Cited by 1,589Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.

Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk

Després, Jean-Pierre, Lemieux, Isabelle, Bergeron, Jean, Pibarot, Philippe, Mathieu, Patrick, Larose, Eric, Rodés-Cabau, Josep, Bertrand, Olivier F., Poirier, Paul·2008·Arteriosclerosis Thrombosis and Vascular Biology

DOI 10.1161/atvbaha.107.159228

Open this paper in CoChat — free account

Abstract

There is currently substantial confusion between the conceptual definition of the metabolic syndrome and the clinical screening parameters and cut-off values proposed by various organizations (NCEP-ATP III, IDF, WHO, etc) to identify individuals with the metabolic syndrome. Although it is clear that in vivo insulin resistance is a key abnormality associated with an atherogenic, prothrombotic, and inflammatory profile which has been named by some the "metabolic syndrome" or by others "syndrome X" or "insulin resistance syndrome", it is more and more recognized that the most prevalent form of this constellation of metabolic abnormalities linked to insulin resistance is found in patients with abdominal obesity, especially with an excess of intra-abdominal or visceral adipose tissue. We have previously proposed that visceral obesity may represent a clinical intermediate phenotype reflecting the relative inability of subcutaneous adipose tissue to act as a protective metabolic sink for the clearance and storage of the extra energy derived from dietary triglycerides, leading to ectopic fat deposition in visceral adipose depots, skeletal muscle, liver, heart, etc. Thus, visceral obesity may partly be a marker of a dysmetabolic state and partly a cause of the metabolic syndrome. Although waist circumference is a better marker of abdominal fat accumulation than the body mass index, an elevated waistline alone is not sufficient to diagnose visceral obesity and we have proposed that an elevated fasting triglyceride concentration could represent, when waist circumference is increased, a simple clinical marker of excess visceral/ectopic fat. Finally, a clinical diagnosis of visceral obesity, insulin resistance, or of the metabolic syndrome is not sufficient to assess global risk of cardiovascular disease. To achieve this goal, physicians should first pay attention to the classical risk factors while also considering the additional risk resulting from the presence of abdominal obesity and the metabolic syndrome, such global risk being defined as cardiometabolic risk.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/atvbaha.107.159228

Cites

129 of 129 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352
Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982
Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project
Conroy, R. (2003) · European Heart Journal · doi:10.1016/s0195-668x(03)00114-3 · Cited by 5,290
The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
Lakka, H.-M. (2002) · JAMA · doi:10.1001/jama.288.21.2709 · Cited by 5,033
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555

Show all 129 references

Research works printed but not linked: 3

10.1161/atvb.20.8.1932 · DOI
10.1161/atvb.21.6.961 · DOI
10.1161/atvb.19.10.2448 · DOI

