Effects of aging on angiogenesis
Open accessAbstract
Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse sequelae in the elderly. Angiogenesis is both an essential adaptive response to physiological stress and an endogenous repair mechanism after ischemic injury. In addition, induction of angiogenesis is a promising therapeutic approach for ischemic diseases. For these reasons, understanding the basis of age-related impairment of angiogenesis and endothelial function has important implications for understanding and managing cardiovascular disease. In this review, we discuss the molecular mechanisms that contribute to impaired angiogenesis in the elderly and potential therapeutic approaches to improving vascular function and angiogenesis in aging patients.
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Endothelial cell senescence directly compromises the endothelial barrier through disruption of cellular proliferation, permeability, and motility, possibly contributing to endothelial erosion and intra-plaque haemorrhage.
“Endothelial cell senescence directly compromised the endothelial barrier through disruption of cellular proliferation, permeability, and motility,112–114 possibly contributing to endothelial erosion and intra-plaque haemorrhage.”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [112]
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Ushio‐Fukai, M., Tang, Y., Fukai, T., Dikalov, S., Ma, Y., Fujimoto, M., Quinn, M. T., Pagano, P. J., Johnson, C., & Alexander, R. W. (2002) · Circulation Research · doi:10.1161/01.res.0000046227.65158.f8 · Cited by 463 · see citing works
RetractedWriting Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889 · see citing works
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029 · see citing works
Molecular mechanisms and clinical applications of angiogenesis
Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467 · see citing works
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461 · see citing works
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409 · see citing works
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
Angiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,258 · see citing works
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works
Regulation of angiogenesis by hypoxia: role of the HIF system
Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520 · see citing works
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works
Genomewide Association Analysis of Coronary Artery Disease
Samani, N. J., Erdmann, J., Hall, A. S., Hengstenberg, C., Mangino, M., Mayer, B., Dixon, R. J., Meitinger, T., Braund, P., Wichmann, H.-E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072366 · Cited by 2,044 · see citing works
Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420302 · Cited by 1,957 · see citing works
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868 · see citing works
The p66shc adaptor protein controls oxidative stress response and life span in mammals
Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712 · see citing works
Telomeres and human disease: ageing, cancer and beyond
Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,690 · see citing works
A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction
Helgadottir, A., Thorleifsson, G., Manolescu, A., Gretarsdottir, S., Blondal, T., Jonasdottir, A., Jonasdottir, A., Sigurdsson, A., Baker, A., Palsson, A., et al. (2007) · Science · doi:10.1126/science.1142842 · Cited by 1,594 · see citing works
Recent progress in the biology and physiology of sirtuins
Finkel, T., Deng, C., & Mostoslavsky, R. (2009) · Nature · doi:10.1038/nature08197 · Cited by 1,484 · see citing works
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484 · see citing works
Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D. J., Lefer, D. J., Sessa, W. C., & Walsh, K. (2000) · Nature Medicine · doi:10.1038/79510 · Cited by 1,437 · see citing works
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319 · see citing works
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
Murohara, T., Asahara, T., Silver, M., Bauters, C., Masuda, H., Kalka, C., Kearney, M., Chen, D., Symes, J. F., Fishman, M. C., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1560 · Cited by 1,201 · see citing works
Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,192 · see citing works
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · see citing works
Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation · doi:10.1161/01.cir.0000013836.85741.17 · Cited by 1,061 · see citing works
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature · doi:10.1038/nature06613 · Cited by 1,054 · see citing works
Self-citationTrends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works
Henry, T. D., Annex, B. H., McKendall, G. R., Azrin, M., López, J. J., Giordano, F. J., Shah, P. K., Willerson, J. T., Benza, R. L., Berman, D. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000061911.47710.8a · Cited by 1,025 · see citing works
Sesso, H. D. (2008) · JAMA · doi:10.1001/jama.2008.600 · Cited by 913 · see citing works
Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881 · see citing works
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Jaskelioff, M., Muller, F. L., Paik, J.-H., Thomas, E., Jiang, S., Adams, A. C., Sahin, E., Kost-Alimova, M., Protopopov, A., Cadiñanos, J., et al. (2011) · Nature · doi:10.1038/nature09603 · Cited by 857 · see citing works
Endothelial Function and Oxidative Stress in Cardiovascular Diseases
Higashi, Y., Noma, K., Yoshizumi, M., & Kihara, Y. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-1102 · Cited by 796 · see citing works
Age-Dependent Impairment of Angiogenesis
Rivard, A., Fabre, J., Silver, M., Chen, D., Murohara, T., Kearney, M., Magner, M., Asahara, T., & Isner, J. M. (1999) · Circulation · doi:10.1161/01.cir.99.1.111 · Cited by 774 · see citing works
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
Lim, J.-H., Lee, Y.-M., Chun, Y.-S., Chen, J., Kim, J.-E., & Park, J.-W. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.023 · Cited by 758 · see citing works
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731 · see citing works
Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.-H., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.002 · Cited by 694 · see citing works
Self-citationEarly Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction
Lee, S. H., Wolf, P. L., Escudero, R., Deutsch, R., Jamieson, S. W., & Thistlethwaite, P. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003023420904 · Cited by 693 · see citing works
Enhanced Peroxynitrite Formation Is Associated with Vascular Aging
van der Loo, B., Labugger, R., Skepper, J. N., Bachschmid, M. M., Kilo, J., Powell, J. M., Palacios‐Callender, M., Erusalimsky, J. D., Quaschning, T., Maliñski, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1731 · Cited by 674 · see citing works
Telomere length and replicative aging in human vascular tissues.
