Resveratrol Treatment of Mice With Pressure-Overload–Induced Heart Failure Improves Diastolic Function and Cardiac Energy Metabolism
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Background—: Although resveratrol has multiple beneficial cardiovascular effects, whether resveratrol can be used for the treatment and management of heart failure (HF) remains unclear. In the current study, we determined whether resveratrol treatment of mice with established HF could lessen the detrimental phenotype associated with pressure-overload–induced HF and identified physiological and molecular mechanisms contributing to this. Methods and Results—: C57Bl/6 mice were subjected to either sham or transverse aortic constriction surgery to induce HF. Three weeks post surgery, a cohort of mice with established HF (% ejection fraction <45) was administered resveratrol (≈320 mg/kg per day). Despite a lack of improvement in ejection fraction, resveratrol treatment significantly increased median survival of mice with HF, lessened cardiac fibrosis, reduced gene expression of several disease markers for hypertrophy and extracellular matrix remodeling that were upregulated in HF, promoted beneficial remodeling, and improved diastolic function. Resveratrol treatment of mice with established HF also restored the levels of mitochondrial oxidative phosphorylation complexes, restored cardiac AMP-activated protein kinase activation, and improved myocardial insulin sensitivity to promote glucose metabolism and significantly improved myocardial energetic status. Finally, noncardiac symptoms of HF, such as peripheral insulin sensitivity, vascular function, and physical activity, were improved with resveratrol treatment. Conclusions—: Resveratrol treatment of mice with established HF lessens the severity of the HF phenotype by lessening cardiac fibrosis, improving molecular and structural remodeling of the heart, and enhancing diastolic function, vascular function, and energy metabolism.
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Mice supplemented with resveratrol exhibit prolonged survival, less frequently occurring cardiac fibrosis, and improved diastolic function.
“Mice supplemented with resveratrol exhibit prolonged survival, less frequently occurring cardiac fibrosis, and improved diastolic function (Sung et al. 2015).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Sung et al. 2015
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Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works
Cardiac Hypertrophy: The Good, the Bad, and the Ugly
Frey, N., & Olson, E. N. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142243 · Cited by 1,458 · see citing works
Franciosa, J. A., Park, M., & Levine, T. B. (1981) · The American Journal of Cardiology · doi:10.1016/0002-9149(81)90286-1 · Cited by 878 · see citing works
Yu, C., Bleeker, G. B., Fung, J. W., Schalij, M. J., Zhang, Q., van der Wall, E. E., Chan, Y. S., Kong, S., & Bax, J. J. (2005) · Circulation · doi:10.1161/circulationaha.105.538272 · Cited by 705 · see citing works
Konstam, M. A., Rousseau, M. F., Kronenberg, M. W., Udelson, J. E., Melin, J., Stewart, D., Dolan, N., Edens, T. R., Ahn, S. A., & Kinan, D. (1992) · Circulation · doi:10.1161/01.cir.86.2.431 · Cited by 602 · see citing works
Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation
Kehat, I., & Molkentin, J. D. (2010) · Circulation · doi:10.1161/circulationaha.110.942268 · Cited by 592 · see citing works
Endothelial Dysfunction, Arterial Stiffness, and Heart Failure
Marti, C. N., Gheorghiade, M., Kalogeropoulos, A. P., Georgiopoulou, V. V., Quyyumi, A. A., & Butler, J. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.082 · Cited by 481 · see citing works
Zhong, J., Basu, R., Guo, D., Chow, F. L., Byrns, S., Schuster, M., Loibner, H., Wang, X., Penninger, J. M., Kassiri, Z., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.955369 · Cited by 457 · see citing works
Self-citationSaddik, M., & Lopaschuk, G. D. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92956-x · Cited by 439 · see citing works
Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart
Creemers, E. E., & Pinto, Y. M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq308 · Cited by 402 · see citing works
Segura, A. M., Frazier, O. H., & Buja, L. M. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9365-4 · Cited by 371 · see citing works
Healing after myocardial infarction.