Sorted by citations

Items 101–200 of 997

Nonalcoholic Fatty Liver Disease in Women
Suzuki, A., & Abdelmalek, M. F. (2009) · Women s Health · doi:10.2217/17455057.5.2.191 · Cited by 157
Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population
Taverna, M. J., Martínez-Larrad, M. T., Frechtel, G. D., & Serrano‐Ríos, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-1039 · Cited by 155
Sexual Dimorphism in Body Fat Distribution and Risk for Cardiovascular Diseases
Nedungadi, T. P., & Clegg, D. J. (2009) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-009-9101-1 · Cited by 154
The Metabolic Syndrome, Its Component Risk Factors, and Progression of Coronary Atherosclerosis
Bayturan, Ö. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.551 · Cited by 154
Validity of cardiometabolic index, lipid accumulation product, and body adiposity index in predicting the risk of hypertension in Chinese population
Wang, H., Chen, Y., Sun, G., Jia, P., Qian, H. R., & Sun, Y. (2018) · Postgraduate Medicine · doi:10.1080/00325481.2018.1444901 · Cited by 149
Oxidative stress, frailty and cognitive decline
Mulero, J., Zafrilla, P., & Martínez‐Cachá, A. (2011) · The journal of nutrition health & aging · doi:10.1007/s12603-011-0130-5 · Cited by 150
Visceral and Intrahepatic Fat Are Associated with Cardiometabolic Risk Factors Above Other Ectopic Fat Depots: The Framingham Heart Study
Lee, J., Pedley, A., Hoffmann, U., Massaro, J. M., Levy, D. A., & Long, M. T. (2018) · The American Journal of Medicine · doi:10.1016/j.amjmed.2018.02.002 · Cited by 148
Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women
Houde, A.-A., Légaré, C., Biron, S., Lescelleur, O., Biertho, L. D., Marceau, S., Tchernof, A., Vohl, M., Hivert, M., & Bouchard, L. (2015) · BMC Medical Genetics · doi:10.1186/s12881-015-0174-1 · Cited by 152
Resistance training does not contribute to improving the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women
Brochu, M., Malita, M. F., Messier, V., Doucet, E., Strychar, I., Lavoie, J.-M., Prud'homme, D., & Rabasa-Lhoret, R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2706 · Cited by 142
Circulating Omentin as a Novel Biomarker of Endothelial Dysfunction
Moreno‐Navarrete, J. M., Ortega, F. J., Castro, A., Sabater, M., Ricart, W., & Fernández‐Real, J. M. (2011) · Obesity · doi:10.1038/oby.2010.351 · Cited by 140
Assessment of abdominal adipose tissue and organ fat content by magnetic resonance imaging
Hu, H., Nayak, K. S., & Goran, M. I. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00824.x · Cited by 140
Flavonoids and metabolic syndrome
Galleano, M., Calabró, V., Prince, P. D., Litterio, M. C., Piotrkowski, B., Prieto, M. A. V., Miatello, R. M., Oteiza, P. I., & Fraga, C. G. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06511.x · Cited by 139
CB1 antagonists for obesity—what lessons have we learned from rimonabant?
Marzo, V. D., & Després, J. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.197 · Cited by 138
The emerging role of the endocannabinoid system in cardiovascular disease
Pacher, P., & Steffens, S. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0145-8 · Cited by 142
The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: a cross-sectional analysis of two population-based studies
Sigit, F. S., Tahapary, D. L., Trompet, S., Sartono, E., van Dijk, K. W., Rosendaal, F. R., & de Mutsert, R. (2020) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0503-1 · Cited by 166
Visceral adiposity is negatively associated with bone density and muscle attenuation
Zhang, P., Peterson, M. D., Su, G. L., & Wang, S. C. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.081778 · Cited by 135
Associations Between Depression, Arterial Stiffness, and Metabolic Syndrome Among Adults in the UK Biobank Population Study: A Mediation Analysis
Dregan, A., Rayner, L., Davis, K. A. S., Bakolis, I., Arias de la Torre, J., Das-Munshi, J., Hatch, S. L., Stewart, R., & Hotopf, M. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4712 · Cited by 132
Abdominal Obesity and Cardiovascular Disease: Is Inflammation the Missing Link?
Després, J. (2012) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2012.06.004 · Cited by 137
