T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Inflammation, Atherosclerosis, and Coronary Artery Disease

Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773

Inflammation and Atherosclerosis

Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664

Interferon-γ: an overview of signals, mechanisms and functions

Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120

Chemokines — Chemotactic Cytokines That Mediate Inflammation

Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,633

Waist circumference and abdominal sagittal diameter: Best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women

Pouliot, M., Després, J., Lemieux, S., Moorjani, S., Bouchard, C., Tremblay, A., Nadeau, A., & Lupien, P. J. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90676-9 · Cited by 2,099

Obesity-induced inflammatory changes in adipose tissue

Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335 · Cited by 1,497

Macrophages, inflammation, and insulin resistance

Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733

Human nutrition, the gut microbiome and the immune system

Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230

Adipose tissue inflammation and metabolic dysfunction in obesity

Kawai, T., Autieri, M. V., & Scalia, R. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2020 · Cited by 1,947

Normalization of obesity-associated insulin resistance through immunotherapy

Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098

Metabolic Inflammation and Insulin Resistance in Obesity

Wu, H., & Ballantyne, C. M. (2020) · Circulation Research · doi:10.1161/circresaha.119.315896 · Cited by 1,059

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

Maury, E., & Brichard, S. M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.031 · Cited by 1,026

Obesity, inflammation, and atherosclerosis

Rocha, V. Z., & Libby, P. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.55 · Cited by 994

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 956

Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis

Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882

Inflammation in Atherosclerosis: Transition From Theory to Practice

Libby, P., Okamoto, Y., Rocha, V. Z., & Folco, E. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0706 · Cited by 799

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

Liu, J., Divoux, A., Sun, J., Zhang, J., Clément, K., Glickman, J. N., Sukhova, G. K., Wolters, P. J., Du, J., Gorgun, C. Z., et al. (2009) · Nature Medicine · doi:10.1038/nm.1994 · Cited by 796

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

Kosteli, A., Sugaru, E., Haemmerle, G., Martin, J. F., Lei, J., Zechner, R., & Ferrante, A. W. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42845 · Cited by 726

Alternative macrophage activation and metabolism

Odegaard, J. I., & Chawla, A. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130138 · Cited by 640

Adipokine dysregulation and adipose tissue inflammation in human obesity

Unamuno, X., Gómez‐Ambrosi, J., Rodríguez, A., Becerril, S., Frühbeck, G., & Catalán, V. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12997 · Cited by 610

The inflammation highway: metabolism accelerates inflammatory traffic in obesity

Johnson, A. R., Justin Milner, J., & Makowski, L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01151.x · Cited by 603

Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 ( Covid ‐19)

Zhou, Y., Chi, J., Lv, W., & Wang, Y. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3377 · Cited by 522

Adaptive immunity in obesity and insulin resistance

Sell, H., Habich, C., & Eckel, J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.114 · Cited by 486

Inflammatory cytokines in general and central obesity and modulating effects of physical activity

Schmidt, F. M., Weschenfelder, J., Sander, C., Minkwitz, J., Thormann, J., Chittka, T., Mergl, R., Kirkby, K. C., Faßhauer, M., Stumvoll, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121971 · Cited by 483

Obesity, Inflammation, and Immune System in Osteoarthritis

Nedunchezhiyan, U., Varughese, I., Sun, A. R., Wu, X., Crawford, R., & Prasadam, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.907750 · Cited by 507

The role of infiltrating immune cells in dysfunctional adipose tissue

Guzik, T. J., Skiba, D. S., Touyz, R. M., & Harrison, D. G. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx108 · Cited by 462

Adipose tissue macrophages: their role in adipose tissue remodeling

Suganami, T., & Ogawa, Y. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0210072 · Cited by 455

Immunological Goings-on in Visceral Adipose Tissue

Mathis, D. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.008 · Cited by 449

Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes

Hummasti, S., & Hotamışlıgil, G. S. (2010) · Circulation Research · doi:10.1161/circresaha.110.225698 · Cited by 445

