The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Lacunar Infarcts Are the Main Correlate With Cognitive Dysfunction in CADASIL
Abstract
Background and Purpose— Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy is caused by mutations in the NOTCH3 gene and is clinically characterized by recurrent stroke and cognitive decline. Previous studies have shown an association between white matter hyperintensities on brain MRI and cognitive dysfunction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. In the general population the presence of lacunar infarcts and microbleeds is also associated with cognitive dysfunction. The objective of this study was to determine to what extent lacunar infarcts and microbleeds on MRI contribute to cognitive decline in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Methods— NOTCH3 mutation analysis was performed in 62 symptomatic and asymptomatic members of 15 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy families. Neuropsychological tests were performed on the same day as the MRI examination. MRI was semi-quantitatively scored for white matter hyperintensities, infarct lesion load, and microbleeds. Regression analysis was performed to test the association between MRI abnormalities and neuropsychological test results. Results— Forty individuals had a NOTCH3 mutation and 22 did not. Severity of cognitive dysfunction in mutation carriers was independently associated with MRI infarct lesion load ( P <0.05). In contrast, WMH lesion load and microbleeds were not associated with cognitive dysfunction after correcting for age. Conclusions— Lacunar infarct lesion load is the most important MRI parameter associated with cognitive dysfunction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As such, the burden of lacunes has been proposed as the most relevant MRI maker with regards to cognitive impairments in CADASIL [36, 40, 73].”
From Clinical and research applications of magnetic resonance imaging in the study of CADASIL (2019) · cites this paper as [40]
In the citing paper
“In contrast with WMH or CM, a larger volume of lacunes has been consistently linked with poorer clinical outcomes or cognitive performances in CADASIL patients [11, 36, 40, 50, 53, 59, 71, 73].”
From Clinical and research applications of magnetic resonance imaging in the study of CADASIL (2019) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Studies of interference in serial verbal reactions
Stroop, J. R. (1935) · Journal of Experimental Psychology · doi:10.1037/h0054651 · Cited by 18,622
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 8,167
A compendium of neuropsychological tests: administration, norms, and commentary
(1991) · Choice Reviews Online · doi:10.5860/choice.29-2400 · Cited by 6,118
Diffusion tensor imaging: Concepts and applications
Le Bihan, D., Mangin, J., Poupon, C., Clark, C. A., Pappata, S., Molko, N., & Chabriat, H. (2001) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1076 · Cited by 3,547
A Standardized Memory Scale for Clinical Use
Wechsler, D. (1945) · The Journal of Psychology · doi:10.1080/00223980.1945.9917223 · Cited by 2,949
Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline
Vermeer, S. E., Prins, N. D., den Heijer, T., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022066 · Cited by 2,313
Roth, M., Tym, E., Mountjoy, C. Q., Huppert, F. A., Hendrie, H., Verma, S., & Goddard, R. (1986) · British Journal of Psychiatry · doi:10.1192/bjp.149.6.698 · Cited by 2,090
Studies of interference in serial verbal reactions.
Stroop, J. R. (1992) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.121.1.15 · Cited by 918
Cited by
Sorted by citations
Duering, M., Zieren, N., Hervé, D., Jouvent, E., Reyes, S., Peters, N., Pachai, C., Opherk, C., Chabriat, H., & Dichgans, M. (2011) · Brain · doi:10.1093/brain/awr169 · Cited by 200
“…between lesion volumes and cognitive performance has been demonstrated for infarcts (Erkinjuntti et al., 1988; Tatemichi et al., 1993; Pohjasvaara et al., 1998), lacunar infarcts (Mungas et al., 2005; Liem et al., 2007) and white matter lesions (O'Brien et al., 2002; Prins et al., 2005).”
BackgroundIncident lacunes influence cognitive decline: The LADIS study
Jokinen, H., Gouw, A. A., Madureira, S., Ylikoski, R., van Straaten, E. C. W., van der Flier, W. M., Barkhof, F., Scheltens, P., Fazekas, F., Schmidt, R., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821d752f · Cited by 200
Tikka, S., Baumann, M., Siitonen, M., Pasanen, P., Pöyhönen, M., Myllykangas, L., Viitanen, M., Fukutake, T., Cognat, E., Joutel, A., et al. (2014) · Brain Pathology · doi:10.1111/bpa.12181 · Cited by 189
“Lacunar infarct lesion load is the most important MRI parameter associated with cognitive dysfunction in CADASIL (77).”
