Cited by 710Nitric Oxide and Endothelin EffectsMitochondrial Function and PathologyRenin-Angiotensin System Studies

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction

Doughan, Abdulrahman K., Harrison, David G., Dikalov, Sergey I.·2008·Circulation Research

Open this paper in CoChat — free account

Abstract

Mitochondrial dysfunction is a prominent feature of most cardiovascular diseases. Angiotensin (Ang) II is an important stimulus for atherogenesis and hypertension; however, its effects on mitochondrial function remain unknown. We hypothesized that Ang II could induce mitochondrial oxidative damage that in turn might decrease endothelial nitric oxide (NO · ) bioavailability and promote vascular oxidative stress. The effect of Ang II on mitochondrial ROS, mitochondrial respiration, membrane potential, glutathione, and endothelial NO · was studied in isolated mitochondria and intact bovine aortic endothelial cells using electron spin resonance, dihydroethidium high-performance liquid chromatography –based assay, Amplex Red and cationic dye fluorescence. Ang II significantly increased mitochondrial H 2 O 2 production. This increase was blocked by preincubation of intact cells with apocynin (NADPH oxidase inhibitor), uric acid (scavenger of peroxynitrite), chelerythrine (protein kinase C inhibitor), N G -nitro- l -arginine methyl ester (nitric oxide synthase inhibitor), 5-hydroxydecanoate (mitochondrial ATP-sensitive potassium channels inhibitor), or glibenclamide. Depletion of p22 phox subunit of NADPH oxidase with small interfering RNA also inhibited Ang II–mediated mitochondrial ROS production. Ang II depleted mitochondrial glutathione, increased state 4 and decreased state 3 respirations, and diminished mitochondrial respiratory control ratio. These responses were attenuated by apocynin, 5-hydroxydecanoate, and glibenclamide. In addition, 5-hydroxydecanoate prevented the Ang II–induced decrease in endothelial NO · and mitochondrial membrane potential. Therefore, Ang II induces mitochondrial dysfunction via a protein kinase C–dependent pathway by activating the endothelial cell NADPH oxidase and formation of peroxynitrite. Furthermore, mitochondrial dysfunction in response to Ang II modulates endothelial NO · and generation, which in turn has ramifications for development of endothelial dysfunction.

Integrity signals

Registry

Crossref · 10.1161/circresaha.107.162800

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mitochondrial free radical generation, oxidative stress, and aging
Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
Mehta, P. K., & Griendling, K. K. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00287.2006 · Cited by 1,924
Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives
Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350
Role of oxidative stress in atherosclerosis
Harrison, D., Griendling, K. K., Landmesser, U., Hornig, B., & Drexler, H. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03144-2 · Cited by 1,275
Self-citation
Complex iii releases superoxide to both sides of the inner mitochondrial membrane
Muller, F. L., Liu, Y., & Van Remmen, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407715200 · Cited by 1,036
Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction
Ide, T., Tsutsui, H., Hayashidani, S., Kang, D., Suematsu, N., Nakamura, K., Utsumi, H., Hamasaki, N., & Takeshita, A. (2001) · Circulation Research · doi:10.1161/01.res.88.5.529 · Cited by 733
Mitochondrial Dysfunction and Reactive Oxygen Species in Excitotoxicity and Apoptosis: Implications for the Pathogenesis of Neurodegenerative Diseases
Rego, A. C., & Oliveira, C. R. (2003) · Neurochemical Research · doi:10.1023/a:1025682611389 · Cited by 476
Mitochondrial reactive oxygen species-mediated signaling in endothelial cells
Zhang, D. X., & Gutterman, D. D. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01283.2006 · Cited by 442
Mitochondrial dysfunction in cardiovascular disease
Ballinger, S. W. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.014 · Cited by 405
Protection of Cardiac Mitochondria by Overexpression of MnSOD Reduces Diabetic Cardiomyopathy
Shen, X., Zheng, S., Metreveli, N. S., & Epstein, P. N. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-1039 · Cited by 375