Adipose tissue macrophages: going off track during obesity

Boutens, L., & Stienstra, R. (2016) · Diabetologia · doi:10.1007/s00125-016-3904-9 · Cited by 454

Oxidative stress and inflammation interactions in human obesity

Bondia‐Pons, I., Ryan, L., & Martínez, J. A. (2012) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0154-2 · Cited by 420

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

Deng, T., Lyon, C. J., Minze, L. J., Lin, J., Zou, J., Liu, J. Z., Ren, Y., Yin, Z., Hamilton, D. J., Reardon, P. R., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.009 · Cited by 396

Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution

Sárvári, A. K., Hauwaert, E. L. V., Markussen, L. K., Gammelmark, E., Marcher, A.-B., Ebbesen, M. F., Nielsen, R., Brewer, J. R., Madsen, J. G. S., & Mandrup, S. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.004 · Cited by 377

Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus

Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 461

T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans

McLaughlin, T., Liu, L.-F., Lamendola, C. A., Shen, L., Morton, J. M., Rivas, H., Winer, D. A., Tolentino, L. L., Choi, O., Zhang, H., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304636 · Cited by 382

Obese visceral fat tissue inflammation: from protective to detrimental?

Kolb, H. (2022) · BMC Medicine · doi:10.1186/s12916-022-02672-y · Cited by 399

Adipose tissue-resident immune cells: key players in immunometabolism

Schipper, H. S., Prakken, B., Kalkhoven, E., & Boes, M. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.05.011 · Cited by 342

Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: Basic mechanisms and clinical associations

Fitzgibbons, T. P., & Czech, M. P. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000582 · Cited by 331

Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice

Miller, A. M., Asquith, D. L., Hueber, A. J., Anderson, L. A., Holmes, W. M., McKenzie, A. N. J., Xu, D., Sattar, N. A., McInnes, I. B., & Liew, F. Y. (2010) · Circulation Research · doi:10.1161/circresaha.110.218867 · Cited by 336

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

Li, P., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3800 · Cited by 327

Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers

Deiuliis, J. A., Shah, Z., Shah, N., NEEDLEMAN, B. J., Mikami, D. J., Narula, V. K., Perry, K. A., Hazey, J. W., Kampfrath, T., Kollengode, M. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016376 · Cited by 325

Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond

Liu, R., & Nikolajczyk, B. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01587 · Cited by 318

Macrophage infiltration into adipose tissue: initiation, propagation and remodeling

Surmi, B. K., & Hasty, A. H. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.545 · Cited by 307

Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity

Duffaut, C., Galitzky, J., Lafontan, M., & Bouloumié, A. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.002 · Cited by 305

Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue

Harford, K. A., Reynolds, C. M., McGillicuddy, F. C., & Roche, H. M. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111000565 · Cited by 309

Intradermal adipocytes mediate fibroblast recruitment during skin wound healing

Schmidt, B. A., & Horsley, V. (2013) · Development · doi:10.1242/dev.087593 · Cited by 318

A saturated fatty acid–rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome

van Dijk, S. J., Feskens, E. J., Bos, M. B., Hoelen, D. W., Heijligenberg, R., Bromhaar, M. G., de Groot, L. C., de Vries, J. H., Müller, M., & Afman, L. A. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27792 · Cited by 291

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

Kolb, H., & Mandrup-Poulsen, T. R. (2009) · Diabetologia · doi:10.1007/s00125-009-1573-7 · Cited by 299

Oxidative stress and metabolic pathologies: from an adipocentric point of view

Le Lay, S., Simard, G., Martinez, M. C., & Andriantsitohaina, R. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/908539 · Cited by 291

The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

Klein-Wieringa, I. R., Kloppenburg, M., Bastiaansen-Jenniskens, Y. M., Yusuf, E., Kwekkeboom, J. C., El-Bannoudi, H., Nelissen, R. G. H. H., Zuurmond, A., Stojanovic-Susulic, V, Van Osch, G. J. V. M., et al. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.140046 · Cited by 289

Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

Rodríguez, A., Ezquerro, S., Méndez-Giménez, L., Becerril, S., & Frühbeck, G. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2015 · Cited by 287

Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence

Villaret, A., Galitzky, J., Decaunes, P., Estève, D., Marques, M.-A., Sengenès, C., Chiotasso, P., Tchkonia, T., Lafontan, M., Kirkland, J. L., et al. (2010) · Diabetes · doi:10.2337/db10-0398 · Cited by 282

T‐Cell Recruitment and Th1 Polarization in Adipose Tissue During Diet‐Induced Obesity in C57BL/6 Mice

Strissel, K. J., DeFuria, J., Shaul, M. E., Bennett, G., Greenberg, A. S., & Obin, M. S. (2010) · Obesity · doi:10.1038/oby.2010.1 · Cited by 276

The vicious circle between oxidative stress and inflammation in atherosclerosis

Hulsmans, M., & Holvoet, P. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00978.x · Cited by 275

Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases

Manabe, I. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-1184 · Cited by 272

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

Blüher, M. (2016) · Clinical Science · doi:10.1042/cs20160005 · Cited by 273

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity

Ramkhelawon, B., Hennessy, E. J., Ménager, M. M., Ray, T. D., Sheedy, F. J., Hutchison, S. B., Wanschel, A. C. B. A., Oldebeken, S. R., Geoffrion, M., Spiro, W., et al. (2014) · Nature Medicine · doi:10.1038/nm.3467 · Cited by 280

Mechanisms of macrophage activation in obesity-induced insulin resistance

Odegaard, J. I., & Chawla, A. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0976 · Cited by 259

Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway

McGillicuddy, F. C., Chiquoine, E. H., Hinkle, C. C., Kim, R. J., Shah, R. D., Roche, H. M., Smyth, E. M., & Reilly, M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.061655 · Cited by 258

Immunity as a link between obesity and insulin resistance

Kalupahana, N. S., Moustaïd‐Moussa, N., & Claycombe, K. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.011 · Cited by 264

Adipose tissue inflammation in obesity: A metabolic or immune response?

Stolarczyk, E. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.08.006 · Cited by 247

Human SGBS Cells – a Unique Tool for Studies of Human Fat Cell Biology

Fischer‐Posovszky, P., Newell, F., Wabitsch, M., & Tornqvist, H. E. (2008) · Obesity Facts · doi:10.1159/000145784 · Cited by 248

Adipocytes properties and crosstalk with immune system in obesity‐related inflammation

Maurizi, G., Guardia, L. D., Maurizi, A., & Poloni, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25855 · Cited by 262

Adiponectin: a versatile player of innate immunity

Luo, Y., & Liu, M. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw012 · Cited by 253

Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice

Shirakawa, J., Fujii, H., Ohnuma, K., Sato, K., Ito, Y., Kaji, M., Sakamoto, E., Koganei, M., Sasaki, H., Nagashima, Y., et al. (2011) · Diabetes · doi:10.2337/db10-1338 · Cited by 246

Defining macrophage phenotype and function in adipose tissue

Dalmas, É., Clément, K., & Guerre-Millo, M. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.008 · Cited by 267

The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications

Zeng, C., Shi, X., Zhang, B., Liu, H., Zhang, L., Ding, W., & Zhao, Y. X. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0816-5 · Cited by 258

Aging and Regional Differences in Fat Cell Progenitors – A Mini-Review

Sepe, A., Tchkonia, T., Thomou, T., Zamboni, M., & Kirkland, J. L. (2011) · Gerontology · doi:10.1159/000279755 · Cited by 232

T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes

Dalmas, É., Venteclef, N., Caer, C., Poitou, C., Cremer, I., Aron‐Wisnewsky, J., Lacroix‐Desmazes, S., Bayry, J., Kaveri, S. V., Clément, K., et al. (2014) · Diabetes · doi:10.2337/db13-1511 · Cited by 256

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Xia, C. Q., Rao, X., & Zhong, J. (2017) · Journal of Diabetes Research · doi:10.1155/2017/6494795 · Cited by 240

