Angiotensin II-Induced Production of Mitochondrial Reactive Oxygen Species: Potential Mechanisms and Relevance for Cardiovascular Disease
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SIGNIFICANCE: The role of reactive oxygen species (ROS) in angiotensin II (AngII) induced endothelial dysfunction, cardiovascular and renal remodeling, inflammation, and fibrosis has been well documented. The molecular mechanisms of AngII pathophysiological activity involve the stimulation of NADPH oxidases, which produce superoxide and hydrogen peroxide. AngII also increases the production of mitochondrial ROS, while the inhibition of AngII improves mitochondrial function; however, the specific molecular mechanisms of the stimulation of mitochondrial ROS is not clear. RECENT ADVANCES: Interestingly, the overexpression of mitochondrial thioredoxin 2 or mitochondrial superoxide dismutase attenuates AngII-induced hypertension, which demonstrates the importance of mitochondrial ROS in AngII-mediated cardiovascular diseases. CRITICAL ISSUES: Although mitochondrial ROS plays an important role in normal physiological cell signaling, AngII, high glucose, high fat, or hypoxia may cause the overproduction of mitochondrial ROS, leading to the feed-forward redox stimulation of NADPH oxidases. This vicious cycle may contribute to the development of pathological conditions and facilitate organ damage in hypertension, atherosclerosis, and diabetes. FUTURE DIRECTIONS: The development of antioxidant strategies specifically targeting mitochondria could be therapeutically beneficial in these disease conditions.
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ATR1 also increases reactive oxygen species from mitochondria in monocytes/macrophages leading to DNA damage and apoptosis of T cells resulting in endothelial injury and lymphopenia.
“ATR1 also increases reactive oxygen species from mitochondria in monocytes/macrophages leading to DNA damage and apoptosis of T cells resulting in endothelial injury and lymphopenia.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [60]
The Introduction describes AT1R-dependent mitochondrial ROS production, and the Conclusions link AngII-related mitochondrial dysfunction to endothelial dysfunction (page numbers unavailable). Neither passage supports the claimed sequence in which ROS from monocytes or macrophages causes T-cell DNA damage and apoptosis, endothelial injury, and lymphopenia. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe rescue of ANGII-induced cerebrovascular dysfunction by Nox2 deletion in PVMs was incomplete, possibly implicating ROS sources other than NOX2.
“However, the rescue of the dysfunction was not complete, possibly implicating ROS sources other than NOX2 (33).”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [33]
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Ushio‐Fukai, M., Griendling, K. K., Becker, P. L., Hilenski, L. L., Halleran, S., & Alexander, R. W. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.4.489 · Cited by 283 · see citing works
RetractedThe Pathobiology of Diabetic Complications
Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339 · see citing works
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125 · see citing works
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886 · see citing works
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1574 · Cited by 1,520 · see citing works
Lassègue, B., Sorescu, D., Szöcs, K., Yin, Q., Akers, M., Zhang, Y., Grant, S. L., Lambeth, J. D., & Griendling, K. K. (2001) · Circulation Research · doi:10.1161/hh0901.090299 · Cited by 839 · see citing works
Mitochondrial Dysfunction in Atherosclerosis
Madamanchi, N. R., & Runge, M. S. (2007) · Circulation Research · doi:10.1161/01.res.0000258450.44413.96 · Cited by 794 · see citing works
Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases
Martyn, K. D., Frederick, L. M., von Loehneysen, K., Dinauer, M. C., & Knaus, U. G. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.03.023 · Cited by 783 · see citing works
Cross talk between mitochondria and NADPH oxidases
Dikalov, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.033 · Cited by 783 · see citing works
Self-citationNADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart
Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D., & Sadoshima, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002178107 · Cited by 772 · see citing works
Therapeutic Targeting of Mitochondrial Superoxide in Hypertension
Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 737 · see citing works
Self-citationDoughan, A. K., Harrison, D. G., & Dikalov, S. I. (2008) · Circulation Research · doi:10.1161/circresaha.107.162800 · Cited by 710 · see citing works
Self-citationAngiotensin II Stimulation of NAD(P)H Oxidase Activity