Show all 43 references

Research works printed but not linked: 2

10.1161/res.88.5.529 · DOI
10.1161/res.89.12.1177 · DOI

Sorted by citations

Items 601–700 of 710

Approaches in Gene Therapy of Cancer and Cardiovascular Diseases
Gardlík, R., Dovinová, I., & Julie, C. D. H. (2011) · InTech eBooks · doi:10.5772/18280 · Cited by 4
Tissue Derivation and Biological Sex Uniquely Mediate Endothelial Cell Protein Expression, Redox Status, and Nitric Oxide Synthesis
Najjar, R. S., Wong, B. J., & Feresin, R. G. (2022) · Cells · doi:10.3390/cells12010093 · Cited by 4
THRA1/PGC-1α/SIRT3 pathway regulates oxidative stress and is implicated in hypertension of maternal hypothyroid rat offspring
Guo, J. X., Shi, Y., Yu, X., Zhao, Y., Wei, B., Huo, M., Lu, L., Li, L., Gao, Q., & Sun, M. (2024) · Hypertension Research · doi:10.1038/s41440-024-02023-9 · Cited by 4
Measurements of Reactive Oxygen Species in Cardiovascular Studies
Dikalov, S., & Nazarewicz, R. R. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_45 · Cited by 4
Self-citation
Functional Implications of Reactive Oxygen Species (ROS) in Human Blood Vessels
Guzik, T. J., Schramm‐Luc, A., & Cześnikiewicz‐Guzik, M. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_178 · Cited by 4
Oxidative Stress, Endothelial Dysfunction, and Its Impact on Smooth Muscle Signaling
Münzel, T. F., & Gori, T. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381510-1.00091-0 · Cited by 4
The Impact of Exercise on Redox Equilibrium in Cardiovascular Diseases
Sutkowy, P., Wróblewska, J., Wróblewski, M., Nuszkiewicz, J., Modrzejewska, M., & Woźniak, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11164833 · Cited by 4
Angiotensin II Reduces Transport-Dependent Oxygen Consumption but Increases Transport-Independent Oxygen Consumption in Immortalized Mouse Proximal Tubular Cells
Friederich‐Persson, M., Welch, W. J., Luo, Z., Palm, F., & Nordquist, L. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0620-8_21 · Cited by 4
Cardiac remodelling: General aspects and mechanisms
Pontes, H. B. D., & Pontes, J. C. D. V. (2016) · Current research. Cardiology · doi:10.4172/2368-0512.1000073 · Cited by 4
Cardiac Aging
Dai, D., Chiao, Y. A., Wessells, R. J., Bodmer, R., Szeto, H. H., & Rabinovitch, P. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00017-4 · Cited by 4
Blocking the mineralocorticoid receptor prevents cardiac and mitochondrial dysfunction through the activation of NOX‐4 in female hormone deprivation rats
Rodrigues, S. M. L., Ximenes, C. F., Rodrigues, N. D. C., Ronconi, K. S., Costa, A. K. N., Vieira, L. B., da Silva, M. L. Y., FERREIRA, K. K. S., Eliezeck, M., Scalzo, S., et al. (2025) · Acta Physiologica · doi:10.1111/apha.70007 · Cited by 3
The core mechanism of hypertension-linked renal fibrosis: “RAAS-ROS-inflammation-fibrosis” axis
Wang, Y., Chen, J., Wang, W., Yi, X., Xing, S., Lei, X., Chen, H., & Xie, X. (2026) · iScience · doi:10.1016/j.isci.2026.115353 · Cited by 8
Molecular and pathophysiological intersections between arterial hypertension, pulmonary inflammation and diabetes mellitus
da Silva, H. J. N., Filho, A. C. M. L., Pereira, E. M., Sousa, I. J. O., Cunha, F. V. M., Lucarini, M., Durazzo, A., Sousa, L. D. R., & Arcanjo, D. D. R. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1734861 · Cited by 3
ALDH2 rs671 variant enhances platelet activation and thrombosis by disrupting mitochondrial complex I assembly
Zhong, H., Waresi, M., Qi, Z., Zhou, L., Zhang, W., Sun, X., Han, L., Chen, Z., Zhou, W., Zhang, P., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf194 · Cited by 3
Vascular Endothelial Function
Widlansky, M. E., & Malik, M. A. (2014) · Springer eBooks · doi:10.1007/978-3-642-37393-0_8-1 · Cited by 3
Reactive Oxygen Species and Cerebrovascular Diseases
Miller, A. A., Silva, T. M. D., Drummond, G. R., Sobey, C. G., & Chrissobolis, S. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_78 · Cited by 3
Ellagic acid protects against angiotensin II ‐induced hypertrophic responses through ROS ‐mediated MAPK pathway in H9c2 cells
Lee, Y., Jou, Y., Chou, W.-C., Tsai, K., Shen, C., & Lee, S. (2024) · Environmental Toxicology · doi:10.1002/tox.24170 · Cited by 3
Coronary microvascular dysfunction, arrythmias, and sudden cardiac death: A literature review
