An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia
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Objective—: Earlier studies have suggested that a common genetic architecture underlies the clinically heterogeneous polygenic Fredrickson hyperlipoproteinemia (HLP) phenotypes defined by hypertriglyceridemia (HTG). Here, we comprehensively analyzed 504 HLP-HTG patients and 1213 normotriglyceridemic controls and confirmed that a spectrum of common and rare lipid-associated variants underlies this heterogeneity. Methods and Results—: First, we demonstrated that genetic determinants of plasma lipids and lipoproteins, including common variants associated with plasma triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) from the Global Lipids Genetics Consortium were associated with multiple HLP-HTG phenotypes. Second, we demonstrated that weighted risk scores composed of common TG-associated variants were distinctly increased across all HLP-HTG phenotypes compared with controls; weighted HDL-C and LDL-C risk scores were also increased, although to a less pronounced degree with some HLP-HTG phenotypes. Interestingly, decomposition of HDL-C and LDL-C risk scores revealed that pleiotropic variants (those jointly associated with TG) accounted for the greatest difference in HDL-C and LDL-C risk scores. The APOE E2/E2 genotype was significantly overrepresented in HLP type 3 versus other phenotypes. Finally, rare variants in 4 genes accumulated equally across HLP-HTG phenotypes. Conclusion—: HTG susceptibility and phenotypic heterogeneity are both influenced by accumulation of common and rare TG-associated variants.
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The genetic aetiology of HTG appears very complex, involving both common and rare genetic variants.
“The genetic aetiology for HTG seems to be very complex, with effects of both common and rare genetic variants. 67,304”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [304]
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- Authors
- Johansen, C. T., Wang, J., Lanktree, M. B., McIntyre, A. D., Ban, M. R., Martins, R. A., Kennedy, B. A., Hassell, R. G., Visser, M. E., Schwartz, S. M., Voight, B. F., Elosua, R., Salomaa, V., O'Donnell, C. J., Dallinga-Thie, G. M., Anand, S. S., Yusuf, S., Huff, M. W., Kathiresan, S., Cao, H., & Hegele, R. A.
- Affiliations
- Broad Institute (US)
- From the Department of Biochemistry, Robarts Research Institute (C.T.J., J.W., M.B.L., A.D.M., M.R.B., R.A.M., B.A.K., R.G.H., M.W.H., H.C., R.A.H.) and Department of Medicine, Schulich School of Medicine and Dentistry (C.T.J., M.W.H., R.A.H.), University of Western Ontario, London, Ontario, Canada; Departments of Experimental Vascular Medicine (M.E.V., G.M.D.-T.) and Vascular Medicine (M.E.V., G.M.D.-T.), Academic Medical Center Amsterdam, Amsterdam, the Netherlands; Cardiovascular Health Research...
- ORCID
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2011-08
- Volume
- 31
- Issue
- 8
- Pages
- 1916-1926
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC3562702
- OpenAlex
- W2122257015
- Cited by
- 97
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 5
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- National Institutes of Health (Z99 HL999999)
- Canadian Institutes of Health Research (79853_1, 79523_1, MOP13430)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- hypertriglyceridemia, Fredrickson classification, genetic architecture, common genetic variants, rare variants, HDL cholesterol, LDL cholesterol, plasma lipids, polygenic risk score, phenotypic heterogeneity
- MeSH terms
- Adult, Aged, Alleles, Female, Humans, Hyperlipoproteinemia Type IV, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Phenotype, Risk Factors, Triglycerides, Genetic Variation, Hypertriglyceridemia, Case-Control Studies, Genetic Predisposition to Disease, Multifactorial Inheritance, Apolipoprotein E2
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