Ertl, G., & Frantz, S. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.01.011 · Cited by 331 · see citing works
Doehner, W., Rauchhaus, M., Ponikowski, P., Godsland, I. F., von Haehling, S., Okonko, D. O., Leyva, F., Proudler, A. J., Coats, A. J. S., & Anker, S. D. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.093 · Cited by 294 · see citing works
Wong, R. H. X., Howe, P. R. C., Buckley, J. D., Coates, A. M., Kunz, I., & Berry, N. M. (2011) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.03.003 · Cited by 277 · see citing works
Zhang, L., Jaswal, J. S., Ussher, J. R., Sankaralingam, S., Wagg, C. S., Zaugg, M., & Lopaschuk, G. D. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.000228 · Cited by 271 · see citing works
Small Animal Models of Heart Failure
Patten, R. D., & Hall-Porter, M. R. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.839761 · Cited by 262 · see citing works
Ventricular-Arterial Coupling, Remodeling, and Prognosis in Chronic Heart Failure
Ky, B., French, B. C., Khan, A. M., Plappert, T. J., Wang, A., Chirinos, J. A., Fang, J. C., Sweitzer, N. K., Borlaug, B. A., Kass, D. A., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.03.085 · Cited by 249 · see citing works
Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1
Dolinsky, V. W., Chan, A. Y. M., Frayne, I. R., Light, P. E., Rosiers, C. D., & Dyck, J. R. B. (2009) · Circulation · doi:10.1161/circulationaha.108.787440 · Cited by 232 · see citing works
Self-citationHaykowsky, M. J., Timmons, M. P., Kruger, C., McNeely, M. L., Taylor, D. A., & Clark, A. M. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.01.303 · Cited by 224 · see citing works
Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice
Dolinsky, V. W., Chakrabarti, S., Pereira, T. J., Oka, T., Levasseur, J. L., Beker, D. L., Zordoky, B. N. M., Morton, J. S., Nagendran, J., Lopaschuk, G. D., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.018 · Cited by 206 · see citing works
Self-citationAbnormal Mitochondrial Respiration in Failed Human Myocardium
Sharov, V. G., Todor, A. V., Silverman, N. A., Goldstein, S., & Sabbah, H. N. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1266 · Cited by 205 · see citing works
Kaga, S., Zhan, L., MATSUMOTO, M., & Maulik, N. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.08.003 · Cited by 199 · see citing works
Polyakova, V. O., Hein, S., Sawa Kostin, D., Ziegelhoeffer, T., & Schaper, J. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.07.023 · Cited by 196 · see citing works
Momken, I., Stevens, L., Bergouignan, A., Desplanches, D., Rudwill, F., Chery, I., Zahariev, A., Zahn, S., Stein, T. P., Sebedio, J. L., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-177295 · Cited by 181 · see citing works
Dolinsky, V. W., Jones, K. E., Sidhu, R. S., Haykowsky, M. J., Czubryt, M. P., Gordon, T., & Dyck, J. R. B. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.230490 · Cited by 174 · see citing works
Self-citationRossi, A., Temporelli, P. L., Quintana, M., Dini, F. L., Ghio, S., Hillis, G. S., Klein, A. L., Marsan, N. A., Prior, D., Yu, C., et al. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp112 · Cited by 173 · see citing works
Total-body and myocardial substrate oxidation in congestive heart failure
Paolisso, G., Gambardella, A., Galzerano, D., D’Amore, A., Rubino, P., Verza, M., Teasuro, P., Varricchio, M., & D’Onofrio, F. (1994) · Metabolism · doi:10.1016/0026-0495(94)90241-0 · Cited by 166 · see citing works
Matsusaka, H., Ide, T., Matsushima, S., Ikeuchi, M., Kubota, T., Sunagawa, K., Kinugawa, S., & Tsutsui, H. (2006) · Hypertension · doi:10.1161/01.hyp.0000208840.30778.00 · Cited by 159 · see citing works
Kanamori, H., Takemura, G., Goto, K., Tsujimoto, A., Ogino, A., Takeyama, T., Kawaguchi, T., Watanabe, T., Morishita, K., Kawasaki, M., et al. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.11.009 · Cited by 155 · see citing works
Dai, D., Hsieh, E. J., Chen, T., Menendez, L. G., Basisty, N., Tsai, L., Beyer, R. P., Crispin, D. A., Shulman, N., Szeto, H. H., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000406 · Cited by 151 · see citing works