BackgroundMorphologic diagnosis of “vascular dementia” — A critical update
Jellinger, K. A. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.03.006 · Cited by 150
Biesbroek, J. M., Kuijf, H. J., van der Graaf, Y., Vincken, K. L., Postma, A., Mali, W. P. T. M., Biessels, G. J., Geerlings, M. I., & on behalf of the SMART Study Group (2013) · PLoS ONE · doi:10.1371/journal.pone.0060541 · Cited by 108
MRI correlates of cognitive decline in CADASIL: A 7-year follow-up study
Liem, M. K., Lesnik Oberstein, S. A. J., Haan, J., van der Neut, I. L., Ferrari, M. D., van Buchem, M. A., Middelkoop, H. A. M., & van der Grond, J. (2009) · Neurology · doi:10.1212/01.wnl.0000339038.65508.96 · Cited by 104
Self-citationVitali, P., Migliaccio, R., Agosta, F., Rosen, H., & Geschwind, M. D. (2008) · Seminars in Neurology · doi:10.1055/s-0028-1083695 · Cited by 105
Craggs, L., Yamamoto, Y., Deramecourt, V., & Kalaria, R. N. (2014) · Brain Pathology · doi:10.1111/bpa.12177 · Cited by 96
“They increase with age and are associated with cognitive impairment (73, 115), but are indistinguishable between sporadic or hereditary SVD disorders.”
BackgroundClinical and Genetic Aspects of CADASIL
Mizuno, T., Mizuta, I., Watanabe-Hosomi, A., Mukai, M., & Koizumi, T. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00091 · Cited by 100
Cognitive impairment of vascular origin: Neuropathology of cognitive impairment of vascular origin
Ferrer, I. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.08.039 · Cited by 80
“The morphological substrate of cognitive impairment in CADASIL seems to be multiple [124,125], although the role of lacunar infarcts is paramount for some authors [126], while not accepted by others [127].”
CADASIL and migraine: A narrative review
Liem, M. K., Oberstein, S. A. J. L., van der Grond, J., Ferrari, M. D., & Haan, J. (2010) · Cephalalgia · doi:10.1177/0333102410370870 · Cited by 78
“Lacunar infarcts are associated with cognitive dysfunction (14).”
BackgroundSelf-citationChoi, J. C. (2010) · Journal of Clinical Neurology · doi:10.3988/jcn.2010.6.1.1 · Cited by 71
Wang, M. M. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64076-5.00047-8 · Cited by 71
Ayata, C. (2010) · Stroke · doi:10.1161/strokeaha.110.595207 · Cited by 69
Choi, J. C., Song, S.-K., Lee, J. S., Kang, S.-Y., & Kang, J.-H. (2013) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2011.07.002 · Cited by 66
“2 mm in diameter with a signal intensity of cerebrospinal fluid in all sequences.(13) The lesions located in the lower third of the corpus striatum of the basal ganglia were excluded.”
BackgroundPinkston, J. B., Alekseeva, N., & Toledo, E. G. (2009) · Neurological Research · doi:10.1179/016164109x12445505689643 · Cited by 66
Imaging evolution of acute lacunar infarction
Koch, S., McClendon, M. S., & Bhatia, R. G. (2011) · Neurology · doi:10.1212/wnl.0b013e31822e1470 · Cited by 65
Liem, M. K., Oberstein, S. A. J. L., Haan, J., van den Boom, R., Ferrari, M. D., van Buchem, M. A., & van der Grond, J. (2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1533 · Cited by 61
“Microbleeds were defined as focal areas of signal intensity loss on T2-weighted spin-echo images that increased in size on the T2*weighted gradient EPI (“blooming effect”).(10) In this way, microbleeds were differentiated from areas of signal intensity loss on the basis of vascular flow void.”
BackgroundSelf-citationYamamoto, Y., Liao, Y., Lee, Y., Ihara, M., & Choi, J. C. (2023) · Journal of Clinical Neurology · doi:10.3988/jcn.2023.19.1.12 · Cited by 63
Dichgans, M. (2008) · Stroke · doi:10.1161/strokeaha.108.534412 · Cited by 51
Kleinfeld, K., Mobley, B. C., Hedera, P., Wegner, A. M., Sriram, S., & Pawate, S. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6680-6 · Cited by 50
“In addition, CADASIL shows a particular predilection for the bilateral anterior temporal lobes [41–43].”