Dyslipidemia in Achilles Tendinopathy Is Characteristic of Insulin Resistance
Gaida, J. E., Alfredson, L., KISS, Z. S., Wilson, A., Alfredson, H., & Cook, J. L. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31819794c3 · Cited by 131
Performance of the waist-to-height ratio in identifying obesity and predicting non-communicable diseases in the elderly population: A systematic literature review
Corrêa, M. M., Thumé, E., de Oliveira, E. R. A., & Tomasi, E. (2016) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2016.03.021 · Cited by 135
Worldwide trends in metabolic syndrome from 2000 to 2023: a systematic review and modelling analysis
Noubiap, J. J., Nansseu, J. R., Nyaga, U. F., Ndoadoumgue, A. L., Ngouo, A. T., Tounouga, D. N., Tianyi, F.-L., Foka, A. J., Lontchi‐Yimagou, E., Nkeck, J. R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67268-5 · Cited by 165
Methodology and Early Findings of the Third Survey of CASPIAN Study: A National School-based Surveillance of Students' High Risk Behaviors.
Kelishadi, R., Heshmat, R., Motlagh, M. E., Majdzadeh, R., Keramatian, K., Qorbani, M., Taslimi, M., Aminaee, T., Ardalan, G., Poursafa, P., et al. (2012) · Europe PMC (PubMed Central) · Cited by 126
Quantitative proton MR techniques for measuring fat
Hu, H., & Kan, H. E. (2013) · NMR in Biomedicine · doi:10.1002/nbm.3025 · Cited by 130
A Black Soybean Seed Coat Extract Prevents Obesity and Glucose Intolerance by Up-regulating Uncoupling Proteins and Down-regulating Inflammatory Cytokines in High-Fat Diet-Fed Mice
Kanamoto, Y., Yamashita, Y., Nanba, F., Yoshida, T., Tsuda, T., Fukuda, I., Nakamura‐Tsuruta, S., & Ashida, H. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201471p · Cited by 127
Validation of a portable bioelectrical impedance analyzer for the assessment of body composition
Karelis, A. D., Chamberland, G., Aubertin‐Leheudre, M., Duval, C., & Ecological mobility in Aging and Parkinson (EMAP) group (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0129 · Cited by 124
Epidemiology of Obesity
Sørensen, T. I. A., Martínez, A. R., & Jørgensen, T. S. H. (2022) · Handbook of experimental pharmacology · doi:10.1007/164_2022_581 · Cited by 138
Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: Relationship to metabolic profile, cardiac function and visceral fat
Gaborit, B., Kober, F., Jacquier, A., Moro, P. J., Cuisset, T., Boullu, S., Dadoun, F., Alessi, M.-C., Morange, P., Clément, K., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.117 · Cited by 116
Risk of nonalcoholic steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease and low visceral adiposity
Fracanzani, A. L., Valenti, L. V. C., Bugianesi, E., Vanni, E., Grieco, A., Miele, L., Consonni, D., Fatta, E., Lombardi, R., Marchesini, G., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.09.037 · Cited by 120
The effects of synbiotic supplementation on some cardio-metabolic risk factors in overweight and obese children: a randomized triple-masked controlled trial
Safavi, S. M., Farajian, S., Kelishadi, R., Mirlohi, M., & Hashemipour, M. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.775224 · Cited by 117
Plasma amino acid profile is associated with visceral fat accumulation in obese Japanese subjects
Yamakado, M., Tanaka, T., Nagao, K., Ishizaka, Y., Mitushima, T., Tani, M., Toda, A., Toda, E., Okada, M., Miyano, H., et al. (2012) · Clinical Obesity · doi:10.1111/j.1758-8111.2012.00039.x · Cited by 117
Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease
Pugh, C. J. A., Sprung, V. S., Kemp, G. J., Richardson, P., Shojaee-Moradie, F., Umpleby, A. M., Green, D. J., Cable, N. T., Jones, H., & Cuthbertson, D. J. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00306.2014 · Cited by 116
Cardiac Adiposity and Global Cardiometabolic Risk New Concept and Clinical Implication
Shimabukuro, M. (2008) · Circulation Journal · doi:10.1253/circj.cj-08-1012 · Cited by 118
Comparison between two methods of bioelectrical impedance analyses for accuracy in measuring abdominal visceral fat area
Park, K. S., Lee, D., Lee, J.-E., Kim, Y. J., Jung, K. Y., Kim, K. M., Kwak, S. H., Choi, S. H., Park, K. S., Jang, H. C., et al. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.10.014 · Cited by 115