Chang, E., & Harley, C. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11190 · Cited by 635 · see citing works
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., et al. (2011) · Nature · doi:10.1038/nature10296 · Cited by 624 · see citing works
Pola, R., Ling, L. E., Silver, M., Corbley, M. J., Kearney, M., Pepinsky, R. B., Shapiro, R. I., Taylor, F. R., Baker, D. P., Asahara, T., et al. (2001) · Nature Medicine · doi:10.1038/89083 · Cited by 610 · see citing works
Telomere shortening in atherosclerosis
Samani, N. J., Boultby, R., Butler, R., Thompson, J. R., & Goodall, A. H. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05633-1 · Cited by 609 · see citing works
Hydrogen peroxide regulation of endothelial function: Origins, mechanisms, and consequences
Cai, H. “. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.06.021 · Cited by 568 · see citing works
Dynamics of endothelial cell behavior in sprouting angiogenesis
Eilken, H. M., & Adams, R. H. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.08.010 · Cited by 566 · see citing works
Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
Csiszár, A., Ungvari, Z. I., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Koller, Á., & Kaley, G. (2002) · Circulation Research · doi:10.1161/01.res.0000020401.61826.ea · Cited by 565 · see citing works
Sessa, W. C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01165 · Cited by 561 · see citing works
Angiogenic Gene Therapy (AGENT) Trial in Patients With Stable Angina Pectoris
Grines, C. L., Watkins, M. W., Helmer, G., Penny, W. F., Brinker, J., Marmur, J. D., West, A., Rade, J. J., Marrott, P. K., Hammond, H. K., et al. (2002) · Circulation · doi:10.1161/hc1102.105595 · Cited by 520 · see citing works
Human Endothelial Cell Life Extension by Telomerase Expression
Yang, J., Chang, E., Cherry, A. M., Bangs, C. D., Oei, Y. A., Bodnar, A. G., Bronstein, A., Chiu, C., & Herron, G. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26141 · Cited by 499 · see citing works
Kurz, D. J., Decary, S., Hong, Y., Trivier, E., Akhmedov, A., & Erusalimsky, J. D. (2004) · Journal of Cell Science · doi:10.1242/jcs.01097 · Cited by 499 · see citing works
Reactive oxygen species as mediators of angiogenesis signaling. Role of NAD(P)H oxidase
Ushio‐Fukai, M., & Alexander, R. W. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000044378.09409.b5 · Cited by 473 · see citing works
Kastrup, J., Jørgensen, E. O., Rück, A., Tägil, K., Glogar, D., Rużyłło, W., Bøtker, H. E., Dudek, D., Drvota, V., Hesse, B., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.068 · Cited by 461 · see citing works
Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women
Coggan, A. R., Spina, R. J., King, D. S., Rogers, M. A., Brown, M., Nemeth, P. M., & Holloszy, J. O. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.72.5.1780 · Cited by 457 · see citing works
Role of Angiogenesis in Cardiovascular Disease
Khurana, R., Simons, M., Martin, J. F., & Zachary, I. C. (2005) · Circulation · doi:10.1161/circulationaha.105.535294 · Cited by 445 · see citing works
Sirt1 modulates premature senescence-like phenotype in human endothelial cells
Ota, H., Akishita, M., Eto, M., Iijima, K., Kaneki, M., & Ouchi, Y. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.08.008 · Cited by 422 · see citing works
Iwakura, A., Luedemann, C., Shastry, S., Hanley, A., Kearney, M., Aikawa, R., Isner, J. M., Asahara, T., & Losordo, D. W. (2003) · Circulation · doi:10.1161/01.cir.0000106906.56972.83 · Cited by 414 · see citing works
Going against the grain: chemotaxis and infection in Vibrio cholerae
Butler, S. M., & Camilli, A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1207 · Cited by 405 · see citing works
Chiu, C., Dragowska, W., Kim, N. W., Vaziri, H., Yui, J., Thomas, T. E., Harley, C. B., & Lansdorp, P. M. (1996) · STEM CELLS · doi:10.1002/stem.140239 · Cited by 388 · see citing works