Zhabyeyev, P., Gandhi, M., Mori, J., Basu, R., Kassiri, Z., Clanachan, A. S., Lopaschuk, G. D., & Oudit, G. Y. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs424 · Cited by 146 · see citing works
Self-citationEzekowitz, J. A., Kaul, P., Bakal, J. A., Quan, H., & McAlister, F. A. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq185 · Cited by 143 · see citing works
Hemodynamic Determinants of Exercise Capacity in Chronic Heart Failure
MYERS, J. N., & Froelicher, V. F. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-5-377 · Cited by 142 · see citing works
Rimbaud, S., Ruiz, M., Piquereau, J., Matéo, P., Fortin, D., Veksler, V., Garnier, A., & Ventura‐Clapier, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026391 · Cited by 142 · see citing works
Dolinsky, V. W., Rogan, K. J., Sung, M. M., Zordoky, B. N., Haykowsky, M. J., Young, M. E., Jones, L. W., & Dyck, J. R. B. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00044.2013 · Cited by 133 · see citing works
Self-citationContribution of Glycogen to Aerobic Myocardial Glucose Utilization
Longnus, S., Wambolt, R. B., Schönekess, B. O., Lopaschuk, G. D., & Allard, M. F. (1996) · Circulation · doi:10.1161/01.cir.93.8.1549 · Cited by 127 · see citing works
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
Gu, X. S., Wang, Z., Ye, Z., Lei, J., Li, L., Su, D., & Zheng, X. (2014) · Genetics and Molecular Research · doi:10.4238/2014.january.17.17 · Cited by 118 · see citing works
Rush, J. W. E., Quadrilatero, J., Levy, A. S., & Ford, R. J. (2007) · Experimental Biology and Medicine · doi:10.3181/00379727-232-2320814 · Cited by 115 · see citing works
Kienesberger, P. C., Pulinilkunnil, T., Sung, M. M. Y., Nagendran, J., Haemmerle, G., Kershaw, E. E., Young, M. E., Light, P. E., Oudit, G. Y., Zechner, R., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06470-11 · Cited by 111 · see citing works
Self-citationMandic, S., Tymchak, W. J., Kim, D., Daub, B., Quinney, H. A., Taylor, D. A., Al-Kurtass, S., & Haykowsky, M. J. (2009) · Clinical Rehabilitation · doi:10.1177/0269215508095362 · Cited by 107 · see citing works
AlZadjali, M. A., Godfrey, V., Khan, F., Choy, A. M., Doney, A. S. F., Wong, A., Petrie, J. R., Struthers, A. D., & Lang, C. C. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.081 · Cited by 106 · see citing works
Regression of pressure overload-induced left ventricular hypertrophy in mice
Gao, X., Kiriazis, H., Moore, X., Feng, X., Sheppard, K. E., Dart, A. M., & Du, X. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00836.2004 · Cited by 90 · see citing works
Fukuta, H., & Little, W. C. (2006) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2006.08.009 · Cited by 85 · see citing works
No Rest for the Weary: Diastolic Calcium Homeostasis in the Normal and Failing Myocardium
Louch, W. E., Stokke, M. K., Sjaastad, I., Christensen, G., & Sejersted, O. M. (2012) · Physiology · doi:10.1152/physiol.00021.2012 · Cited by 82 · see citing works
Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery
Nagendran, J., Pulinilkunnil, T., Kienesberger, P. C., Sung, M. M. Y., Fung, D., Febbraio, M., & Dyck, J. R. B. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.07.020 · Cited by 77 · see citing works
Self-citationMeta-analysis Research Group in Echocardiography (MeRGE) Heart Failure Collaborators (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.06.005 · Cited by 77 · see citing works
Dolinsky, V. W., Rueda‐Clausen, C. F., Morton, J. S., Davidge, S. T., & Dyck, J. R. B. (2011) · Diabetes · doi:10.2337/db11-0374 · Cited by 73 · see citing works
Self-citationConraads, V. M., Craenenbroeck, E. M. V., Maeyer, C. D., Berendoncks, A. M. V., Beckers, P. J., & Vrints, C. J. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9324-0 · Cited by 61 · see citing works
Gardin, J. M., Leifer, E., Fleg, J. L., Whellan, D. J., Kokkinos, P. F., Leblanc, M.-H., Wolfel, E. E., & Kitzman, D. W. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.07.015 · Cited by 59 · see citing works
Xuan, W., Wu, B., Chen, C., Chen, B., Zhang, W., Xu, D., Bin, J., & Liao, Y. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31825fd7da · Cited by 58 · see citing works
Vascular dysfunction and heart failure: Epiphenomenon or etiologic agent?