CADASIL: pathogenesis, clinical and radiological findings and treatment
André, C. (2010) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2010000200026 · Cited by 50
Microbleeds in vascular dementia: Clinical aspects
van der Flier, W. M., & Cordonnier, C. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.07.007 · Cited by 48
Nannucci, S., Rinnoci, V., Pracucci, G., MacKinnon, A. D., Pescini, F., Adib‐Samii, P., Bianchi, S., Dotti, M. T., Federico, A., Inzitari, D., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190878 · Cited by 46
MRI Features of Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathy (PADMAL)
Ding, X. Q., Hagel, C., Ringelstein, E. B., Buchheit, S., Zeumer, H., Kuhlenbäumer, G., Appenzeller, S., & Fiehler, J. (2010) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2008.00336.x · Cited by 50
Serum Neurofilament light correlates with CADASIL disease severity and survival
Gravesteijn, G., Rutten, J. W., Verberk, I. M. W., Böhringer, S., Liem, M. K., van der Grond, J., Aartsma-Rus, A. M., Teunissen, C. E., & Oberstein, S. A. J. L. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.678 · Cited by 43
Self-citationLiem, M. K., Lesnik Oberstein, S. A. J., Haan, J., van der Neut, I. L., van den Boom, R., Ferrari, M. D., van Buchem, M. A., & van der Grond, J. (2008) · Radiology · doi:10.1148/radiol.2492080357 · Cited by 40
“Microbleeds were defined as focal areas of signal loss on T2-weighted spinecho images that were increased in size on T2*-weighted gradient-echo echoplanar images (blooming effect) (6).”
BackgroundInfluentialSelf-citationYao, M., Jouvent, E., During, M., Godin, O., Hervé, D., Guichard, J. P., Zhu, Y.-C., Gschwendtner, A., Opherk, C., Dichgans, M., et al. (2012) · Stroke · doi:10.1161/strokeaha.112.664854 · Cited by 42
“Second, WMH are poorly related to the clinical severity in CADASIL and can be detected at the late stage of the disease in the total absence of lacunar infarction.(21,22) Third, WMH are detected early in the temporal lobes during the course of the disease, a long time before the onset of ischemic stroke usually occurr…”
BackgroundLiu, J., Xia, S., Hanks, R. A., Wiseman, N. M., Peng, C., Zhou, S., Haacke, E. M., & Kou, Z. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3856 · Cited by 41
Ling, Y., Guio, F. D., Duering, M., Jouvent, É., Hervé, D., Godin, O., Dichgans, M., & Chabriat, H. (2016) · Stroke · doi:10.1161/strokeaha.116.015750 · Cited by 39
Clinical and research applications of magnetic resonance imaging in the study of CADASIL
Schoemaker, D., Quiroz, Y. T., Torrico-Teave, H., & Arboleda-Velasquez, J. F. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.01.014 · Cited by 36
Vasoreactivity in CADASIL: comparison to structural MRI and neuropsychology
Moreton, F. C., Cullen, B., Delles, C., Santosh, C., Gonzalez, R. L., Dani, K., & Muir, K. W. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17710375 · Cited by 37
“Combining ASL with a hypercapnia challenge, again novel in this disease, we showed impaired cerebral vasoreactivity, was related to number of lacunes and brain atrophy, important correlates of clinical impairment.(26) Patients with greater disability, depression and impaired processing speed, also tended to have worse…”
BackgroundNardone, R., Blasi, P. D., Seidl, M., Höller, Y., Caleri, F., Tezzon, F., Ladurner, G., Golaszewski, S. M., & Trinka, E. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0650-5 · Cited by 38
“Only in CADASIL patients MBs were previously found not to be associated with cognitive dysfunction (Liem et al. 2007).”
Enhanced Rapid-Onset Cortical Plasticity in CADASIL as a Possible Mechanism of Preserved Cognition
List, J., Duning, T., Meinzer, M., Kürten, J., Schirmacher, A., Deppe, M., Evers, S., Young, P., & Flöel, A. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr071 · Cited by 35
“Quantification of lacunar lesions The burden of lacunar lesions was determined by assessing parenchymal defects not extending to the cortical gray matter, with signal intensity corresponding to that of cerebrospinal fluid and a diameter between 2 and 15 mm on T1weighted scans (Liem et al. 2007).”
