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Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture
Open accessAbstract
Rationale: The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of human heart growth by these processes is poorly understood. Objective: We seek to elucidate the responses of immature human myocardium to mechanical load and vascularization using tissue engineering approaches. Methods and Results: Using human embryonic stem cell and human induced pluripotent stem cell–derived cardiomyocytes in a 3-dimensional collagen matrix, we show that uniaxial mechanical stress conditioning promotes 2-fold increases in cardiomyocyte and matrix fiber alignment and enhances myofibrillogenesis and sarcomeric banding. Furthermore, cyclic stress conditioning markedly increases cardiomyocyte hypertrophy (2.2-fold) and proliferation rates (21%) versus unconditioned constructs. Addition of endothelial cells enhances cardiomyocyte proliferation under all stress conditions (14% to 19%), and addition of stromal supporting cells enhances formation of vessel-like structures by ≈10-fold. Furthermore, these optimized human cardiac tissue constructs generate Starling curves, increasing their active force in response to increased resting length. When transplanted onto hearts of athymic rats, the human myocardium survives and forms grafts closely apposed to host myocardium. The grafts contain human microvessels that are perfused by the host coronary circulation. Conclusions: Our results indicate that both mechanical load and vascular cell coculture control cardiomyocyte proliferation, and that mechanical load further controls the hypertrophy and architecture of engineered human myocardium. Such constructs may be useful for studying human cardiac development as well as for regenerative therapy.
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“but not pressure- and volume-based metrics directly representing pump performance of the heart”
From Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells (2018) · cites this paper as [9]
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“engineered cardiac thin films, micro-tissues and strips allow the assessment of twitch force [9,12–19]”
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“Although hPSC-vCMs have been organized as monolayers and patches for electrophysiological assessment [6–8] and even surgical engraftment [9–11]”
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Embryonic Stem Cell Lines Derived from Human Blastocysts
Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
Laflamme, M. A., Chen, K. Y., Naumova, A. V., Muskheli, V., Fugate, J. A., Dupras, S. K., Reinecke, H., Xu, C., Hassanipour, M., Police, S., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1327 · Cited by 2,235
Self-citationStrauer, B. E., Brehm, M. U., Zeus, T., Köstering, M., Hernandez, A., Sorg, R. V., Kögler, G., & Wernet, P. (2002) · Circulation · doi:10.1161/01.cir.0000034046.87607.1c · Cited by 2,065
Kehat, I., Kenyagin‐Karsenti, D., Snir, M., Segev, H., Amit, M., Gepstein, A., Livne, E., Binah, O., Itskovitz‐Eldor, J., & Gepstein, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12131 · Cited by 1,814
Murry, C. E., & Keller, G. M. (2008) · Cell · doi:10.1016/j.cell.2008.02.008 · Cited by 1,760
Self-citationKehat, I., Kenyagin‐Karsenti, D., Snir, M., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112131 · Cited by 1,536
Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
Zhang, J., Wilson, G. F., Soerens, A. G., Koonce, C. H., Yu, J., Palecek, S. P., Thomson, J. A., & Kamp, T. J. (2009) · Circulation Research · doi:10.1161/circresaha.108.192237 · Cited by 1,426
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Chery, J., Wong, J. H., Huang, S., Wang, S., & Si, M. (2016) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0136 · Cited by 15
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Yu, D., Wang, X., & Ye, L. (2021) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd8110153 · Cited by 15
Rivera‐Arbeláez, J. M., Cofiño‐Fabrés, C., Schwach, V., Boonen, T., ten Den, S. A., Vermeul, K., van den Berg, A., Segerink, L. I., Ribeiro, M. C., & Passier, R. C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266834 · Cited by 17
Sobral-Reyes, M. F., & Lemos, D. R. (2019) · Stem Cells · doi:10.1002/stem.3131 · Cited by 14
3D conductive material strategies for modulating and monitoring cells
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Calamaio, S., Serzanti, M., Boniotti, J., Fra, A., Garrafa, E., Cominelli, M., Verardi, R., Poliani, P. L., Dotti, S., Villa, R., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11082114 · Cited by 15
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Vanderslice, E. J., Golding, S. G. H., & Jacot, J. G. (2023) · Journal of Biomedical Materials Research. Part A · doi:10.1002/jbm.a.37662 · Cited by 13
Elkhoury, K., Kodeih, S., Enciso‐Martínez, E., Maziz, A., & Bergaud, C. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303288 · Cited by 15
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Wong, T., Chang, S., Jhong, R., Tseng, C.-J., Sun, G., & Cheng, P. (2019) · Cells · doi:10.3390/cells8090942 · Cited by 14
Cell orientation under stretch: Stability of a linear viscoelastic model
Lucci, G., Giverso, C., & Preziosi, L. (2021) · Mathematical Biosciences · doi:10.1016/j.mbs.2021.108630 · Cited by 14
Odedra, D., Chiu, L. L. Y., Reis, L. A., Rask, F., Chiang, K., & Radisic, M. (2010) · Springer eBooks · doi:10.1007/978-3-7091-0385-2_15 · Cited by 14
Multi-cellularity in cardiac tissue engineering, how close are we to native heart tissue?