Fang, Z. Y., & Marwick, T. H. (2002) · American Heart Journal · doi:10.1067/mhj.2002.120780 · Cited by 54 · see citing works
Vuckovic, K. M., Piano, M. R., & Phillips, S. A. (2013) · Heart Lung and Circulation · doi:10.1016/j.hlc.2012.12.006 · Cited by 27 · see citing works
Bussoni, M., Guirado, G., Roscani, M., Polegato, B., Matsubara, L., Bazan, S., & Matsubara, B. B. (2013) · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · doi:10.1590/1414-431x20132902 · Cited by 18 · see citing works
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Dubois‐Deruy, E., Peugnet, V., Turkieh, A., & Pinet, F. (2020) · Antioxidants · doi:10.3390/antiox9090864 · Cited by 667 · see citing works
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Karwi, Q. G., Uddin, G. M., Ho, K. L., & Lopaschuk, G. D. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00068 · Cited by 441 · see citing works
Byrne, N. J., Matsumura, N., Maayah, Z. H., Ferdaoussi, M., Takahara, S., Darwesh, A. M., Levasseur, J. L., Jahng, J. W. S., Vos, D. Y., Parajuli, N., et al. (2020) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006277 · Cited by 260 · see citing works
Self-citationResveratrol and endothelial function: A literature review
Parsamanesh, N., Asghari, A., Sardari, S., Tasbandi, A., Jamialahmadi, T., Xu, S., & Sahebkar, A. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105725 · Cited by 210 · see citing works
Dyck, G. J. B., Raj, P., Zieroth, S. R., Dyck, J. R. B., & Ezekowitz, J. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040904 · Cited by 203 · see citing works
Self-citationNatural Products as a Source for Antifibrosis Therapy
Chen, D., Feng, Y., Cao, G., & Zhao, Y. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.09.002 · Cited by 190 · see citing works
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity
Timm, K. N., & Tyler, D. J. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-06941-x · Cited by 189 · see citing works
Byrne, N. J., Parajuli, N., Levasseur, J. L., Boisvenue, J., Beker, D. L., Masson, G., Fedak, P. W. M., Verma, S., & Dyck, J. R. B. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.07.003 · Cited by 172 · see citing works
Self-citationZhang, X., Ma, Z., Yuan, Y., Xu, S., Wei, W., Song, P. K., Kong, C., Deng, W., & Tang, Q. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0123-3 · Cited by 137 · see citing works
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Fukushima, A., & Lopaschuk, G. D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.03.020 · Cited by 139 · see citing works
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Daskalopoulos, E. P., Dufeys, C., Bertrand, L., Beauloye, C., & Horman, S. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.01.001 · Cited by 119 · see citing works
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Das, S. K., Wang, W., Zhabyeyev, P., Basu, R., McLean, B. A., Dong, F., Parajuli, N., DesAulniers, J., Patel, V. B., Hajjar, R. J., et al. (2015) · Scientific Reports · doi:10.1038/srep18132 · Cited by 115 · see citing works
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Self-citationFeng, H., Mou, S.-Q., Li, W., Zhang, N., Zhou, Z., Ding, W., Bian, Z., & Liao, H.-H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2647807 · Cited by 83 · see citing works
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He, Y., Huang, W., Zhang, C., Chen, L., Xu, R., Li, N., Wang, F., Han, L., Yang, M., & Zhang, D. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.007 · Cited by 73 · see citing works
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Self-citationSung, M. M. Y., Byrne, N. J., Kim, T. T., Levasseur, J. L., Masson, G., Boisvenue, J., Febbraio, M., & Dyck, J. R. B. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00626.2016 · Cited by 60 · see citing works
