The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
An Updated Overview on Wnt Signaling Pathways: A Prelude for More
Abstract
Abstract : Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and tissue homeostasis. Misregulation of intracellular signal transduction can lead to developmental defects during embryogenesis or particular diseases in the adult. One family of growth factors important for these aspects is given by the Wnt proteins. In particular, Wnts have important functions in stem cell biology, cardiac development and differentiation, angiogenesis, cardiac hypertrophy, cardiac failure, and aging. Knowledge of growth factor signaling during differentiation will allow for improvement of targeted differentiation of embryonic or adult stem cells toward functional cardiomyocytes or for understanding the basis of diseases. Our major aim here is to provide a state of the art review summarizing our present knowledge of the intracellular Wnt-mediated signaling network. In particular, we provide evidence that the subdivision into canonical and noncanonical Wnt signaling pathways solely based on the identity of Wnt ligands or Frizzled receptors is not appropriate anymore. We thereby deliver a solid base for further upcoming articles of a review series focusing on the role of Wnt proteins on different aspects of cardiovascular development and dysfunction.
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Cites
Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
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Function and biological roles of the Dickkopf family of Wnt modulators
Niehrs, C. (2006) · Oncogene · doi:10.1038/sj.onc.1210054 · Cited by 995
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
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Identification of Vangl2 and Scrb1 as planar polarity genes in mammals
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Cited by
Crosstalk in NF-κB Signaling Pathways
Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942
The Role of Wnt Signaling in Physiological and Pathological Angiogenesis
Dejana, E. (2010) · Circulation Research · doi:10.1161/circresaha.110.223750 · Cited by 347
Novel insights into the development and maintenance of the blood-brain barrier
Engelhardt, B., & Liebner, S. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1811-2 · Cited by 313
The Wnt/beta-catenin pathway in adrenocortical development and cancer
El Wakil, A., & Lalli, E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.014 · Cited by 134
Wnt Signaling in Renal Cell Carcinoma
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Metadata
- Authors
- Rao, T. P., & Kühl, M.
- Venue
- Circulation Research
- Published
- 2010-06-25
- Volume
- 106
- Issue
- 12
- Pages
- 1798-1806
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2164356078
- Cited by
- 638
- References
- 16
- FWCI
- 14.41
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