Seshiah, P., Weber, D. S., Ročić, P., Valppu, L., Taniyama, Y., & Griendling, K. K. (2002) · Circulation Research · doi:10.1161/01.res.0000033523.08033.16 · Cited by 709 · see citing works
Minireview: Overview of the Renin-Angiotensin System—An Endocrine and Paracrine System
Lavoie, J. L., & Sigmund, C. D. (2003) · Endocrinology · doi:10.1210/en.2003-0150 · Cited by 576 · see citing works
Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells
Hilenski, L. L., Clempus, R. E., Quinn, M. T., Lambeth, J. D., & Griendling, K. K. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000112024.13727.2c · Cited by 573 · see citing works
Wang, Y., & Wang, Q. J. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.19.2126 · Cited by 572 · see citing works
The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4
Takac, I., Schröder, K., Zhang, L., Lardy, B., Anilkumar, N. P., Lambeth, J. D., Shah, A. M., Morel, F., & Brandes, R. P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.192138 · Cited by 524 · see citing works
Ago, T., Kuroda, J., Pain, J., Fu, C., Li, H., & Sadoshima, J. (2010) · Circulation Research · doi:10.1161/circresaha.109.213116 · Cited by 506 · see citing works
Disruption of the Ang II type 1 receptor promotes longevity in mice
Benigni, A., Corna, D., Zoja, C., Sonzogni, A., Latini, R., Salio, M., Conti, S., Rottoli, D., Longaretti, L., Cassis, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36703 · Cited by 486 · see citing works
Subcellular localization of Nox4 and regulation in diabetes
Block, K. L., Gorin, Y. C., & Abboud, H. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906805106 · Cited by 476 · see citing works
Zhang, M., Brewer, A. C., Schröder, K., Santos, C. X. C., Grieve, D., Wang, M., Anilkumar, N. P., Yu, B., Dong, X., Walker, S. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009700107 · Cited by 447 · see citing works
Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells
Lyle, A. N., Deshpande, N. N., Taniyama, Y., Seidel-Rogol, B., Pounkova, L., Du, P., Papaharalambus, C., Lassègue, B., & Griendling, K. K. (2009) · Circulation Research · doi:10.1161/circresaha.109.193722 · Cited by 428 · see citing works
Superoxide Mediates the Actions of Angiotensin II in the Central Nervous System
Zimmerman, M. C., Lazartigues, E. D., Lang, J., Sinnayah, P., Ahmad, I. M., Spitz, D. R., & Davisson, R. L. (2002) · Circulation Research · doi:10.1161/01.res.0000043501.47934.fa · Cited by 394 · see citing works
Dikalov, S., Dikalova, A., Bikineyeva, A. T., Schmidt, H. H. H. W., Harrison, D. G., & Griendling, K. K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.013 · Cited by 386 · see citing works
Self-citationMitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy
Dai, D., Chen, T., Szeto, H. H., Nieves‐Cintrón, M., Kutyavin, V. I., Santana, L. F., & Rabinovitch, P. S. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.12.044 · Cited by 363 · see citing works
Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling
Gao, L., & Mann, G. E. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp031 · Cited by 330 · see citing works
Salt Intake, Oxidative Stress, and Renal Expression of NADPH Oxidase and Superoxide Dismutase
Kitiyakara, C., Chabrashvili, T., Chen, Y., Blau, J., Karber, A., Aslam, S., Welch, W. J., & Wilcox, C. S. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000092145.90389.65 · Cited by 310 · see citing works
Guzik, T. J., Chen, W., Gongora, M. C., Guzik, B., Lob, H. E., Mangalat, D., Hoch, N., Dikalov, S., Rudzinski, P., Kapelak, B., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.063 · Cited by 281 · see citing works
Self-citationKimura, S., Zhang, G.-X., Nishiyama, A., Shokoji, T., Yao, L., Fan, Y.-Y., Rahman, M., Suzuki, T., Maeta, H., & Abe, Y. (2005) · Hypertension · doi:10.1161/01.hyp.0000163462.98381.7f · Cited by 264 · see citing works
Mitochondria in the diabetic heart
Bugger, H., & Abel, E. D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq239 · Cited by 261 · see citing works
Involvement of Nox2 NADPH Oxidase in Adverse Cardiac Remodeling After Myocardial Infarction
Looi, Y. H., Grieve, D., Siva, A., Walker, S. J., Anilkumar, N. P., Cave, A. C., Marber, M. S., Monaghan, M. J., & Shah, A. M. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.101980 · Cited by 255 · see citing works
Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction
Silberman, G. A., Fan, T. M., Liu, H., Jiao, Z., Xiao, H., Lovelock, J. D., Boulden, B. M., Widder, J. D., Fredd, S., Bernstein, K. E., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.883777 · Cited by 254 · see citing works
Self-citationNox2 NADPH Oxidase Promotes Pathologic Cardiac Remodeling Associated with Doxorubicin Chemotherapy