Dankar, R., Wehbi, J., Atasi, M. M., Alam, S., & Refaat, M. M. (2024) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2024.100389 · Cited by 3
Reactive Oxygen Species (ROS) and Cardiac Ischemia and Reperfusion Injury
Camara, A. K. S., & Stowe, D. F. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_75 · Cited by 3
Protective effects of appropriate Zn2+ levels against UVB radiation-induced damage in human lens epithelial cells in vitro
Du, Y., Guo, D., Wu, Q., Shi, J., Liu, D., & Bi, H. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-015-1324-9 · Cited by 3
Oxidase Interactions in Cardiovascular Disease
Youn, J. Y., Siu, K. L., Li, Q., Harrison, D. G., & Cai, H. “. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_43 · Cited by 3
Self-citation
MnSOD protects against vascular calcification independent of changes in vascular function in hypercholesterolemic mice
Roos, C. M., Zhang, B., Hagler, M. A., Arghami, A., & Miller, J. D. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.06.005 · Cited by 3
Reactive Oxygen Species, Oxidative Stress, and Hypertension
Touyz, R. M., Chignalia, A. Z., & Sedeek, M. H. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_15 · Cited by 2
From ST segments to endothelial pathophysiology: hypercholesterolemia and endothelial superoxide production
Harrison, D. G. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70336 · Cited by 2
Self-citation
Role of Oxidative Stress, Mitochondrial Dysfunction, and Autophagy in Cardiovascular Disease: Its Pathogenesis and Amelioration by Different Small Natural Molecules
Chatterjee, S., Hossain, U., & Sil, P. C. (2019) · Springer eBooks · doi:10.1007/978-981-13-8946-7_19 · Cited by 2
Characteristics of the Endothelium in Both Sexes
Costa, T. J. D., Echem, C., Colli, L. G., Akamine, E. H., Dantas, A. P., & de Carvalho, M. H. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812348-5.00006-4 · Cited by 2
Roles of Hydrogen Peroxide in the Regulation of Vascular Tone
Stanley, C. P., Maghzal, G. J., & Stocker, R. (2017) · CRC Press eBooks · doi:10.1201/9781315154831-24 · Cited by 2
Pathogenesis of CoViD19—Miscellaneous Mechanisms
Mallick, U. (2022) · Springer eBooks · doi:10.1007/978-3-030-90065-6_10 · Cited by 2
Contribution of Insulin Resistance in Pathogenesis of Alzheimer Disease
Erol, A. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch3 · Cited by 2
Effect of Irbesartan-Poloxamer-188 Solid Dispersion on Intercellular Cell Adhesion Molecule-1 and Interleukin-8 on Hypertension Rats
Harmely, F., Nasrul, E., Zaini, E., & Aldi, Y. (2019) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2019.753 · Cited by 1
Oxidative Stress and Antioxidant Strategies in Human Diseases
Yuan, K., & Zhang, Y. (2021) · Springer eBooks · doi:10.1007/978-981-16-0522-2_1 · Cited by 2
Angiotensin-converting enzyme: a well-known stranger. Part I
Олеговна, Н. Е. (2023) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2023-29-4-353-370 · Cited by 1
GBA1 Gene-Associated Transcriptomic Signatures Reveal Risk Genes in Parkinson’s Disease
Liu, Y., Luo, X., & Fleming, R. M. T. (2025) · Biomedicines · doi:10.3390/biomedicines13112799 · Cited by 1
Living photonics: monitoring light propagation through cells (LiPhos)
King, D., Hedegaard, E. R., Ackermann, T. N., Rius, C., Muñoz‐Berbel, X., Knudsen, H., Rodríguez-Ruiz, I., Dorado, B., Alvarez, E., Ducrée, J., et al. (2015) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2181306 · Cited by 1
Intracellular mitochondrial-subcellular communication: A regulator of myocardial energy metabolic homeostasis in heart failure
Kang, Y., Sun, X.-T., Li, A.-L., Zhang, A., Fan, X., Shang, W.-Y., Jia, Y., Zhao, Y.-X., Miao-miao, W., Cao, Y.-X., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103192 · Cited by 1
Oxygen, Free Radicals, and the Kidney
O'Connor, P. M., Schreck, C., & Evans, R. G. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_112 · Cited by 1
Does Renin‐Angiotensin‐Aldosterone System Inhibition Impact Obesity as a Co–Risk Factor?
Hsueh, W. A., & Wyne, K. L. (2009) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2009.00215.x · Cited by 1
Do We Have a Chance to Translate Bench-top Results to the Clinic Adequately? An Opinion