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Takahara, S., Soni, S., Phaterpekar, K., Kim, T. T., Maayah, Z. H., Levasseur, J. L., Silver, H. L., Freed, D. H., Ferdaoussi, M., & Dyck, J. R. B. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13634 · Cited by 44 · see citing works
Self-citationByrne, N. J., Levasseur, J. L., Sung, M. M. Y., Masson, G., Boisvenue, J., Young, M. E., & Dyck, J. R. B. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw051 · Cited by 43 · see citing works
Self-citationZou, L., Chen, C., Yan, X., Lin, Q., Fang, J., Li, P., Han, X., Wang, Q., Guo, S., Li, H., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900418 · Cited by 43 · see citing works
Role of resveratrol in inhibiting pathological cardiac remodeling
Fan, S., Hu, Y., You, Y., Xue, W., Chai, R., Zhang, X., Shou, X., & Shi, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.924473 · Cited by 44 · see citing works
Aryankalayil, M. J., Martello, S. E., Bylicky, M. A., Chopra, S., May, J. M., Shankardass, A., MacMillan, L., Sun, L. T., Sanjak, J. S., Vanpouille‐Box, C., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02998-w · Cited by 42 · see citing works
Jaglan, P., Buttar, H. S., bawareed, O. A., & Chibisov, S. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819815-5.00026-4 · Cited by 42 · see citing works
Resveratrol prevents Ang II-induced cardiac hypertrophy by inhibition of NF-κB signaling
Ma, E., Wu, C., Chen, J., Wo, D., Ren, D., Yan, H., Peng, L., & Zhu, W. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115275 · Cited by 41 · see citing works
Fan, Y., Liu, L., Fang, K., Huang, T., Wan, L., Liu, Y., Zhang, S., Yan, D., Li, G., Gao, Y., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002648 · Cited by 41 · see citing works
Jiang, J., Gu, X., Wang, H., & Ding, S. (2021) · PeerJ · doi:10.7717/peerj.11501 · Cited by 41 · see citing works
Yin, K., Zhao, L., Feng, D., Ma, W., Liu, Y., Wang, Y., Liang, J., Yang, F., Bi, C., Chen, H., et al. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000374045 · Cited by 39 · see citing works
Ren, J., Zhang, N., Liao, H., Chen, S., Xu, L., Li, J., Yang, Z., Deng, W., & Tang, Q. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.04.016 · Cited by 39 · see citing works
Caloric restriction mimetics for the treatment of cardiovascular diseases
Sciarretta, S., Forte, M., Castoldi, F., Frati, G., Versaci, F., Sadoshima, J., Kroemer, G., & Maiuri, M. C. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa297 · Cited by 38 · see citing works
Yan, L., Zhu, J., Zhang, X., Wang, J., Xiao, W. L., Li, B., Li, J., Lian, J., Li, Z., & Liu, J. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000447788 · Cited by 37 · see citing works
Zi, M., Stafford, N., Prehar, S., Baudoin, F., Oceandy, D., Wang, X., Bùi, T. A., Shaheen, M. A., Neyses, L., & Cartwright, E. J. (2019) · Current Research in Physiology · doi:10.1016/j.crphys.2019.10.001 · Cited by 37 · see citing works
Animal Models of Dysregulated Cardiac Metabolism
Bugger, H., Byrne, N. J., & Abel, E. D. (2022) · Circulation Research · doi:10.1161/circresaha.122.320334 · Cited by 37 · see citing works
Self-citationZhong, P., Peng, J., Hu, Y., Zhang, J., & Shen, C. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17551 · Cited by 34 · see citing works
Raj, P., Aloud, B. M., Louis, X. L., Yu, L., Zieroth, S. R., & Netticadan, T. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.09.025 · Cited by 34 · see citing works
Li, P., Song, X., Zhang, D., Guo, N., Wu, C., Chen, K., Liu, Y., Yuan, L., Chen, X., & Huang, X. (2019) · BioFactors · doi:10.1002/biof.1584 · Cited by 33 · see citing works
