The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Inflammatory Cell Phenotypes in AAAs: Their Role and Potential as Targets for Therapy
Open accessAbstract
Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammatory cell infiltration. AAA is typically an asymptomatic disease and caused ≈15 000 deaths annually in the United States. Previous studies have examined both human and murine aortic tissue for the presence of various inflammatory cell types. Studies show that in both human and experimental AAAs, prominent inflammatory cell infiltration, such as CD4 + T cells and macrophages, occurs in the damaged aortic wall. These cells have the ability to undergo phenotypic modulation based on microenvironmental cues, potentially influencing disease progression. Proinflammatory CD4 + T cells and classically activated macrophages dominate the landscape of aortic infiltrates. The skew to proinflammatory phenotypes alters disease progression and plays a role in causing chronic inflammation. The local cytokine production and presence of inflammatory mediators, such as extracellular matrix breakdown products, influence the uneven balance of the inflammatory infiltrate phenotypes. Understanding and developing new strategies that target the proinflammatory phenotype could provide useful therapeutic targets for a disease with no current pharmacological intervention.
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Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction
Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J., & Gusovsky, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10689 · Cited by 1,924
Essential role of Stat6 in IL-4 signalling
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Cited by
Monocytes and macrophages in abdominal aortic aneurysm
Raffort, J., Lareyre, F., Clément, M., Hassen-Khodja, R., Chinetti, G., & Mallat, Z. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.52 · Cited by 432
A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?
Balistreri, C. R., Buffa, S., Allegra, A., Pisano, C., Ruvolo, G., Colonna-Romano, G., Lio, D., Mazzesi, G., Schiavon, S., Greco, E., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/5879281 · Cited by 363
Lai, C.-H., Chang, C.-W., Lee, F.-T., Kuo, C.-H., Hsu, J.-H., Liu, C.-P., Wu, H.-L., & Yeh, J.-L. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.01.029 · Cited by 34
Steffen, B. T., Pankow, J. S., Norby, F. L., Lutsey, P. L., Demmer, R. T., Guan, W., Pankratz, N., Li, A., Liu, G., Matsushita, K., et al. (2023) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.122.317984 · Cited by 18
Ghaghada, K. B., Ren, P., Devkota, L., Starosolski, Z., Zhang, C., Vela, D., Stupin, I. V., Tanifum, E. A., Annapragada, A. V., Shen, Y. H., et al. (2021) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.120.315210 · Cited by 15
Metadata
- Authors
- Dale, M. A., Ruhlman, M. K., & Baxter, B. T.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2015-08
- Volume
- 35
- Issue
- 8
- Pages
- 1746-1755
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2527829745
- Cited by
- 269
- References
- 4
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Dale, M. A., Ruhlman, M. K., & Baxter, B. T. (2015). Inflammatory Cell Phenotypes in AAAs: Their Role and Potential as Targets for Therapy. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.115.305269
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
