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Li, P., Meng, X., Bian, H., Burns, N., Zhao, K., & Song, R. (2015) · Oncotarget · doi:10.18632/oncotarget.6076 · Cited by 38 · see citing works

Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway

Song, R., Ao, L., Zhao, K.-S., Zheng, D., Venardos, N., Fullerton, D. A., & Meng, X. (2014) · Inflammation Research · doi:10.1007/s00011-014-0743-3 · Cited by 37 · see citing works

High-mobility group box-1 protein induces osteogenic phenotype changes in aortic valve interstitial cells

Wang, B., Li, F., Zhang, C., Wei, G., Liao, P., & Dong, N. (2015) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2015.09.077 · Cited by 37 · see citing works

Hierarchically Demineralized Cortical Bone Combined With Stem Cell–Derived Extracellular Matrix for Regeneration of the Tendon-Bone Interface

He, S.-K., Ning, L., Yao, X., Hu, R.-N., Cui, J., Zhang, Y., Ding, W., Luo, J., & Qin, T. (2021) · The American Journal of Sports Medicine · doi:10.1177/0363546521994511 · Cited by 36 · see citing works

Augmented Osteogenic Responses in Human Aortic Valve Cells Exposed to oxLDL and TLR4 Agonist: A Mechanistic Role of Notch1 and NF-κB Interaction

Zeng, Q., Song, R., Ao, L., Xu, D., Venardos, N. M., Fullerton, D. A., & Meng, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095400 · Cited by 34 · see citing works

The cytoprotective effect of biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes

Gáspár, R., Pipicz, M., Hawchar, F., Kovács, D., Djirackor, L., Görbe, A., Varga, Z. V., Kiricsi, M., Petrovski, G., Gácser, A., et al. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.08.006 · Cited by 33 · see citing works

Effects of Toll-Like Receptors 3 and 4 in the Osteogenesis of Stem Cells

Chen, Q., Xiaofeng, X., & Xiaoguang, W. (2014) · Stem Cells International · doi:10.1155/2014/917168 · Cited by 32 · see citing works

Degenerative aortic valve disease and diabetes: Implications for a link between proteoglycans and diabetic disorders in the aortic valve

Barth, M., Selig, J. I., Klose, S., Schomakers, A., Kiene, L. S., Raschke, S., Boeken, U., Akhyari, P., Fischer, J. W., & Lichtenberg, A. (2018) · Diabetes and Vascular Disease Research · doi:10.1177/1479164118817922 · Cited by 32 · see citing works

Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-κB pathway in BMP-2 expression

Wang, D., Zeng, Q., Song, R., Ao, L., Fullerton, D. A., & Meng, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.07.017 · Cited by 30 · see citing works

Oxidized Low-Density Lipoprotein Promotes Osteoblastic Differentiation of Valvular Interstitial Cells through RAGE/MAPK

Li, F., Zhao, Z., Cai, Z., Dong, N., & Liu, Y. (2014) · Cardiology · doi:10.1159/000369126 · Cited by 30 · see citing works

Synergy between Sphingosine 1-Phosphate and Lipopolysaccharide Signaling Promotes an Inflammatory, Angiogenic and Osteogenic Response in Human Aortic Valve Interstitial Cells

Fernández‐Pisonero, I., López, J., Onecha, E., Dueñas, A. I., Maeso, P. A., Crespo, M. S., Román, J. A. S., & García‐Rodríguez, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109081 · Cited by 30 · see citing works

Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9

Li, F., Yao, Q., Ao, L., Cleveland, J. C., Dong, N., Fullerton, D. A., & Meng, X. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1527-3 · Cited by 30 · see citing works

Proteoglycans in Toll-like receptor responses and innate immunity

Garantziotis, S., & Savani, R. C. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00088.2022 · Cited by 29 · see citing works

MicroRNA-204 Deficiency in Human Aortic Valves Elevates Valvular Osteogenic Activity

Song, R., Zhai, Y., Ao, L., Fullerton, D. A., & Meng, X. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010076 · Cited by 28 · see citing works

Novel regulators of cardiac inflammation: Matricellular proteins expand their repertoire

Rienks, M., & Papageorgiou, A. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.01.008 · Cited by 28 · see citing works

Chronic inflammation: A key role in degeneration of bicuspid aortic valve

Manno, G., Bentivegna, R., Morreale, P., Nobile, D., Santangelo, A., Novo, S., & Novo, G. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.03.013 · Cited by 26 · see citing works

Enhancement of tenogenic differentiation of rat tendon‐derived stem cells by biglycan

Zhang, Y., Qing, Q., Zhang, Y., Ning, L., Cui, J., Yao, X., Luo, J., Ding, W., & Qin, T. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28247 · Cited by 24 · see citing works

Small leucine‐rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development

Dupuis, L. E., & Kern, C. B. (2013) · Developmental Dynamics · doi:10.1002/dvdy.24100 · Cited by 23 · see citing works

Durability of transcatheter aortic valve implantation: A translational review

Fauvel, C., Capoulade, R., Durand, É., Béziau, D. M., Schott, J., Tourneau, T. L., & Eltchaninoff, H. (2020) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2019.11.007 · Cited by 19 · see citing works