Zhao, Y., McLaughlin, D., Robinson, E., Harvey, A., Hookham, M. B., Shah, A. M., McDermott, B. J., & Grieve, D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2664 · Cited by 244 · see citing works
Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS
Rodríguez‐Pallares, J., Rey, P., Parga, J. A., Muñoz, A., Guerra, M. J., & Labandeira-García, J. L. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.03.003 · Cited by 212 · see citing works
Stanley, B. A., Sivakumaran, V., Shi, S., McDonald, I., Lloyd, D., Watson, W. H., Aon, M. A., & Paolocci, N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.284612 · Cited by 197 · see citing works
Anilkumar, N. P., Weber, R., Zhang, M., Brewer, A. C., & Shah, A. M. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.164277 · Cited by 195 · see citing works
NAD(P)H Oxidase-Derived Reactive Oxygen Species as Mediators of Angiotensin II Signaling
Hanna, I. R., Taniyama, Y., Szöcs, K., Ročić, P., & Griendling, K. K. (2002) · Antioxidants and Redox Signaling · doi:10.1089/152308602762197443 · Cited by 194 · see citing works
Hsieh, T., Zhang, S., Filep, J. G., Tang, S., Ingelfinger, J. R., & Chan, J. S. D. (2002) · Endocrinology · doi:10.1210/endo.143.8.8931 · Cited by 190 · see citing works
Enalapril and losartan attenuate mitochondrial dysfunction in aged rats
de Cavanagh, E. M. V., Piotrkowski, B., Basso, N., Stella, I., Inserra, F., Ferder, L., & Fraga, C. G. (2003) · The FASEB Journal · doi:10.1096/fj.02-0063fje · Cited by 185 · see citing works
Cai, H. “., Li, Z., Dikalov, S., Holland, S. M., Hwang, J., Jo, H., Dudley, S. C., & Harrison, D. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208884200 · Cited by 182 · see citing works
Self-citationIncreased Nox2 expression in human cardiomyocytes after acute myocardial infarction
Krijnen, P. A. J., Meischl, C., Hack, C. E., Meijer, C. J. L. M., Visser, C. A., Roos, D., & Niessen, H. W. M. (2003) · Journal of Clinical Pathology · doi:10.1136/jcp.56.3.194 · Cited by 176 · see citing works
Lob, H. E., Marvar, P. J., Guzik, T. J., Sharma, S., McCann, L. A., Weyand, C. M., Gordon, F. J., & Harrison, D. G. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.142646 · Cited by 175 · see citing works
Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo
Brewer, A. C., Murray, T. V., Arno, M. J., Zhang, M., Anilkumar, N. P., Mann, G. E., & Shah, A. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.022 · Cited by 167 · see citing works
Hingtgen, S., Tian, X., Yang, J., Dunlay, S. M., Peek, A. S., Wu, Y., Sharma, R. V., Engelhardt, J. F., & Davisson, R. L. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00029.2005 · Cited by 155 · see citing works
Nishino, Y., Miura, T., Miki, T., Sakamoto, J., Nakamura, Y., Ikeda, Y., Kobayashi, H., & Shimamoto, K. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.022 · Cited by 144 · see citing works
Superoxide Mediates Angiotensin II–Induced Influx of Extracellular Calcium in Neural Cells
Zimmerman, M. C., Sharma, R. V., & Davisson, R. L. (2005) · Hypertension · doi:10.1161/01.hyp.0000153463.22621.5e · Cited by 144 · see citing works
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
de Cavanagh, E. M. V., Inserra, F., & Ferder, L. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq285 · Cited by 136 · see citing works
Widder, J. D., Fraccarollo, D., Galuppo, P., Hansen, J. M., Jones, D. P., Ertl, G., & Bauersachs, J. K. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.127928 · Cited by 136 · see citing works
Quast, U., Stephan, D., Bieger, S., & Ruß, U. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s156 · Cited by 123 · see citing works
de Cavanagh, E. M. V., Toblli, J. E., Ferder, L., Piotrkowski, B., Stella, I., & Inserra, F. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00615.2005 · Cited by 120 · see citing works
Rodríguez‐Iturbe, B., Sepassi, L., Quiroz, Y., Ni, Z., & Vaziri, N. D. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00513.2006 · Cited by 115 · see citing works
Sun, L., Xiao, L., Nie, J., Liu, F.-Y., Ling, G.-H., Zhu, X.-J., Tang, W.-B., Chen, W.-C., Xia, Y.-C., Zhan, M., et al. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00414.2010 · Cited by 114 · see citing works
Redox regulation of the mitochondrial KATP channel in cardioprotection
Queliconi, B. B., Wojtovich, A. P., Nadtochiy, S. M., Kowaltowski, A. J., & Brookes, P. S. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.11.005 · Cited by 99 · see citing works
Pivotal role of NOX‐2‐containing NADPH oxidase in early ischemic preconditioning
Bell, R. M., Cave, A. C., Johar, S., Hearse, D. J., Shah, A. M., & Shattock, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2774fje · Cited by 94 · see citing works
Lou, M., Blume, A., Zhao, Y., Gohlke, P., Deuschl, G., Herdegen, T., & Čulman, J. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200405000-00008 · Cited by 90 · see citing works
