Diabetes mellitus, a predictor of morbidity and mortality in the Studies of Left Ventricular Dysfunction (SOLVD) Trials and Registry
Abstract
Diabetes is an independent predictor of morbidity and mortality in patients with symptomatic heart failure, patients with asymptomatic left ventricular dysfunction (defined as an ejection fraction of 35% or less), and in a broader registry population with less stringent entry criteria. Although the SOLVD Trials made a major clinical contribution by proving the value of enalapril, diabetes remains a significant predictor of outcome even after adjusting for treatment with enalapril.
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The majority of the available data suggests that T2DM is associated with higher risk of mortality in both patients of ischaemic and non-ischaemic aetiology.
“The majority of the available data suggests that T2DM is associated with higher risk of mortality in both patients of ischaemic and non-ischaemic aetiology (Table 6).29,88,94,96 -99”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [88]
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- Authors
- Shindler, D. M., Kostis, J. B., Yusuf, S., Quinones, M. A., Pitt, B., Stewart, D., Pinkett, T., Ghali, J. K., Wilson, A. C., & The SOLVD Investigators
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 77
- Issue
- 11
- Pages
- 1017-1020
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2161659925
- Cited by
- 516
- References
- 22
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 9 · 2023: 13 · 2022: 11 · 2021: 11 · 2020: 20 · 2019: 12 · 2018: 16 · 2017: 16 · 2016: 20 · 2015: 22 · 2014: 22 · 2013: 14 · 2012: 19
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetes mellitus, left ventricular dysfunction, heart failure, mortality, morbidity, SOLVD trial, enalapril, ejection fraction, prognosis
- MeSH terms
- Angiotensin-Converting Enzyme Inhibitors, Diabetes Mellitus, Enalapril, Female, Heart Failure, Humans, Male, Prognosis, Registries, Regression Analysis, Risk Factors, Multicenter Studies as Topic, Odds Ratio, Randomized Controlled Trials as Topic, Ventricular Dysfunction, Left, Diabetes Complications
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