Lysophosphatidylcholine activates the Akt pathway to upregulate extracellular matrix protein production in human aortic valve cells

Cheng, H., Yao, Q., Song, R., Zhai, Y., Wang, W., Fullerton, D. A., & Meng, X. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.02.028 · Cited by 19 · see citing works

Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity

Zhang, P., The, E., Luo, Z., Zhai, Y., Yao, Q., Ao, L., Fullerton, D. A., Xu, D., & Meng, X. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00433-4 · Cited by 17 · see citing works

Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-κB pathway

Zhan, Q., Song, R., Li, F., Ao, L., Zeng, Q., Xu, D., Fullerton, D. A., & Meng, X. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2016 · Cited by 17 · see citing works

Lentiviral delivery of biglycan promotes proliferation and increases osteogenic potential of bone marrow-derived mesenchymal stem cells in vitro

Wu, B., Ma, X., Zhu, D., Liu, Y., Sun, Z., Liu, S., Xue, B., Du, M., & Yin, X. (2013) · Journal of Molecular Histology · doi:10.1007/s10735-013-9497-4 · Cited by 16 · see citing works

Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level

Zhang, P., The, E., Nedumaran, B., Ao, L., Jarrett, M. J., Xu, D., Fullerton, D. A., & Meng, X. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.49332 · Cited by 15 · see citing works

Lazaroid U-74389G inhibits the osteoblastic differentiation of IL-1β-indcued aortic valve interstitial cells through glucocorticoid receptor and inhibition of NF-κB pathway

Sun, F., Shi, J., Chen, S., Deng, C., Hu, X., Li, H., Geng, L., Liu, Y., & Dong, N. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.05.001 · Cited by 15 · see citing works

Influence of Aortic Valve Stenosis and Wall Shear Stress on Platelets Function

Bańka, P., Wybraniec, M. T., Bochenek, T., Gruchlik, B., Burchacka, A., Swinarew, A. S., & Mizia­‐Stec, K. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12196301 · Cited by 15 · see citing works

Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions

Xian, G., Huang, R., Xu, M., Zhao, H., Xu, X., Chen, Y., Ren, H., Xu, D., & Zeng, Q. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01256-5 · Cited by 14 · see citing works

Toll-like receptor-3 contributes to the development of aortic valve stenosis

Niepmann, S. T., Willemsen, N., Boucher, A. S., Stei, M., Goody, P. R., Zietzer, A., Bulic, M., Billig, H., Odainic, A., Weisheit, C. K., et al. (2023) · Basic Research in Cardiology · doi:10.1007/s00395-023-00980-9 · Cited by 13 · see citing works

TLR4 Stimulation Promotes Human AVIC Fibrogenic Activity through Upregulation of Neurotrophin 3 Production

Yao, Q., The, E., Ao, L., Zhai, Y., Osterholt, M. K., Fullerton, D. A., & Meng, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041276 · Cited by 12 · see citing works

Wnt Signaling Mediates Pro-Fibrogenic Activity in Human Aortic Valve Interstitial Cells

Jarrett, M. J., Houk, A. K., McCuistion, P. E., Weyant, M. J., Reece, T. B., Meng, X., & Fullerton, D. A. (2020) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2020.08.068 · Cited by 11 · see citing works

Aortic Valve Regurgitation: Pathophysiology and Implications for Surgical Intervention in the Era of TAVR

Ravalli, F., Kossar, A. P., Takayama, H., Grau, J. B., & Ferrari, G. M. (2020) · Structural Heart · doi:10.1080/24748706.2020.1719446 · Cited by 10 · see citing works

Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk–Akt pathway

Yao, Q., Song, R., Ao, L., Zhan, Q., Cleveland, J. C., Yu, X., Fullerton, D. A., & Meng, X. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.06.021 · Cited by 9 · see citing works

Crosstalk of Diabetic Conditions with Static Versus Dynamic Flow Environment—Impact on Aortic Valve Remodeling

Selig, J. I., Boulgaropoulos, J., Niazy, N., Ouwens, D. M., Preuß, K., Horn, P., Westenfeld, R., Lichtenberg, A., Akhyari, P., & Barth, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136976 · Cited by 10 · see citing works

Proteoglycans and Diseases of Soft Tissues

Hwang, C. T., & Halper, J. T. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-80614-9_5 · Cited by 8 · see citing works

Interleukin-37 attenuates aortic valve lesions by inhibiting N6-methyladenosine-mediated interleukin-1 receptor-associated kinase M degradation

Xian, G., Huang, R., Hu, D., Xu, M., Chen, Y., Ren, H., Xu, D., & Zeng, Q. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf012 · Cited by 7 · see citing works

Segmentally Demineralized Cortical Bone With Stem Cell-Derived Matrix Promotes Proliferation, Migration and Differentiation of Stem Cells in vitro

He, S.-K., Ning, L., Hu, R.-N., Yao, X., Cui, J., Ding, W., Luo, J., & Qin, T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.776884 · Cited by 6 · see citing works

