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Cited by 332

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia.

Open access
Kaplan, B, Brint, S, Tanabe, J, Jacewicz, M, Wang, X J, Pulsinelli, W·1991·Stroke
DOI 10.1161/01.str.22.8.1032
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Abstract

We investigated the temporal threshold for focal cerebral infarction in the spontaneously hypertensive rat. The right middle cerebral artery and common carotid artery were occluded for 0, 1, 2, 3, 4, or 24 hours, and all the animals were sacrificed 24 hours after the onset of ischemia. Cortical infarct volumes and edema volumes were quantified in serial frozen sections of hematoxylin and eosin-stained tissue using image analysis. Upon occlusion, blood flow in the core of the ischemic zone, measured with laser-Doppler flowmetry, fell to a mean +/- standard deviation of 21 +/- 7% of the preocclusion baseline value (n = 26). During the first hour of ischemia, blood flow in the densely ischemic zone rose to 27 +/- 8% of baseline (n = 25). Release of the middle cerebral artery and common carotid artery occlusions rapidly restored cortical blood flow to 213 +/- 83% of baseline (n = 21). Focal ischemia of 1 hour's duration caused little or no infarction, while ischemic intervals of 2 and 3 hours produced successively larger volumes of infarcted cortex. Ischemic intervals of 3-4 hours' duration followed by approximately 20 hours of recirculation yielded infarct volumes that were not significantly different from those after 24 hours of permanent focal ischemia. The results indicate that 3-4 hours of focal cerebral ischemia in this rat model is sufficient to attain maximal infarction and suggest that recirculation or pharmacological interventions after this time will provide little benefit.

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Metadata

Authors
Kaplan, B., Brint, S., Tanabe, J., Jacewicz, M., Wang, X. J., & Pulsinelli, W.
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1991-08
Volume
22
Issue
8
Pages
1032-1039
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.22.8.1032
OpenAlex
W2082870893
Cited by
332
References
26
FWCI
14.27
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia. https://app.cochat.ai/papers/10.1161/01.str.22.8.1032
The paper
Kaplan, B., Brint, S., Tanabe, J., Jacewicz, M., Wang, X. J., & Pulsinelli, W. (1991). Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke. https://doi.org/10.1161/01.str.22.8.1032

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.