The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Signaling During Platelet Adhesion and Activation
Open accessAbstract
Upon vascular injury, platelets are activated by adhesion to adhesive proteins, such as von Willebrand factor and collagen, or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A 2 . These adhesive proteins and soluble agonists induce signal transduction via their respective receptors. The various receptor-specific platelet activation signaling pathways converge into common signaling events that stimulate platelet shape change and granule secretion and ultimately induce the “inside-out” signaling process leading to activation of the ligand-binding function of integrin α IIb β 3 . Ligand binding to integrin α IIb β 3 mediates platelet adhesion and aggregation and triggers “outside-in” signaling, resulting in platelet spreading, additional granule secretion, stabilization of platelet adhesion and aggregation, and clot retraction. It has become increasingly evident that agonist-induced platelet activation signals also cross talk with integrin outside-in signals to regulate platelet responses. Platelet activation involves a series of rapid positive feedback loops that greatly amplify initial activation signals and enable robust platelet recruitment and thrombus stabilization. Recent studies have provided novel insight into the molecular mechanisms of these processes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
RETH, M. (1989) · Nature · doi:10.1038/338383b0 · Cited by 1,438
Identification of the platelet ADP receptor targeted by antithrombotic drugs
Hollopeter, G., Jantzen, H.-M., Vincent, D., Li, G., England, L., Ramakrishnan, V., Yang, R.-B., Nurden, P., Nurden, A., Julius, D., et al. (2001) · Nature · doi:10.1038/35051599 · Cited by 1,423
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation
Tadokoro, S., Shattil, S. J., Eto, K., Tai, V., Liddington, R. C., de Pereda, J. M., Ginsberg, M. H., & Calderwood, D. A. (2003) · Science · doi:10.1126/science.1086652 · Cited by 1,209
Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor
Savage, B., Saldívar, E., & Ruggeri, Z. M. (1996) · Cell · doi:10.1016/s0092-8674(00)80983-6 · Cited by 1,196
Platelet α-granules: Basic biology and clinical correlates
Blair, P., & Flaumenhaft, R. (2009) · Blood Reviews · doi:10.1016/j.blre.2009.04.001 · Cited by 1,157
Platelet-collagen interaction: is GPVI the central receptor?
Nieswandt, B., & Watson, S. P. (2003) · Blood · doi:10.1182/blood-2002-12-3882 · Cited by 1,150
The final steps of integrin activation: the end game
Shattil, S. J., Kim, C., & Ginsberg, M. H. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2871 · Cited by 1,086
Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production
Boilard, E., Nigrovic, P. A., Larabee, K., Watts, G. F. M., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Remold-O’Donnell, E., Farndale, R. W., Ware, J., et al. (2010) · Science · doi:10.1126/science.1181928 · Cited by 1,085
Protease‐activated receptors in hemostasis, thrombosis and vascular biology
COUGHLIN, S. R. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01377.x · Cited by 1,035
A dual thrombin receptor system for platelet activation
Kahn, M. L., Zheng, Y.-W., Huang, W., Bigornia, V., Zeng, D., Moff, S., Farese, R. V., Tam, C., & Coughlin, S. R. (1998) · Nature · doi:10.1038/29325 · Cited by 979
Cited by
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Qi, Z., Hu, L., Zhang, J., Yang, W., Liu, X., Jia, D., Yao, Z., Chang, L., Pan, G., Zhong, H., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.046290 · Cited by 268
Cloutier, N., Allaeys, I., Marcoux, G., Machlus, K. R., Mailhot, B., Zufferey, A., Levesque, T., Becker, Y., Tessandier, N., Melki, I., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720553115 · Cited by 219
Velmurugan, S., Kapil, V., Ghosh, S. M., Davies, S., McKnight, A., Aboud, Z., Khambata, R. S., Webb, A. J., Poole, A., & Ahluwalia, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.031 · Cited by 114
Dietrich-Muszalska, A., & Wachowicz, B. (2017) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2016.1155748 · Cited by 78
Metadata
- Authors
- Li, Z., Delaney, M. K., O'Brien, K. A., & Du, X.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2010-12
- Volume
- 30
- Issue
- 12
- Pages
- 2341-2349
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2103888323
- Cited by
- 911
- References
- 111
- FWCI
- 20.47
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Signaling During Platelet Adhesion and Activation. https://app.cochat.ai/papers/10.1161/atvbaha.110.207522
- The paper
- Li, Z., Delaney, M. K., O'Brien, K. A., & Du, X. (2010). Signaling During Platelet Adhesion and Activation. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.110.207522
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
