The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Temporal Trends in Patient Characteristics and Treatment With Intravenous Thrombolysis Among Acute Ischemic Stroke Patients at Get With the Guidelines–Stroke Hospitals
Open accessAbstract
Background—: Substantial efforts over the past decade have increased rates of intravenous tissue plasminogen activator (tPA) use in the United States. We sought to determine changes in patient characteristics and rates of tPA use over time among hospitalized acute ischemic stroke (AIS) patients. Methods and Results—: We analyzed all AIS patients (n=1 093 895) and those arriving ≤2 hours and treated with tPA ≤3 hours after onset (n=50 798) from 2003 to 2011 in the American Heart Association’s Get with the Guideline–Stroke (GWTG–Stroke). Categorical data were analyzed by Pearson χ 2 and continuous data by Wilcoxon test. Intravenous tPA use ≤3 hours after onset increased from 4.0% to 7.0% in all AIS admissions and 42.6% to 77.0% in AIS patients arriving ≤2 hours and fully eligible for tPA ( P <0.001). In univariate analysis, tPA use increased over time, especially in those aged >85 years, nonwhite, and with milder strokes (National Institutes of Health Stroke Scale 0–4). Door-to-image time (median 24 versus 20 minutes) and door-to-tPA time (median 81 versus 72 minutes) also improved, with ≈65% of tPA-treated patients getting brain imaging ≤25 minutes after arrival. Multivariable analysis showed that with each additional calendar year, the odds that an eligible patient would receive tPA increased by 1.37-fold, adjusting for other covariates. Conclusions—: The frequency of IV tPA use among all AIS patients, regardless of contraindications, nearly doubled from 2003 to 2011. Treatment with tPA has expanded to include more patients with mild deficits, nonwhite race/ethnicity, and oldest old age.
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Citations
Cites
Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Jauch, E. C., Saver, J. L., Adams, H. P., Bruno, A., Connors, J. J. (., Demaerschalk, B. M., Khatri, P., McMullan, P. W., Qureshi, A. I., Rosenfield, K., et al. (2013) · Stroke · doi:10.1161/str.0b013e318284056a · Cited by 7,634
Self-citationHeart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149
Roger, V. L. (2011) · Circulation · Cited by 719
Why are stroke patients excluded from TPA therapy?: An analysis of patient eligibility
Barber, P. A., Zhang, J., Demchuk, A. M., Hill, M. D., & Buchan, A. M. (2001) · Neurology · doi:10.1212/wnl.56.8.1015 · Cited by 704
Use of Tissue-Type Plasminogen Activator for Acute Ischemic Stroke: The Cleveland Area Experience
Katzan, I. L., Furlan, A. J., Lloyd, L. E., Frank, J. I., Harper, D. L., Hinchey, J. A., Hammel, J. P., Qu, A., & Sila, C. A. (2000) · JAMA · doi:10.1001/jama.283.9.1151 · Cited by 648
Schwamm, L. H., Fonarow, G. C., Reeves, M. J., Pan, W., Frankel, M. R., Smith, E. E., Ellrodt, G., Cannon, C. P., Liang, L., Peterson, E., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.783688 · Cited by 568
Self-citationAdeoye, O., Hornung, R., Khatri, P., & Kleindorfer, D. (2011) · Stroke · doi:10.1161/strokeaha.110.612358 · Cited by 474
Fonarow, G. C., Smith, E. E., Saver, J. L., Reeves, M. J., Hernandez, A. F., Peterson, E. D., Sacco, R. L., & Schwamm, L. H. (2011) · Stroke · doi:10.1161/strokeaha.111.621342 · Cited by 401
Self-citationSchwamm, L. H., Pancioli, A., Acker, J. E., Goldstein, L. B., Zorowitz, R. D., Shephard, T. J., Moyer, P., Gorman, M., Johnston, S. C., Duncan, P. W., et al. (2005) · Circulation · doi:10.1161/01.cir.0000154252.62394.1e · Cited by 395
Self-citation
Research works printed but not linked: 3
- 10.1097/NRL.0b013e318248ea3c · doi:10.1097/nrl.0b013e318248ea3c
- 10.1212/WNL.57.9.1739 · doi:10.1212/wnl.57.9.1739
- 10.1161/strokeaha.111.626374 · doi:10.1161/strokeaha.111.626374
Cited by
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591
Self-citationHeart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596
Self-citationHeart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797
Self-citationNeurogenesis and Inflammation after Ischemic Stroke: What is Known and Where We Go from Here
Tobin, M. K., Bonds, J. A., Minshall, R. D., Pelligrino, D. A., Testai, F. D., & Lazarov, O. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.130 · Cited by 310
Metadata
- Authors
- Schwamm, L. H., Ali, S. F., Reeves, M. J., Smith, E. E., Saver, J. L., Messe, S., Bhatt, D. L., Grau-Sepulveda, M. V., Peterson, E. D., & Fonarow, G. C.
- Venue
- Circulation: Cardiovascular Quality and Outcomes
- Published
- 2013-09
- Volume
- 6
- Issue
- 5
- Pages
- 543-549
- ISSN
- 1941-7705 (ISSN-L)
- 1941-7713
- OpenAlex
- W2069149215
- Cited by
- 305
- References
- 25
- FWCI
- 18.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schwamm, L. H., Ali, S. F., Reeves, M. J., Smith, E. E., Saver, J. L., Messe, S., Bhatt, D. L., Grau-Sepulveda, M. V., Peterson, E. D., & Fonarow, G. C. (2013). Temporal Trends in Patient Characteristics and Treatment With Intravenous Thrombolysis Among Acute Ischemic Stroke Patients at Get With the Guidelines–Stroke Hospitals. Circulation: Cardiovascular Quality and Outcomes. https://doi.org/10.1161/circoutcomes.111.000095
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