Salvadori, E., Brambilla, M., Maestri, G., Nicotra, A., Cova, I., Pomati, S., & Pantoni, L. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12650 · Cited by 34
Stromillo, M. L., Dotti, M. T., Battaglini, M., Mortilla, M., Bianchi, S., Plewnia, K., Pantoni, L., Inzitari, D., Federico, A., & Stefano, N. D. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.155853 · Cited by 33
Prediction of 3-year clinical course in CADASIL
Jouvent, E., Duchesnay, E., Hadj-Selem, F., De Guio, F., Mangin, J.-F., Hervé, D., Duering, M., Ropele, S., Schmidt, R., Dichgans, M., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003252 · Cited by 30
White-matter lesions without lacunar infarcts in CADASIL
Benisty, S., Reyes, S., Godin, O., Hervé, D., Zieren, N., Jouvent, E., Zhu, Y., During, M., Dichgans, M., & Chabriat, H. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-111784 · Cited by 30
von Willebrand Factor Permeates Small Vessels in CADASIL and Inhibits Smooth Muscle Gene Expression
Zhang, X., Meng, H., Blaivas, M., Rushing, E. J., Moore, B. E., Schwartz, J., Lopes, M. B. S., Worrall, B. B., & Wang, M. M. (2011) · Translational Stroke Research · doi:10.1007/s12975-011-0112-2 · Cited by 31
Lee, J. S., Choi, J. C., Kang, S.-Y., Kang, J.-H., Na, H. R., & Park, J.-K. (2011) · Journal of Clinical Neurology · doi:10.3988/jcn.2011.7.4.210 · Cited by 30
Headache among CADASIL patients with R544C mutation: Prevalence, characteristics, and associations
Choi, J. C., Song, S., Lee, J. S., Kang, S., & Kang, J. (2013) · Cephalalgia · doi:10.1177/0333102413497598 · Cited by 29
“We evaluated the severity of white-matter hyperintensity (WMH) lesions, the involvement of anterior temporal lobe (17), the number of cerebral microbleeds (18), and the number of lacunar infarcts (19).”
BackgroundSu, J., Huang, Q., Ren, S., Xie, F., Zhai, Y., Guan, Y., Liu, J., & Hua, F. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.07.048 · Cited by 27
Su, J., Wang, M., Ban, S., Wang, L., Cheng, X., Hua, F., Tang, Y., Zhou, H., Zhai, Y., Du, X., et al. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-0982-3 · Cited by 23
Genetic Animal Models of Cerebral Vasculopathies
Lee, J. H., Bacskai, B. J., & Ayata, C. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394596-9.00002-0 · Cited by 21
Screening for NOTCH3 Gene Mutations Among 151 Consecutive Korean Patients with Acute Ischemic Stroke
Choi, J. C., Lee, K.-H., Song, S., Lee, J. S., Kang, S., & Kang, J. (2011) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2011.10.013 · Cited by 22
CADASIL management or what to do when there is little one can do
Río-Espínola, A. D., Mendióroz, M., Domingues‐Montanari, S., Pozo‐Rosich, P., Solé, E., Fernández‐Morales, J., Fernández‐Cadenas, I., & Montaner, J. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.9.2.197 · Cited by 21
Vascular Contributions to Cognitive Impairment in Late Life
Chui, H. C., & Gomez, L. A. R. (2017) · Neurologic Clinics · doi:10.1016/j.ncl.2017.01.007 · Cited by 19
Su, J., Ban, S., Wang, M., Hua, F., Wang, L., Cheng, X., Tang, Y., Zhou, H., Zhai, Y., Du, X., et al. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-1052-6 · Cited by 17
Advances in Vascular Cognitive Impairment 2007
Gorelick, P. B., & Bowler, J. V. (2008) · Stroke · doi:10.1161/strokeaha.107.509570 · Cited by 17
Confluent Thalamic Hyperintensities in CADASIL
Camus-Jacqmin, D. M., Hervé, D., Viswanathan, A., Guichard, J., Duering, M., Dichgans, M., & Chabriat, H. (2010) · Cerebrovascular Diseases · doi:10.1159/000319607 · Cited by 17
Moreton, F. C., Cullen, B., Dickie, D. A., Lopez-Gonzalez, R., Santosh, C., Delles, C., & Muir, K. W. (2020) · European Journal of Neurology · doi:10.1111/ene.14534 · Cited by 17
“Magnetic resonance imaging (MRI) markers of cerebral small vessel disease such as lacunes [8] and atrophy [9] have been shown to predict clinical worsening to varying degrees [10].”
