Relationship between Adipocyte Size and Adipokine Expression and Secretion
Abstract
CONTEXT: Adipocytes are known to release a variety of factors that may contribute to the proinflammatory state characteristic for obesity. This secretory function is considered to provide the basis for obesity-related complications such as type 2 diabetes and atherosclerosis. OBJECTIVE: To get a better insight into possible underlying mechanisms, we investigated the effect of adipocyte size on adipokine production and secretion. DESIGN, PATIENTS, AND MAIN OUTCOME MEASURES: Protein secretion and mRNA expression in cultured adipocytes separated according to cell size from 30 individuals undergoing elective plastic surgery were investigated. RESULTS: The mean adipocyte volume of the four fractions ranged from 205 +/- 146 to 1.077 +/- 471 pl. There were strong linear correlations for the secretion of adipokines over time. Secretion of leptin, IL-6, IL-8, TNF-alpha, monocyte chemoattractant protein-1, interferon-gamma-inducible protein 10, macrophage inflammatory protein-1beta, granulocyte colony stimulating factor, IL-1ra, and adiponectin was positively correlated with cell size. After correction for cell surface, there was still a significant difference between fraction IV (very large) and fraction I (small cells), for leptin, IL-6, IL-8, monocyte chemoattractant protein-1, and granulocyte colony-stimulating factor. In contrast, antiinflammatory factors such as IL-1ra and adiponectin lost their association after correction for cell surface area comparing fraction I and IV. In addition, there was a decrease of IL-10 secretion with increasing cell size. CONCLUSIONS: The results clearly suggest that adipocyte size is an important determinant of adipokine secretion. There seems to be a differential expression of pro- and antiinflammatory factors with increasing adipocyte size resulting in a shift toward dominance of proinflammatory adipokines largely as a result of a dysregulation of hypertrophic, very large cells.
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In obese subjects with abdominal adiposity, those with CRP >3 mg/l were less likely to adopt Mediterranean diet.
“In another observational study with obese subjects (625 men and 712 women with abdominal adiposity), those with high CRP levels (. 3 mg/l) were less likely to adopt the Mediterranean diet (287) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [287]
Mediterranean diet plus moderate physical activity was associated with a 72% reduced likelihood of high CRP.
“The authors reported that adoption of the Mediterranean diet in conjunction with moderate physical activity was associated with a reduced likelihood of having high CRP levels by 72 %, highlighting the potential importance of the Mediterranean diet in diminishing inflammation.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [287]
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- Authors
- Skurk, T., Alberti-Huber, C., Herder, C., & Hauner, H.
- Affiliations
- Else Kröner Fresenius Zentrum für Ernährungsmedizin (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2007-03-01
- Volume
- 92
- Issue
- 3
- Pages
- 1023-1033
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1993959456
- Cited by
- 1,288
- References
- 70
- Citations by year
- 2026: 17 · 2025: 48 · 2024: 52 · 2023: 57 · 2022: 74 · 2021: 84 · 2020: 67 · 2019: 71 · 2018: 76 · 2017: 79 · 2016: 62 · 2015: 80 · 2014: 84 · 2013: 90 · 2012: 68
- FWCI
- 31.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipocyte size, adipokine secretion, adipocyte hypertrophy, leptin, adiponectin, interleukin-6, MCP-1, granulocyte colony-stimulating factor, interleukin-1 receptor antagonist, IL-10, anti-inflammatory adipokines, obesity, adipose tissue inflammation
- MeSH terms
- Adult, Cell Separation, Cells, Cultured, Female, Humans, Interleukins, Male, Middle Aged, RNA, Messenger, Time Factors, Adipocytes, Leptin, Cell Size, Adiponectin
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