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Cited by 683Neurobiology of Language and BilingualismStroke Rehabilitation and RecoveryLanguage Development and Disorders

Constraint-Induced Therapy of Chronic Aphasia After Stroke

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Pulvermüller, Friedemann, Neininger, Bettina, Elbert, Thomas, Mohr, Bettina, Rockstroh, Brigitte, Koebbel, Peter, Taub, Edward·2001·Stroke
DOI 10.1161/01.str.32.7.1621
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Abstract

Abstract —Patients with chronic aphasia were assigned randomly to a group to receive either conventional aphasia therapy or constraint-induced (CI) aphasia therapy, a new therapeutic technique requiring intense practice over a relatively short period of consecutive days. CI aphasia therapy is realized in a communicative therapeutic environment constraining patients to practice systematically speech acts with which they have difficulty. Patients in both groups received the same amount of treatment (30 to 35 hours) as 10 days of massed-practice language exercises for the CI aphasia therapy group (3 hours per day minimum; 10 patients) or over a longer period of ≈4 weeks for the conventional therapy group (7 patients). CI aphasia therapy led to significant and pronounced improvements on several standard clinical tests, on self-ratings, and on blinded-observer ratings of the patients’ communicative effectiveness in everyday life. Patients who received the control intervention failed to achieve comparable improvements. Data suggest that the language skills of patients with chronic aphasia can be improved in a short period by use of an appropriate massed-practice technique that focuses on the patients’ communicative needs.

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  • Current research on speech-language therapy for aphasia following stroke supports the effectiveness of high intensity-high dose speech-language training on functional and expressive language skills.

    “Current research on speech-language therapy for aphasia following stroke supports the effectiveness of high intensity - high dose speech-language training on functional and expressive language skills [3, 4, 5].”

    From The effect of augmented speech-language therapy delivered by telerehabilitation on poststroke aphasia—a pilot randomized controlled trial (2020) · cites this paper as [5]

  • Of the two studies matched for dose, one compared different treatments in high and low intensity arms, and the other found no significant difference in the primary outcome for high versus low intensity treatment in the subacute phase.

    “Of the two studies that were matched for dose, one of them compared different treatments in high and low intensity arms [14] and the other found no significant difference in the primary outcome measure for high versus low intensity treatment given in the subacute phase.”

    From Aphasia Recovery: When, How and Who to Treat? (2018) · cites this paper as [14]

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Authors
Pulvermüller, F., Neininger, B., Elbert, T., Mohr, B., Rockstroh, B., Koebbel, P., & Taub, E.
Affiliations
  • From the MRC Cognition and Brain Sciences Unit (F.P.), Cambridge, UK; Department of Psychology (F.P., B.G., T.E. B.M., B.R.), University of Konstanz, Konstanz; Lurija Institute of Rehabilitation Research (F.P., B.G.); Neurological Hospital Schmieder (P.K.), Allensbach, Germany; and the Department of Psychology (E.T.), University of Alabama at Birmingham, Birmingham, Ala.
  • University of Konstanz (DE)
ORCID
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-07
Volume
32
Issue
7
Pages
1621-1626
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.32.7.1621
OpenAlex
W2099440903
Cited by
683
References
28
Citations by year
2026: 17 · 2025: 25 · 2024: 15 · 2023: 23 · 2022: 26 · 2021: 32 · 2020: 36 · 2019: 21 · 2018: 23 · 2017: 39 · 2016: 31 · 2015: 40 · 2014: 48 · 2013: 32 · 2012: 43
FWCI
6.81
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
  • KOPS (University of Konstanz) (submittedVersion, cc-by-nc-nd)
Funders
  • U.S. Department of Veterans Affairs
  • Deutsche Forschungsgemeinschaft
  • Universität Konstanz
  • Rehabilitation Research and Development Service
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
Keywords
constraint-induced movement therapy, chronic aphasia, aphasia rehabilitation, massed practice, speech acts, communication effectiveness
MeSH terms
Adult, Aged, Aphasia, Chronic Disease, Female, Humans, Male, Middle Aged, Speech Therapy, Treatment Outcome, Stroke

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