Cited by 95Hormonal and reproductive studiesAdipokines, Inflammation, and Metabolic DiseasesSperm and Testicular Function

Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay

Open access
Mammi, Caterina, Calanchini, Matilde, Antelmi, Antonella, Cinti, Francesca, Rosano, Giuseppe M. C., Lenzi, Andrea, Caprio, Massimiliano, Fabbri, Andrea·2012·International Journal of Endocrinology

Abstract

Clinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a “hallmark” of metabolic syndrome in men. These observations indicate that there is a strict connection between anatomically and functionally distinct cell types such as white adipocytes and Leydig cells, that synthesize testosterone. Adipose tissue is able to control several functions of the testis through its products secreted in the bloodstream. On the other hand, circulating levels of testosterone and estradiol deeply affect adipocyte proliferation, differentiation, and fat mass distribution, hereby controlling critical metabolic functions, such as food intake, insulin sensitivity, vascular reactivity, and immunity. This paper highlights the existing clinical and experimental evidence linking androgens and adipose tissue and illustrates the consequences occurring when the balance between fat mass distribution and eugonadism is lost.

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  1. [25]Caprio M Fabbrini E Isidori AM Aversa A Fabbri A Leptin in reproduction Trends in Endocrinology and Metabolism 2001 12 2 65 72 11167124

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Authors
Mammi, C., Calanchini, M., Antelmi, A., Cinti, F., Rosano, G. M. C., Lenzi, A., Caprio, M., & Fabbri, A.
Affiliations
  • Istituti di Ricovero e Cura a Carattere Scientifico (IT)
  • University of Rome Tor Vergata (IT)
  • Sapienza University of Rome (IT)
Corresponding author
Mammi, Caterina
Venue
International Journal of Endocrinology
Published
2012
Volume
2012
Pages
1-8
ISSN
  • 1687-8337 (ISSN-L)
  • 1687-8345
OpenAlex
W2070191401
Cited by
95
References
89
Citations by year
2026: 4 · 2025: 5 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 1 · 2015: 8 · 2014: 9 · 2013: 12 · 2012: 5
FWCI
6.82
Type
journal article
Language
en
Open access
Locations
  • International Journal of Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
  • Università degli Studi di Roma Tor Vergata
  • Ministero dell'Università e della Ricerca
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
androgens, adipose tissue, testosterone, hypogonadism, obesity, Leydig cells, white adipocytes, metabolic syndrome, body fat distribution, estradiol, insulin sensitivity, dietary intake, vascular reactivity, immunity

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