Danielyan, K. E. (2017) · Translational medicine research · doi:10.1007/978-981-10-5804-2_26 · Cited by 1
Regulation of Biogenesis and Fusion/Fission Processes of Vascular Mitochondria In Aldosterone-Induced Hypertension
Olivares-Álvaro, E., Ruiz-Roso, M. B., Klett‐Mingo, M., Ballesteros, S., Gredilla, R., Galiana, A., Heras, N. D. L., Lahera, V., & Martín‐Fernández, B. (2018) · The Open Hypertension Journal · doi:10.2174/1876526201810010076 · Cited by 1
Mitochondria: A Key Protagonist of the Renin Angiotensin System
Varghese, R. S., & Majumdar, A. S. (2023) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-14952-8_8 · Cited by 1
Reactive Oxygen Species, Vascular Disease, and Hypertension
Montezano, A. C. I., & Touyz, R. M. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_56 · Cited by 1
Clinical Endothelial Dysfunction: Prognosis and Therapeutic Target
Haas, E. A., Nishiyama, M., & da Luz, P. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812348-5.00048-9 · Cited by 1
Evaluation of involvement of adrenergic receptor modulator in hypertension induced experimental Vascular Dementia in Rats
Sharma, B. M., & Sharma, B. (2021) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2021.01152 · Cited by 1
The Renin-Angiotensin System in COVID19
Mallick, U. (2022) · Springer eBooks · doi:10.1007/978-3-030-90065-6_8 · Cited by 1
An Introduction to the Pathogenetic Mechanisms of CoViD19 Complications
Mallick, U. (2022) · Springer eBooks · doi:10.1007/978-3-030-90065-6_6 · Cited by 1
Plant-Derived Substances and Cardiovascular Diseases : Effects of Flavonoids, Terpenes and Sterols on Angiotensin-Converting Enzyme and Nitric Oxide
Persson, I. A. ‐. (2009) · DiVA (Linkoping University) · Cited by 1
Vascular dysfunction in diet-induced hypertension and obesity in mice : Role of endothelium, reactive oxygen species and periadventitial fat
Ketonen, J. (2010) · UEF eRepo (University of Eastern Finland) · Cited by 1
JAK and MEK Pathways as Therapeutic Targets for Saphenous Vein Smooth Muscle Cell Dysfunction in Type 2 Diabetes via Regulation of Mitochondrial ActivityPreprint
Bolanle, I. O., Moshapa, F. T., Durham, G. A., Hobkirk, J., Riches‐Suman, K., Loubani, M., Sturmey, R. G., & Palmer, T. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.17.682556 · Cited by 1
Induction of atrial endothelial senescence by angiotensin II and thrombin : role of oxidative stress and characterization of pro-thrombotic, pro-adhesive, proteolytic and pro-fibrotic phenotype
Hasan, H. (2018) · theses.fr (ABES) · doi:10.70675/e177e853zeb28z4e25z8f7az2250434081c0 · Cited by 1
Endothelial Mitochondria: Contribution to Cardiovascular Function and Disease
Marín-García, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4599-9_7
Relationship of Oxidative Stress with Cardiovascular Disease
White, R. E., Barman, S. A., Zhu, S., & Han, G. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-041-0_15
Vascular inflammation : Implications for microvascular reconstructive surgery after irradiation
Halle, M. (2010) · Figshare
Signaling in the Cardiovascular System
Simon, M. C., Liu, L., Barnhart, B. C., & Young, R. M. (2008)
SPECIAL TOPIC Intracrine Renin-Angiotensin System: A New Paradigm in Cardiovascular and Renal Control Lessons from in vitro studies and a related intracellular angiotensin II transgenic mouse model
Cook, J. L., & Ré, R. N. (2012)
Evaluation of pharmacological properties of Danshen compounds by computational and biochemical approaches
Zhou, Z. (2016) · RMIT Research Repository (RMIT University Library) · doi:10.25439/rmt.27581778
MOLECULAR MECHANISMS OF HYPERTENSION-INDUCED HEART FAILURE Experimental studies with special emphasis on local renin-angiotensin system, cardiac metabolism and levosimendan
Biala, A. K. (2011) · Työväentutkimus Vuosikirja
AMPK Targets Involved in Energy Homeostasis and Epigenetic Regulation of Mitochondrial Function-related Genes
Marin, T. (2013) · eScholarship (California Digital Library)
THE ROLE OF THE ACE2/ANG-(1-7)/MASR AXIS IN THE DEVELOPMENT OF OBESITY-HYPERTENSION IN MALE AND FEMALE MICE
Wang, Y. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.037
In vitro effects of Alba strawberry cultivars on two murine breast cancer cell lines