BackgroundCADASIL: The Most Common Hereditary Subcortical Vascular Dementia
Kalimo, H., Miao, Q., Tikka, S., Mykkänen, K., Junna, M., Roine, S., Viitanen, M. H., Pöyhönen, M., & Baumann, M. (2008) · Future Neurology · doi:10.2217/14796708.3.6.683 · Cited by 16
Price, C. C., Tanner, J. J., Schmalfuss, I. M., Brumback, B., Heilman, K. M., & Libon, D. J. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150407 · Cited by 15
Cao, L., Guo, Y. C., & Zhu, Z. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1744597 · Cited by 17
Liu, Y., Wu, Y. F., Xie, S., Luan, X., & Yuan, Y. (2008) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2008.01825.x · Cited by 15
“Cranial MRI reveal punctuate, nodular or confluent white matter hyper-intensities (WMH) that are most evident on T2-weighted MRI and have been considered to reflect ischaemic lesions secondary to small vessel disease.(3,4) Retina is extension of central nerve system.”
BackgroundKarvelas, N., Oh, B. C., Wang, E., Cobigo, Y., Tsuei, T., Fitzsimons, S., Younes, K., Ehrenberg, A. J., Geschwind, M. D., Schwartz, D., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae071 · Cited by 17
Tang, S., Jeng, J., Lee, M., & Yip, P. (2009) · PubMed · Cited by 13
Neoplastic lesions in CADASIL syndrome: report of an autopsied Japanese case.
Hassan, W. A., Udaka, N., Ueda, A., Ando, Y., & Ito, T. (2015) · Europe PMC (PubMed Central) · Cited by 13
Gold, G. (2009) · Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences · doi:10.1159/000197887 · Cited by 12
Kou, Z., Ye, Y., & Haacke, E. M. (2015) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0000000000000064 · Cited by 11
Recurrent transient global amnesia as presenting symptoms of CADASIL
Pradotto, L., Orsi, L., Mencarelli, M., Caglio, M., Lauro, D., Milesi, A., Blasio, A. D., & Mauro, A. (2016) · Clinical Case Reports · doi:10.1002/ccr3.666 · Cited by 12
“Cognitive impairment in CADASIL is similar to that reported for sporadic subcortical ischemic vascular dementia and is thought to the result of dysfunction within the subcortical/frontal network due to the leukoaraiosis, although a multi-infarction origin based on the accumulation of cerebral infarcts was also propose…”
BackgroundNeuroimagem cerebral com imagem ponderada em susceptibilidade.
Lima, P. B., de Freitas, D. L., Marques, C., & Rio, F. (2012) · Acta Médica Portuguesa · doi:10.20344/amp.1409 · Cited by 11
Monogenetic Stroke Syndromes in Children and Young Adults
Doig, D., Davagnanam, I., Taranath, A., Zlatareva, D., Alwis, A., Siddiqui, A. U., & Mankad, K. (2020) · American Journal of Roentgenology · doi:10.2214/ajr.19.22360 · Cited by 11
Vascular cognitive impairment: prodrome to VaD?
Mayda, A., & DeCarli, C. (2009) · Vascular Cognitive Impairment in Clinical Practice · doi:10.1017/cbo9780511575976.003 · Cited by 7
The Notch Signaling Pathway: A Potential Target for Mental Disorders
Zhang, Q. Y., Zheng, J., Sun, H., Zheng, J., Ma, Y., Ji, Q., Chen, D., Tang, Z., Zhang, J., He, Y., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05034-w · Cited by 9
“Mutant Notch3 impairs vascular function [154], which may have an important correlation with cerebral vascular lesions in this disease, and lacunar infarction is also the main factor leading to cognitive impairment in these patients [155, 156].”
