Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: Relationship to metabolic profile, cardiac function and visceral fat
Abstract
Objective To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function.Research design and methods Sixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4 ± 2.0 kg m(-2)) and 30 obese (BMI: 41.8 ± 6 kg m(-2)) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy.Results EFV and MTGC were positively correlated (r=0.52, P<0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141 ± 18 versus 79 ± 7 ml, P=0.0001; 1.0 ± 0.1 versus 0.6 ± 0.1%, P=0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213 ± 34 versus 141 ± 18 ml, P=0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters (P<0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume (β=-0.38, P=0.01), suggesting an impact of cardiac steatosis in cardiac function.Conclusions These data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition.
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EAT expansion is associated with intramyocardial accumulation of triglycerides in severely obese subjects, and intramyocardial fat is correlated with LV diastolic dysfunction.
“In studies using proton magnetic resonance spectroscopy, EAT expansion was associated with intramyocardial accumulation of triglycerides in severely obese subjects and intramyocardial fat was correlated with LV diastolic dysfunction [88].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [88]
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- Authors
- Gaborit, B., Kober, F., Jacquier, A., Moro, P. J., Cuisset, T., Boullu, S., Dadoun, F., Alessi, M.-C., Morange, P., Clément, K., Bernard, M., & Dutour, A.
- Affiliations
- Hôpital Nord (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Corresponding author
- Gaborit, B
- ORCID
- Venue
- International Journal of Obesity
- Published
- 2011-07-05
- Volume
- 36
- Issue
- 3
- Pages
- 422-430
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2052264647
- Cited by
- 116
- References
- 49
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 5 · 2015: 9 · 2014: 11 · 2013: 12 · 2012: 6
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- epicardial fat volume, myocardial triglyceride content, cardiac steatosis, ectopic fat deposition, visceral fat, morbid obesity, metabolic profile, insulin resistance, diabetes mellitus, lipid profile, inflammation, cardiac function, stroke volume, 1H NMR, cardiovascular MRI
- MeSH terms
- Adult, Diabetes Mellitus, Type 2, Female, Humans, Male, Magnetic Resonance Spectroscopy, Obesity, Morbid, Pericardium, Triglycerides, Ventricular Dysfunction, Left, Intra-Abdominal Fat, Lipid Metabolism, Metabolome
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