Zhang, Q., Wang, Z., Chen, H., Zhou, S., Zheng, W., Liu, G., Wei, Y.-S., Cai, H. “., Liu, D., & Liang, C. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn224 · Cited by 388 · see citing works
Haendeler, J., Hoffmann, J., Diehl, J. F., Vasa‐Nicotera, M., Spyridopoulos, I., Zeiher, A. M., & Dimmeler, S. (2004) · Circulation Research · doi:10.1161/01.res.0000121104.05977.f3 · Cited by 382 · see citing works
Napoli, C., Martin-Padura, I., de Nigris, F., Giorgio, M., Mansueto, G., Somma, P., Condorelli, M., Sica, G., De Rosa, G., & Pelicci, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336359100 · Cited by 380 · see citing works
The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle
Chinsomboon, J., Ruas, J., Gupta, R. K., Thom, R., Shoag, J., Rowe, G. C., Sawada, N., Raghuram, S., & Arany, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909131106 · Cited by 379 · see citing works
Arany, Z., Novikov, M., Chin, S., Ma, Y., Rosenzweig, A., & Spiegelman, B. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603615103 · Cited by 374 · see citing works
Self-citationeNOS uncoupling and endothelial dysfunction in aged vessels
Yang, Y., Huang, A., Kaley, G., & Sun, D. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00230.2009 · Cited by 370 · see citing works
HIF hydroxylation and the mammalian oxygen-sensing pathway
Safran, M., & Kaelin, W. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318181 · Cited by 365 · see citing works
HIF hydroxylation and the mammalian oxygen-sensing pathway
Safran, M., & Kaelin, W. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18181 · Cited by 363 · see citing works
(1999) · PubMed · Cited by 354 · see citing works
The power of exercise: buffering the effect of chronic stress on telomere length
Puterman, E., Lin, J., Blackburn, E., O'Donovan, A., Adler, N., & Epel, E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010837 · Cited by 339 · see citing works
Alterations of Nitric Oxide Synthase Expression With Aging and Hypertension in Rats
Chou, T.-C., Yen, M., Li, C., & Ding, Y.-A. (1998) · Hypertension · doi:10.1161/01.hyp.31.2.643 · Cited by 339 · see citing works
Yan, Z., Okutsu, M., Akhtar, Y., & Lira, V. A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00993.2010 · Cited by 338 · see citing works
VEGF-A: a critical regulator of blood vessel growth
Ferrara, N. (2009) · European Cytokine Network · doi:10.1684/ecn.2009.0170 · Cited by 328 · see citing works
Genes involved in senescence and immortalization
Lundberg, A. S., Hahn, W. C., Gupta, P., & Weinberg, R. A. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00155-1 · Cited by 313 · see citing works
Davis, M. E., Cai, H. “., Drummond, G. R., & Harrison, D. G. (2001) · Circulation Research · doi:10.1161/hh2301.100806 · Cited by 310 · see citing works
Rivard, A., Berthou-Soulié, L., Principe, N., Kearney, M., Curry, C., Branellec, D., Semenza, G. L., & Isner, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001029200 · Cited by 305 · see citing works
Murasawa, S., Llevadot, J., Silver, M., Isner, J. M., Losordo, D. W., & Asahara, T. (2002) · Circulation · doi:10.1161/01.cir.0000027584.85865.b4 · Cited by 303 · see citing works
eNOS Activity Is Reduced in Senescent Human Endothelial Cells
Matsushita, H., Chang, E., Glassford, A. J., Cooke, J. P., Chiu, C., & Tsao, P. S. (2001) · Circulation Research · doi:10.1161/hh2101.098443 · Cited by 302 · see citing works
Förstermann, U., & Li, H. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01196.x · Cited by 299 · see citing works
Bosch‐Marcé, M., Okuyama, H., Wesley, J. B., Sarkar, K., Kimura, H., Liu, Y. V., Zhang, H., Strazza, M., Rey, S., Savino, L., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.153346 · Cited by 298 · see citing works
Deletion of p66 <sup>shc</sup> Gene Protects Against Age-Related Endothelial Dysfunction
