The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Lacunar Infarcts Are the Main Correlate With Cognitive Dysfunction in CADASIL
Abstract
Background and Purpose— Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy is caused by mutations in the NOTCH3 gene and is clinically characterized by recurrent stroke and cognitive decline. Previous studies have shown an association between white matter hyperintensities on brain MRI and cognitive dysfunction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. In the general population the presence of lacunar infarcts and microbleeds is also associated with cognitive dysfunction. The objective of this study was to determine to what extent lacunar infarcts and microbleeds on MRI contribute to cognitive decline in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Methods— NOTCH3 mutation analysis was performed in 62 symptomatic and asymptomatic members of 15 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy families. Neuropsychological tests were performed on the same day as the MRI examination. MRI was semi-quantitatively scored for white matter hyperintensities, infarct lesion load, and microbleeds. Regression analysis was performed to test the association between MRI abnormalities and neuropsychological test results. Results— Forty individuals had a NOTCH3 mutation and 22 did not. Severity of cognitive dysfunction in mutation carriers was independently associated with MRI infarct lesion load ( P <0.05). In contrast, WMH lesion load and microbleeds were not associated with cognitive dysfunction after correcting for age. Conclusions— Lacunar infarct lesion load is the most important MRI parameter associated with cognitive dysfunction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
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“As such, the burden of lacunes has been proposed as the most relevant MRI maker with regards to cognitive impairments in CADASIL [36, 40, 73].”
From Clinical and research applications of magnetic resonance imaging in the study of CADASIL (2019) · cites this paper as [40]
In the citing paper
“In contrast with WMH or CM, a larger volume of lacunes has been consistently linked with poorer clinical outcomes or cognitive performances in CADASIL patients [11, 36, 40, 50, 53, 59, 71, 73].”
From Clinical and research applications of magnetic resonance imaging in the study of CADASIL (2019) · cites this paper as [40]
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Duering, M., Zieren, N., Hervé, D., Jouvent, E., Reyes, S., Peters, N., Pachai, C., Opherk, C., Chabriat, H., & Dichgans, M. (2011) · Brain · doi:10.1093/brain/awr169 · Cited by 200
“…between lesion volumes and cognitive performance has been demonstrated for infarcts (Erkinjuntti et al., 1988; Tatemichi et al., 1993; Pohjasvaara et al., 1998), lacunar infarcts (Mungas et al., 2005; Liem et al., 2007) and white matter lesions (O'Brien et al., 2002; Prins et al., 2005).”
BackgroundIncident lacunes influence cognitive decline: The LADIS study
Jokinen, H., Gouw, A. A., Madureira, S., Ylikoski, R., van Straaten, E. C. W., van der Flier, W. M., Barkhof, F., Scheltens, P., Fazekas, F., Schmidt, R., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821d752f · Cited by 200
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“Lacunar infarct lesion load is the most important MRI parameter associated with cognitive dysfunction in CADASIL (77).”
BackgroundMorphologic diagnosis of “vascular dementia” — A critical update
Jellinger, K. A. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.03.006 · Cited by 150
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Metadata
- Authors
- Liem, M. K., van der Grond, J., Haan, J., van den Boom, R., Ferrari, M. D., Knaap, Y. M., Breuning, M. H., van Buchem, M. A., Middelkoop, H. A. M., & Lesnik Oberstein, S. A. J.
- Affiliations
- Leiden University (NL)
- From the Departments of Radiology (M.K.L., J.v.d.G., R.v.d.B., M.A.v.B.), Clinical Genetics (M.H.B., S.A.J.L.O.), Neurology (J.H., M.D.F.), and Neuropsychology (Y.M.K., H.A.M.M.), Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology (J.H.), Rijnland Hospital, Leiderdorp, The Netherlands; Department of Psychology (H.A.M.M.), Neuropsychology unit, Leiden University, The Netherlands.
- Venue
- Stroke
- Published
- 2007-03
- Volume
- 38
- Issue
- 3
- Pages
- 923-928
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2061620398
- Cited by
- 114
- References
- 35
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 12 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 5 · 2014: 8 · 2013: 2 · 2012: 8
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- CADASIL, NOTCH3 mutations, lacunar infarction, cognitive decline, white matter hyperintensities, microbleeds
- MeSH terms
- Receptor, Notch3, Adult, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mutation, Brain Infarction, CADASIL, Receptors, Notch
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