Netherlands: a protocol of a comparative study
Huijben‐Schoenmakers, M., Rademaker, A. C. H. J., van Rooden, P., & Scherder, E. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-68 · Cited by 8
Dosage of Preventive or Therapeutic Exercise Interventions: Review of Published Randomized Controlled Trials and Survey of Authors
Gallois, M., Davergne, T., Ledinot, P., Ravaud, P., & Régnaux, J.-P. (2017) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2017.03.030 · Cited by 7
Viability of using a computer tablet to monitor an upper limb home exercise program in stroke
Levy, T., Killington, M., Lannin, N. A., & Crotty, M. (2019) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2019.1625092 · Cited by 7
A six-degree-of-freedom robotic system for lower extremity rehabilitation
Yurkewich, A., Atashzar, S. F., Ayad, A., & Patel, R. V. (2015) · International Conference on Rehabilitation Robotics · doi:10.1109/icorr.2015.7281302 · Cited by 7
Robot adaptive behavior to suit patient needs and enable more intensive rehabilitation tasks
Rodriguez‐Guerrero, C., Fraile, J. C., & Turiel, J. P. (2009) · IEEE International Conference on Mechatronics (ICM) · doi:10.1109/icmech.2009.4957230 · Cited by 7

Authors: Kwakkel, G., van Peppen, R., Wagenaar, R. C., Wood Dauphinee, S., Richards, C., Ashburn, A., Miller, K., Lincoln, N., Partridge, C., Wellwood, I., & Langhorne, P.
Affiliations: Boston University (US)
From the Department of Physical Therapy and Research Institute for Fundamental and Clinical Human Movement Sciences (G.K., R.v.P.), VU University Medical Center, Amsterdam, the Netherlands; the Center of Excellence for Rehabilitation Medicine “De Hoogstraat” (G.K.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; the Department of Rehabilitation Sciences and Center for Neurorehabilitation (R.C.W.), Sargent College of Health and Rehabilitation Sciences,...
ORCID: Kwakkel, Gert
Wagenaar, Robert C.
Richards, Carol
Ashburn, Ann
Miller, Kimberly
Lincoln, Nadina
Wellwood, Ian
Langhorne, Peter
Venue: Stroke
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-11
Volume: 35
Issue: 11
Pages: 2529-2539
ISSN: 0039-2499 (ISSN-L)
1524-4628
DOI: 10.1161/01.str.0000143153.76460.7d
OpenAlex: W2141635852
Cited by: 1,081
References: 54
Citations by year: 2026: 30 · 2025: 39 · 2024: 30 · 2023: 32 · 2022: 53 · 2021: 59 · 2020: 52 · 2019: 56 · 2018: 57 · 2017: 47 · 2016: 56 · 2015: 73 · 2014: 70 · 2013: 51 · 2012: 55
FWCI: 4.83
Type: journal article
Language: en
Open access: closed
Locations: Stroke (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Kent Academic Repository (University of Kent) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: ZonMw
Koninklijk Nederlands Genootschap voor Fysiotherapie
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
Keywords: stroke rehabilitation, exercise therapy, treatment intensity, dose-response relationship, activities of daily living, walking speed, dexterity, instrumental activities of daily living, early rehabilitation, chronic stroke, treatment duration, walking training, upper limb training, gait training, balance training, stroke mortality, stroke recurrence, stroke complications, stroke risk factors
MeSH terms: Stroke Rehabilitation, Activities of Daily Living, Exercise Therapy, Humans

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Effects of Augmented Exercise Therapy Time After Stroke: A Meta-Analysis

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