The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.
Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis
Abstract
Tissue factor (TF) is the high-affinity receptor and cofactor for factor (F)VII/VIIa. The TF-FVIIa complex is the primary initiator of blood coagulation and plays an essential role in hemostasis. TF is expressed on perivascular cells and epithelial cells at organ and body surfaces where it forms a hemostatic barrier. TF also provides additional hemostatic protection to vital organs, such as the brain, lung, and heart. Under pathological conditions, TF can trigger both arterial and venous thrombosis. For instance, atherosclerotic plaques contain high levels of TF on macrophage foam cells and microvesicles that drives thrombus formation after plaque rupture. In sepsis, inducible TF expression on monocytes leads to disseminated intravascular coagulation. In cancer patients, tumors release TF-positive microvesicles into the circulation that may contribute to venous thrombosis. TF also has nonhemostatic roles. For instance, TF-dependent activation of the coagulation cascade generates coagulation proteases, such as FVIIa, FXa, and thrombin, which induce signaling in a variety of cells by cleavage of protease-activated receptors. This review will focus on the roles of TF in protective hemostasis and pathological thrombosis.
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Thrombin signalling and protease-activated receptors
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Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy
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A Cell-based Model of Hemostasis
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Blood-borne tissue factor: Another view of thrombosis
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Cited by
Cancer-associated venous thromboembolism
Khorana, A. A., Mackman, N., Falanga, A., Pabinger, I., Noble, S., Ageno, W., Moik, F., & Lee, A. Y. Y. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00336-y · Cited by 470
Self-citationInflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis
Wu, C., Lu, W., Zhang, Y., Zhang, G., Shi, X., Hisada, Y., Grover, S. P., Zhang, X., Li, L., Xiang, B., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.003 · Cited by 417
Self-citationPyroptosis-Induced Inflammation and Tissue Damage
Vasudevan, S. O., Behl, B., & Rathinam, V. A. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101781 · Cited by 412
COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms
Loo, J., Spittle, D. A., & Newnham, M. (2021) · Thorax · doi:10.1136/thoraxjnl-2020-216243 · Cited by 341
Yang, X., Cheng, X., Tang, Y., Qiu, X., Wang, Y., Kang, H., Wu, J., Wang, Z., Liu, Y., Chen, F., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.11.005 · Cited by 325
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Metadata
- Authors
- Grover, S. P., & Mackman, N.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2018-04
- Volume
- 38
- Issue
- 4
- Pages
- 709-725
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2786262376
- Cited by
- 667
- References
- 205
- FWCI
- 37.54
- Type
- journal article
- Language
- en
- Open access
- closed
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