Francia, P., delli Gatti, C., Bachschmid, M., Martin-Padura, I., Savoia, C., Migliaccio, E., Pelicci, P. G., Schiavoni, M., Lüscher, T. F., Volpe, M., et al. (2004) · Circulation · doi:10.1161/01.cir.0000147731.24444.4d · Cited by 298 · see citing works
Hydrogen peroxide release by mitochondria increases during aging
Sohal, R. S., & Sohal, B. H. (1991) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(91)90034-w · Cited by 296 · see citing works
Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium
Lantin-Hermoso, R. L., Rosenfeld, C. R., Yuhanna, I. S., German, Z., Chen, Z., & Shaul, P. W. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.273.1.l119 · Cited by 284 · see citing works
Weinstein, R. S., Wan, C., Liu, Q., Wang, Y., Almeida, M., O’Brien, C. A., Thostenson, J., Roberson, P. K., Boskey, A. L., Clemens, T. L., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00545.x · Cited by 276 · see citing works
Zhou, S., Chen, H., Wan, Y.-Z., Zhang, Q.-J., Wei, Y.-S., Huang, S., Liu, J., Lu, Y., Zhang, Z., Yang, R., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.243592 · Cited by 273 · see citing works
Human Studies of Angiogenic Gene Therapy
Gupta, R., Tongers, J., & Losordo, D. W. (2009) · Circulation Research · doi:10.1161/circresaha.109.200386 · Cited by 273 · see citing works
Role of gp91 phox (Nox2)-Containing NAD(P)H Oxidase in Angiogenesis in Response to Hindlimb Ischemia
Tojo, T., Ushio‐Fukai, M., Yamaoka‐Tojo, M., Ikeda, S., Patrushev, N. A., & Alexander, R. W. (2005) · Circulation · doi:10.1161/01.cir.0000164261.62586.14 · Cited by 261 · see citing works
Kim, J. H., Bugaj, L. J., Oh, Y. J., Bivalacqua, T. J., Ryoo, S., Soucy, K. G., Santhanam, L., Webb, A. K., Camara, A., Sikka, G., et al. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91393.2008 · Cited by 244 · see citing works
Furumoto, K., Inoue, E., Nagao, N., Hiyama, E., & Miwa, N. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00351-8 · Cited by 240 · see citing works
Telomere Biology and Cardiovascular Disease
Fuster, J. J., & Andrés, V. (2006) · Circulation Research · doi:10.1161/01.res.0000251281.00845.18 · Cited by 237 · see citing works
Protective roles of SIRT1 in atherosclerosis
Stein, S., & Matter, C. M. (2011) · Cell Cycle · doi:10.4161/cc.10.4.14863 · Cited by 228 · see citing works
Relationship between Physical Activity Level, Telomere Length, and Telomerase Activity
Ludlow, A. T., Zimmerman, J. B., Witkowski, S., Hearn, J. W., Hatfield, B. D., & Roth, S. M. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31817c92aa · Cited by 226 · see citing works
Hayashi, T., Matsui‐Hirai, H., Miyazaki, A., Fukatsu, A., Funami, J., Ding, Q., Sumitra, K., Hattori, Y., Ignarro, L. J., & Iguchi, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607873103 · Cited by 222 · see citing works
Anatomic Heterogeneity of Vascular Aging
Barton, M., Cosentino, F., Brandes, R. P., Moreau, P. R., Shaw, S., & Lüscher, T. F. (1997) · Hypertension · doi:10.1161/01.hyp.30.4.817 · Cited by 222 · see citing works
Antoniades, C., Bakogiannis, C., Leeson, P., Guzik, T. J., Zhang, M.-H., Tousoulis, D., Antonopoulos, A. S., Demosthenous, M., Marinou, K., Hale, A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.985150 · Cited by 219 · see citing works
Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00679.x · Cited by 218 · see citing works
Brodsky, S. V., Gealekman, O., Chen, J., Zhang, F., Togashi, N., Crabtree, M. J., Gross, S. S., Nasjletti, A., & Goligorsky, M. S. (2003) · Circulation Research · doi:10.1161/01.res.0000111802.09964.ef · Cited by 213 · see citing works
Calvert, J. W., Condit, M. E., Aragón, J. P., Nicholson, C. K., Moody, B. F., Hood, R. L., Sindler, A. L., Gundewar, S., Seals, D. R., Barouch, L. A., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.241117 · Cited by 207 · see citing works
Mechanisms of adaptive angiogenesis to tissue hypoxia