Cognitive Profile of CADASIL Patients with R544C Notch3 Mutation
Song, J.-K., Noh, Y., & Lee, J. S. (2014) · European Neurology · doi:10.1159/000356199 · Cited by 9
Lee, J. S., Ko, K. H., Oh, J.-H., Kim, J., Kang, C., Song, S., Kang, S., Kang, J., Park, J. H., Koh, M. J., et al. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.591879 · Cited by 9
Wiggins, M. E., Jones, J. D., Tanner, J. J., Schmalfuss, I. M., Aalaei‐Andabili, S. H., Heilman, K. M., Libon, D. J., Beaver, T. M., & Price, C. C. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00271 · Cited by 8
Altered Regional Brain Homogeneity of BOLD Signal in CADASIL: A Resting State fMRI Study
Orsolini, S., Marzi, C., Gavazzi, G., Bianchi, A., Salvadori, E., Giannelli, M., Donnini, I., Rinnoci, V., Pescini, F., Pantoni, L., et al. (2020) · Journal of Neuroimaging · doi:10.1111/jon.12821 · Cited by 7
Small Fiber Pathology in CADASIL
Cheng, Y., Chao, C., Chen, C., Yeh, T., Jeng, J., Tang, S., & Hsieh, S. (2022) · Neurology · doi:10.1212/wnl.0000000000200672 · Cited by 7
Chapter 4 Neuroimaging of Cognitive Impairments in Vascular Disease
Perri, C. D., Dalaker, T. O., Beyer, M. K., & Zivadinov, R. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)00404-8 · Cited by 4
“, 2005), in CADASIL disease (Liem et al., 2007), as well as in the executive dysfunction of nondemented patients (Carey et al.”
Clinical and MRI Profiles Predicting Clinical Overt Stroke in Patients with CADASIL
Seok, L. J., Chol, C. J., Yoon, K. S., Keun, S. S., Hoon, K. J., Song, J.-K., & Na, H. R. (2012) · Journal of the Korean Neurological Association · Cited by 4
Jacobs, H. I. L., Schoemaker, D., Torrico‐Teave, H., Zuluaga, Y., Velilla-Jiménez, L. M., Ospina, C., Lopera, F. J., Arboleda‐Velásquez, J. F., & Quiroz, Y. T. (2021) · Brain Connectivity · doi:10.1089/brain.2020.0980 · Cited by 4
“In particular, the presence of lacunar infarcts is an important predictor of cognitive dysfunction and disability (Lee et al., 2011; Liem et al., 2007; Viswanathan et al., 2007).”
Wang, M., Li, Y., Song, Y., YingYu, Z., & Zhao, X. (2021) · Acta Radiologica · doi:10.1177/02841851211066583 · Cited by 4
Zhang, M., Xie, B., Gao, J., Mak, H. K., Kwong, A. S. K., Chan, D. C. P., & Cheung, R. T. F. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.06.028 · Cited by 5
Angiogenesis in the Central Nervous System
de Almodóvar, C. R., Zacchigna, S., & Carmeliet, P. (2008) · Springer eBooks · doi:10.1007/978-0-387-71518-6_42 · Cited by 5
Chui, H. C., & Ramirez-Gomez, L. A. (2016) · Wiley eBooks · doi:10.1002/9781118797662.ch4 · Cited by 4
Cavitation of symptomatic acute single small subcortical infarctions
Zhang, X., Ge, Y., Liang, C., & Wang, Y. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04509-z · Cited by 3
Choi, J. C., Lee, J. S., & Kim, K. (2020) · Journal of Medicine and Life Science · doi:10.22730/jmls.2020.17.3.65 · Cited by 3
Bettcher, B. M., Bevan, C. J., & Geschwind, M. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800105-9.00041-x · Cited by 3
SQSTM1 gene as a potential genetic modifier of CADASIL phenotype
Almeida, M. R., Silva, A. R., Elias, I., Fernandes, C., Machado, R., Galego, O., & Cordeiro, G. (2020) · Journal of Neurology · doi:10.1007/s00415-020-10308-5 · Cited by 3
Rounding up the usual suspects
Kalaria, R. N. (2007) · Neurology · doi:10.1212/01.wnl.0000271882.58578.61 · Cited by 3
Karvelas, N., Oh, B. C., Wang, E., Cobigo, Y., Tsuei, T., Fitzsimons, S., Ehrenberg, A. J., Geschwind, M. D., Schwartz, D., Kramer, J. H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.17.553732 · Cited by 3
NOTCH3 Mutations in CADASIL: a multicellular perspective on neurodegeneration
Lee, J. W. L., Ng, A. S. L., Tan, E., & Zeng, L. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02764-9 · Cited by 2
“…of CADASIL is the predominance of subcortical symptoms, including slowed processing speed, executive dysfunction, gait disturbance, mood changes, and apathy [31–33], with comparatively rare cortical manifestations such as aphasia, apraxia, or focal seizures, even in advanced disease [27, 34–36].”