Owen, T. J., & Harding, S. E. (2019) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-019-09528-8 · Cited by 14
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Lucci, G., & Preziosi, L. (2021) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-020-01406-4 · Cited by 14
Golob, J. L., Kumar, R., Guenther, M. G., Pabon, L., Pratt, G. A., Loring, J. F., Laurent, L. C., Young, R. A., & Murry, C. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022416 · Cited by 14
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Huebsch, N., Charrez, B., Siemons, B., Boggess, S. C., Wall, S., Neiman, G., Charwat, V., Jæger, K. H., Cleres, D., Telle, Å., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/485169 · Cited by 14
Masumoto, H., & Yamashita, J. K. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0084-7 · Cited by 13
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Martínez, E., St‐Pierre, J., & Variola, F. (2019) · Advances in Physics X · doi:10.1080/23746149.2019.1622451 · Cited by 14
Gu, X., Zhou, F., & Mu, J. (2021) · Medical Science Monitor · doi:10.12659/msm.931063 · Cited by 15
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Testa, G., Benedetto, G. D., & Passaro, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179517 · Cited by 13
Geuss, L. R., Wu, D. C., Ramamoorthy, D., Alford, C. D., & Suggs, L. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113982 · Cited by 13
Tissue-Engineering for the Study of Cardiac Biomechanics
Ma, S. P., & Vunjak‐Novakovic, G. (2015) · Journal of Biomechanical Engineering · doi:10.1115/1.4032355 · Cited by 13
Engineering Concepts in Stem Cell Research
Narayanan, K., Mishra, S., Singh, S., Pei, M., Gulyás, B. Z., & Padmanabhan, P. (2017) · Biotechnology Journal · doi:10.1002/biot.201700066 · Cited by 13
Bioprinting approaches in cardiac tissue engineering to reproduce blood-pumping heart function
Kim, M. J., Hwang, D. G., & Jang, J. (2024) · iScience · doi:10.1016/j.isci.2024.111664 · Cited by 16
Marino, S., Al-Hijailan, R. S., Alonaizan, R., Gabetti, S., Massai, D., & Pesce, M. (2025) · Gels · doi:10.3390/gels11080593 · Cited by 13
Advances in the design, generation, and application of tissue-engineered myocardial equivalents
Bernava, G., & Iop, L. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1247572 · Cited by 14
A micro-LED array based platform for spatio-temporal optogenetic control of various cardiac models
Junge, S., Signorini, M. E. R., Masri, M. A., Gülink, J., Brüning, H., Kasperek, L., Szepes, M., Bakar, M., Gruh, I., Heisterkamp, A., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-46149-1 · Cited by 13
Dynamic control of contractile resistance to iPSC‐derived micro‐heart muscle arrays
Schuftan, D. R., Kooh, Y. K. G., Guo, J., Sun, Y., Aryan, L., Stottlemire, B. J., Berkland, C. J., Genin, G. M., & Huebsch, N. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37642 · Cited by 12
Dou, W., Shan, G., Zhao, Q., Malhi, M., Jiang, A., Zhang, Z., González-Guerra, A., Fu, S., Law, J., Hamilton, R. M., et al. (2024) · Science Robotics · doi:10.1126/scirobotics.adm8233 · Cited by 12
Josvai, M. B., Lawson, J., Kanade, H., Kalluri, M., Anderson, C. L., Zhang, J., Stempien, A., Eckhardt, L. L., Kamp, T. J., & Crone, W. C. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1546483 · Cited by 12
Tompkins, J. D., & Riggs, A. D. (2014) · Frontiers in Biology · doi:10.1007/s11515-014-1340-0 · Cited by 12
