Cited by 279Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsNanoparticle-Based Drug Delivery

Delivery of peptide and protein drugs over the blood–brain barrier

Brasnjevic, Ivona, Steinbusch, Harry W.M., Schmitz, Christoph, Martinez-Martinez, Pilar·2009·Progress in Neurobiology

Abstract

Peptide and protein (P/P) drugs have been identified as showing great promises for the treatment of various neurodegenerative diseases. A major challenge in this regard, however, is the delivery of P/P drugs over the blood-brain barrier (BBB). Intense research over the last 25 years has enabled a better understanding of the cellular and molecular transport mechanisms at the BBB, and several strategies for enhanced P/P drug delivery over the BBB have been developed and tested in preclinical and clinical-experimental research. Among them, technology-based approaches (comprising functionalized nanocarriers and liposomes) and pharmacological strategies (such as the use of carrier systems and chimeric peptide technology) appear to be the most promising ones. This review combines a comprehensive overview on the current understanding of the transport mechanisms at the BBB with promising selected strategies published so far that can be applied to facilitate enhanced P/P drug delivery over the BBB.

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Crossref · 10.1016/j.pneurobio.2008.12.002

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  • Tight junctions are not perfect; small and soluble substances can sufficiently cross through the paracellular pathway.

    “But the tight junctions are not perfect, small and soluble substances could sufficiently cross through the paracellular pathway.149”

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Authors
Brasnjevic, I., Steinbusch, H. W. M., Schmitz, C., & Martinez-Martinez, P.
Affiliations
Maastricht University (NL)
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2009-04
Volume
87
Issue
4
Pages
212-251
ISSN
0301-0082 (ISSN-L)
OpenAlex
W2009244092
Cited by
279
References
32
Citations by year
2026: 2 · 2025: 16 · 2024: 9 · 2023: 17 · 2022: 9 · 2021: 13 · 2020: 25 · 2019: 15 · 2018: 15 · 2017: 22 · 2016: 21 · 2015: 17 · 2014: 18 · 2013: 22 · 2012: 16
FWCI
1.53
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
blood-brain barrier, peptide therapeutics, protein drugs, neurodegenerative diseases, liposomes, carrier systems
MeSH terms
Animals, Biological Transport, Blood-Brain Barrier, Drug Carriers, Humans, Peptides, Proteins, Drug Delivery Systems

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