Mazzoni, L. (2015) · Università Politecnica delle Marche (Università Politecnica delle Marche)
Review Article Brain angiotensin and dopaminergic degeneration: relevance to Parkinson's disease
Labandeira-García, J. L., Rodríguez‐Pallares, J., Rodriguez-Perez, A. I., Garrido‐Gil, P., Valenzuela, R., & Guerra, M. J. (2012)
Effects of pomegranate extract supplementation on cardiovascular disease risk and physical function in patients with chronic renal failure
Wu, P.-T. (2013) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Oxidative stress and its haemodynamic consequences in chronic kidney disease
Gillis, K. A. (2016) · Enlighten: Theses (The University of Glasgow)
Induced by Angiotensin II Uncoupling and Nitro-oxidative Stress Endothelial Nitric-oxide Synthase Inflammatory Monocytes Determine
Daiber, A., Wenzel, P., Bauersachs, J. K., Widder, J. D., Becker, C., Oelze, M. W., Knorr, M., Brandt, M., Schönfelder, T., & Hu, H. (2014)
The Role of Angiotensin II in Skeletal Muscle Metabolism
Wahlberg, K. A. (2011) · VTechWorks (Virginia Tech)
Étude physiopathologique de l'hypertension artérielle essentielle
Duong, R., Brion, F., Lelong, H., Yannoutsos, A., & Blacher, J. (2016)
Hypoxia and Hyperoxia
Wedgwood, S., Schumacker, P. T., & Steinhorn, R. H. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2682-4.00004-4
Evolutionary Diversity of the Mitochondrial Calcium Uniporter and Its Contribution to Cardiac and Vascular Homeostasis
Bick, A. G. (2016) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Clinical and biochemical factors associated with acute myocardial infarction: Risk factors for acute myocardial infarction
Mehri, S., & Hammami, M. (2017) · International Conference on Engineering & MIS (ICEMIS) · doi:10.1109/icemis.2017.8273109
Characterizing the Role of IL-1β in Macrophage Clearance of Citrobacter rodentium Infection
Bording‐Jorgensen, M. (2018) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3td9nq61
ROLE OF PKCBETA AND OXIDANT SIGNALING IN NEONATAL PULMONARY HYPERTENSION
Sheak, J. R. (2019) · UNM’s Digital Repository (University of New Mexico)
TRAIL: A novel atheroprotective mechanism in the vasculature
Cholan, P. M. (2019)
Angiotensin-II and acute pancreatitis
Huang, Z., Lv, Y.-C., Lei, J.-J., & Liu, Q. (2021) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v29.i1.34
NADPH Oxidase in Choroidal Neovascularization
Li, Q., Verma, A., Dinculescu, A., Lewin, A. S., & Hauswirth, W. W. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-606-7_14
Vascular Reactive Oxygen Species Biology – Insights from Transgenic and Knockout Mouse Models
Tan, S. M., & de Haan, J. B. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_22
H2S Signals and Renin Angiotensin System in Cardiovascular Diseases
Zhu, J., & Yang, G. (2023) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-14952-8_24
Crosstalk Between Abnormal Electrical Activity and Angiotensin II Cell Signaling in the Hyperglycemic Mammalian Heart
Turan, B. (2023) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-14952-8_3
Aspects of the intracellular renin–angiotensin system
Chappell, M. C., Yamaleyeva, L. M., Shaltout, H. A., & Gwathmey, T. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99618-1.00004-0
Impact of N-Acetylcysteine on Modulating Inflammation in Patients Hospitalized with Moderate COVID-19 Infections: A Prospective Randomized Trial
Sherkawy, S., Elwakeel, L., Schaalan, M. F., Moharram, A., & Abouelwafa, M. Y. (2023) · Archives of Pharmaceutical Sciences Ain Shams University · doi:10.21608/aps.2023.212265.1122 · Cited by 1
Evidence that the monoamine oxidase B (MAO-B) plays a central role in the inotropic dysfunction induced by genetic deletion of the Mas-related-G protein-coupled receptor D (MrgD) in micePreprint
Rodrigues‐Ribeiro, L., Rezende-Ribeiro, J., Scalzo, S., Dias, M. L., Sanches, B., Eliezeck, M., de Jesus, I. C. G., Evaristo, J. A. M., Sampaio, K. H., Peruchetti, D. B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.27.586916
Cellular and Molecular Basis of Calcific Aortic Valve Disease
Miller, J. D. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4860-0.00003-7
Hydrogen sulfide improves vascular endothelial function in hypertensive states through SIRT6 anti-inflammatory signaling