Hsu, C., Hou, C., & Tain, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084210 · Cited by 33 · see citing works
Bernal‐Ramírez, J., Silva‐Platas, C., Carlos Jerjes-Sánchez, D., Ramos-González, M. R., Vázquez‐Garza, E., Chapoy‐Villanueva, H., Ramírez‐Rivera, A., Zarain‐Herzberg, Á., Garcı́a, N., & García‐Rivas, G. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9912434 · Cited by 32 · see citing works
Zheng, X., Hai, J., Yang, Y., Zhang, C., Ma, X., Kong, B., Zhao, Y., Hu, Y., Bu, P., & Ti, Y. (2023) · Hypertension Research · doi:10.1038/s41440-023-01231-z · Cited by 32 · see citing works
Stankovic, S. D., Mutavdžin, S., Djuric, D. M., Milošević, V., & Milenković, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030915 · Cited by 35 · see citing works
Resveratrol and derivatives for the treatment of atrial fibrillation
Baczkó, I., & Light, P. E. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12843 · Cited by 28 · see citing works
Potential application of resveratrol in nanocarriers against cancer: Overview and future trends
Moshawih, S., Mydin, R. B. S. M. N., Shanker, K., & Jarrar, Q. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101187 · Cited by 28 · see citing works
Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease
Song, J.-Y., Shen, T.-C., Hou, Y., Chang, J., Lu, C., Liu, W.-C., Chen, P.-J., Chen, B.-H., Zheng, C., & Lu, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176294 · Cited by 28 · see citing works
Aldolase promotes the development of cardiac hypertrophy by targeting AMPK signaling
Li, Y., Zhang, D., Kong, L., Shi, H., Tian, X., Gao, L., Liu, Y., Wu, L., Du, B., Huang, Z., et al. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.06.009 · Cited by 25 · see citing works
Resveratrol and Cardiac Fibrosis Prevention and Treatment
Zivarpour, P., Reiner, Ž., Hallajzadeh, J., & Mirsafaei, L. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210212125003 · Cited by 27 · see citing works
Parajuli, N., Takahara, S., Matsumura, N., Kim, T. T., Ferdaoussi, M., Migglautsch, A. K., Zechner, R., Breinbauer, R., Kershaw, E. E., & Dyck, J. R. B. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00308.2018 · Cited by 26 · see citing works
Self-citationStrunz, C. M. C., Roggério, A., Cruz, P. L., Pacanaro, A. P., Salemi, V. M. C., Benvenuti, L. A., Mansur, A. D. P., & Irigoyen, M. C. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.11.015 · Cited by 25 · see citing works
Wang, L., Gao, M., Chen, J., Yang, Z.-Q., Sun, J., Wang, Z., Huang, X., Yuan, T., Shen, X., & Xian, S. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000290 · Cited by 24 · see citing works
Icariside II attenuates cardiac remodeling via AMPKα2/mTORC1 in vivo and in vitro
Liu, X., Liao, H.-H., Feng, H., Zhang, N., Yang, J., Li, W., Chen, S., Deng, W., & Tang, Q. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.08.010 · Cited by 23 · see citing works
Modulatory Effects of Chinese Herbal Medicines on Energy Metabolism in Ischemic Heart Diseases
Li, F., Li, J., Li, S., Guo, S., & Li, P. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00995 · Cited by 23 · see citing works
Impact of Oxidative Stress in Premature Aging and Iron Overload in Hemodialysis Patients
Murillo-Ortiz, B. O., Ramı́rez-Emiliano, J., Vázquez, W. I. H., Martı́nez-Garza, S., Solorio, S., Albarrán-Tamayo, F., Ramos-Rodríguez, E., & Bribiesca, L. B. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1578235 · Cited by 23 · see citing works
Shah, A., Quon, A., Morton, J. S., & Davidge, S. T. (2017) · Physiological Reports · doi:10.14814/phy2.13109 · Cited by 23 · see citing works
Gong, W., Sun, P., Li, X., Wang, X., Zhang, X., Cui, H., & Yang, J. (2024) · Nutrients · doi:10.3390/nu16152488 · Cited by 21 · see citing works