Whaley‐Connell, A. T., Habibi, J., Nistala, R., Cooper, S. A., Karuparthi, P. R., Hayden, M. R., Rehmer, N., DeMarco, V. G., Andresen, B. T., Wei, Y., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.102467 · Cited by 89 · see citing works
Infanger, D. W., Cao, X., Butler, S. D., Burmeister, M. A., Zhou, Y., Stupinski, J. A., Sharma, R. V., & Davisson, R. L. (2010) · Circulation Research · doi:10.1161/circresaha.109.213025 · Cited by 88 · see citing works
Mitochondrial Dysfunction as an Initiating Event in Atherogenesis: A Plausible Hypothesis
Puddu, P., Puddu, G. M., Galletti, L., Cravero, E., & Muscari, A. (2005) · Cardiology · doi:10.1159/000083440 · Cited by 87 · see citing works
Dai, D., & Rabinovitch, P. S. (2011) · Autophagy · doi:10.4161/auto.7.8.15813 · Cited by 73 · see citing works
Rossi, R., Cioni, E., Nuzzo, A., Origliani, G., & Modena, M. G. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.702 · Cited by 72 · see citing works
Role of Vascular Extracellular Superoxide Dismutase in Hypertension
Lob, H. E., Vinh, A., Li, L., Blinder, Y., Offermanns, S., & Harrison, D. G. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.172718 · Cited by 58 · see citing works
de Cavanagh, E. M. V., Ferder, L., Toblli, J. E., Piotrkowski, B., Stella, I., Fraga, C. G., & Inserra, F. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00926.2007 · Cited by 54 · see citing works
Angiotensin II and angiotensin-1-7 redox signaling in the central nervous system
Zimmerman, M. C. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.01.001 · Cited by 48 · see citing works
Renin-angiotensin-aldosterone system-mediated redox effects in chronic kidney disease
Nistala, R., Wei, Y., Sowers, J. R., & Whaley‐Connell, A. T. (2009) · Translational research · doi:10.1016/j.trsl.2008.12.008 · Cited by 46 · see citing works
Angiotensin II blockade improves mitochondrial function in spontaneously hypertensive rats.
de Cavanagh, E. M. V., Toblli, J. E., Ferder, L., Piotrkowski, B., Stella, I., Fraga, C. G., & Inserra, F. (2005) · PubMed · Cited by 39 · see citing works
Valsartan improves mitochondrial function in hearts submitted to acute ischemia
Monteiro, P. F., Duarte, A. I., Gonçalves, L. M. M., & Providência, L. A. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.06.013 · Cited by 24 · see citing works
Pomerantz, B. J., Robinson, T. N., Heimbach, J. K., Calkins, C. M., Miller, S. A., Banerjee, A. M., & Harken, A. H. (2000) · Surgery · doi:10.1067/msy.2000.107423 · Cited by 19 · see citing works
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Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.028 · Cited by 785 · see citing works
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · EP Europace · doi:10.1093/europace/euw161 · Cited by 782 · see citing works
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Weidinger, A., & Kozlov, A. V. (2015) · Biomolecules · doi:10.3390/biom5020472 · Cited by 648 · see citing works
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Faraco, G., Sugiyama, Y., Lane, D., Garcia-Bonilla, L., Chang, H., Santisteban, M. M., Racchumi, G., Murphy, M., Van Rooijen, N., Anrather, J., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86950 · Cited by 350 · see citing works
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Daiber, A., Lisa, F. D., Oelze, M. W., Kröller‐Schön, S., Steven, S., Schulz, E., & Münzel, T. F. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13403 · Cited by 271 · see citing works
Kröller‐Schön, S., Steven, S., Kossmann, S., Scholz, A., Daub, S., Oelze, M. W., Xia, N., Hausding, M., Mikhed, Y., Zinßius, E., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4953 · Cited by 246 · see citing works
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Kawai, T., Forrester, S. J., O’Brien, S. L., Baggett, A., Rizzo, V., & Eguchi, S. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.008 · Cited by 218 · see citing works
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy
Herzog, M. J., Müller, P., Lechner, K., Stiebler, M., Arndt, P., Kunz, M., Ahrens, D., Schmeißer, A., Schreiber, S., & Braun-Dullaeus, R. C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02346-0 · Cited by 246 · see citing works
Role of mitochondrial oxidative stress in hypertension
Dikalov, S., & Ungvari, Z. I. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00089.2013 · Cited by 202 · see citing works
Self-citationUnderstanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology
Eguchi, S., Kawai, T., Scalia, R., & Rizzo, V. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.10266 · Cited by 189 · see citing works
Oxidative Stress in Hypertension: Role of the Kidney
Araújo, M., & Wilcox, C. S. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5259 · Cited by 187 · see citing works
COVID-19, Myocarditis and Pericarditis
Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 181 · see citing works
The metabolic syndrome and chronic kidney disease
Zhang, X., & Lerman, L. O. (2016) · Translational research · doi:10.1016/j.trsl.2016.12.004 · Cited by 177 · see citing works
Reactive Oxygen Species Scavenging Nanomedicine for the Treatment of Ischemic Heart Disease
Zhang, Z., Dalan, R., Hu, Z., Wang, J., Chew, N., Poh, K. K., Tan, R., Soong, T. W., Dai, Y., Ye, L., et al. (2022) · Advanced Materials · doi:10.1002/adma.202202169 · Cited by 174 · see citing works
Martínez‐Revelles, S., Avendaño, M. S., García‐Redondo, A. B., Álvarez, Y., Aguado, A., Pérez-Girón, J. V., García-Redondo, L., Esteban, V., Redondo, J. M., Alonso, M. J., et al. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4335 · Cited by 159 · see citing works
Beltrán-García, J., Osca-Verdegal, R., Pallardó, F. V., Ferreres, J., Rodríguez, M. D. P., Mulet, S., Sanchis‐Gomar, F., Carbonell, N., & García‐Giménez, J. L. (2020) · Antioxidants · doi:10.3390/antiox9100936 · Cited by 161 · see citing works
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Journal of Arrhythmia · doi:10.1016/j.joa.2016.05.002 · Cited by 148 · see citing works
Kirkman, D. L., Robinson, A. T., Rossman, M. J., Seals, D. R., & Edwards, D. G. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00917.2020 · Cited by 146 · see citing works
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress
Chang, R. P., Mamun, A., Dominic, A., & Le, N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.605908 · Cited by 131 · see citing works
Cardiac Pathophysiology and the Future of Cardiac Therapies in Duchenne Muscular Dystrophy
Meyers, T. A., & Townsend, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174098 · Cited by 130 · see citing works
Martínez‐Revelles, S., García‐Redondo, A. B., Avendaño, M. S., Varona, S., Palao, T., Orriols, M., Roque, F. R., Fortuño, A., Touyz, R. M., Martínez‐González, J., et al. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6642 · Cited by 129 · see citing works
The interplay between Angiotensin II, TLR4 and hypertension
Biancardi, V. C., Bomfim, G. F., Reis, W. L., Al-Gassimi, S., & Nunes, K. P. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.03.017 · Cited by 126 · see citing works
Lee, D.-Y., Wauquier, F., Eid, A. A., Roman, L. J., Ghosh-Choudhury, G., Khazim, K., Block, K. L., & Gorin, Y. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.470971 · Cited by 125 · see citing works
Brand, M. D. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1828258 · Cited by 123 · see citing works
Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis
Qu, K., Fang, Y., Qin, X., Zhang, K., He, W., Dong, M., & Wu, G. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1084604 · Cited by 121 · see citing works
Nox as a target for diabetic complications
Gorin, Y. C., & Block, K. L. (2013) · Clinical Science · doi:10.1042/cs20130065 · Cited by 119 · see citing works
Inflammation, Oxidative Stress, Vascular Aging and Atherosclerotic Ischemic Stroke
Koutsaliaris, I. K., Moschonas, I. C., Pechlivani, L., Tsouka, A. N., & Tselepis, A. D. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210921161711 · Cited by 120 · see citing works
Angiotensin-Converting Enzymes Play a Dominant Role in Fertility
Pan, P., Zhan, Q., Fang, L., Zheng, Y., & Jin, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141021071 · Cited by 113 · see citing works
Biomarkers of Oxidative Stress Tethered to Cardiovascular Diseases
Panda, P., Verma, H. K., Lakkakula, S., Merchant, N., Kadir, F. B. M., Rahman, S., Jeffree, M. S., Bhaskar, L. V., & Pasupuleti, V. R. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9154295 · Cited by 119 · see citing works
Maltese, G., Psefteli, P., Rizzo, B., Srivastava, S., Gnudi, L., Mann, G. E., & Siow, R. C. M. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12996 · Cited by 110 · see citing works
Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress
Sumien, N., Cunningham, J. T., Davis, D., Engelland, R. E., Fadeyibi, O., Farmer, G. E., Mabry, S., Mensah-Kane, P., Trinh, O. T. P., Vann, P. H., et al. (2021) · Endocrinology · doi:10.1210/endocr/bqab185 · Cited by 102 · see citing works
Expression of Human ACE2 in Lactobacillus and Beneficial Effects in Diabetic Retinopathy in Mice
Verma, A., Xu, K., Du, T., Zhu, P., Liang, Z., Liao, S., Zhang, J., Raizada, M. K., Grant, M. B., & Li, Q. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.06.007 · Cited by 102 · see citing works
de Alencar, J. C. G., Moreira, C. D. L., Veiga, A. D. M., Chaves, C. E., Fukuhara, M. A., da Silva, E. A., Miyamoto, M. D. F. S., Pinto, V. B., Bueno, C. G., Neto, F. L., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1443 · Cited by 96 · see citing works
