Cited by 865Healthcare Systems and Public HealthCardiovascular Health and Risk FactorsGlobal Health and Epidemiology

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Mortality From Ischemic Heart Disease: Analysis of Data From the World Health Organization and Coronary Artery Disease Risk Factors From NCD Risk Factor Collaboration

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Nowbar, Alexandra N., Gitto, Mauro, Howard, James P., Francis, Darrel P., Al-Lamee, Rasha·2019·Circulation: Cardiovascular Quality and Outcomes

DOI 10.1161/circoutcomes.118.005375PMC PMC6613716

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Abstract

Background: Ischemic heart disease (IHD) has been considered the top cause of mortality globally. However, countries differ in their rates and there have been changes over time. Methods and Results: We analyzed mortality data submitted to the World Health Organization from 2005 to 2015 by individual countries. We explored patterns in relationships with age, sex, and income and calculated age-standardized mortality rates for each country in addition to crude death rates. In 5 illustrative countries which provided detailed data, we analyzed trends of mortality from IHD and 3 noncommunicable diseases (lung cancer, stroke, and chronic lower respiratory tract diseases) and examined the simultaneous trends in important cardiovascular risk factors. Russia, United States, and Ukraine had the largest absolute numbers of deaths among the countries that provided data. Among 5 illustrative countries (United Kingdom, United States, Brazil, Kazakhstan, and Ukraine), IHD was the top cause of death, but mortality from IHD has progressively decreased from 2005 to 2015. Age-standardized IHD mortality rates per 100 000 people per year were much higher in Ukraine (324) and Kazakhstan (97) than in United States (60), Brazil (54), and the United Kingdom (46), with much less difference in other causes of death. All 5 countries showed a progressive decline in IHD mortality, with a decline in smoking and hypertension and in all cases a rise in obesity and type II diabetes mellitus. Conclusions: IHD remains the single largest cause of death in countries of all income groups. Rates are different between countries and are falling in most countries, indicating great potential for further gains. On the horizon, future improvements may become curtailed by increasing hypertension in some developing countries and more importantly global growth in obesity.

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Figure 1. Changes in (A) crude death rates and (B) age-standardized mortality rates between 2005 and 2015. These are the 16 countries who provided longitudinal mortality data.CC BY · PubMed Central

Figure 2. Variation in age- and sex-specific mortality in (A) United Kingdom, (B) Brazil, (C) United States, (D) Kazakhstan, and (E) Ukraine. All data are from 2015 except Kazakhstan which is from 2012.CC BY · PubMed Central

Figure 3. Mortality trends from major causes of death from 2005 to 2015 in (A) United Kingdom, (B) Brazil, (C) United States, (D) Kazakhstan, and (E) Ukraine. Age-standardized mortality rates per 100 000 people from ischemic heart disease (red line), stroke (light blue line), cirrhosis and other liver diseases (green line), chronic lower respiratory tract diseases (yellow line), lung cancer (blue line), transport accidents (orange line), and infectious diseases (purple line).CC BY · PubMed Central

Figure 4. Mortality trends from ischemic heart disease (IHD) compared with variations in Gross National Income (GNI) and prevalence of cardiovascular risk factors from 2005 to 2015 in (A) United Kingdom, (B) Brazil, (C) United States, (D) Kazakhstan, and (E) Ukraine. The red line and right axis represent the IHD mortality trend. Behind this are a family of area charts showing trends of GNI (yellow), age-standardized mean body mass index (BMI; purple), age-standardized prevalence of smoking (green), type II diabetes mellitus (DM II; light blue), and hypertension (HTN; orange).CC BY · PubMed Central

Figure 5. Statin prescription rates in the United Kingdom from 2005 to 2013. Rates of prescription in the population over 18 y old.CC BY · PubMed Central

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“Ischemic heart disease (IHD) is the leading cause of morbidity and mortality across the globe, accounting for 9 million deaths annually (1, 2).”
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Authors: Nowbar, A. N., Gitto, M., Howard, J. P., Francis, D. P., & Al-Lamee, R.
Affiliations: Hammersmith Hospital (GB)
International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, United Kingdom (A.N.N., M.G., J.P.H., D.P.F., R.A.-L.).
Corresponding author: Nowbar, Alexandra N.
ORCID: Nowbar, Alexandra N.
Gitto, Mauro
Howard, James P.
Al-Lamee, Rasha
Venue: Circulation: Cardiovascular Quality and Outcomes
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2019-06
Volume: 12
Issue: 6
Pages: e005375-e005375
ISSN: 1941-7705 (ISSN-L)
1941-7713
DOI: 10.1161/circoutcomes.118.005375
PMC: PMC6613716
OpenAlex: W2950663303
Cited by: 860
References: 20
Citations by year: 2026: 58 · 2025: 121 · 2024: 149 · 2023: 155 · 2022: 147 · 2021: 133 · 2020: 83 · 2019: 12
FWCI: 71.55
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Circulation Cardiovascular Quality and Outcomes (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Spiral (Imperial College London) (submittedVersion, cc-by)
Funders: Wellcome Trust (212183/Z/18/Z)
National Institute for Health and Care Research
Topics: Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Health and Epidemiology
Keywords: ischemic heart disease, mortality trends, age-standardized mortality rates, non-communicable diseases, lung cancer, stroke, cardiovascular risk factors, smoking, hypertension, obesity, type 2 diabetes, income inequality, sex differences, global burden of disease
MeSH terms: Adult, Aged, Aged, 80 and over, Cause of Death, Diabetes Mellitus, Female, Humans, Hypertension, Male, Middle Aged, Obesity, Risk Factors, Smoking, Time Factors, Global Health, World Health Organization, Comorbidity, Prevalence, Myocardial Ischemia, Age Distribution, Sex Distribution, Risk Assessment, Health Status Disparities

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Mortality From Ischemic Heart Disease: Analysis of Data From the World Health Organization and Coronary Artery Disease Risk Factors From NCD Risk Factor Collaboration

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