Molecular Interaction of Soluble Klotho with FGF23 in the Pathobiology of Aortic Valve Lesions Induced by Chronic Kidney Disease

The, E., Zhai, Y., Yao, Q., Ao, L., Fullerton, D. A., & Meng, X. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.92447 · Cited by 6 · see citing works

Extracellular matrix dynamics in aortic valve health and disease: Insights into fibrocalcific remodeling and creation of biomimetic platforms

Patterson, A. J. S., Patil, V. A., Rios, L. F., Borelli, A. N., & Masters, K. S. B. (2024) · Journal of the Heart Valve Society · doi:10.1177/30494826241296675 · Cited by 5 · see citing works

The Ryanodine Receptor Contributes to the Lysophosphatidylcholine-Induced Mineralization in Valvular Interstitial Cells

Wilson, R. L., Sylvester, C. B., Wiltz, D. C., Kumar, A., Malik, T., Morrisett, J. D., & Grande-Allen, K. J. (2020) · Cardiovascular Engineering and Technology · doi:10.1007/s13239-020-00463-1 · Cited by 5 · see citing works

Recombinant IL-37 Exerts an Anti-inflammatory Effect on Human Aortic Valve Interstitial Cells through Extracellular and Intracellular Actions

The, E., Zhai, Y., Yao, Q., Ao, L., Li, S., Fullerton, D. A., Dinarello, C. A., & Meng, X. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85745 · Cited by 3 · see citing works

Sodium–Glucose Cotransporter 2 Inhibitors in Valvular Heart Disease: Cardiovascular Benefit, Valve-Specific Effects, and Evidence Gaps—A Structured Narrative Review

Rada, M., Craciun, M.-L., Pah, A.-M., Stoichescu-Hogea, G., Gurguş, D., Velimirovici, M. D., Surducan, D. A., Mahmoud, A., Uţu, D., & Avram, A. C. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15166355 · Cited by 1 · see citing works

Could Biglycan be a biomarker of coronary artery disease? A pilot human study

Mohammadpour, A., Rezapour, A., Moradian, M., Nazemi, S., Moallem, S. A., Issazadeh, S., Elyasi, S., Afshar, M., Baghshani, Z., & Zaerzadeh, A. (2018) · Research in Cardiovascular Medicine · doi:10.4103/rcm.rcm_23_18 · Cited by 1 · see citing works

Aortic stenosis is largely a boney affair

Luft, F. C. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1245-z

Molecular mechanisms of calcific aortic valve disease

Mahmut, A., & Mathieu, P. (2015) · doi:10.2217/ebo.13.723

Effects of interferons and their interactions with other ligands in human aortic valve cells

Izquierdo, I. P. (2019) · doi:10.35376/10324/39470

Diabetesinduzierte Aortenklappendegeneration in statischer Kultur und im Bioreaktor

Selig, J. I., Boulgaropoulos, J., Niazy, N., Ouwens, D. M., Preuß, K., Horn, P., Westenfeld, R., Lichtenberg, A., Akhyari, P., & Barth, M. (2023) · Zeitschrift für Herz- Thorax- und Gefäßchirurgie · doi:10.1007/s00398-023-00612-3

Cathepsin D elevates the fibrocalcific activity in human aortic valve cells through the ERK1/2-Sox9 pathway

Yao, Q.-Z., The, E., Nedumaran, B., Zhai, Y.-F., Ao, L., Fullerton, D. A., & Meng, X.-Z. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1410862 · Cited by 1 · see citing works

Abstract 486: Soluble Biglycan Induces the Osteogenic Response in Human Aortic Valve Interstitial Cells via TLR2 and Mediates the Pro-osteogenic Effect of OxLDL

Song, R., Zeng, Q., Ao, L., Yu, J. A., Cleveland, J. C., Fullerton, D. A., & Meng, X. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.32.suppl_1.a486

BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells

Song, R., Fullerton, D. A., Ao, L., Zheng, D., Zhao, K., & Meng, X. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1229-z · Cited by 62 · see citing works

Pro-Osteogenic Phenotype of Human Aortic Valve Interstitial Cells Is Associated With Higher Levels of Toll-Like Receptors 2 and 4 and Enhanced Expression of Bone Morphogenetic Protein 2

Yang, X., Fullerton, D. A., Su, X., Ao, L., Cleveland, J. C., & Meng, X. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.09.052 · Cited by 162 · see citing works

Augmented Osteogenic Responses in Human Aortic Valve Cells Exposed to oxLDL and TLR4 Agonist: A Mechanistic Role of Notch1 and NF-κB Interaction

Zeng, Q., Song, R., Ao, L., Xu, D., Venardos, N. M., Fullerton, D. A., & Meng, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095400 · Cited by 34 · see citing works

Abstract 8608: Oxidized Low Density Lipoprotein Synergizes with Toll-Like Receptor 4 Agonist to Induce the Inflammatory and Osteogenic Responses in Human Aortic Valve Interstitial Cells

Zeng, Q., Ao, L., Zhai, Y., Fullerton, D. A., & Meng, X. (2011) · Circulation · doi:10.1161/circ.124.suppl_21.a8608