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Cited by 162Acute Ischemic Stroke ManagementAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Plasma Adiponectin Levels and Five-Year Survival After First-Ever Ischemic Stroke

Efstathiou, Stamatis P., Tsioulos, Dimitrios I., Tsiakou, Aphrodite G., Gratsias, Yannis E., Pefanis, Angelos V., Mountokalakis, Theodore D.·2005·Stroke
DOI 10.1161/01.str.0000177874.29849.f0
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Abstract

Background and Purpose— This study aimed to investigate the association between plasma adiponectin levels and 5-year survival after first-ever ischemic stroke. Methods— Plasma adiponectin measured within 24 hours after first-ever ischemic stroke was related to 5-year outcome. The Kaplan–Meier technique was applied in survival analysis, and the Cox proportional hazards model was used to evaluate the relationship between risk factors and prognosis. Results— The probabilities of death were 92.8%, 52.5%, and 10.5% ( P <0.001) for patients stratified according to tertiles of adiponectin (<4 μg/mL, 4 to 7 μg/mL, and >7 μg/mL, respectively). The relative risk of death was 8.1 (95% CI, 3.1, 24.5; P <0.001) for individuals with adiponectin levels in the lowest tertile compared with the upper tertile. Adiponectin <4 μg/mL (hazard ratio [HR], 5.2; 95% CI, 2.1, 18.4; P <0.001), score >15 in the National Institutes of Health Stroke Scale (HR, 3.6; 95% CI, 1.7, 15.9; P <0.001), and coronary heart disease (HR, 2.9; 95% CI, 1.5, 12.3; P <0.001) were independently associated with mortality. Conclusions— Low plasma adiponectin is related to an increased risk of 5-year mortality after first-ever ischemic stroke, independently of other adverse predictors.

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  • Low plasma adiponectin was related to an increased risk of 5-yr mortality after first-ever ischemic stroke.

    “In another case, low plasma adiponectin was related to an increased risk of 5-yr mortality after first-ever ischemic stroke (94).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [94]

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Research works printed but not linked: 5

  1. Efstathiou SP, Tsioulos DI, Tsiakou AG, Gratsias YE, Pefanis AV, Mountokalakis TD. Plasma adiponectin levels and 5-year survival after first-ever ischemic stroke. Stroke. 2005;36:1915-1919.
  2. Goldstein BJ, Scalia R. Adiponectin: a novel adipokine linking adi- pocytes and vascular functioin. J Clin Endocrinol Metab. 2004;89: 2563-2568.
  3. Pischon CJ, Girman GS, Hotamisligil GS. Plasma apidonectin levels and risk of myocardial infarction in men. JAMA. 2004;291:1730 -1737.
  4. Beamer NB, Coull BM, Clark WM, Briley DP, Wynn M, Sexton G. Persistent inflammatory response in stroke survivors. Neurology. 1998; 50:1722-1728.
  5. Packard CJ, O'Reilly DS, Caslake MJ. Lipoprotein-associated phospho- lipase A2 as an independent predictor of coronary heart disease: West of Scotland Coronary Prevention Study Group. N Engl J Med. 2000;343: 1148 -1155.

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Authors
Efstathiou, S. P., Tsioulos, D. I., Tsiakou, A. G., Gratsias, Y. E., Pefanis, A. V., & Mountokalakis, T. D.
Affiliations
Metropolitan Hospital (GR)
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-09
Volume
36
Issue
9
Pages
1915-1919
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.0000177874.29849.f0
OpenAlex
W2088840838
Cited by
162
References
36
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 8 · 2012: 7
FWCI
10.17
Type
journal article
Language
en
Open access
closed
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
adiponectin, ischemic stroke, mortality, prognostic factors, plasma adiponectin levels, stroke severity, NIHSS, coronary artery disease, five-year survival
MeSH terms
Aged, Brain Ischemia, Female, Follow-Up Studies, Humans, Inflammation, Male, Middle Aged, Prognosis, Risk, Risk Factors, Time Factors, Vascular Diseases, Multivariate Analysis, Proportional Hazards Models, Odds Ratio, Treatment Outcome, Stroke, Adiponectin

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