The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Prognostic Value of Nonobstructive and Obstructive Coronary Artery Disease Detected by Coronary Computed Tomography Angiography to Identify Cardiovascular Events
Abstract
Background—: The contribution of plaque extent to predict cardiovascular events among patients with nonobstructive and obstructive coronary artery disease (CAD) is not well defined. Our objective was to evaluate the prognostic value of plaque extent detected by coronary computed tomography angiography. Methods and Results—: All consecutive patients without prior CAD referred for coronary computed tomography angiography to evaluate for CAD were included. Examination findings were classified as normal, nonobstructive (<50% stenosis), or obstructive (≥50%). Based on the number of segments with disease, extent of CAD was classified as nonextensive (≤4 segments) or extensive (>4 segments). The cohort included 3242 patients followed for the primary outcome of cardiovascular death or myocardial infarction for a median of 3.6 (2.1–5.0) years. In a multivariable analysis, the presence of extensive nonobstructive CAD (hazard ratio, 3.1; 95% confidence interval, 1.5–6.4), nonextensive obstructive (hazard ratio, 3.0; 95% confidence interval, 1.3–6.9), and extensive obstructive CAD (hazard ratio, 3.9; 95% confidence interval, 2.2–7.2) were associated with an increased rate of events, whereas nonextensive, nonobstructive CAD was not. The addition of plaque extent to a model that included clinical probability as well as the presence and severity of CAD improved risk prediction. Conclusions—: Among patients with nonobstructive CAD, those with extensive plaque experienced a higher rate of cardiovascular death or myocardial infarction, comparable with those who have nonextensive disease. Even among patients with obstructive CAD, greater extent of nonobstructive plaque was associated with higher event rate. Our findings suggest that regardless of whether obstructive or nonobstructive disease is present, the extent of plaque detected by coronary computed tomography angiography enhances risk assessment.
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Cites
Harris, P. A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., & Conde, J. G. (2009) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2008.08.010 · Cited by 51,384
Diagnosis and classification of diabetes mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc10-s062 · Cited by 5,491
Optimal Medical Therapy with or without PCI for Stable Coronary Disease
Boden, W. E., O'Rourke, R. A., Teo, K. K., Hartigan, P. M., Maron, D. J., Kostuk, W. J., Knudtson, M., Dada, M., Casperson, P., Harris, C. L., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa070829 · Cited by 4,699
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e318282ab8f · Cited by 1,294
Min, J. K., Shaw, L. J., Devereux, R. B., Okin, P. M., Weinsaft, J. W., Russo, D. J., Lippolis, N. J., Berman, D. S., & Callister, T. Q. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.03.067 · Cited by 1,055
Hadamitzky, M., Freißmuth, B., Meyer, T., Hein, F., Kastrati, A., Martinoff, S., Schömig, A., & Hausleiter, J. (2009) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2008.11.015 · Cited by 280
Cited by
Libby, P., Buring, J. E., Badimon, L., Hansson, G. K., Deanfield, J., Bittencourt, M. S., Tokgözoğlu, L., & Lewis, E. F. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0106-z · Cited by 3,211
Self-citationOutcomes of Anatomical versus Functional Testing for Coronary Artery Disease
Douglas, P. S., Hoffmann, U., Patel, M. R., Mark, D. B., Al-Khalidi, H. R., Cavanaugh, B., Cole, J., Dolor, R. J., Fordyce, C. B., Huang, M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1415516 · Cited by 1,543
Self-citationCoronary Artery Calcium Scoring
Blaha, M. J., Mortensen, M. B., Kianoush, S., Tota-Maharaj, R., & Cainzos-Achirica, M. (2017) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2017.05.007 · Cited by 276
Tomizawa, N., Nojo, T., Inoh, S., & Nakamura, S. (2015) · The International Journal of Cardiovascular Imaging · doi:10.1007/s10554-014-0542-5 · Cited by 39
Su, X., Cai, X., Pan, Y., Sun, J., Jing, J., Wang, M., Meng, X., Wang, Y., Wei, T., & He, Y. (2022) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwac223 · Cited by 34
Metadata
- Authors
- Bittencourt, M. S., Hulten, E., Ghoshhajra, B., O’Leary, D., Christman, M. P., Montana, P., Truong, Q. A., Steigner, M., Murthy, V. L., Rybicki, F. J., Nasir, K., Gowdak, L. H. W., Hainer, J., Brady, T. J., Di Carli, M. F., Hoffmann, U., Abbara, S., & Blankstein, R.
- Venue
- Circulation: Cardiovascular Imaging
- Published
- 2014-03
- Volume
- 7
- Issue
- 2
- Pages
- 282-291
- ISSN
- 1941-9651 (ISSN-L)
- 1942-0080
- OpenAlex
- W2152705713
- Cited by
- 403
- References
- 6
- FWCI
- 31.75
- Type
- journal article
- Language
- en
- Open access
- closed
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