The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?
Open accessAbstract
Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated the circulating levels of T and B lymphocyte subsets associated with the development of vascular diseases in patients with bicuspid aortic valve or tricuspid aortic valve with and without thoracic aortic aneurysm. We unveiled that the circulating levels of the MAIT, CD4+IL−17A+, and NKT T cell subsets were significantly reduced in bicuspid valve disease cases, when compared to tricuspid aortic valve cases in either the presence or the absence of thoracic aortic aneurysm. Among patients with tricuspid aortic valve, these cells were higher in those also affected by thoracic aortic aneurysm. Similar data were obtained by examining CD19+ B cells, naïve B cells (IgD+CD27−), memory unswitched B cells (IgD+CD27+), memory switched B cells (IgD−CD27+), and double‐negative B cells (DN) (IgD−CD27−). These cells resulted to be lower in subjects with bicuspid valve disease with respect to patients with tricuspid aortic valve. In whole, our data indicate that patients with bicuspid valve disease show a quantitative reduction of T and B lymphocyte cell subsets. Future studies are encouraged to understand the molecular mechanisms underlying this observation and its pathophysiological significance.
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Cites
Mutations in NOTCH1 cause aortic valve disease
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Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells
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Inflammation, Immunity, and Hypertensive End-Organ Damage
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Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms
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Inflammatory Cell Phenotypes in AAAs: Their Role and Potential as Targets for Therapy
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Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve
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Liu, S., Xiu, J., Zhu, C., Meng, K., Li, C., Han, R., Du, T., Li, L., Xu, L., Liu, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27044-7 · Cited by 118
Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease
Zheng, S.-Y., Li, H.-X., Xu, R.-C., Miao, W.-T., Dai, M.-Y., Ding, S.-T., & Liu, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101347 · Cited by 101
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Metadata
- Authors
- Balistreri, C. R., Buffa, S., Allegra, A., Pisano, C., Ruvolo, G., Colonna-Romano, G., Lio, D., Mazzesi, G., Schiavon, S., Greco, E., Palmerio, S., Sciarretta, S., Cavarretta, E., Marullo, A. G. M., & Frati, G.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2018-01
- Volume
- 2018
- Issue
- 1
- Pages
- 5879281-5879281
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2796447596
- Cited by
- 363
- References
- 34
- FWCI
- 61.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Balistreri, C. R., Buffa, S., Allegra, A., Pisano, C., Ruvolo, G., Colonna-Romano, G., Lio, D., Mazzesi, G., Schiavon, S., Greco, E., Palmerio, S., Sciarretta, S., Cavarretta, E., Marullo, A. G. M., & Frati, G. (2018). A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status? Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2018/5879281
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
