The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance
Abstract
Background— Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue inflammation and IR. Methods and Results— In a mouse model of obesity-mediated IR, high-fat diet (HFD) induced IR already after 5 weeks, which was associated with a marked T-lymphocyte infiltration in visceral adipose tissue. In contrast, recruitment of macrophages was delayed with an increase of MAC3-positive staining and F4/80 mRNA expression after 10 weeks of HFD, suggesting a dissociation of macrophage invasion into adipose tissue and IR initiation. In patients with type 2 diabetes, lymphocyte content in adipose tissue biopsies significantly correlated with waist circumference, a marker of IR. Immunohistochemical staining of human adipose tissue revealed the presence of mainly CD4-positive lymphocytes as well as macrophage infiltration. Most macrophages were HLA-DR–positive, reflecting activation through IFNγ, a cytokine released from CD4-positive lymphocytes. Conclusions— Proinflammatory T-lymphocytes are present in visceral adipose tissue and may contribute to local inflammatory cell activation before the appearance of macrophages, suggesting that these cells could play an important role in the initiation and perpetuation of adipose tissue inflammation as well as the development of IR.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Serum or plasma concentrations of TNF-a or IL-6 in healthy adults are typically 0•01-2 pmol/l (6) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [6]
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,633
Pouliot, M., Després, J., Lemieux, S., Moorjani, S., Bouchard, C., Tremblay, A., Nadeau, A., & Lupien, P. J. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90676-9 · Cited by 2,099
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335 · Cited by 1,497
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
Weisberg, S. P. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335c1 · Cited by 1,425
Relationship between Adipocyte Size and Adipokine Expression and Secretion
Skurk, T., Alberti-Huber, C., Herder, C., & Hauner, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1055 · Cited by 1,288
Self-citationWu, H., Ghosh, S., Perrard, X. D., Feng, L., García, G., Perrard, J. L., Sweeney, J. F., Peterson, L. E., Chan, L., Smith, C. W., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.638379 · Cited by 696
Rausch, M. E., Weisberg, S., Vardhana, P., & Tortoriello, D. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803744 · Cited by 585
IFN-γ production by antigen-presenting cells: mechanisms emerge
Frucht, D. M., Fukao, T., Bogdan, C., Schindler, H., O’Shea, J. J., & Koyasu, S. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)02005-1 · Cited by 474
The prediction of abdominal visceral fat level from body composition and anthropometry: ROC analysis
Rankinen, T., Kim, S.-Y., Pérusse, L., Després, J.-P., & Bouchard, C. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800929 · Cited by 414
Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages
Bourlier, V., Zakaroff‐Girard, A., Miranville, A., Barros, S. D., Maumus, M., Sengenès, C., Galitzky, J., Lafontan, M., Karpe, F., Frayn, K. N., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.724096 · Cited by 390
Schupp, M., Clemenz, M., Gineste, R., Witt, H., Janke, J., Helleboid, S., Hennuyer, N., Ruíz, P., Unger, T., Staels, B., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3442 · Cited by 273
Self-citationBornstein, S. R., Abu-Asab, M. S., Glasow, A., Päth, G., Hauner, H., Tsokos, M., Chrousos, G. P., & Scherbaum, W. A. (2000) · Diabetes · doi:10.2337/diabetes.49.4.532 · Cited by 189
Self-citationIFN-γ Expression in Macrophages and Its Possible Biological Significance
Gessani, S., & Belardelli, F. (1998) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)00007-0 · Cited by 166
Gaudet, D., Vohl, M., Perron, P., Tremblay, G., Gagné, C., Lesiège, D., Bergeron, J., Moorjani, S., & Després, J. (1998) · Circulation · doi:10.1161/01.cir.97.9.871 · Cited by 99
Relation of abdominal obesity to hyperinsulinemia and high blood pressure in men.
Johnson, D., Prud’homme, D., Després, J., Nadeau, A., Tremblay, A., & Bouchard, C. (1992) · PubMed · Cited by 74
Herder, C., Hauner, H., Kempf, K., Kolb, H., & Skurk, T. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803432 · Cited by 50
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230
Adipose tissue inflammation and metabolic dysfunction in obesity
Kawai, T., Autieri, M. V., & Scalia, R. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2020 · Cited by 1,947
Normalization of obesity-associated insulin resistance through immunotherapy
Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370
Metadata
- Authors
- Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., Fischer-Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., Hauner, H., Blüher, M., Unger, T., Wolf, A.-M., Knippschild, U., Hombach, V., & Marx, N.
- Affiliations
- Universität Ulm (DE)
- From the Center for Cardiovascular Research (U.K., M.H., A.F.-L., M.C., T.U.), Institute of Pharmacology, Charité-Universitaetsmedizin, Berlin, Germany; the Department of Internal Medicine II – Cardiology (K.H., V.H., N.M.), University of Ulm, Germany; the Division of Pediatric Endocrinology, Department of Pediatrics and Adolescent Medicine (M.W., P.F.-P.), University of Ulm, Germany; the Department of Pathology (T.F.E.B.), University of Ulm, Germany; the Department of Nephrology, Campus Virchow...
- ORCID
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2008-07
- Volume
- 28
- Issue
- 7
- Pages
- 1304-1310
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2163270865
- Cited by
- 692
- References
- 23
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 21 · 2023: 23 · 2022: 27 · 2021: 34 · 2020: 39 · 2019: 30 · 2018: 34 · 2017: 45 · 2016: 41 · 2015: 41 · 2014: 55 · 2013: 74 · 2012: 52
- FWCI
- 37.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- T cell infiltration, visceral adipose tissue, adipose tissue inflammation, insulin resistance, obesity, high-fat diet, macrophage recruitment, CD4-positive lymphocytes, HLA-DR, interferon-gamma, type 2 diabetes, waist circumference
- MeSH terms
- Aged, Animals, Cell Movement, Cells, Cultured, Diabetes Mellitus, Type 2, Dietary Fats, Disease Models, Animal, Humans, Insulin Resistance, Interferon-gamma, Macrophages, Male, Mice, Inbred C57BL, Middle Aged, Obesity, Time Factors, Panniculitis, CD4-Positive T-Lymphocytes, Adipocytes, Chemokine CCL2, Body Size, Intra-Abdominal Fat, Mice, Chemokine CXCL12
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