Determination of Blood NOTCH3 Extracellular Domain and Jagged-1 Levels in Healthy Subjects
Kim, H., Jang, B. G., Kim, Y.-J., & Choi, J. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810547 · Cited by 2
CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)
Rumboldt, Z. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139030854.023 · Cited by 2
Benisty, S., & Chabriat, H. (2020) · Springer eBooks · doi:10.1007/978-3-030-49586-2_7 · Cited by 2
Onodera, O., Sekine, Y., Kato, T., Koyama, A., Nozaki, H., & Nishizawa, M. (2014) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.134 · Cited by 1
A Japanese CADASIL kindred with a novel two‐base NOTCH 3 mutation
Suda, S., Okubo, S., Ueda, M., Sowa, K., Abe, A., Aoki, J., Muraga, K., Suzuki, K., Sakamoto, Y., Mizuta, I., et al. (2016) · European Journal of Neurology · doi:10.1111/ene.12977 · Cited by 1
“thermore, lacunar infarct load, but not WMH lesion load, is an important MRI parameter associated with cognitive dysfunction in CADASIL [7].”
BackgroundClinical Correlation of Magnetic Resonance Imaging Features of Cerebral Small Vessel Disease
Liu, D.-T., Liu, Y., Kong, Y.-Q., Zhou, L., & Hu, W. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2019.02.099 · Cited by 1
Dowling, M. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410529-4.00100-5 · Cited by 1
Lee, J. S., Ko, K., Oh, J., Choi, J. C., & Kim, J. (2018) · Journal of Medicine and Life Science · doi:10.22730/jmls.2018.15.2.89 · Cited by 1
Impact of Brain MRI Markers on Major and Mild Vascular Cognitive Impairment in CADASIL
Lee, J. S., Koh, M. J., Lee, H. K., & Choi, J. C. (2022) · Journal of the Korean Neurological Association · doi:10.17340/jkna.2022.1.5 · Cited by 1
CADASIL: a genetic model of arteriolar degeneration, white matter injury and dementia in later life
Salloway, S., Brennan-Krohn, T., Correia, S., Mellion, M. L., & DeLaMonte, S. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511581410.022 · Cited by 1
CADASIL: a genetic model of arteriolar degeneration, white matter injury, and dementia in later life
Goldfarb, D., Mellion, M. L., Salloway, S., Brennan-Krohn, T., Correia, S., & DeLaMonte, S. (2016) · Cambridge University Press eBooks · doi:10.1017/9781139924771.021 · Cited by 1
Molecular Genetics of Ischaemic Stroke
Floßmann, E. (2010) · Wiley eBooks · doi:10.1002/9780470015902.a0022411
Dalaker, T. O., Beyer, M. K., Stosic, M., & Zivadinov, R. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9831-4_2
Confluent Thalamic Hyperintensities in CADASIL
de Médecine, F. (2010)
SÍNDROME CADASIL: EPIDEMIOLOGIA, CLÍNICA E
Correia, N. M. F. (2011)
NEUROIMAGEM CEREBRAL Com Imagem Ponderada Em Susceptibilidade
Lima, P. B., Freitas, D., Marques, C., & Rio, F. (2011)
Metadata
- Authors
- Liem, M. K., van der Grond, J., Haan, J., van den Boom, R., Ferrari, M. D., Knaap, Y. M., Breuning, M. H., van Buchem, M. A., Middelkoop, H. A. M., & Lesnik Oberstein, S. A. J.
- Affiliations
- Leiden University (NL)
- From the Departments of Radiology (M.K.L., J.v.d.G., R.v.d.B., M.A.v.B.), Clinical Genetics (M.H.B., S.A.J.L.O.), Neurology (J.H., M.D.F.), and Neuropsychology (Y.M.K., H.A.M.M.), Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology (J.H.), Rijnland Hospital, Leiderdorp, The Netherlands; Department of Psychology (H.A.M.M.), Neuropsychology unit, Leiden University, The Netherlands.
- Venue
- Stroke
- Published
- 2007-03
- Volume
- 38
- Issue
- 3
- Pages
- 923-928
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2061620398
- Cited by
- 114
- References
- 35
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 12 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 5 · 2014: 8 · 2013: 2 · 2012: 8
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- CADASIL, NOTCH3 mutations, lacunar infarction, cognitive decline, white matter hyperintensities, microbleeds
- MeSH terms
- Receptor, Notch3, Adult, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mutation, Brain Infarction, CADASIL, Receptors, Notch
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