Nazerian, Y., Ghasemi, M., Yassaghi, Y., Nazerian, A., & Hashemi, S. M. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109428 · Cited by 96 · see citing works
Platelet mitochondrial dysfunction and the correlation with human diseases
Wang, L., Wu, Q., Fan, Z., Xie, R., Wang, Z., & Lu, Y. (2017) · Biochemical Society Transactions · doi:10.1042/bst20170291 · Cited by 94 · see citing works
Ablation of the stress protease OMA1 protects against heart failure in mice
Acín‐Pérez, R., Lechuga‐Vieco, A. V., Muñoz, M. D. M., Nieto-Arellano, R., Torroja, C., Sánchez‐Cabo, F., Jiménez, C., González-Guerra, A., Carrascoso, I., Benincá, C., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan4935 · Cited by 93 · see citing works
Environmental Endocrine Disruption of Energy Metabolism and Cardiovascular Risk
Kirkley, A. G., & Sargis, R. M. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0494-0 · Cited by 91 · see citing works
Blood pressure variability: A potential marker of aging
Bencivenga, L., Barreto, P. D. S., Rolland, Y., Hanon, O., Vidal, J., Cestac, P., Vellas, B. J., & Rouch, L. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101677 · Cited by 94 · see citing works
Wijnker, P. J. M., Sequeira, V., Kuster, D. W. D., & van der Velden, J. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7236 · Cited by 88 · see citing works
Bhat, S. A., Sood, A., Shukla, R., & Hanif, K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1272-9 · Cited by 82 · see citing works
Law, M. L., Cohen, H., Martin, A. A., Angulski, A. B. B., & Metzger, J. M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020520 · Cited by 86 · see citing works
Cao, X., Yang, F., Shi, T., Yuan, M., Zhong, X., Xie, R.-R., Li, S., Li, H., & Yang, J. (2016) · Scientific Reports · doi:10.1038/srep21592 · Cited by 86 · see citing works
Carnagarin, R., Matthews, V. B., Zaldivia, M. T. K., Peter, K., & Schlaich, M. P. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14481 · Cited by 82 · see citing works
Springó, Z., Tarantini, S., Tóth, P., Tucsek, Z., Koller, Á., Sonntag, W. E., Csiszár, A., & Ungvari, Z. I. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu244 · Cited by 81 · see citing works
Monoamine Oxidase-Related Vascular Oxidative Stress in Diseases Associated with Inflammatory Burden
Sturza, A., Popoiu, C. M., Ionică, M., Duicu, O., Olariu, S., Muntean, D. M., & Boia, E. S. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8954201 · Cited by 80 · see citing works
Dikalov, S., & Dikalova, A. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7632 · Cited by 79 · see citing works
Self-citationMuscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future
Łoboda, A., & Dulak, J. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00134-x · Cited by 80 · see citing works
Bouhamida, E., Morciano, G., Perrone, M., Kahsay, A. E., Della Sala, M., Wieckowski, M. R., Fiorica, F., Pinton, P., Giorgi, C., & Patergnani, S. (2022) · Biology · doi:10.3390/biology11020300 · Cited by 87 · see citing works
Choi, Y. S., de Mattos, A. B. M., Shao, D., Li, T., Nabben, M., Kim, M., Wang, W., Tian, R., & Kolwicz, S. C. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.09.001 · Cited by 78 · see citing works
The role of autophagy in angiotensin II-induced pathological cardiac hypertrophy
Zhou, L., Ma, B., & Han, X. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0086 · Cited by 75 · see citing works
Noncoding RNAs in age-related cardiovascular diseases
Jusic, A., Thomas, P. B., Wettinger, S. B., Dogan, S., Farrugia, R., Gaetano, C., Tuna, B. G., Pinet, F., Robinson, E. L., Tual-Chalot, S., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101610 · Cited by 70 · see citing works
Marón, F. J. M., Ferder, L., Reiter, R. J., & Manucha, W. A. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105595 · Cited by 74 · see citing works
Marón, F. J. M., Ferder, L., Saraví, F. D., & Manucha, W. A. (2018) · Stress · doi:10.1080/10253890.2018.1542683 · Cited by 76 · see citing works
Deng, Y., Li, S., Chen, Z., Wang, W., Geng, B., & Cai, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111689 · Cited by 72 · see citing works
Wnt/β-catenin signaling and renin–angiotensin system in chronic kidney disease
Zhou, L., & Liu, Y. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000205 · Cited by 72 · see citing works
Contribution of mitochondrial oxidative stress to hypertension
Dikalov, S., & Dikalova, A. (2015) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000198 · Cited by 69 · see citing works
Self-citationAngiotensin II receptor type 1 – An update on structure, expression and pathology
Eckenstaler, R., Sandori, J., Gekle, M., & Benndorf, R. A. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114673 · Cited by 68 · see citing works
Is Ferroptosis a Key Component of the Process Leading to Multiorgan Damage in COVID-19?