Abdominal obesity and lung cancer risk: Systematic review and meta-analysis of prospective studies
Hidayat, K., Du, X., Chen, G., Shi, M., & Shi, B. (2016) · Nutrients · doi:10.3390/nu8120810 · Cited by 114
Prediction of early childhood obesity with machine learning and electronic health record data
Pang, X., Forrest, C. B., Lê‐Scherban, F., & Masino, A. J. (2021) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2021.104454 · Cited by 119
Waist circumference is a better predictor of risk for frailty than BMI in the community-dwelling elderly in Beijing
Liao, Q., Zheng, Z., Xiu, S., & Chan, P. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-0933-x · Cited by 104
Impact of increased visceral and cardiac fat on cardiometabolic risk and disease
Sironi, A., Petz, R., Marchi, D. D., Buzzigoli, E., Ciociaro, D., Positano, V., Lombardi, M., Ferrannini, E., & Gastaldelli, A. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03503.x · Cited by 114
Impact of fat mass and distribution on lipid turnover in human adipose tissue
Spalding, K. L., Bernard, S., Näslund, E. B., Salehpour, M., Possnert, G., Appelsved, L., Fu, K., Alkass, K., Druid, H., Thorell, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms15253 · Cited by 117
Effect of Aerobic Interval Training on Exercise Capacity and Metabolic Risk Factors in People With Cardiometabolic Disorders: A META-ANALYSIS
Hwang, C.-L., Wu, Y.-T., & Chou, C.-H. (2011) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0b013e31822f16cb · Cited by 111
Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction
Traish, A. M., Feeley, R. J., & Guay, A. T. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07305.x · Cited by 115
Exposure to bioaccumulative organochlorine compounds alters adipogenesis, fatty acid uptake, and adipokine production in NIH3T3-L1 cells
Howell, G., & Mangum, L. H. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.10.015 · Cited by 110
Cardiac Steatosis Associates With Visceral Obesity in Nondiabetic Obese Men
Granér, M., Sirén, R., Nyman, K., Lundbom, J., Hakkarainen, A., Pentikäinen, M. O., Lauerma, K., Lundbom, N. M. I., Adiels, M., Nieminen, M. S., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3190 · Cited by 111
Objective Sleep Characteristics and Cardiometabolic Health in Young Adolescents
Feliciano, E. M. C., Quante, M., Rifas‐Shiman, S. L., Redline, S. S., Oken, E., & Taveras, E. M. (2018) · PEDIATRICS · doi:10.1542/peds.2017-4085 · Cited by 115
Adipose tissue changes in obesity and the impact on metabolic function
Sam, S., & Mazzone, T. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.008 · Cited by 113
A two-step convolutional neural network based computer-aided detection scheme for automatically segmenting adipose tissue volume depicting on CT images
Wang, Y., Qiu, Y., Thai, T., Moore, K., Liu, H., & Zheng, B. (2017) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2017.03.017 · Cited by 110
Health consequences of obesity and projected future obesity health burden in China
Sun, X., Yan, Q., Shi, Z., Zhao, B., Yan, N., Li, K., Gao, L., Xue, H., Peng, W. H., Cheskin, L. J., et al. (2022) · Obesity · doi:10.1002/oby.23472 · Cited by 113
Exosomal proteins constitute an essential part of the human adipose tissue secretome
Hartwig, S., Filippo, E. D., Göddeke, S., Knebel, B., Kotzka, J., Al‐Hasani, H., Roden, M., Lehr, S., & Sell, H. (2018) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2018.11.009 · Cited by 112
Waist circumference and waist‐to‐height ratio in Norwegian children 4–18 years of age: Reference values and cut‐off levels
Brannsether, B., Roelants, M., Bjerknes, R., & Júlíusson, P. B. (2011) · Acta Paediatrica · doi:10.1111/j.1651-2227.2011.02370.x · Cited by 113
Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoea
Sivam, S., Phillips, C. L., Trenell, M. I., Yee, B. J., Liu, P. Y., WONG, K. K. H., & Grunstein, R. R. (2012) · European Respiratory Journal · doi:10.1183/09031936.00177011 · Cited by 108
Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: A comparison of older with young men
Karaouzene, N., Merzouk, H., Aribi, M., Merzouk, S. A., Yahia Berrouiguet, A., Tessier, C., & Narce, M. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.02.007 · Cited by 106