Fong, G. (2008) · Angiogenesis · doi:10.1007/s10456-008-9107-3 · Cited by 201 · see citing works
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
Viswanathan, M., & Guarente, L. (2011) · Nature · doi:10.1038/nature10440 · Cited by 191 · see citing works
Rajagopalan, S., Olin, J. W., Deitcher, S. R., Pieczek, A., Laird, J. R., Grossman, P. M., Goldman, C. K., McEllin, K., Kelly, R. A., & Chronos, N. A. F. (2007) · Circulation · doi:10.1161/circulationaha.106.607994 · Cited by 186 · see citing works
Arteriogenesis, a new concept of vascular adaptation in occlusive disease
Scholz, D., Cai, W., & Schaper, W. K. A. (2001) · Angiogenesis · doi:10.1023/a:1016094004084 · Cited by 180 · see citing works
Effect of estrogen on endothelial function and angiogenesis
Rubanyi, G. M., Johns, A., & Kauser, K. Z. (2002) · Vascular Pharmacology · doi:10.1016/s0306-3623(02)00131-3 · Cited by 169 · see citing works
Lower skeletal muscle capillarization and VEGF expression in aged vs. young men
Ryan, N. A., Zwetsloot, K. A., Westerkamp, L. M., Hickner, R. C., Pofahl, W. E., & Gavin, T. P. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00827.2005 · Cited by 165 · see citing works
Song, Z., Von Figura, G., Liu, Y., Kraus, J. M., Torrice, C., Dillon, P., Rudolph‐Watabe, M., Ju, Z., Kestler, H. A., Sanoff, H., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00583.x · Cited by 163 · see citing works
Namba, T., Koike, H., Murakami, K., Aoki, M., Makino, H., Hashiya, N., Ogihara, T., Kaneda, Y., Kohno, M., & Morishita, R. (2003) · Circulation · doi:10.1161/01.cir.0000093190.53478.78 · Cited by 162 · see citing works
Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles
Sindler, A. L., Delp, M. D., Reyes, R., Wu, G., & Muller‐Delp, J. M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172221 · Cited by 156 · see citing works
Telomerized human microvasculature is functional in vivo
Yang, J., Nagavarapu, U., Relloma, K., Sjaastad, M. D., Moss, W. C., Passaniti, A., & Herron, G. S. (2001) · Nature Biotechnology · doi:10.1038/85655 · Cited by 147 · see citing works
Zhang, H., Luo, Y., Zhang, W., He, Y., Dai, S., Zhang, R., Huang, Y., Bernatchez, P., Giordano, F. J., Shadel, G., et al. (2007) · American Journal of Pathology · doi:10.2353/ajpath.2007.060960 · Cited by 145 · see citing works
Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity
Imanishi, T., Hano, T., & Nishio, I. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000176788.12376.20 · Cited by 144 · see citing works
Iemitsu, M., Maeda, S., Jesmin, S., Otsuki, T., & Miyauchi, T. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00820.2005 · Cited by 144 · see citing works
Schlager, O., Giurgea, A., Schuhfried, O., Seidinger, D., Hammer, A., Gröger, M., Fialka‐Moser, V., Gschwandtner, M. E., Koppensteiner, R., & Steiner, S. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.03.018 · Cited by 143 · see citing works
Watanabe, Y., Lee, S. W., Detmar, M. J., Ajioka, I., & Dvorak, H. F. (1997) · Oncogene · doi:10.1038/sj.onc.1201033 · Cited by 141 · see citing works
Altered Angiogenesis Underlying Age-Dependent Changes in Tumor Growth
Пили, Р., Guo, Y., Chang, J., Nakanishi, H., Martin, G. R., & Passaniti, A. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.17.1303 · Cited by 139 · see citing works
Duan, J., Murohara, T., Ikeda, H., Katoh, A., Shintani, S., Sasaki, K.-I., Kawata, H., Yamamoto, N., & Imaizumi, T. (2000) · Circulation · doi:10.1161/01.cir.102.suppl_3.iii-370 · Cited by 133 · see citing works
Craenenbroeck, E. M. V., Hoymans, V. Y., Beckers, P. J., Possemiers, N. M., Wuyts, K., Paelinck, B. P., Vrints, C. J., & Conraads, V. M. (2010) · Basic Research in Cardiology · doi:10.1007/s00395-010-0105-4 · Cited by 131 · see citing works
Endothelial precursors in vascular repair
Kirton, J. P., & Xu, Q. (2010) · Microvascular Research · doi:10.1016/j.mvr.2010.02.009 · Cited by 130 · see citing works
