The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Exercise Protects Against Myocardial Ischemia–Reperfusion Injury via Stimulation of β 3 -Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols
Open accessAbstract
Rationale: Exercise training confers sustainable protection against ischemia–reperfusion injury in animal models and has been associated with improved survival following a heart attack in humans. It is still unclear how exercise protects the heart, but it is apparent that endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) play a role. Objective: To determine the role of β 3 -adrenergic receptors (β 3 -ARs), eNOS activation, and NO metabolites (nitrite and nitrosothiols) in the sustained cardioprotective effects of exercise. Methods and Results: Here we show that voluntary exercise reduces myocardial injury in mice following a 4-week training period and that these protective effects can be sustained for at least 1 week following the cessation of the training. The sustained cardioprotective effects of exercise are mediated by alterations in the phosphorylation status of eNOS (increase in serine 1177 and decrease in threonine 495), leading to an increase in NO generation and storage of NO metabolites (nitrite and nitrosothiols) in the heart. Further evidence revealed that the alterations in eNOS phosphorylation status and NO generation were mediated by β 3 -AR stimulation and that in response to exercise a deficiency of β 3 -ARs leads to an exacerbation of myocardial infarction following ischemia–reperfusion injury. Conclusions: Our findings clearly demonstrate that exercise protects the heart against myocardial ischemia–reperfusion injury by stimulation of β 3 -ARs and increased cardiac storage of nitric oxide metabolites (ie, nitrite and nitrosothiols).
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Webb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
Bryan, N. S., Fernandez, B. O., Bauer, S. M., Garcia-Saura, M. F., Milsom, A. B., Rassaf, T., Maloney, R. E., Bharti, A., Rodriguez, J., & Feelisch, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio734 · Cited by 518
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
Jansson, E. Å., Huang, L., Malkey, R., Govoni, M., Nihlén, C., Olsson, A., Stensdotter, M., Petersson, J., Holm, L., Weitzberg, E., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.92 · Cited by 356
Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
Bryan, N. S., Calvert, J. W., Elrod, J. W., Gundewar, S., Ji, S. Y., & Lefer, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706579104 · Cited by 347
Self-citationHull, S. S., Vanoli, E., Adamson, P. B., Verrier, R. L., Foreman, R. D., & Schwartz, P. J. (1994) · Circulation · doi:10.1161/01.cir.89.2.548 · Cited by 299
Zhang, Y., Lee, T.-S., Kolb, E. M., Sun, K., Lu, X., Sladek, F. M., Kassab, G. S., Garland, T., & Shyy, J. Y.-J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000221230.08596.98 · Cited by 212
Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide
Elrod, J. W., Calvert, J. W., Gundewar, S., Bryan, N. S., & Lefer, D. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800700105 · Cited by 137
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Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors
Fiuza-Luces, C., Santos-Lozano, A., Joyner, M., Carrera-Bastos, P., Picazo, O., Zugaza, J. L., Izquierdo, M., Ruilope, L. M., & Lucia, A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0065-1 · Cited by 803
Effects of aging on angiogenesis
Lähteenvuo, J., & Rosenzweig, A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246116 · Cited by 292
Bax regulates primary necrosis through mitochondrial dynamics
Whelan, R. S., Konstantinidis, K., Wei, A.-C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201608109 · Cited by 290
Self-citationExercise benefits in cardiovascular diseases: From mechanisms to clinical implementation
Valenzuela, P. L., Ruilope, L. M., Santos-Lozano, A., Wilhelm, M., Kränkel, N., Fiuza-Luces, C., & Lucia, A. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad170 · Cited by 237
Ferguson, S. K., Holdsworth, C. T., Wright, J. L., Fees, A. J., Allen, J. D., Jones, A. M., Musch, T. I., & Poole, D. C. (2015) · Nitric Oxide · doi:10.1016/j.niox.2014.09.157 · Cited by 120
Metadata
- Authors
- Calvert, J. W., Condit, M. E., Aragón, J. P., Nicholson, C. K., Moody, B. F., Hood, R. L., Sindler, A. L., Gundewar, S., Seals, D. R., Barouch, L. A., & Lefer, D. J.
- Venue
- Circulation Research
- Published
- 2011-06-10
- Volume
- 108
- Issue
- 12
- Pages
- 1448-1458
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2107554716
- Cited by
- 207
- References
- 7
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Calvert, J. W., Condit, M. E., Aragón, J. P., Nicholson, C. K., Moody, B. F., Hood, R. L., Sindler, A. L., Gundewar, S., Seals, D. R., Barouch, L. A., & Lefer, D. J. (2011). Exercise Protects Against Myocardial Ischemia–Reperfusion Injury via Stimulation of β 3 -Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols. Circulation Research. https://doi.org/10.1161/circresaha.111.241117
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