Brown adipose tissue is associated with healthier body fat distribution and metabolic benefits independent of regional adiposity
Wibmer, A. G., Becher, T., Eljalby, M., Crane, A., Andrieu, P. C., Jiang, C. S., VAUGHAN, R. D., Schöder, H. M., & Cohen, P. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100332 · Cited by 112
Exercise Like a Hunter-Gatherer: A Prescription for Organic Physical Fitness
O’Keefe, J. H., Vogel, R. A., Lavie, C. J., & Cordain, L. (2011) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2011.03.009 · Cited by 114
Excess Visceral Adipose Tissue/Ectopic Fat
Després, J. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.063 · Cited by 103
Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis
Stancu, C. S., Toma, L., & Sima, A. V. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1437-1 · Cited by 110
Utility of Waist-To-Height Ratio in Detecting Central Obesity and Related Adverse Cardiovascular Risk Profile Among Normal Weight Younger Adults (from the Bogalusa Heart Study)
Srinivasan, S. R., Wang, R., Chen, W., Wei, C. Y., Xu, J.-H., & Berenson, G. S. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.04.037 · Cited by 100
The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance
Chavakis, T., Chmelař, J., & Chung, K. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-09-0703 · Cited by 106
Insulin and the Lung: Connecting Asthma and Metabolic Syndrome
Singh, S., Prakash, Y. S., Linneberg, A. R., & Agrawal, A. (2013) · Journal of Allergy · doi:10.1155/2013/627384 · Cited by 103
IRF-1 and miRNA126 Modulate VCAM-1 Expression in Response to a High-Fat Meal
Sun, C., Alkhoury, K., Wang, Y. I., Foster, G. A., Radecke, C. E., Tam, K., Edwards, C. M., Facciotti, M. T., Armstrong, E. J., Knowlton, A. A., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.270314 · Cited by 102
Fully automated segmentation and quantification of visceral and subcutaneous fat at abdominal CT: application to a longitudinal adult screening cohort
Lee, S., Liu, J., Yao, J., Kanarek, A. A., Summers, R. M., & Pickhardt, P. J. (2018) · British Journal of Radiology · doi:10.1259/bjr.20170968 · Cited by 100
Human Mesenteric Adipose Tissue Plays Unique Role Versus Subcutaneous and Omental Fat in Obesity Related Diabetes
Yang, Y., Chen, M., Clements, R. H., Abrams, G. A., Aprahamian, C. J., & Harmon, C. M. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000185527 · Cited by 100
Predictive performance of the visceral adiposity index for a visceral adiposity-related risk: Type 2 Diabetes
Bozorgmanesh, M., Hadaegh, F., & Azizi, F. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-88 · Cited by 102
Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus
Sohail, M. U., Thani, A. A. A., Anwar, H., Rizzi, R., & Marei, H. E. S. (2017) · Journal of Diabetes Research · doi:10.1155/2017/9631435 · Cited by 104
Visceral adiposity as a target for the management of the metabolic syndrome
Kishida, K., Funahashi, T., Matsuzawa, Y., & Shimomura, I. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.564202 · Cited by 101
AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis
Cordero‐Herrera, I., Kozyra, M., Zhuge, Z., Haworth, S. M., Moretti, C. H., Peleli, M., Caldeira-Dias, M., Jahandideh, A., Huirong, H., Cruz, J. C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809406115 · Cited by 100
Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay
Mammi, C., Calanchini, M., Antelmi, A., Cinti, F., Rosano, G. M. C., Lenzi, A., Caprio, M., & Fabbri, A. (2012) · International Journal of Endocrinology · doi:10.1155/2012/789653 · Cited by 95
Diets Rich in Fruits and Vegetables Are Associated with Lower Cardiovascular Disease Risk in Adolescents
Mellendick, K. M., Shanahan, L., Wideman, L., Calkins, S. D., Keane, S. P., & Lovelady, C. A. (2018) · Nutrients · doi:10.3390/nu10020136 · Cited by 94
Hypertriglyceridemic waist: an alternative to the metabolic syndrome? Results of the IMAP Study (multidisciplinary intervention in primary care)
Gómez-Huelgas, R., Bernal-López, M. R., Villalobos, A., Mancera‐Romero, J., Baca-Osorio, A., Jansen, S., Guijarro, R., Salgado, F., Tinahones, F. J., & Serrano‐Ríos, M. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.127 · Cited by 94
