Cited by 320Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsAcute Ischemic Stroke Management

Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke.

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Gottesman, Rebecca F, Hillis, Argye E·2010·The Lancet Neurology

Abstract

Stroke remains a primary cause of morbidity throughout the world mainly because of its effect on cognition. Individuals can recover from physical disability resulting from stroke, but might be unable to return to their previous occupations or independent life because of cognitive impairments. Cognitive dysfunction ranges from focal deficits, resulting directly from an area of infarction or from hypoperfusion in adjacent tissue, to more global cognitive dysfunction. Global dysfunction is likely to be related to other underlying subclinical cerebrovascular disease, such as white-matter disease or subclinical infarcts. Study of cognitive dysfunction after stroke is complicated by varying definitions and lack of measurement of cognition before stroke. Additionally, stroke can affect white-matter connectivity, so newer imaging techniques, such as diffusion-tensor imaging and magnetisation transfer imaging, that can be used to assess this subclinical injury are important tools in the assessment of cognitive dysfunction after stroke. As research is increasingly focused on the role of preventable risk factors in the development of dementia, the role of stroke in the development of cognitive impairment and dementia could be another target for prevention.

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  1. [99]Reis J Robertson E Krakauer JW Consensus: “Can TDCS and TMS enhance motor learning and memory formation?” Brain Stimulat 2008 1 363 369 PMC2621080 20633394

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Authors
Gottesman, R. F., & Hillis, A. E.
Affiliations
Johns Hopkins University (US)
Corresponding author
Hillis, Argye E
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2010-09
Volume
9
Issue
9
Pages
895-905
ISSN
1474-4422 (ISSN-L)
OpenAlex
W2105495864
Cited by
319
References
105
Citations by year
2026: 13 · 2025: 15 · 2024: 26 · 2023: 25 · 2022: 24 · 2021: 21 · 2020: 33 · 2019: 16 · 2018: 30 · 2017: 17 · 2016: 29 · 2015: 17 · 2014: 19 · 2013: 19 · 2012: 8
FWCI
1.45
Type
journal article
Language
en
Open access
Locations
  • The Lancet Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Deafness and Other Communication Disorders (R01 DC 05375, R01DC005375)
  • National Institute of Neurological Disorders and Stroke (R01NS047691)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
ischemic stroke, cognitive impairment, post-stroke cognitive impairment, white matter disease, white matter connectivity, diffusion tensor imaging, magnetization transfer imaging, dementia risk, stroke prevention, risk factors
MeSH terms
Cognition Disorders, Humans, Magnetic Resonance Imaging, Neuropsychological Tests, Predictive Value of Tests, Stroke

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