Butyrate Attenuates Inflammation and Lipolysis Generated by the Interaction of Adipocytes and Macrophages

Ohira, H., Fujioka, Y., Katagiri, C., Mamoto, R., Aoyama-Ishikawa, M., Amako, K., Izumi, Y., Nishiumi, S., Yoshida, M., Usami, M., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.15065 · Cited by 242

The Mechanism behind Influenza Virus Cytokine Storm

Gu, Y., Zuo, X., Zhang, S., Ouyang, Z., Jiang, S., Wang, F., & Wang, G. (2021) · Viruses · doi:10.3390/v13071362 · Cited by 241

Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences.

van Greevenbroek, M. M. J., Schalkwijk, C., & Stehouwer, C. D. A. (2013) · PubMed · Cited by 233

Interplay Between Human Adipocytes and T Lymphocytes in Obesity

Duffaut, C., Zakaroff‐Girard, A., Bourlier, V., Decaunes, P., Maumus, M., Chiotasso, P., Sengenès, C., Lafontan, M., Galitzky, J., & Bouloumié, A. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.192583 · Cited by 242

Role of Adaptive and Innate Immunity in Type 2 Diabetes Mellitus

Zhou, T., Hu, Z., Yang, S., Sun, L., Yu, Z., & Wang, G. (2018) · Journal of Diabetes Research · doi:10.1155/2018/7457269 · Cited by 243

Obesity, pregnancy, inflammation, and vascular function

Denison, F. C., Roberts, K. A., Barr, S. M., & Norman, J. E. (2010) · Reproduction · doi:10.1530/rep-10-0074 · Cited by 221

Maternal Obesity, Inflammation, and Developmental Programming

Segovia, S. A., Vickers, M. H., Gray, C. L., & Reynolds, C. M. (2014) · BioMed Research International · doi:10.1155/2014/418975 · Cited by 233

Post-Translational Modifications of Nuclear Receptors and Human Disease

Anbalagan, M., Huderson, B. P., Murphy, L. C., & Rowan, B. G. (2012) · Nuclear Receptor Signaling · doi:10.1621/nrs.10001 · Cited by 232

Recent advances in obesity-induced inflammation and insulin resistance

Tateya, S., Kim, F., & Tamori, Y. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00093 · Cited by 211

Obesity Impairs Lymphatic Fluid Transport and Dendritic Cell Migration to Lymph Nodes

Weitman, E. S., Aschen, S. Z., Farias-Eisner, G. T., Albano, N. J., Cuzzone, D. A., Ghanta, S., Zampell, J. C., Thorek, D. L. J., & Mehrara, B. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070703 · Cited by 209

Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome

Eduardo Fuentes, Q., Fuentes, F., Vilahur, G., Badimón, L., & Palomo, I. F. (2013) · Mediators of Inflammation · doi:10.1155/2013/136584 · Cited by 212

Adipose tissue inflammation and ectopic lipid accumulation [Review]

Suganami, T., Tanaka, M., & Ogawa, Y. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0271 · Cited by 207

Polyphenols and their effects on diabetes management: A review

Aryaeian, N., Sedehi, S. K., & Arablou, T. (2017) · Medical Journal of the Islamic Republic of Iran · doi:10.14196/mjiri.31.134 · Cited by 213

PET Imaging of Inflammation Biomarkers

Wu, C., Li, F., Niu, G., & Chen, X. S. (2013) · Theranostics · doi:10.7150/thno.6592 · Cited by 204

Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet–Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis

McGillicuddy, F. C., Harford, K. A., Reynolds, C. M., Oliver, E., Claessens, M., Mills, K. H. G., & Roche, H. M. (2011) · Diabetes · doi:10.2337/db10-1278 · Cited by 199

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

O’Rourke, R. W., Metcalf, M. D., White, A. E., Madala, A., Winters, B. R., Maizlin, I. I., Jobe, B. A., Roberts, C. T., Slifka, M. K., & Marks, D. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.133 · Cited by 206

Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia

Gutierrez, D. A., Puglisi, M. J., & Hasty, A. H. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0006-9 · Cited by 197