Fructose metabolism, cardiometabolic risk, and the epidemic of coronary artery disease
Mirtschink, P., Jang, C., Arany, Z. P., & Krek, W. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx518 · Cited by 95
Sex Differences in Early Carotid Atherosclerosis (from the Community-Based Gutenberg-Heart Study)
Sinning, C., Wild, P. S., Echevarria, F. M. O., Wilde, S., Schnabel, R. B., Lubos, E., Herkenhoff, S., Bickel, C., Klimpe, S., Gori, T., et al. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.02.318 · Cited by 93
Concerted Action of Aldehyde Dehydrogenases Influences Depot-Specific Fat Formation
Reichert, B., Yasmeen, R., Jeyakumar, S. M., Yang, F., Thomou, T., Alder, H., Duester, G., Maiseyeu, A., Mihai, G., Harrison, E. H., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0465 · Cited by 93
Clinical significance of visceral adiposity assessed by computed tomography: A Japanese perspective
Ryo, M. (2014) · World Journal of Radiology · doi:10.4329/wjr.v6.i7.409 · Cited by 96
Association of Central Adiposity With Adverse Cardiac Mechanics
Selvaraj, S., Martinez, E. E., Aguilar, F. G., Kim, K. A., Peng, J., Sha, J., Irvin, M. R., Lewis, C. E., Hunt, S. C., Arnett, D. K., et al. (2016) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.115.004396 · Cited by 93
Linking perceived control, physical activity, and biological health to memory change.
Infurna, F. J., & Gerstorf, D. (2013) · Psychology and Aging · doi:10.1037/a0033327 · Cited by 92
Vitamin D in Overweight/Obese Women and Its Relationship With Dietetic and Anthropometric Variables
Rodríguez‐Rodríguez, E., Navia, B., López-Sobaler, A. M., & Anta, R. M. O. (2009) · Obesity · doi:10.1038/oby.2008.649 · Cited by 90
Effects of canola and high‐oleic‐acid canola oils on abdominal fat mass in individuals with central obesity
Liu, X., Kris‐Etherton, P. M., West, S. G., Lamarche, B., Jenkins, D. J. A., Fleming, J. A., McCrea, C. E., Pu, S., Couture, P., Connelly, P. W., et al. (2016) · Obesity · doi:10.1002/oby.21584 · Cited by 92
Plasma vaspin concentrations are elevated in metabolic syndrome in men and are correlated with coronary atherosclerosis in women
Choi, S. H., Kwak, S. H., Lee, Y., Moon, M. K., Lim, S. K., Park, Y. J., Jang, H. C., & Kim, M. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04095.x · Cited by 91
A Simple Screening Score for Diabetes for the Korean Population
Lee, Y., Bang, H., Kim, H. C., Kim, H. M., Park, S. W., & Kim, D. J. (2012) · Diabetes Care · doi:10.2337/dc11-2347 · Cited by 91
Differential effect of subcutaneous abdominal and visceral adipose tissue on cardiometabolic risk
Sam, S. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0014 · Cited by 98
Segmentation and quantification of adipose tissue by magnetic resonance imaging
Hu, H. H., Chen, J., & Shen, W. (2016) · Magnetic Resonance Materials in Physics, Biology and Medicine · doi:10.1007/s10334-015-0498-z · Cited by 90
Cardiovascular Risk-Benefit Profile of Sibutramine
Scheen, A. J. (2010) · American Journal of Cardiovascular Drugs · doi:10.2165/11584800-000000000-00000 · Cited by 89
Normal-Weight Central Obesity and Mortality Risk in Older Adults With Coronary Artery Disease
Sharma, S., Batsis, J. A., Coutinho, T. A., Somers, V. K., Hodge, D. O., Carter, R. E., Sochor, O., Kragelund, C., Kanaya, A. M., Zeller, M., et al. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.12.007 · Cited by 89
Central Adiposity Is Negatively Associated with Hippocampal-Dependent Relational Memory among Overweight and Obese Children
Khan, N. A., Baym, C. L., Monti, J. M., Raine, L. B., Drollette, E. S., Scudder, M. R., Moore, R. D., Kramer, A. F., Hillman, C. H., & Cohen, N. J. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.10.008 · Cited by 97
Serum metabolic profiles in overweight and obese women with and without metabolic syndrome
Wiklund, P., Pekkala, S., Autio, R., Munukka, E., Xu, L., Saltevo, J. T., Cheng, S., Kujala, U. M., Alén, M., & Cheng, S. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-40 · Cited by 94
Effect of genetic and environmental influences on cardiometabolic risk factors: a twin study
Jermendy, G., Horváth, T., Littvay, L., Steinbach, R., Jermendy, Á. L., Tárnoki, Á. D., Tárnoki, D. L., Métneki, J., & Osztovits, J. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-96 · Cited by 87