Lu, F., Qin, X., Lu, S., Wan, J., Miao, Y., Teng, X., Jin, S., Xiao, L., Xue, H., Guo, Q., et al. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025221
High Glucose and Human Endothelial Cell Ageing
Bowers, L.-L. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Telomere length in cardiovascular disease and type 2 diabetes
Salpea, K. D. (2011) · UCL Discovery (University College London)
Additional file 1 of Altered local RAS in the liver increased the risk of NAFLD in male mouse offspring produced by in vitro fertilization
Bo, L., Wei, L., Shi, L., Luo, C., Gao, S., Zhou, A., & Mao, C. (2023) · Figshare · doi:10.6084/m9.figshare.22815210
Pathophysiology of Cerebral Ischemia
Mouchtouris, N., & Amin‐Hanjani, S. (2026) · Springer eBooks · doi:10.1007/978-3-032-08934-2_3
Potentiel des polyphénols à prévenir la dysfonction endothéliale liée au vieillissement et la sénescence des cellules endothéliales
Idris-Khodja, N. (2012) · theses.fr (ABES) · doi:10.70675/b7dd5e95z7adbz45f4zb349z90e37c85791d
Fusion Mitochondriale et Effets Vasculaires : rôle de OPA 1 dans l'hypertension artérielle et le vieillissement
Nguyen, P. M. C. (2015) · theses.fr (ABES) · doi:10.70675/f5d28b69zead0z45d6z8d1cz92ab36aab66c
Régulation de l’angiogenèse par le chlordécone : implication du stress oxydatif et de la mitochondrie
Alibrahim, E. A. (2016) · doi:10.70675/e8ead245z56eez4d51zaa30z7f780d167521
Potential of omega-3 EPA/DHA 6/1 to ameliorate ageing-related endothelial dysfunction
Farooq, M. A. (2018) · doi:10.70675/4ebe1147z08fbz4397za37az9bc31dcfe64f
Regulation of homeoproteins intercellular transfer
Amblard, I. (2020) · theses.fr (ABES) · doi:10.70675/bbf68b66zb816z4669z84f4zec67820f5b54
The Regulatory Landscape of Ferroptosis and Iron Homeostasis: Pathophysiological Mechanisms and Therapeutic Horizons in Cardiovascular Disease
Zhang, T., Xiao, S., Xia, Y., Chen, K., Liu, H., Zhang, P., & Luo, L. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s581236
AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence
Jouabadi, S. M., Jüttner, A. A., Claringbould, A., VRIES, R. D., Garrelds, I. M., Musterd‐Bhaggoe, U. M., Stricker, B. H. C., Kavousi, M., Danser, A. H. J., Ahmadizar, F., et al. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70533 · Cited by 1
Role of NADPH oxidase 2-derived reactive oxygen species in cardiac electrophysiological disorders
Li, B., Dong, Y., Chen, Y., Liu, C., & Li, Y. (2026) · Channels · doi:10.1080/19336950.2026.2696810
Mitoquinone Prevents Cardiac Dysfunction by Normalizing Mitochondrial ROS and Calcium Handling in Acute Myocardial Infarction
Ximenes, C. F., Lorencini, P. Z., Castardeli, C., Machado, M. R. R., FERREIRA, K. K. S., Mendes, S. B. O., Costa, A., Silva, M. M., Scalzo, S., Eliezeck, M., et al. (2026) · Acta Physiologica · doi:10.1111/apha.70276
The Subfornical organ: A central target for renin-angiotensin system regulation
Molaei, F., Rahmati, S., Fordooii, F. A., Esmaeili, N., Hasani, A., MPH, Pashaei, P., Behboodi, K., Izadpanahi, K., & Shafiee, A. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101273
Beyond the guidelines: Vascular function as the central determinant and therapeutic target in hypertension
Higashi, Y. (2026) · Hypertension Research · doi:10.1038/s41440-026-02762-x
COX14 Variants Are Associated With Mitochondrial Complex IV Deficiency Nuclear Type 10 ( MC4DN10 )
Awad, E. K., Waskow, E., Tunuguntla, H., Spinner, J. A., Tadros, H. J. J., Emrick, L., Calame, D. G., & Scaglia, F. (2026) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.70260
Endothelial CD36 mediates Porphyromonas gingivalis-induced insulin resistance and vascular aging via mitochondrial dysfunction
Chen, Y., Zhang, X., Huang, S., & Febbraio, M. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.08.050
Therapeutic Implication of Anti‐CTGF in Neointimal Hyperplasia via Regulating Mitochondrial Dysfunction and VSMC Phenotypic Switch
Hwang, A.-R., Woo, C.-H., & Kang, Y. J. (2026) · Cardiovascular Therapeutics · doi:10.1155/cdr/5400858
The cGAS-STING Pathway: A Double-Edged Regulator of Neuroinflammation and Myelin Regeneration
Chen, X., Yu, X., Cao, X., Feng, J., Meng, Z., & Wang, X. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06174-3