Qiang, L., Lin, H. V., Kim-Muller, J. Y., Welch, C. L., Gu, W. J., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.007 · Cited by 129 · see citing works
Human endothelial function and microvascular ageing
Gates, P. E., Strain, W. D., & Shore, A. C. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2008.043349 · Cited by 127 · see citing works
Stem Cells and the Regeneration of the Aging Cardiovascular System
Ballard, V. L. T., & Edelberg, J. M. (2007) · Circulation Research · doi:10.1161/01.res.0000261964.19115.e3 · Cited by 124 · see citing works
Gavin, T. P., Ruster, R. S., Carrithers, J. A., Zwetsloot, K. A., Kraus, R. M., Evans, C. A., Knapp, D. J., Drew, J. L., McCartney, J. S., Garry, J. P., et al. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.143198 · Cited by 121 · see citing works
Therapeutic angiogenesis for heart failure
Isner, J. M., & Losordo, D. W. (1999) · Nature Medicine · doi:10.1038/8374 · Cited by 117 · see citing works
SMITH, A. R. W., Visioli, F., Frei, B. B., & Hagen, T. M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00232.x · Cited by 116 · see citing works
Luk, T.-H., Dai, Y.-L., Siu, C., Yiu, K., Chan, H.-T., Lee, S. W. L., Li, S.-W., Fong, B. M.-W., Wong, W.-K., Tam, S., et al. (2011) · European Journal of Preventive Cardiology · doi:10.1177/1741826711415679 · Cited by 115 · see citing works
Involvement of the INK4a/Arf gene locus in senescence
Collins, C. J., & Sedivy, J. M. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00048.x · Cited by 113 · see citing works
Croley, A. N., Zwetsloot, K. A., Westerkamp, L. M., Ryan, N. A., Pendergast, A. M., Hickner, R. C., Pofahl, W. E., & Gavin, T. P. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00498.2005 · Cited by 111 · see citing works
p16INK4a and the control of cellular proliferative life span
Huschtscha, L. I. (1999) · Carcinogenesis · doi:10.1093/carcin/20.6.921 · Cited by 110 · see citing works
Aspirin reduces endothelial cell senescence
Bode‐Böger, S. M., Martens‐Lobenhoffer, J., Täger, M., Schröder, H., & Scalera, F. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.014 · Cited by 110 · see citing works
Cheng, X. W., Kuzuya, M., Kim, W., Song, H., Hu, L., Inoue, A., Nakamura, K., Di, Q., Sasaki, T., Tsuzuki, M., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.909218 · Cited by 98 · see citing works
Mechanisms of endothelial senescence
Erusalimsky, J. D., & Skene, C. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2008.043133 · Cited by 97 · see citing works
Özüyaman, B., Ebner, P., Niesler, U., Ziemann, J., Kleinbongard, P., Jax, T. W., Gödecke, A., Kelm, M., & Kalka, C. (2005) · Thrombosis and Haemostasis · doi:10.1160/th05-01-0038 · Cited by 94 · see citing works
Somatic mutations of mitochondrial DNA in aging and cancer progression
Lee, H., Chang, C., & Chi, C. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.009 · Cited by 93 · see citing works
Grasselli, A., Nanni, S., Colussi, C., Aiello, A., Benvenuti, V., Ragone, G., Moretti, F., Sacchi, A., Bacchetti, S., Gaetano, C., et al. (2008) · Circulation Research · doi:10.1161/circresaha.107.169037 · Cited by 91 · see citing works
Franco, S., Segura, I., Riese, H. H., & Blasco, M. A. (2002) · PubMed · Cited by 88 · see citing works
Ylä‐Herttuala, S., Markkanen, J. E., & Rissanen, T. T. (2004) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2004.09.001 · Cited by 87 · see citing works
Zaccagnini, G., Gaetano, C., Pietra, L. D., Nanni, S., Grasselli, A., Mangoni, A., Benvenuto, R., Fabrizi, M. M., Truffa, S., Germani, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414644200 · Cited by 87 · see citing works
Angiogenesis and hypertension: an update
Humar, R., Zimmerli, L., & Battegay, E. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.63 · Cited by 83 · see citing works
Body composition, aerobic capacity, and density of muscle capillaries in young and old men.
