The Wnt/beta-catenin pathway in adrenocortical development and cancer

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How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions

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Wnt signaling and cancer

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The history of cancer epigenetics

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DNA hypermethylation in tumorigenesis: epigenetics joins genetics

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Secreted antagonists of the Wnt signalling pathway

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Female development in mammals is regulated by Wnt-4 signalling

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Towards an integrated view of Wnt signaling in development

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

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Function and biological roles of the Dickkopf family of Wnt modulators

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WNT Signaling Pathway and Stem Cell Signaling Network

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Lack of β-catenin affects mouse development at gastrulation

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An Updated Overview on Wnt Signaling Pathways

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β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation

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Specific inhibition of gene expression using a stably integrated, inducible small‐interfering‐RNA vector

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Activation of -catenin signaling by Rspo1 controls differentiation of the mammalian ovary

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Essential function of Wnt-4 in mammary gland development downstream of progesterone signalingPreprint

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Mutations of <i>β-Catenin</i> in Adrenocortical Tumors: Activation of the Wnt Signaling Pathway Is a Frequent Event in both Benign and Malignant Adrenocortical Tumors

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Phosphorylation of β-Catenin by Cyclic AMP-dependent Protein Kinase

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Phosphorylation of β-Catenin by Cyclic AMP-Dependent Protein Kinase Stabilizes β-Catenin through Inhibition of Its Ubiquitination

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Wnt/β-catenin signaling: new (and old) players and new insights

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Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling

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Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis

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Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival

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Interaction of Nuclear Receptors with the Wnt/β-Catenin/Tcf Signaling Axis: Wnt You Like to Know?

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Stabilization of β-catenin in XY gonads causes male-to-female sex-reversal

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R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

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Functional Epigenomics Identifies Genes Frequently Silenced in Prostate Cancer

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Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease

Schimmer, B. P., & White, P. C. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0519 · Cited by 268 · see citing works

Tumor formation by genetic mutations in the components of the Wnt signaling pathway

Kikuchi, A. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01424.x · Cited by 258 · see citing works

Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis

Veeck, J., Niederacher, D., An, H., Klopocki, E., Wiesmann, F., Betz, B., Galm, O., Camara, O., Dürst, M., Kristiansen, G., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209386 · Cited by 254 · see citing works

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

Suzuki, H., Toyota, M., Caraway, H., Gabrielson, E. W., Ohmura, T., Fujikane, T., Nishikawa, N., Sogabe, Y., Nojima, M., Sonoda, T., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604259 · Cited by 239 · see citing works

Constitutive β-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development

Berthon, A. S., Sahut‐Barnola, I., Lambert-Langlais, S., de Joussineau, C., Damon‐Soubeyrand, C., Louiset, E., Taketo, M. M., Tissier, F., Bertherat, J. Y., Lefrançois‐Martinez, A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq029 · Cited by 239 · see citing works

Wnt-4 Deficiency Alters Mouse Adrenal Cortex Function, Reducing Aldosterone Production

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Targeted disruption of β-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex

Kim, A. C., Reuter, A. L., Zubair, M., Else, T., Serecky, K., Bingham, N. C., Lavery, G. G., Parker, K. L., & Hammer, G. D. (2008) · Development · doi:10.1242/dev.021493 · Cited by 202 · see citing works

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/β-catenin synergy

Jordan, B. K., Shen, J. H.-C., Olaso, R., Ingraham, H. A., & Vilain, E. J. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834480100 · Cited by 192 · see citing works

Sex-specific roles of -catenin in mouse gonadal development

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Gene Expression Profiling of Childhood Adrenocortical Tumors

West, A. N., Neale, G. A. M., Pounds, S. B., de Figueiredo, B. C., Galindo, C. R., Pianovski, M. A. D., Filho, A. G. O., Malkin, D. M., Lalli, E., Ribeiro, R. C., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3767 · Cited by 165 · see citing works

Identification of SFRP1 as a Candidate Mediator of Stromal-to-Epithelial Signaling in Prostate Cancer

Joesting, M. S., Perrin, S., Elenbaas, B., Fawell, S. E., Rubin, J. S., Franco, O. E., Hayward, S. W., Cunha, G. R., & Marker, P. C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0824 · Cited by 159 · see citing works

Frequent mutations of <i>β‐catenin</i> gene in sporadic secreting adrenocortical adenomas*

Tadjine, M., Lampron, A., Ouadi, L., & Bourdeau, I. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03033.x · Cited by 153 · see citing works

Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension

Whaley‐Connell, A. T., Johnson, M. S., & Sowers, J. R. (2010) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.12.004 · Cited by 152 · see citing works

Wnt/β-catenin and 3′,5′-cyclic adenosine 5′-monophosphate/protein kinase A signaling pathways alterations and somatic β-catenin gene mutations in the progression of adrenocortical tumors

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Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1) Gene Transcription Is Regulated by Wnt4 in the Female Developing Gonad

Mizusaki, H., Kawabe, K., Mukai, T., Ariyoshi, E., Kasahara, M., Yoshioka, H., Swain, A., & Morohashi, K.-I. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0362 · Cited by 140 · see citing works

Frequent loss of SFRP1 expression in multiple human solid tumours: association with aberrant promoter methylation in renal cell carcinoma

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Detection of somatic β-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD)

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Adrenal masses are associated with familial adenomatous polyposis

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The T cell factor/β-Catenin Antagonist PKF115–584 Inhibits Proliferation of Adrenocortical Carcinoma Cells

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Autocrine/Paracrine Secreted Frizzled-related Protein 2 Induces Cellular Resistance to Apoptosis

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Wnt Signaling in Human Development: Beta-Catenin Nuclear Translocation in Fetal Lung, Kidney, Placenta, Capillaries, Adrenal, and Cartilage

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Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma

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MicroRNA Signature of Primary Pigmented Nodular Adrenocortical Disease: Clinical Correlations and Regulation of Wnt Signaling

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Adrenocortical cells with stem/progenitor cell properties: Recent advances

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Synergistic Cooperation between the β-Catenin Signaling Pathway and Steroidogenic Factor 1 in the Activation of the Mullerian Inhibiting Substance Type II Receptor

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Female Development in Mammals is Regulated by Wnt-4-Signaling

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Gonadotropin-Induced Adrenocortical Neoplasia in NU/J Nude Mice

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Zonal expression of dickkopf-3 and components of the Wnt signalling pathways in the human adrenal cortex

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Expression of sFRP-4 and β-catenin in human colorectal carcinoma

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Pathogenesis of adrenocortical cancer

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Adrenal Gland Tumorigenesis after Gonadectomy in Mice Is a Complex Genetic Trait Driven by Epistatic Loci

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Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development

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The Advantages and Disadvantages of Sfrp1 and Sfrp2 Expression in Pathological Events

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Adrenocortical development and cancer: focus on SF-1

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Pathophysiological aspects of Wnt-signaling in endocrine disease

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Vascular synthesis of aldosterone: role in hypertension

Takeda, Y. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.10.012 · Cited by 44 · see citing works

Adenovirus-delivered DKK3/WNT4 and Steroidogenesis in Primary Cultures of Adrenocortical Cells

Chen, M., & Hornsby, P. J. (2006) · Hormone and Metabolic Research · doi:10.1055/s-2006-950500 · Cited by 35 · see citing works

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Program, T. M. V., Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0205-x · Cited by 1,381 · see citing works

Adrenocortical carcinoma

Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892 · see citing works

60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

Gallo-Payet, N. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0257 · Cited by 98 · see citing works

Wnt/β-catenin pathway deregulation in childhood adrenocortical tumors

Leal, L. F., Mermejo, L. M., Ramalho, L. Z., Martinelli, C. E., Yunes, J. A., Seidinger, A. L., Mastellaro, M. J., Cardinalli, I. A., Brandalise, S. R., Moreira, A. C., et al. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-0363 · Cited by 55 · see citing works

Two-pore domain potassium channels in the adrenal cortex.

Bandulik, S., Tauber, P., Lalli, E., Barhanin, J., & Warth, R. (2015) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1628-6 · Cited by 38 · see citing works

Context-Dependent Activation or Inhibition of Wnt-β-Catenin Signaling by Kremen

Cselenyi, C. S., & Lee, E. N. (2008) · Science Signaling · doi:10.1126/stke.18pe10 · Cited by 52 · see citing works

LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044 · see citing works

Wnt-4 activates the canonical β-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/β-catenin activity in kidney epithelial cells

Lyons, J. P., Mueller, U. W., Ji, H. L., Everett, C. M., Fang, X., Hsieh, J.-C., Barth, A. I. M., & McCrea, P. D. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.036 · Cited by 138 · see citing works

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

Gong, Y., Bourhis, E., Chiu, C., Stawicki, S. S., DeAlmeida, V. I., Liu, B. Y., Phamluong, K., Cao, T. C., Carano, R. A. D., Ernst, J. A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012682 · Cited by 206 · see citing works

LRP6 mediates Wnt/β-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells

Peröbner, I., Karow, M., Jochum, M., & Neth, P. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.07.025 · Cited by 24 · see citing works