Authors: Doughan, A. K., Harrison, D. G., & Dikalov, S. I.
Affiliations: United States Department of Veterans Affairs (US)
ORCID: Harrison, David G.
Dikalov, Sergey I.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-02-29
Volume: 102
Issue: 4
Pages: 488-496
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.107.162800
OpenAlex: W2164444293
Cited by: 710
References: 43
Citations by year: 2026: 24 · 2025: 24 · 2024: 19 · 2023: 32 · 2022: 33 · 2021: 44 · 2020: 39 · 2019: 31 · 2018: 31 · 2017: 36 · 2016: 54 · 2015: 29 · 2014: 58 · 2013: 51 · 2012: 50
FWCI: 25.60
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health (5p01hl075209-05)
National Heart, Lung, and Blood Institute (P0-1 HL-075209, R01HL094469, P01HL058000)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords: angiotensin II, mitochondrial dysfunction, endothelial nitric oxide, NADPH oxidase, peroxynitrite, protein kinase C, mitochondrial reactive oxygen species, mitochondrial glutathione, mitochondrial respiration, endothelial dysfunction, oxidative stress, atherogenesis, hypertension
MeSH terms: Angiotensin II, Animals, Aorta, Cattle, Cells, Cultured, Glutathione, Hydrogen Peroxide, Mitochondria, Nitric Oxide, Superoxides, Vascular Diseases, Vasoconstrictor Agents, Oxidative Stress, Cell Respiration, Mitochondrial Diseases, Endothelial Cells, Membrane Potential, Mitochondrial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks