Cited by 629Fatty Acid Research and HealthNutritional Studies and DietEdible Oils Quality and Analysis

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Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease: A Science Advisory From the American Heart Association

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Siscovick, David S., Barringer, Thomas A., Fretts, Amanda M., Wu, Jason H.Y., Lichtenstein, Alice H., Costello, Rebecca B., Kris-Etherton, Penny M., Jacobson, Terry A., Engler, Mary B., Alger, Heather M., Appel, Lawrence J., Mozaffarian, Dariush·2017·Circulation

DOI 10.1161/cir.0000000000000482PMC PMC6903779

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Abstract

Multiple randomized controlled trials (RCTs) have assessed the effects of supplementation with eicosapentaenoic acid plus docosahexaenoic acid (omega-3 polyunsaturated fatty acids, commonly called fish oils) on the occurrence of clinical cardiovascular diseases. Although the effects of supplementation for the primary prevention of clinical cardiovascular events in the general population have not been examined, RCTs have assessed the role of supplementation in secondary prevention among patients with diabetes mellitus and prediabetes, patients at high risk of cardiovascular disease, and those with prevalent coronary heart disease. In this scientific advisory, we take a clinical approach and focus on common indications for omega-3 polyunsaturated fatty acid supplements related to the prevention of clinical cardiovascular events. We limited the scope of our review to large RCTs of supplementation with major clinical cardiovascular disease end points; meta-analyses were considered secondarily. We discuss the features of available RCTs and provide the rationale for our recommendations. We then use existing American Heart Association criteria to assess the strength of the recommendation and the level of evidence. On the basis of our review of the cumulative evidence from RCTs designed to assess the effect of omega-3 polyunsaturated fatty acid supplementation on clinical cardiovascular events, we update prior recommendations for patients with prevalent coronary heart disease, and we offer recommendations, when data are available, for patients with other clinical indications, including patients with diabetes mellitus and prediabetes and those with high risk of cardiovascular disease, stroke, heart failure, and atrial fibrillation.

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Authors: Siscovick, D. S., Barringer, T. A., Fretts, A. M., Wu, J. H. Y., Lichtenstein, A. H., Costello, R. B., Kris-Etherton, P. M., Jacobson, T. A., Engler, M. B., Alger, H. M., Appel, L. J., & Mozaffarian, D.
ORCID: Siscovick, David S.
Fretts, Amanda M.
Wu, Jason H.Y.
Lichtenstein, Alice H.
Costello, Rebecca B.
Jacobson, Terry A.
Alger, Heather M.
Appel, Lawrence J.
Mozaffarian, Dariush
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2017-04-11
Volume: 135
Issue: 15
Pages: e867-e884
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/cir.0000000000000482
PMC: PMC6903779
OpenAlex: W2597054569
Cited by: 629
References: 52
Citations by year: 2026: 21 · 2025: 42 · 2024: 57 · 2023: 57 · 2022: 64 · 2021: 66 · 2020: 90 · 2019: 90 · 2018: 100 · 2017: 40
FWCI: 9.00
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL101236, R01HL085710)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Keywords: omega-3 polyunsaturated fatty acids, fish oil supplementation, eicosapentaenoic acid, docosahexaenoic acid, cardiovascular disease prevention, secondary prevention, coronary artery disease, diabetes mellitus, prediabetes, high cardiovascular risk, stroke, heart failure, atrial fibrillation
MeSH terms: Atrial Fibrillation, Cardiovascular Diseases, Diabetes Mellitus, Fish Oils, Heart Failure, Cardiac Surgical Procedures, Humans, Primary Prevention, Risk, Fatty Acids, Omega-3, Dietary Supplements, Stroke, Diabetes Complications, Secondary Prevention

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Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease: A Science Advisory From the American Heart Association

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