Lin, R., Zhu, Y., Liu, Y.-J., Guo, Z., Wei, J., Li, Y., & Yu, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107936 · Cited by 18 · see citing works
Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy
Das, S. K., Zhabyeyev, P., Basu, R., Patel, V. B., Dyck, J. R. B., Kassiri, Z., & Oudit, G. Y. (2017) · Bioscience Reports · doi:10.1042/bsr20171302 · Cited by 18 · see citing works
Self-citationZhou, N., Chen, X., Xi, J., Ma, B., Leimena, C., Stoll, S., Qin, G., Wang, C., & Qiu, H. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101662 · Cited by 16 · see citing works
Esfandiarei, M., Hoxha, B., Talley, N., Anderson, M., Alkhouli, M. F., Squire, M., Eckman, D. M., Babu, J. R., Lopaschuk, G. D., & Broderick, T. L. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s196119 · Cited by 16 · see citing works
The role of pyroptosis in heart failure and related traditional chinese medicine treatments
Qin, J., Yang, Q., Wang, Y., Shi, M., Zhao, X., & Zhou, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1377359 · Cited by 15 · see citing works
A novel complex I inhibitor protects against hypertension-induced left ventricular hypertrophy
Matsumura, N., Robertson, I. M., Hamza, S. M., Soltys, C.-L. M., Sung, M. M. Y., Masson, G., Beker, D. L., & Dyck, J. R. B. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00604.2016 · Cited by 15 · see citing works
Self-citationAmirazodi, M., Daryanoosh, F., Mehrabi, A., Gaeini, A. A., Jahromi, M. K., Salesi, M., & Zarifkar, A. H. (2022) · BioMed Research International · doi:10.1155/2022/8638714 · Cited by 13 · see citing works
Palombaro, M., Raoul, P. C., Cintoni, M., Rinninella, E., Pulcini, G., Aspromonte, N., Ianiro, G., Gasbarrini, A., & Mele, M. C. (2022) · Metabolites · doi:10.3390/metabo12121271 · Cited by 12 · see citing works
AMPK/Sirt1-mediated inflammation is positively correlated with myocardial fibrosis during ageing
Song, Y., Zhang, Y., Zhang, X., Hu, S., Wang, J., Deng, G., & Zhou, Z. (2022) · Acta cardiologica. Supplementum · doi:10.1080/00015385.2022.2119667 · Cited by 10 · see citing works
Resveratrol in the Treatment of Gynecological Cancer: Mechanisms and Therapeutic Potential
Mozafaryan, M. J., Rezaei, P., Masoudpoor, F., Bahri, A., Samini, M., Farkhondeh, T., Pourhanifeh, M. H., & Samarghandian, S. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673290941240430171146 · Cited by 9 · see citing works
Galiuto, L., & Locorotondo, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-40010-5_9 · Cited by 9 · see citing works
Energy metabolism and redox balance: How phytochemicals influence heart failure treatment
Chen, C., Wang, J., Zhu, X., Hu, J., Liu, C., & Liu, L. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116136 · Cited by 9 · see citing works
Impact of plant-derived antioxidants on heart aging: a mechanistic outlook
Khoso, M. A., Liu, H., Zhao, T., Zhao, W., Huang, Q., Sun, Z., Dinislam, K., Chen, C., Kong, L.-Y., Zhang, Y., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1524584 · Cited by 7 · see citing works
Pepin, M. E., Gong, X., Schulze, A., & Backs, J. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00343-y · Cited by 8 · see citing works
Luo, X. W., Wang, R., Zhang, X., Wen, X., & Xie, W. (2023) · Medicine · doi:10.1097/md.0000000000035959 · Cited by 5 · see citing works
Herbal Intervention in Cardiovascular Diseases
Varghese, J. F., Patel, R. P., Singh, M. M., & Yadav, U. C. S. (2018) · Springer eBooks · doi:10.1007/978-981-13-1123-9_14 · Cited by 4 · see citing works
Bisset, E. S., & Howlett, S. E. (2022) · Nutrients · doi:10.3390/nu14142806 · Cited by 3 · see citing works
Saroj, S., Mehta, K., Pandey, K. K., Kaur, B., Jhajhria, S. K., & Dhar, P. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10439-x · Cited by 2 · see citing works
