The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Prognostic Relevance of Left Atrial Dysfunction in Heart Failure With Preserved Ejection Fraction
Open accessAbstract
Background—: Left atrial (LA) size is an established marker of risk for adverse outcomes in heart failure with preserved ejection fraction (HFpEF). However, the independent prognostic importance of LA function in HFpEF is not known. Methods and Results—: We assessed LA function measured by speckle-tracking echocardiography in 357 patients with HFpEF enrolled in the Treatment Of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial who were in sinus rhythm at the time of echocardiography. Lower peak LA strain, indicating LA dysfunction, was associated with older age, higher prevalence of atrial fibrillation and left ventricular (LV) hypertrophy, worse LV and right ventricular systolic function, and worse LV diastolic function. At a mean follow-up of 31 months (interquartile range, 18–43months), 91 patients (25.5%) experienced the primary composite end point of cardiovascular death, HF hospitalization, and aborted sudden death. Lower peak LA strain was associated with a higher risk of the composite end point (hazard ratio, 0.96 per unit of reduction in strain; 95% confidence interval, 0.94–0.99; P =0.009) and of HF hospitalization alone (hazard ratio, 0.95 per unit of reduction in strain; 95% confidence interval, 0.92–0.98; P =0.003). The association of LA strain with incident HF hospitalization remained significant after adjustment for clinical confounders, but not after further adjustment for LV global longitudinal strain and the E/E′ ratio, parameters of LV systolic and diastolic function, respectively. Conclusions—: LA dysfunction in HFpEF is associated with a higher risk of HF hospitalization independent of potential clinical confounders, but not independent of LV strain and filling pressure. Impairment in LV systolic and diastolic function largely explains the association between impaired LA function and higher risk of HF hospitalization in HFpEF. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00094302.
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Cites
Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.10.003 · Cited by 12,362
Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography
Nagueh, S. F., Appleton, C. P., Gillebert, T. C., Marino, P. N., Oh, J. K., Smiseth, O. A., Waggoner, A. D., Flachskampf, F. A., Pellikka, P. A., & Evangelista, A. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2008.11.023 · Cited by 4,367
Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction
Owan, T. E., Hodge, D. O., Herges, R. M., Jacobsen, S. J., Roger, V. L., & Redfield, M. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052256 · Cited by 4,191
Recommendations for the evaluation of left ventricular diastolic function by echocardiography
Nagueh, S. F., Appleton, C. P., Gillebert, T. C., Marino, P. N., Oh, J. K., Smiseth, O. A., Waggoner, A. D., Flachskampf, F. A., Pellikka, P. A., & Evangelisa, A. (2008) · European Journal of Echocardiography · doi:10.1093/ejechocard/jep007 · Cited by 3,351
Antlanger, M., Aschauer, S., Kopecky, C., Hecking, M., Kovarik, J. J., Werzowa, J., Mascherbauer, J., Genser, B., Säemann, M. D., & Bonderman, D. (2017) · Kidney and Blood Pressure Research · doi:10.1159/000473868 · Cited by 2,808
Outcome of Heart Failure with Preserved Ejection Fraction in a Population-Based Study
Bhatia, R. S., Tu, J. V., Lee, D. S., Austin, P. C., Fang, J., Haouzi, A., Gong, Y., & Liu, P. P. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa051530 · Cited by 1,967
Self-citationAtrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation
Burstein, B., & Nattel, S. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.064 · Cited by 1,242
Lakatta, E. G. (2003) · Circulation · doi:10.1161/01.cir.0000048894.99865.02 · Cited by 1,084
Pfeffer, M. A., Claggett, B., Assmann, S. F., Boineau, R., Anand, I. S., Clausell, N., Desai, A. S., Diaz, R., Fleg, J. L., Gordeev, I., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013255 · Cited by 1,065
Self-citationYancy, C. W., Lopatin, M., Stevenson, L. W., De Marco, T., & Fonarow, G. C. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.022 · Cited by 927
Cited by
Morris, D. A., Belyavskiy, E., Aravind-Kumar, R., Kropf, M., Frydas, A., Braunauer, K., Marquez, E., Krisper, M., Lindhorst, R., Osmanoglou, E., et al. (2018) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2017.07.029 · Cited by 388
Reddy, Y. N. V., Obokata, M., Egbe, A., Yang, J. H., Pislaru, S., Lin, G., Carter, R., & Borlaug, B. A. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1464 · Cited by 316
Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction
Obokata, M., Reddy, Y. N. V., & Borlaug, B. A. (2020) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2018.12.034 · Cited by 316
Solomon, S. D., Ostrominski, J. W., Wang, X., Shah, S. J., Borlaug, B. A., Butler, J., Davies, M. J., Kitzman, D. W., Verma, S., Abildstrøm, S. Z., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.08.021 · Cited by 154
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Metadata
- Authors
- Santos, A. B. S., Roca, G. Q., Claggett, B., Sweitzer, N. K., Shah, S. J., Anand, I. S., Fang, J. C., Zile, M. R., Pitt, B., Solomon, S. D., & Shah, A. M.
- Venue
- Circulation: Heart Failure
- Published
- 2016-04
- Volume
- 9
- Issue
- 4
- Pages
- e002763-e002763
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- OpenAlex
- W2342191447
- Cited by
- 326
- References
- 45
- FWCI
- 16.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Santos, A. B. S., Roca, G. Q., Claggett, B., Sweitzer, N. K., Shah, S. J., Anand, I. S., Fang, J. C., Zile, M. R., Pitt, B., Solomon, S. D., & Shah, A. M. (2016). Prognostic Relevance of Left Atrial Dysfunction in Heart Failure With Preserved Ejection Fraction. Circulation: Heart Failure. https://doi.org/10.1161/circheartfailure.115.002763
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