Toll-like receptors
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Hepatic stellate cells express all known human TLRs and respond to TLR4 ligands, which also downregulate a TGF-β1 decoy receptor sensitizing HSC to TGF-β1.
“HSCs express all known human TLRs and respond to TLR4 ligands127,163, which also downregulate a TGF-β1 decoy receptor sensitizing HSC to the action of TGF-β1127”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [163]
Cites
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- Authors
- Moresco, E. M. Y., LaVine, D., & Beutler, B.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Beutler, Bruce
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 21
- Issue
- 13
- Pages
- R488-R493
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2023746601
- Cited by
- 500
- References
- 11
- Citations by year
- 2026: 19 · 2025: 25 · 2024: 33 · 2023: 27 · 2022: 31 · 2021: 45 · 2020: 36 · 2019: 47 · 2018: 29 · 2017: 28 · 2016: 30 · 2015: 35 · 2014: 40 · 2013: 39 · 2012: 30
- FWCI
- 15.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 747 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- Toll-like receptors, innate immunity, adaptive immunity, host-pathogen interaction, inflammation, phagocytosis, epithelial barrier function, immune system evolution
- MeSH terms
- Animals, Humans, Immunity, Innate, Signal Transduction, Protein Structure, Tertiary, Models, Immunological, Toll-Like Receptors, Mice
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