Pasini, A. M. F., Stranieri, C., Girelli, D., Busti, F., & Cominacini, L. (2021) · Antioxidants · doi:10.3390/antiox10111677 · Cited by 69 · see citing works
Gender Differences in Oxidative Stress in Relation to Cancer Susceptibility and Survival
Allegra, A., Caserta, S., Genovese, S., Pioggia, G., & Gangemi, S. (2023) · Antioxidants · doi:10.3390/antiox12061255 · Cited by 68 · see citing works
The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance
Vajapey, R. S., Rini, D. A., Walston, J. D., & Abadir, P. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00439 · Cited by 69 · see citing works
Wang, J., Wen, Y., Lv, L., Liu, H., Tang, R., Ma, K., & Liu, B. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.21 · Cited by 68 · see citing works
Feng, Q., Liu, D., Lu, Y., & Liu, Z. (2020) · Journal of Immunology Research · doi:10.1155/2020/6193407 · Cited by 68 · see citing works
Lu, Y., Su, L., Wu, H., Bian, Z., Xu, J.-D., Gu, C., Chen, X., & Yang, D. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2345 · Cited by 67 · see citing works
Melatonin, mitochondria and hypertension
Baltatu, O. C., do Amaral, F. G., Campos, L. A., & Cipolla‐Neto, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2613-y · Cited by 66 · see citing works
Insights into the Molecular Mechanisms of NRF2 in Kidney Injury and Diseases
Lin, D.-W., Hsu, Y., Chang, C., Hsieh, C., & Lin, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076053 · Cited by 69 · see citing works
Pasini, A. M. F., Stranieri, C., Cominacini, L., & Mozzini, C. (2021) · Antioxidants · doi:10.3390/antiox10020272 · Cited by 66 · see citing works
The Role of NRF2 in Obesity-Associated Cardiovascular Risk Factors
Gutiérrez‐Cuevas, J., Galicia‐Moreno, M., Monroy-Ramírez, H. C., Sandoval-Rodriguez, A. S., Garcia-Bañuelos, J. J., Santos, A., & Armendáriz‐Borunda, J. (2022) · Antioxidants · doi:10.3390/antiox11020235 · Cited by 66 · see citing works
Giordo, R., Ahmed, Y. M. A., Allam, H., Abusnana, S., Pappalardo, L., Nasrallah, G. K., Mangoni, A. A., & Pintus, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683594 · Cited by 63 · see citing works
The Genetics and Typical Traits of Thoracic Aortic Aneurysm and Dissection
Bento, J. R., Meester, J., Luyckx, I., Peeters, S., Verstraeten, A., & Loeys, B. (2022) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-111521-104455 · Cited by 62 · see citing works
Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II
Forrester, S. J., Elliott, K. J., Kawai, T., Obama, T., Boyer, M. J., Preston, K. J., Yan, Z., Eguchi, S., & Rizzo, V. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.08278 · Cited by 61 · see citing works
Understanding the cross-talk between mediators of infertility and COVID-19
Rajak, P., Roy, S., Dutta, M., Podder, S., Sarkar, S., Ganguly, A., Mandi, M., & Khatun, S. (2021) · Reproductive Biology · doi:10.1016/j.repbio.2021.100559 · Cited by 60 · see citing works
Li, M., Liu, X. Z., He, Y., Zheng, Q., Wang, M., Wu, Y. C., Zhang, Y., & Wang, C. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.01.027 · Cited by 59 · see citing works
Increased Hydration Can Be Associated with Weight Loss
Thornton, S. N. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00018 · Cited by 57 · see citing works
COVID-19, Oxidative Stress, and Neuroinflammation in the Depression Route
Mingoti, M. E. D., Bertollo, A. G., Simões, J. L. B., Francisco, G. R., Bagatini, M. D., & Ignácio, Z. M. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02004-y · Cited by 56 · see citing works
A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19
Logette, E., Lorin, C., Favreau, C., Oshurko, E., Coggan, J. S., Casalegno, F., Sy, M. F., Monney, C., Bertschy, M., Delattre, É., et al. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.695139 · Cited by 55 · see citing works
Vascular Stress Signaling in Hypertension
Cicalese, S. M., da Silva, J. F., Priviero, F., Webb, R. C., Eguchi, S., & Tostes, R. C. (2021) · Circulation Research · doi:10.1161/circresaha.121.318053 · Cited by 54 · see citing works
