Cardiac resynchronization therapy reduces the risk of cardiac events in patients with diabetes enrolled in the multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy (MADIT-CRT)

Martin, David T.; McNitt, Scott; Nesto, Richard W.; Rutter, Martin K.; Moss, Arthur J.

doi:10.1161/circheartfailure.110.959510

Cited by 51Cardiac pacing and defibrillation studiesCardiac Arrest and ResuscitationCardiac electrophysiology and arrhythmias

Cardiac resynchronization therapy reduces the risk of cardiac events in patients with diabetes enrolled in the multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy (MADIT-CRT)

Martin, David T., McNitt, Scott, Nesto, Richard W., Rutter, Martin K., Moss, Arthur J.·2011·Circulation Heart Failure

DOI 10.1161/circheartfailure.110.959510

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Abstract

BACKGROUND: Data are limited regarding whether the presence of diabetes mellitus (DM) influences the benefit of cardiac resynchronization with defibrillator therapy (CRT-D) in heart failure (HF) patients. METHODS AND RESULTS: The effect of CRT-D was evaluated in 1817 patients who were enrolled in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT). Patients were minimally symptomatic (New York Heart Association class I or II), with ejection fraction ≤0.30 and QRS ≥130 ms. We used Cox regression to determine hazard ratio (HR) of CRT-D versus implantable cardioverter-defibrillator (ICD) therapy for the risk of HF event or death, whichever came first (MADIT-CRT primary end point), in DM (n=552) and non-DM (n=1265) patients. Compared with the non-DM patients, those with DM had more coronary risk factors. During an average follow-up of 2.4 years, DM patients had significantly more primary end point events than non-DM patients (26.6% versus 18%, P<0.001). CRT-D was associated with a significant reduction in risk of primary end point in both DM (HR=0.56, P<0.001) and non-DM patients (HR=0.67, P=0.003). Compared with non-DM patients, CRT-D:ICD HRs in DM patients were lower in the total population, and in subgroups with ischemic cardiomyopathy (0.63 versus 0.64), nonischemic cardiomyopathy (0.39 versus 0.73), and left bundle-branch block (0.36 versus 0.50). There were no significant differences in ventricular remodeling, arrhythmia events, or device-related complications between DM and non-DM patients. CONCLUSIONS: Patients with diabetes, left ventricular dysfunction, mildly symptomatic HF, and wide QRS complex derive similar benefit from CRT-D compared with patients without diabetes. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00180271.

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Crossref · 10.1161/circheartfailure.110.959510

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In MADIT-CRT, CRT-D treatment, compared with optimal medical therapy plus ICD, led to a similar reduction in the risk of all-cause death or HF hospitalization in patients with and without T2DM (adjusted HRs 0.56 and 0.67, respectively).
“In MADIT-CRT, CRT-D treatment, compared with optimal medical therapy plus ICD, led to a similar reduction in the risk of all-cause death or HF hospitalization in patients with and without T2DM (adjusted HRs 0.56 and 0.67, respectively).169,173”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [173]

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Cardiac resynchronization therapy reduces the risk of cardiac events in patients with diabetes enrolled in the multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy (MADIT-CRT),” Circulation: Heart Failure
Martin, D. T., McNitt, S. A., Richard, M., Nesto, W., Rutter, M. K., Arthur, F., Moss, J., & Fail, C. H. (2011)
Self-citation
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Long-term outcome in patients with heart failure and diabetes mellitus treated with cardiac resynchronization therapy
Jędrzejczyk‐Patej, E., Mazurek, M., Kotalczyk, A., Gumprecht, J., Lenarczyk, R., Sokal, A., Pruszkowska, P., Szulik, M., Kowalski, O., Średniawa, B., et al. (2023) · EP Europace · doi:10.1093/europace/euad122.454
Abstract 12114: Effect of Cardiac Resynchronization Therapy in Diabetic Patients: MADIT-CRT
Martin, D. T., McNitt, S. A., Nesto, R. W., Moss, A. J., & Rutter, M. K. (2010) · Circulation
Self-citation

Authors: Martin, D. T., McNitt, S., Nesto, R. W., Rutter, M. K., & Moss, A. J.
Affiliations: Lahey Hospital and Medical Center (US)
ORCID: Martin, David T.
McNitt, Scott
Rutter, Martin K.
Moss, Arthur J.
Venue: Circulation Heart Failure
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-05
Volume: 4
Issue: 3
Pages: 332-338
ISSN: 1941-3289 (ISSN-L)
1941-3297
DOI: 10.1161/circheartfailure.110.959510
OpenAlex: W2119984358
Cited by: 51
References: 31
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 3 · 2012: 13
FWCI: 4.60
Type: journal article
Language: en
Open access: closed
Locations: Circulation Heart Failure (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: cardiac resynchronization therapy, CRT-D, diabetes mellitus, heart failure, implantable cardioverter-defibrillator, MADIT-CRT, ischemic cardiomyopathy, non-ischemic cardiomyopathy, left bundle branch block, ventricular remodeling, cardiac arrhythmias, device complications, primary endpoint, wide QRS complex, left ventricular dysfunction
MeSH terms: Aged, Diabetes Mellitus, Female, Heart Block, Heart Failure, Humans, Male, Risk Factors, Proportional Hazards Models, Defibrillators, Implantable, Cardiac Resynchronization Therapy

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Cardiac resynchronization therapy reduces the risk of cardiac events in patients with diabetes enrolled in the multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy (MADIT-CRT)

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