Management of Obesity in Cardiovascular Practice
Després, J.-P., Carpentier, A. C., Tchernof, A., Neeland, I. J., & Poirier, P. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.05.035 · Cited by 87
Self-citation
Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle
Tsutsumi, R., Yoshida, T., Yoshitaka, N. I. I., Okahisa, N., Iwata, S., Tsukayama, M., Hashimoto, R., Taniguchi, Y., Sakaue, H., Hosaka, T., et al. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-32 · Cited by 85
Characterization of stromal vascular fraction and adipose stem cells from subcutaneous, preperitoneal and visceral morbidly obese human adipose tissue depots
Silva, K. R., Côrtes, I., Liechocki, S., Carneiro, J. R. I., de Souza, A. A. P., Borojević, R., Maya‐Monteiro, C. M., & Baptista, L. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174115 · Cited by 93
The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders
Dionysopoulou, S., Charmandari, E., Bargiota, Α., Vlahos, N., Mastorakos, G. P., & Valsamakis, G. (2021) · Nutrients · doi:10.3390/nu13020498 · Cited by 91
Distinctive modulation of inflammatory and metabolic parameters in relation to zinc nutritional status in adult overweight/obese subjects
Costarelli, L., Muti, E., Malavolta, M., Cipriano, C., Giacconi, R., Tesei, S., Piacenza, F., Pierpaoli, S., Gasparini, N., Faloia, E., et al. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.02.001 · Cited by 85
Obesity and risk for its comorbidities diabetes, hypertension, and dyslipidemia in Japanese individuals aged 65 years
Yamada, T., Kimura-Koyanagi, M., Sakaguchi, K., Ogawa, W., & Tamori, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-29276-7 · Cited by 82
Clinical utility of visceral adipose tissue for the identification of cardiometabolic risk in white and African American adults
Katzmarzyk, P. T., Heymsfield, S. B., & Bouchard, C. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.047787 · Cited by 82
Network Meta-Analysis of Metabolic Effects of Olive-Oil in Humans Shows the Importance of Olive Oil Consumption With Moderate Polyphenol Levels as Part of the Mediterranean Diet
Tsartsou, E., Proutsos, N. D., Castanas, E., & Kampa, M. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00006 · Cited by 87
Tracing the fate of dietary fatty acids: metabolic studies of postprandial lipaemia in human subjects
Fielding, B. A. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s002966511100084x · Cited by 81
Perceived control relates to better functional health and lower cardio-metabolic risk: The mediating role of physical activity.
Infurna, F. J., & Gerstorf, D. (2012) · Health Psychology · doi:10.1037/a0030208 · Cited by 93
Impact of obesity on total and cardiovascular mortality—fat or fiction?
Cepeda-Valery, B., Pressman, G. S., Figueredo, V. M., & Romero‐Corral, A. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.209 · Cited by 81
Overweight, Obesity, and CVD Risk: a Focus on Visceral/Ectopic Fat
Chartrand, D. J., Murphy-Després, A., Alméras, N., Lemieux, I., Larose, É., & Després, J. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-00996-x · Cited by 87
Gut Dysbiosis and Adaptive Immune Response in Diet-induced Obesity vs. Systemic Inflammation
Pindjáková, J., Sartini, C., Re, O. L., Rappa, F., Coupé, B., Lelouvier, B., Pazienza, V., & Vinciguerra, M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01157 · Cited by 82
The Novel Secreted Adipokine WNT1-inducible Signaling Pathway Protein 2 (WISP2) Is a Mesenchymal Cell Activator of Canonical WNT
Grünberg, J. R., Hammarstedt, A., Hedjazifar, S., & Smith, U. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.511964 · Cited by 78
Gender differences in adiponectin levels and body composition in older adults: Hallym aging study
Song, H. J., Oh, S., Quan, S., Ryu, O., Jeong, J.-Y., Hong, K.-S., & Kim, D.-H. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-8 · Cited by 80
Central obesity and cardiovascular outcomes in patients with acute coronary syndrome: observations from the MERLIN-TIMI 36 trial
Kadakia, M. B., Fox, C. S., Scirica, B. M., Murphy, S. A., Bonaca, M. P., & Morrow, D. A. (2011) · Heart · doi:10.1136/heartjnl-2011-300231 · Cited by 78

