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Cited by 384

The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.

Adipose Tissue and Atherosclerosis: Exploring the Connection

Open access
Fantuzzi, Giamila, Mazzone, Theodore·2007·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/atvbaha.106.131755
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Abstract

The prevalence of obesity, especially among the young, is dramatically increasing in the United States. Obesity is associated with accelerated atherosclerosis and increased rates of cardiovascular death. There are many plausible mechanisms by which an increase in adipose tissue could adversely affect the vessel wall. These include the changes in blood pressure, glucose level, lipid/lipoprotein metabolism, and systemic inflammation. In addition, factors secreted by adipose tissue may directly influence vessel wall homeostasis by influencing the function of endothelial cells, arterial smooth muscle cells, and macrophages in the vessel wall. There is general agreement that central, as opposed to peripheral, adipose tissue confers the most cardio-metabolic risk. Although the basis of this differential risk has not been not established, the pattern of gene expression and secretory products in visceral fat would be predicted to be more atherogenic compared with that in subcutaneous peripheral fat. Numerous studies have shown the beneficial effects of weight loss on markers of cardiovascular risk but fewer have demonstrated improvement in direct measures of large vessel disease. The unfolding role of adipose tissue as an important metabolic and secretory organ provides new opportunities for developing more effective approaches for preventing obesity and its atherosclerotic complications.

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Metadata

Authors
Fantuzzi, G., & Mazzone, T.
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-05
Volume
27
Issue
5
Pages
996-1003
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/atvbaha.106.131755
OpenAlex
W2152084424
Cited by
384
References
116
FWCI
22.03
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Adipose Tissue and Atherosclerosis: Exploring the Connection. https://app.cochat.ai/papers/10.1161/atvbaha.106.131755
The paper
Fantuzzi, G., & Mazzone, T. (2007). Adipose Tissue and Atherosclerosis: Exploring the Connection. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.106.131755

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.