Micropatterning and Assembly of 3D Microvessels
Redd, M. A., Kotha, S. S., Phong, K. T., & Zheng, Y. Y. (2016) · Journal of Visualized Experiments · doi:10.3791/54457 · Cited by 12
Jaganathan, S. K., Mani, M. P., & Sivalingam, S. (2019) · Polymer Composites · doi:10.1002/pc.25237 · Cited by 12
Concise Review: Precision Matchmaking: Induced Pluripotent Stem Cells Meet Cardio-Oncology
Nair, P., Prado, M., Perea‐Gil, I., & Karakikes, I. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0279 · Cited by 12
‘Shovel-Ready’ applications of stem cell advances for pediatric heart disease
Files, M. D., & Boucek, R. J. (2012) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e328357a4cf · Cited by 11
Therapeutic potential of perivascular cells from human pluripotent stem cells
Dar, A., & Itskovitz‐Eldor, J. (2013) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1698 · Cited by 11
UESUGI, K., Shima, F., Fukumoto, K. I., Hiura, A., Tsukamoto, Y., Miyagawa, S., Sawa, Y., Akagi, T., Akashi, M., & Morishima, K. (2019) · Micromachines · doi:10.3390/mi10070487 · Cited by 11
Tao, Z., Jarrell, D. K., Taylor-Robinson, A. W., Cosgriff‐Hernandez, E., & Jacot, J. G. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101018 · Cited by 11
Stimulating Calcium Handling in hiPSC-Derived Engineered Cardiac Tissues Enhances Force Production
Minor, A. J., & Coulombe, K. L. K. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szab002 · Cited by 11
Induced Pluripotent Stem Cells in Cardiovascular Research
Sinnecker, D., Dirschinger, R. J., Goedel, A., Moretti, A., Lipp, P., & Laugwitz, K. (2012) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2012_6 · Cited by 13
Remuscularization of the failing heart
Zimmermann, W. (2017) · The Journal of Physiology · doi:10.1113/jp273098 · Cited by 11
Hadová, K., Kráľová, E., Dóka, G., Pivackova, L. B., Kmecová, Z., Křenek, P., & Klimas, J. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-01929-3 · Cited by 11
Defined Engineered Human Myocardium for Disease Modeling, Drug Screening, and Heart Repair
Tiburcy, M., Meyer, T., Satin, P.-L., & Zimmermann, W. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2261-2_14 · Cited by 11
Lieu, D. K., Turnbull, I. C., Costa, K. D., & Li, R. A. (2012) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2012.06.002 · Cited by 11
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Zhuang, R. Z., Chesnais, F., & Vunjak‐Novakovic, G. (2025) · Advanced Materials · doi:10.1002/adma.202509242 · Cited by 10
Dai, W., Kay, G. L., & Kloner, R. A. (2014) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248413517746 · Cited by 10
Ly, O. T., Brown, G. E., Han, Y. D., Darbar, D., & Khetani, S. R. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211009146 · Cited by 12
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Guo, J., & Huebsch, N. (2020) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-020-00007-8 · Cited by 11
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Tulloch, N. L., & Murry, C. E. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2013.04.001 · Cited by 9
Self-citationEng, G. M., Lee, B. W., Radisic, M., & Vunjak‐Novakovic, G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398358-9.00038-0 · Cited by 9
Turnbull, I. C., Lieu, D. K., Li, R. A., & Costa, K. D. (2012) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2012.11.001 · Cited by 9
Engineering cardiac muscle: new ways to refurbish old hearts?