Authors: Després, J.-P., Lemieux, I., Bergeron, J., Pibarot, P., Mathieu, P., Larose, E., Rodés-Cabau, J., Bertrand, O. F., & Poirier, P.
Affiliations: From the Hôpital Laval Research Centre (J.-P.D., I.L., P. Pibarot, P.M., E.L., J.R.-C., O.F.B., P. Poirier); the Institut universitaire de cardiologie et de pneumologie (J.-P.D., P.M., E.L., J.R.-C., O.F.B., P. Poirier), Hôpital Laval; the Division of Kinesiology (J.-P.D.), Department of Social and Preventive Medicine, Université Laval; the Lipid Research Centre (J.B.), CHUQ Research Centre; the Department of Medicine (P. Pibarot), Université Laval; the Department of Surgery (P.M.), Université...
Université Laval (CA)
ORCID: Lemieux, Isabelle
Bergeron, Jean
Mathieu, Patrick
Bertrand, Olivier F.
Poirier, Paul
Venue: Arteriosclerosis Thrombosis and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-06
Volume: 28
Issue: 6
Pages: 1039-1049
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/atvbaha.107.159228
OpenAlex: W2106690226
Cited by: 1,589
References: 129
Citations by year: 2026: 39 · 2025: 52 · 2024: 63 · 2023: 71 · 2022: 120 · 2021: 92 · 2020: 86 · 2019: 74 · 2018: 91 · 2017: 86 · 2016: 91 · 2015: 108 · 2014: 115 · 2013: 101 · 2012: 97
FWCI: 12.68
Type: journal article
Language: en
Update notices: correction (2008-07-01)
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Corpus Université Laval (Université Laval) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: abdominal obesity, metabolic syndrome, visceral adipose tissue, insulin resistance, cardiometabolic risk, waist circumference, fasting triglycerides, ectopic fat deposition, cardiovascular risk, diagnostic thresholds
MeSH terms: Cardiovascular Diseases, Humans, Insulin Resistance, Obesity, Risk Factors, Triglycerides, Metabolic Syndrome, Intra-Abdominal Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks