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Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture
Open accessAbstract
Rationale: The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of human heart growth by these processes is poorly understood. Objective: We seek to elucidate the responses of immature human myocardium to mechanical load and vascularization using tissue engineering approaches. Methods and Results: Using human embryonic stem cell and human induced pluripotent stem cell–derived cardiomyocytes in a 3-dimensional collagen matrix, we show that uniaxial mechanical stress conditioning promotes 2-fold increases in cardiomyocyte and matrix fiber alignment and enhances myofibrillogenesis and sarcomeric banding. Furthermore, cyclic stress conditioning markedly increases cardiomyocyte hypertrophy (2.2-fold) and proliferation rates (21%) versus unconditioned constructs. Addition of endothelial cells enhances cardiomyocyte proliferation under all stress conditions (14% to 19%), and addition of stromal supporting cells enhances formation of vessel-like structures by ≈10-fold. Furthermore, these optimized human cardiac tissue constructs generate Starling curves, increasing their active force in response to increased resting length. When transplanted onto hearts of athymic rats, the human myocardium survives and forms grafts closely apposed to host myocardium. The grafts contain human microvessels that are perfused by the host coronary circulation. Conclusions: Our results indicate that both mechanical load and vascular cell coculture control cardiomyocyte proliferation, and that mechanical load further controls the hypertrophy and architecture of engineered human myocardium. Such constructs may be useful for studying human cardiac development as well as for regenerative therapy.
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“but not pressure- and volume-based metrics directly representing pump performance of the heart”
From Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells (2018) · cites this paper as [9]
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“engineered cardiac thin films, micro-tissues and strips allow the assessment of twitch force [9,12–19]”
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“Although hPSC-vCMs have been organized as monolayers and patches for electrophysiological assessment [6–8] and even surgical engraftment [9–11]”
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Cites
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Embryonic Stem Cell Lines Derived from Human Blastocysts
Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
Laflamme, M. A., Chen, K. Y., Naumova, A. V., Muskheli, V., Fugate, J. A., Dupras, S. K., Reinecke, H., Xu, C., Hassanipour, M., Police, S., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1327 · Cited by 2,235
Self-citationStrauer, B. E., Brehm, M. U., Zeus, T., Köstering, M., Hernandez, A., Sorg, R. V., Kögler, G., & Wernet, P. (2002) · Circulation · doi:10.1161/01.cir.0000034046.87607.1c · Cited by 2,065
Kehat, I., Kenyagin‐Karsenti, D., Snir, M., Segev, H., Amit, M., Gepstein, A., Livne, E., Binah, O., Itskovitz‐Eldor, J., & Gepstein, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12131 · Cited by 1,814
Murry, C. E., & Keller, G. M. (2008) · Cell · doi:10.1016/j.cell.2008.02.008 · Cited by 1,760
Self-citationKehat, I., Kenyagin‐Karsenti, D., Snir, M., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112131 · Cited by 1,536
Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
Zhang, J., Wilson, G. F., Soerens, A. G., Koonce, C. H., Yu, J., Palecek, S. P., Thomson, J. A., & Kamp, T. J. (2009) · Circulation Research · doi:10.1161/circresaha.108.192237 · Cited by 1,426
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
Yang, L., Soonpaa, M. H., Adler, E. D., Roepke, T. K., Kattman, S. J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G. W., Linden, R. M., et al. (2008) · Nature · doi:10.1038/nature06894 · Cited by 1,389
Engineering vascularized skeletal muscle tissue
Levenberg, S., Rouwkema, J., Macdonald, M. L., Garfein, E. S., Kohane, D. S., Darland, D. C., Marini, R. P., van Blitterswijk, C., Mulligan, R. C., D'Amore, P. A., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1109 · Cited by 1,293
Multiple essential functions of neuregulin in development
Meyer, D., & Birchmeier, C. (1995) · Nature · doi:10.1038/378386a0 · Cited by 1,273
Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
Gassmann, M., Casagranda, F., Orioli, D., Simon, H. H., Lai, C., Klein, R., & Lemke, G. (1995) · Nature · doi:10.1038/378390a0 · Cited by 1,151
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
Zimmermann, W., Melnychenko, I., Wasmeier, G. H., Didié, M., Naito, H., Nixdorff, U., Heß, A., Budinský, L., Brune, K., Michaelis, B., et al. (2006) · Nature Medicine · doi:10.1038/nm1394 · Cited by 996
Dumont, D. J., Gradwohl, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A., & Breitman, M. L. (1994) · Genes & Development · doi:10.1101/gad.8.16.1897 · Cited by 985
Tissue Engineering of a Differentiated Cardiac Muscle Construct
Zimmermann, W.-H., Schneiderbanger, K., Schubert, P., Didié, M., Münzel, F., Heubach, J. F., Kostin, S., Neuhuber, W. L., & Eschenhagen, T. (2002) · Circulation Research · doi:10.1161/hh0202.103644 · Cited by 917
Characterization and Enrichment of Cardiomyocytes Derived From Human Embryonic Stem Cells
Xu, C., Police, S., Rao, N., & Carpenter, M. K. (2002) · Circulation Research · doi:10.1161/01.res.0000035254.80718.91 · Cited by 902
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance
Berry, M. F., Engler, A. J., Woo, Y.-P. J., Pirolli, T. J., Bish, L. T., Jayasankar, V., Morine, K., Gardner, T. J., Discher, D. E., & Sweeney, H. L. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01017.2005 · Cited by 692
Tissue engineering of vascularized cardiac muscle from human embryonic stem cells
Caspi, O., Lesman, A., Basevitch, Y., Gepstein, A., Arbel, G., Habib, I. H. M., Gepstein, L., & Levenberg, S. (2007) · Circulation Research · doi:10.1161/01.res.0000257776.05673.ff · Cited by 558
Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium.
Weber, K. T., Janicki, J. S., Shroff, S. G., Pick, R., Chen, R. M., & Bashey, R. I. (1988) · Circulation Research · doi:10.1161/01.res.62.4.757 · Cited by 556
Survival, Integration, and Differentiation of Cardiomyocyte Grafts
Reinecke, H., Zhang, M., Bartosek, T., & Murry, C. E. (1999) · Circulation · doi:10.1161/01.cir.100.2.193 · Cited by 516
Self-citationWhittaker, P., Kloner, R. A., Boughner, D. R., & Pickering, J. G. (1994) · Basic Research in Cardiology · doi:10.1007/bf00788278 · Cited by 496
Formation of Human Myocardium in the Rat Heart from Human Embryonic Stem Cells
Laflamme, M. A., Gold, J., Xu, C., Hassanipour, M., Rosler, E. S., Police, S., Muskheli, V., & Murry, C. E. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62041-x · Cited by 448
Self-citationStevens, K. R., Kreutziger, K. L., Dupras, S. K., Korte, F. S., Regnier, M., Muskheli, V., Nourse, M. B., Bendixen, K., Reinecke, H., & Murry, C. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908381106 · Cited by 423
Self-citationOptimization of cardiac cell seeding and distribution in 3D porous alginate scaffolds
Dar, A., Shachar, M., Leor, J., & Cohen, S. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10372 · Cited by 384
Chronic stretch of engineered heart tissue induces hypertrophy and functional improvement
Fink, C., Ergün, S., Kralisch, D., Remmers, U., Weil, J., & Thomas Eschenhagen, A. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.5.669 · Cited by 378
Olivetti, G., Capasso, J. M., Sonnenblick, E. H., & Anversa, P. (1990) · Circulation Research · doi:10.1161/01.res.67.1.23 · Cited by 344
Velling, T., Risteli, J., Wennerberg, K., Mosher, D., & Johansson, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206286200 · Cited by 339
Katritsis, D. G., Sotiropoulou, P. A., Karvouni, E., Karabinos, I. K., Korovesis, S., Perez, S. A., Voridis, E. M., & Papamichail, M. (2005) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.20406 · Cited by 335
Kadler, K. E., Hojima, Y., & Prockop, D. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47783-6 · Cited by 324
Culture media for the differentiation of mesenchymal stromal cells
Vater, C., Kasten, P., & Stiehler, M. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.037 · Cited by 279
Paige, S. L., Osugi, T., Afanasiev, O. K., Pabon, L., Reinecke, H., & Murry, C. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011134 · Cited by 274
Self-citationCardiovascular ephrinB2 function is essential for embryonic angiogenesis
Gerety, S. S., & Anderson, D. J. (2002) · Development · doi:10.1242/dev.129.6.1397 · Cited by 263
ENDOTHELIAL-CARDIOMYOCYTE INTERACTIONS IN CARDIAC DEVELOPMENT AND REPAIR
Hsieh, P. C. H., Davis, M. E., Lisowski, L. K., & Lee, R. T. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124629 · Cited by 253
Arts, T. G. J., Delhaas, T., Bovendeerd, P. H. M., Verbeek, X. A. A. M., & Prinzen, F. W. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00444.2004 · Cited by 252
Zhu, W.-Z., Xie, Y., Moyes, K. W., Gold, J. D., Askari, B., & Laflamme, M. A. (2010) · Circulation Research · doi:10.1161/circresaha.110.223917 · Cited by 228
O’Connell, T. D., Ishizaka, S., Nakamura, A., Swigart, P. M., Rodrigo, M. C., Simpson, G. L., Cotecchia, S., Rokosh, G. D., Grossman, W., Foster, E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16100 · Cited by 205
Radisic, M., Park, H., Martens, T. P., Salazar-Lazzaro, J. E., Geng, W., Wang, Y., Langer, R., Freed, L. E., & Vunjak‐Novakovic, G. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31578 · Cited by 186
McDevitt, T. C., Laflamme, M. A., & Murry, C. E. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.09.007 · Cited by 183
Self-citationCalcium Handling in Human Embryonic Stem Cell-Derived Cardiomyocytes
Satin, J., Itzhaki, I., Rapoport, S., Schroder, E. A., Izu, L. T., Arbel, G., Beyar, R., Balke, C. W., Schiller, J., & Gepstein, L. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0591 · Cited by 174
Nf1 has an essential role in endothelial cells
Gitler, A. D., Zhu, Y., Ismat, F. A., Lu, M. M., Yamauchi, Y., Parada, L. F., & Epstein, J. A. (2002) · Nature Genetics · doi:10.1038/ng1059 · Cited by 173
VEGF Induces Differentiation of Functional Endothelium From Human Embryonic Stem Cells
Nourse, M. B., Halpin, D. E., Scatena, M., Mortisen, D. J., Tulloch, N. L., Hauch, K. D., Torok‐Storb, B., Ratner, B. D., Pabon, L., & Murry, C. E. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.194233 · Cited by 173
Self-citationCollagen in the scarless fetal skin wound: Detection with Picrosirius-polarization
Cuttle, L., Nataatmadja, M. I., Fraser, J. F., Kempf, M., Kimble, R. M., & Hayes, M. T. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.130211.x · Cited by 171
O’Connell, T. D., Ishizaka, S., Nakamura, A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316100 · Cited by 169
Scaffold-Free Human Cardiac Tissue Patch Created from Embryonic Stem Cells
Stevens, K. R., Pabon, L., Muskheli, V., & Murry, C. E. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0151 · Cited by 164
Self-citationSTEM/TEM studies of collagen fibril assembly
Holmes, D. F., Graham, H. K., Trotter, J. A., & Kadler, K. E. (2001) · Micron · doi:10.1016/s0968-4328(00)00040-8 · Cited by 127
Cellular and molecular effects of mechanical stretch on vascular cells and cardiac myocytes
Shyu, K. (2009) · Clinical Science · doi:10.1042/cs20080163 · Cited by 125
Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width
Russell, B., Curtis, M. W., Koshman, Y. E., & Samarel, A. M. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.02.016 · Cited by 123
The role of mechanical forces in dextral rotation during cardiac looping in the chick embryo
Voronov, D. A., Alford, P. W., Xu, G., & Taber, L. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.04.033 · Cited by 120
Neuregulin 1 Sustains the Gene Regulatory Network in Both Trabecular and Nontrabecular Myocardium
Lai, D., Liu, X., Forrai, A., Wolstein, O., Michalicek, J., Ahmed, I. M., Garratt, A. N., Birchmeier, C., Zhou, M., Hartley, L., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.218693 · Cited by 115
Tobita, K., & Keller, B. B. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.3.h959 · Cited by 108
Shimko, V. F., & Claycomb, W. C. (2008) · Tissue Engineering Part A · doi:10.1089/ten.a.2007.0092 · Cited by 107
Mansour, H., de Tombe, P. P., Samarel, A. M., & Russell, B. (2004) · Circulation Research · doi:10.1161/01.res.0000121101.32286.c8 · Cited by 104
Adaptation of cardiac structure by mechanical feedback in the environment of the cell: a model study
Arts, T. G. J., Prinzen, F. W., Snoeckx, L. H. E. H., Rijcken, J. M., & Reneman, R. S. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80876-8 · Cited by 98
Xu, C., Police, S., Hassanipour, M., & Gold, J. D. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.631 · Cited by 94
Mechanical aspects of cardiac development
Taber, L. A. (1998) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(98)00010-8 · Cited by 91
Borges, L. D. F., Gutierrez, P. S., Marana, H. R. C., & Taboga, S. R. (2006) · Micron · doi:10.1016/j.micron.2006.10.005 · Cited by 85
Design and fabrication of heart muscle using scaffold‐based tissue engineering
Blan, N. R., & Birla, R. K. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31642 · Cited by 78
Local Control of Excitation-Contraction Coupling in Human Embryonic Stem Cell-Derived Cardiomyocytes
Zhu, W., Santana, L. F., & Laflamme, M. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005407 · Cited by 75
Development of a Novel Bioreactor for the Mechanical Loading of Tissue-Engineered Heart Muscle
Birla, R. K., Huang, Y. C., & Dennis, R. G. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0359 · Cited by 70
STAT3-Mediated Activation of Myocardial Capillary Growth
Hilfiker‐Kleiner, D., Limbourg, A., & Drexler, H. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.05.002 · Cited by 64
Chacko, S. M., Khan, M., Kuppusamy, M. L., Pandian, R. P., Varadharaj, S., Selvendiran, K., Bratasz, A., Rivera, B. K., & Kuppusamy, P. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01311.2008 · Cited by 53
Molecular mechanisms in endothelial regulation of cardiac function
Kuruvilla, L., & Kartha, C. S. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1026061507004 · Cited by 49
Calcium Handling in Embryonic Stem Cell–Derived Cardiac Myocytes
Itzhaki, I., Schiller, J., Beyar, R., Satin, J., & Gepstein, L. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1380.017 · Cited by 45
Senyo, S. E., Koshman, Y. E., & Russell, B. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.07.070 · Cited by 44
Molecular mechanisms controlling the coupled development of myocardium and coronary vasculature
Bhattacharya, S., MacDonald, S. T., & Farthing, C. R. (2006) · Clinical Science · doi:10.1042/cs20060003 · Cited by 37
Mechanical effects of looping in the embryonic chick heart
Lin, I.-E., & Taber, L. A. (1994) · Journal of Biomechanics · doi:10.1016/0021-9290(94)90007-8 · Cited by 32
Endothelial cells regulate cardiomyocyte development from embryonic stem cells
Chen, K., Bai, H., Arzigian, M., Gao, Y., Bao, J., Wu, W., Shen, W., Wu, L., & Wang, Z. Z. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22680 · Cited by 29
Cell therapy enhances function of remote non-infarcted myocardium
Moreno‐Gonzalez, A., Korte, F. S., Dai, J., Chen, K., Ho, B., Reinecke, H., Murry, C. E., & Regnier, M. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.07.030 · Cited by 26
Self-citationKira, Y., Nakaoka, T., Hashimoto, E., Okabe, F., Asano, S., & SEKINE, I. (1994) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00877334 · Cited by 26
Stevens, K. R., Rolle, M. W., Minami, E., Ueno, S., Nourse, M. B., Virag, J. A. I., Reinecke, H., & Murry, C. E. (2007) · Human Gene Therapy · doi:10.1089/hum.2006.161 · Cited by 19
Self-citationAlterations in sheep fetal right ventricular tissue with induced hemodynamic pressure overload
MONTGOMERY, M., Jiao, Y., Phillips, S. J., Singh, G. K., Xu, J., Balsara, R. K., & Litvin, J. (1998) · Basic Research in Cardiology · doi:10.1007/s003950050086 · Cited by 13
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Metadata
- Authors
- Tulloch, N. L., Muskheli, V., Razumova, M. V., Korte, F. S., Regnier, M., Hauch, K. D., Pabon, L., Reinecke, H., & Murry, C. E.
- Affiliations
- University of Washington (US)
- Venue
- Circulation Research
- Published
- 2011-06-24
- Volume
- 109
- Issue
- 1
- Pages
- 47-59
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3140796
- OpenAlex
- W2163068618
- Cited by
- 666
- References
- 72
- Citations by year
- 2026: 12 · 2025: 28 · 2024: 26 · 2023: 30 · 2022: 27 · 2021: 59 · 2020: 42 · 2019: 56 · 2018: 43 · 2017: 66 · 2016: 57 · 2015: 51 · 2014: 54 · 2013: 57 · 2012: 45
- FWCI
- 54.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1u24dk076126-01, 5r01hl064387-10)
- National Heart, Lung, and Blood Institute (R01-HL064387, R01 HL64387, T32HL007312, P01HL094374, R01HL084642)
- National Institute of General Medical Sciences (P01GM081619)
- National Institute of Diabetes and Digestive and Kidney Diseases (U24-DK076126)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- mechanical loading, vascularization, cardiomyocyte hypertrophy, cardiomyocyte proliferation, myofibrillogenesis, collagen matrix, endothelial cells, stromal cells, Starling curve, heart development, regenerative therapy, human embryonic stem cell-derived cardiomyocytes, iPSC-derived cardiomyocytes
- MeSH terms
- Animals, Animals, Newborn, Biomechanical Phenomena, Cells, Cultured, Extracellular Matrix, Humans, Rats, Inbred F344, Stress, Mechanical, Coculture Techniques, Tissue Engineering, Myocytes, Cardiac, Pluripotent Stem Cells, Endothelial Cells, Cell Proliferation, Rats, Embryonic Stem Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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