Martin, U., & Haverich, A. (2013) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezt490 · Cited by 9
Bannerman, D., Lu, R. X. Z., Korolj, A., Kim, L. H., & Radisic, M. (2017) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2017.12.003 · Cited by 10
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Wang, B., Kit‐Anan, W., & Terracciano, C. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113361 · Cited by 13
Zeinstra, N., Frey, A. L., Xie, Z., Blakely, L. P., Wang, R. K., Murry, C. E., & Zheng, Y. Y. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122250 · Cited by 9
Self-citationSirabella, D., Cimetta, E., & Vunjak‐Novakovic, G. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215589910 · Cited by 9
Cardiac Atrophy and Remodeling
Harvey, P. A., & Leinwand, L. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405206-2.00003-x · Cited by 8
Maturation of pluripotent stem cell derived cardiomyocytes: The new challenge
Aigha, I. I., & Raynaud, C. M. (2016) · Global Cardiology Science and Practice · doi:10.21542/gcsp.2016.6 · Cited by 8
Application of tissue engineering in stem cell therapy
Hong, J. K., & Kwon, S. (2014) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2014.72010 · Cited by 8
Maturation of Stem cell-derived Human Heart Tissue By Mimicking Fetal Heart Rate
Nunes, S. S., Miklas, J. W., & Radisic, M. (2013) · Future Cardiology · doi:10.2217/fca.13.71 · Cited by 8
Bioengineered cardiac patch scaffolds
Azhar, Z., Haque, N., Ali, S. W., Mozafari, M., & Sefat, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102563-5.00033-2 · Cited by 8
Zhang, R., Guo, T., Han, Y., Huang, H., Shi, J., Hu, J., Li, H., Wang, J., Saleem, A., Zhou, P., et al. (2020) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34759 · Cited by 8
Regulatory aspects of small molecule drugs for heart regeneration
Rodgers, K. E., Papinska, A., & Mordwinkin, N. M. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.06.013 · Cited by 8
The Beat Goes On: Human Heart Muscle From Pluripotent Stem Cells
Eschenhagen, T. (2011) · Circulation Research · doi:10.1161/circresaha.111.248039 · Cited by 8
Yang, X., & Murry, C. E. (2017) · Circulation · doi:10.1161/circulationaha.117.024751 · Cited by 7
Self-citationShin, T. H., Noh, J.-M., Choi, S.-C., Song, M., Kang, M., Song, M.-H., Heo, R., Jeon, Y. K., Kim, S. J., Kim, S., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.10.040 · Cited by 8
Vuorenpää, H., Valtonen, J., Penttinen, K., Koskimäki, S., Hovinen, E., Ahola, A., Gering, C., Párraga, J. E., Kelloniemi, M., Hyttinen, J., et al. (2024) · Cytotechnology · doi:10.1007/s10616-024-00630-5 · Cited by 9
Recapitulating Long-QT Syndrome Using Induced Pluripotent Stem Cell Technology
Dirschinger, R. J., Goedel, A., Moretti, A., Laugwitz, K., & Sinnecker, D. (2012) · Pediatric Cardiology · doi:10.1007/s00246-012-0286-8 · Cited by 7
Jones, A. R. C., Edwards, D. H., Cummins, M. J., Williams, A. J., & George, C. H. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00089 · Cited by 7
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Prevedello, L., Michielin, F., Balcon, M., Savio, E., Pavan, P. G., & Elvassore, N. (2018) · Annals of Biomedical Engineering · doi:10.1007/s10439-018-02121-z · Cited by 7
Iop, L. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.591583 · Cited by 8
Non-viral reprogramming and induced pluripotent stem cells for cardiovascular therapy
Panda, A., Gurusamy, N., Rajasingh, S., Carter, H.-K., Thomas, E. L., & Rajasingh, J. (2020) · Differentiation · doi:10.1016/j.diff.2019.12.001 · Cited by 8
Zhao, Y., Khosravi, R., Cheung, K., Shen, K., Wang, Y., Landau, S., Okhovatian, S., Wu, Q., Lu, R. X. Z., Wagner, K. T., et al. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100075 · Cited by 7
Gvirtz, M., Sarig, U., Baruch, L., & Machluf, M. (2025) · Bio-Design and Manufacturing · doi:10.1631/bdm.2400370 · Cited by 6
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Gilbert, G. (2021) · Current Stem Cell Reports · doi:10.1007/s40778-021-00197-3 · Cited by 6
In Silico Analysis of Stem Cells Mechanical Stimulations for Mechnoregulation Toward Cardiomyocytes
Ebad, M., & Vahidi, B. (2022) · International Journal of Engineering · doi:10.5829/ije.2022.35.11b.18 · Cited by 6
Bridging high resolution sub-cellular imaging with physiologically relevant engineered tissues
Kooh, Y. K. G., & Huebsch, N. (2024) · Frontiers in Mechanical Engineering · doi:10.3389/fmech.2024.1481933 · Cited by 7
Lui, K. O., Stachel, M., Lieu, D. K., Li, R. A., & Bu, L. (2012) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2012.09.001 · Cited by 6
Gowran, A., Rasponi, M., Visone, R., Nigro, P., Perrucci, G. L., Righetti, S., Zanobini, M., & Pompilio, G. (2016) · Stem Cells International · doi:10.1155/2016/4287158 · Cited by 6
Establishing Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs
Wang, B., Patnaik, S. S., Brazile, B. L., Butler, J. R., Claude, A. K., Zhang, G., Guan, J., Hong, Y., & Liao, J. (2015) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.2016016066 · Cited by 7
Zhao, Y., Eng, G. M., Lee, B. W., Radisic, M., & Vunjak‐Novakovic, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818422-6.00033-2 · Cited by 6
Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?