Colli, L. G., Belardin, L. B., Echem, C., Akamine, E. H., Antoniassi, M. P., Andretta, R. R., Mathias, L. S., Rodrigues, S. F., Bertolla, R. P., & de Carvalho, M. H. C. (2019) · Scientific Reports · doi:10.1038/s41598-019-47157-w · Cited by 53 · see citing works
Hao, P., Yang, J., Zhang, M., Zhang, K., Chen, Y., Zhang, C., & Zhang, Y. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00563.2014 · Cited by 51 · see citing works
Durgin, B. G., Hahn, S. A., Schmidt, H. M., Miller, M. P., Hafeez, N., Mathar, I., Freitag, D. F., Sandner, P., & Straub, A. C. (2019) · JCI Insight · doi:10.1172/jci.insight.129183 · Cited by 51 · see citing works
Simulated microgravity‐induced mitochondrial dysfunction in rat cerebral arteries
Zhang, R., Ran, H., Cai, L., Zhu, L., Sun, J., Peng, L., Liu, X., Zhang, L. Y., Fang, Z., Fan, Y., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-245654 · Cited by 48 · see citing works
Malek, V., Suryavanshi, S. V., Sharma, N., Kulkarni, Y. A., Mulay, S. R., & Gaikwad, A. B. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_50 · Cited by 48 · see citing works
Son, M., Chan, C. B., & Wu, J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700602 · Cited by 47 · see citing works
Akomolafe, S. F., Olasehinde, T. A., Oyeleye, S. I., Aluko, B. T., Adewale, O. O., & Ijomone, O. M. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00205-0 · Cited by 47 · see citing works
Danilenko, V., Devyatkin, A., Marsova, M., Shibilova, M., Ilyasov, R. A., & Shmyrev, V. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s333887 · Cited by 53 · see citing works
Mitochondrial Dysfunction in Kidney Tubulopathies
Hoogstraten, C. A., Hoenderop, J. G. J., & de Baaij, J. H. F. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042222-025000 · Cited by 46 · see citing works
Mitochondrial Fission of Smooth Muscle Cells Is Involved in Artery Constriction
Liu, M., Jin, J., Li, S., Yan, J., Zhen, C., Gao, J., Zhang, Y.-H., Zhang, Y., Shen, X., Zhang, L., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07974 · Cited by 45 · see citing works
Isocitrate dehydrogenase 2 deficiency aggravates prolonged high-fat diet intake-induced hypertension
Noh, M. R., Kong, M. J., Han, S. J., Kim, J. I., & Park, K. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101548 · Cited by 45 · see citing works
Robinson, A. T., Franklin, N. C., Norkeviciute, E., Bian, J. T., Babana, J. C., Szczurek, M. R., & Phillips, S. A. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000946 · Cited by 44 · see citing works
Miyao, M., Cicalese, S. M., Kawai, T., Cooper, H. A., Boyer, M. J., Elliott, K. J., Forrester, S. J., Kuroda, R., Rizzo, V., Hashimoto, T. N., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093112 · Cited by 44 · see citing works
Innervation of the arterial wall and its modification in atherosclerosis
Chistiakov, D. A., Ashwell, K. W. S., Orekhov, A. N., & Bobryshev, Y. V. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.06.005 · Cited by 44 · see citing works
- Authors
- Dikalov, S. I., & Nazarewicz, R. R.
- Affiliations
- Vanderbilt University Medical Center (US)
- ORCID
- Dikalov, Sergey I.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2013-10
- Volume
- 19
- Issue
- 10
- Pages
- 1085-1094
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- PMC
- PMC3771548
- OpenAlex
- W2085076776
- Cited by
- 356
- References
- 68
- Citations by year
- 2026: 25 · 2025: 29 · 2024: 22 · 2023: 38 · 2022: 32 · 2021: 49 · 2020: 34 · 2019: 22 · 2018: 19 · 2017: 21 · 2016: 26 · 2015: 20 · 2014: 9 · 2013: 8 · 2012: 2
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL094469, HL094469)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- angiotensin II, mitochondrial reactive oxygen species, NADPH oxidase, superoxide, hydrogen peroxide, thioredoxin 2, mitochondrial superoxide dismutase, hypertension, atherosclerosis, diabetes mellitus, endothelial dysfunction, renal remodeling, mitochondrial dysfunction, antioxidant therapy
- MeSH terms
- Angiotensin II, Animals, Cardiovascular Diseases, Humans, Hydrogen Peroxide, Mitochondria, Superoxide Dismutase, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases
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