Powell, C. A., Zhang, J., Bowman, J. D., & Choudhury, M. (2017) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-5225-2092-4.ch016 · Cited by 2 · see citing works
Medeiros, S. G. F., Guimarães, R. D. C. A., Inada, A. C., Fernandes, C. D. P., Ferreira, R. D. S., Freitas, K. D. C., Donadon, J. R., do Nascimento, V. A., & Hiane, P. A. (2026) · Antioxidants · doi:10.3390/antiox15030322 · Cited by 1 · see citing works
Xie, X., Ge, H., Hu, X., Gao, X., Song, Y., Xie, L., Wu, H., Huang, F., Wang, C., Shi, H., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121660 · Cited by 1 · see citing works
Sharma, A., McDonagh, J., Ngo, D. T. M., Blasio, M. J. D., Ferguson, C., & Ritchie, R. H. (2026) · Heart Lung and Circulation · doi:10.1016/j.hlc.2026.04.113 · Cited by 1 · see citing works
Potential Food Nutraceutical Ingredients
Sharma, A., Rani, J., Kaur, P., Dwivedi, S. K. D., & Sharma, M. (2024) · Springer eBooks · doi:10.1007/978-3-030-69677-1_2-1 · Cited by 1 · see citing works
Novel pharmacotherapies for heart failure
Rajapreyar, I. N., Lenneman, A., & Prabhu, S. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813706-2.00018-x
The Role of Subterminal Hydroxyeicosatetraenoic Acids in the Pathogenesis of Cardiac Hypertrophy
Shoieb, S. M. (2021) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-8b1m-6p97
The Blueprint for Retarding and Reversing Cardiovascular Aging
Nikhra, V. (2018) · Open Access Journal of Gerontology & Geriatric Medicine · doi:10.19080/oajggm.2018.04.555644
Resveratrolün Kronik Hastalıklar Üzerindeki Etkileri
BAŞKURT, B. T., & Yılmaz, S. E. (2023) · Current Perspectives on Health Sciences · doi:10.58208/cphs.1345889
Phytochemicals in Cardioprotection and Cardiotoxicity
Scott, S. S., Albers, C., Iqbal, M., Ailemen, I., Smith, S. A., & Parinandi, N. L. (2025) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-031-97517-2_4
Potential Food Nutraceutical Ingredients
Sharma, A., Rani, J., Kaur, P., Dwivedi, S. K., & Sharma, M. (2026) · Springer eBooks · doi:10.1007/978-3-031-98791-5_2
Fourny, N. (2019) · theses.fr (ABES) · doi:10.70675/846aa6e5z8362z45a5z8e8dz2452913634b4
Zhang, Q., Wei, Y., Li, H., Wang, W., & Wang, Y. W. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108259
de Mello, M. M. B., Pernomian, L., Ramos, L. V. R., & Castro, M. M. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1873305
- Authors
- Sung, M. M., Das, S. K., Levasseur, J., Byrne, N. J., Fung, D., Kim, T. T., Masson, G., Boisvenue, J., Soltys, C.-L., Oudit, G. Y., & Dyck, J. R. B.
- Affiliations
- University of Alberta (CA)
- ORCID
- Venue
- Circulation: Heart Failure
- Published
- 2015-01
- Volume
- 8
- Issue
- 1
- Pages
- 128-137
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- OpenAlex
- W2156697471
- Cited by
- 102
- References
- 53
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 10 · 2019: 8 · 2018: 10 · 2017: 10 · 2016: 9 · 2015: 8
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alberta Innovates
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- resveratrol, heart failure, pressure overload, transverse aortic constriction, diastolic function, myocardial fibrosis, cardiac remodeling, cardiac hypertrophy, extracellular matrix remodeling, mitochondrial oxidative phosphorylation, AMPK, myocardial energy metabolism, peripheral insulin sensitivity, vascular function, survival
- MeSH terms
- Resveratrol, Animals, Disease Models, Animal, Energy Metabolism, Male, Mice, Inbred C57BL, Myocardial Contraction, Myocardium, Ribonucleotide Reductases, Stilbenes, Stroke Volume, Vasodilator Agents, Ventricular Function, Left, Ventricular Remodeling, Mice, Heart Failure, Diastolic
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