Bissoli, I., D’Adamo, S., Pignatti, C., Agnetti, G., Flamigni, F., & Cetrullo, S. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1129263 · Cited by 6
Kanda, M., Nagai, T., Kondo, N., Matsuura, K., Akazawa, H., Komuro, I., & Kobayashi, Y. (2023) · Cell Transplantation · doi:10.1177/09636897231174078 · Cited by 6
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Martin, U. (2015) · Human Gene Therapy · doi:10.1089/hum.2015.022 · Cited by 6
Spatial and Electrical Factors Regulating Cardiac Regeneration and Assembly
Pahnke, A., Montgomery, M., & Radisic, M. (2014) · Springer eBooks · doi:10.1007/978-3-319-10972-5_3 · Cited by 6
Bioengineered Cardiac Tissue Based on Human Stem Cells for Clinical Application
Avaca, M. J., & Gruh, I. (2017) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2017_24 · Cited by 6
Inductive factors for generation of pluripotent stem cell-derived cardiomyocytes
Jin, G., & Palecek, S. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816221-7.00006-9 · Cited by 6
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Coffee, M., Biswanath, S., Bolesani, E., & Zweigerdt, R. (2020) · Learning materials in biosciences · doi:10.1007/978-3-030-33923-4_6 · Cited by 6
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Metadata
- Authors
- Tulloch, N. L., Muskheli, V., Razumova, M. V., Korte, F. S., Regnier, M., Hauch, K. D., Pabon, L., Reinecke, H., & Murry, C. E.
- Affiliations
- University of Washington (US)
- Venue
- Circulation Research
- Published
- 2011-06-24
- Volume
- 109
- Issue
- 1
- Pages
- 47-59
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3140796
- OpenAlex
- W2163068618
- Cited by
- 666
- References
- 72
- Citations by year
- 2026: 12 · 2025: 28 · 2024: 26 · 2023: 30 · 2022: 27 · 2021: 59 · 2020: 42 · 2019: 56 · 2018: 43 · 2017: 66 · 2016: 57 · 2015: 51 · 2014: 54 · 2013: 57 · 2012: 45
- FWCI
- 54.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1u24dk076126-01, 5r01hl064387-10)
- National Heart, Lung, and Blood Institute (R01-HL064387, R01 HL64387, T32HL007312, P01HL094374, R01HL084642)
- National Institute of General Medical Sciences (P01GM081619)
- National Institute of Diabetes and Digestive and Kidney Diseases (U24-DK076126)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- mechanical loading, vascularization, cardiomyocyte hypertrophy, cardiomyocyte proliferation, myofibrillogenesis, collagen matrix, endothelial cells, stromal cells, Starling curve, heart development, regenerative therapy, human embryonic stem cell-derived cardiomyocytes, iPSC-derived cardiomyocytes
- MeSH terms
- Animals, Animals, Newborn, Biomechanical Phenomena, Cells, Cultured, Extracellular Matrix, Humans, Rats, Inbred F344, Stress, Mechanical, Coculture Techniques, Tissue Engineering, Myocytes, Cardiac, Pluripotent Stem Cells, Endothelial Cells, Cell Proliferation, Rats, Embryonic Stem Cells
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