Mast Cells in Human Adipose Tissue: Link with Morbid Obesity, Inflammatory Status, and Diabetes

Divoux, A., Moutel, S., Poitou, C., Lacasa, D., Veyrie, N., Aissat, A., Arock, M., Guerre-Millo, M., & Clément, K. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1532 · Cited by 187

Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance

Khan, I. M., Perrard, X.-Y., Brunner, G., Lui, H., Sparks, L. M., Smith, S. R., Wang, X., Shi, Z.-Z., Lewis, D. E., Wu, H., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.104 · Cited by 182

The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis

Meneses-Echávez, J. F., Correa-Bautista, J. E., González-Jiménez, E., Schmidt Río-Valle, J., Elkins, M. R., Lobelo, F., & Ramírez-Vélez, R. (2016) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-1061 · Cited by 169

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Li, P., Spann, N. J., Kaikkonen, M. U., Lu, M. M., Oh, D. Y., Fox, J. N., Bandyopadhyay, G. K., Talukdar, S., Xu, J., Lagakos, W., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.054 · Cited by 179

Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk

Wagner, N., Brandhorst, G., Czepluch, F. S., Lankeit, M., Eberle, C. S., Herzberg, S., Faustin, V., Riggert, J., Oellerich, M., Hasenfuss, G. P., et al. (2013) · Obesity · doi:10.1002/oby.20087 · Cited by 182

A Potential Role for Dendritic Cell/Macrophage-Expressing DPP4 in Obesity-Induced Visceral Inflammation

Zhong, J., Rao, X., Deiuliis, J. A., Braunstein, Z., Narula, V. K., Hazey, J. W., Mikami, D. J., NEEDLEMAN, B. J., Satoskar, A. R., & Rajagopalan, S. (2012) · Diabetes · doi:10.2337/db12-0230 · Cited by 179

Enhanced Inflammation in Epicardial Fat in Patients With Coronary Artery Disease

Hirata, Y., Kurobe, H., Akaike, M., Chikugo, F., Hori, T., Bando, Y., Nishio, C., Higashida, M., Nakaya, Y., Kitagawa, T., et al. (2011) · International Heart Journal · doi:10.1536/ihj.52.139 · Cited by 173

Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4+ T Cells With Skewing Toward a Treg- and Th2-Dominated Phenotype

van der Weerd, K., Dik, W. A., Schrijver, B., Schweitzer, D. H., Langerak, A. W., Drexhage, H. A., Kiewiet, R. M., van Aken, M. O., van Huisstede, A., van Dongen, J. J. M., et al. (2012) · Diabetes · doi:10.2337/db11-1065 · Cited by 180

Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations

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Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling

Monteiro-Sepulveda, M., Touch, S., Mendes-Sá, C., André, S., Poitou, C., Allatif, O., Cotillard, A., Fohrer-Ting, H., Hubert, E.-L., Remark, R., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.020 · Cited by 170

‘Metabolically healthy obesity’: Origins and implications

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Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity

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Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice

Dobrian, A. D., Ma, Q., Lindsay, J. W., Leone, K. A., Ma, K., Coben, J., Galkina, E. V., & Nadler, J. L. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00463.2010 · Cited by 166

T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arteriosclerosis, thrombosis, and vascular biology

Kintscher, U., Hartge, M., Hess, K., Foryst‐Ludwig, A., Clemenz, M., Wabitsch, M., Fischer‐Posovszky, P., Barth, T. F. E., Dragun, D., Skurk, T., et al. (2008)

Abstract 3592: Early Detection Of CD4-positive Lymphocytes In Adipose Tissue During The Development Of Insulin Resistance

Heß, K., Marx, N., Wabitsch, M., Skurk, T., Hauner, H., Hartge, M., & Kintscher, U. (2007) · Circulation · doi:10.1161/circ.116.suppl_16.ii_813-c

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Stutte, S., Lynch, L., & von Andrian, U. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.188.supp.173.38

Immunological Goings-on in Visceral Adipose Tissue

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