Pařízková, J., Eiselt, E., Sprynarová, S., & Wachtlová, M. (1971) · Journal of Applied Physiology · doi:10.1152/jappl.1971.31.3.323 · Cited by 79 · see citing works
Aging-Associated Vascular Phenotype in Mutant Mice With Low Levels of BubR1
Matsumoto, T., Baker, D. J., d’Uscio, L. V., Mozammel, G., Katusic, Z. S., & van Deursen, J. M. (2007) · Stroke · doi:10.1161/01.str.0000257967.86132.01 · Cited by 77 · see citing works
Garfinkel, S., Hu, X., Prudovsky, I. A., McMahon, G. A., Kapnik, E. M., McDowell, S. D., & Maciag, T. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.3.783 · Cited by 76 · see citing works
Acute lower limb ischemia: Determinants of outcome
Ouriel, K. M., & Veith, F. J. (1998) · Surgery · doi:10.1016/s0039-6060(98)70139-4 · Cited by 74 · see citing works
Jin, S., & Patterson, C. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.161539 · Cited by 74 · see citing works
Chromosome 9p21 and Coronary Artery Disease
McPherson, R. (2010) · New England Journal of Medicine · doi:10.1056/nejmcibr1002359 · Cited by 69 · see citing works
Circulating Endothelial Progenitors — Cells as Biomarkers
Rosenzweig, A. (2005) · New England Journal of Medicine · doi:10.1056/nejme058134 · Cited by 67 · see citing works
Self-citationEffect of aging on expression of angiogenesis-related factors in mouse skeletal muscle
Wagatsuma, A. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.003 · Cited by 64 · see citing works
Yoon, H. J., Cho, S. W., Ahn, B. W., & Yang, S. Y. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.010 · Cited by 63 · see citing works
Estrogen Reduces Angiotensin II-Induced Acceleration of Senescence in Endothelial Progenitor Cells
Imanishi, T., Hano, T., & Nishio, I. (2005) · Hypertension Research · doi:10.1291/hypres.28.263 · Cited by 60 · see citing works
Yamamori, T., White, A. R., Mattagajasingh, I., Khanday, F. A., Haile, A., Qi, B., Jeon, B. H., Bugayenko, A., Kasuno, K., & Berkowitz, D. E. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.09.003 · Cited by 58 · see citing works
Endothelial progenitor cells in vascular health: Focus on lifestyle
Craenenbroeck, E. M. V., & Conraads, V. M. (2010) · Microvascular Research · doi:10.1016/j.mvr.2009.12.009 · Cited by 56 · see citing works
Yang, D., Liu, L., & Zheng, X. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2008.02.001 · Cited by 55 · see citing works
Yu, J., Lei, L., Liang, Y., Hinh, L., Hickey, R. P., Huang, Y., Liu, D., Yeh, J. L., Rebar, E. J., Case, C. C., et al. (2006) · The FASEB Journal · doi:10.1096/fj.04-3670fje · Cited by 53 · see citing works
Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice
Lake-Bruse, K. D., Faraci, F. M., Shesely, E. G., Maeda, N., Sigmund, C. D., Heistad, D. D., & Brown), (. T. T. A. O. K. L. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h770 · Cited by 50 · see citing works
Veitonmäki, N., Fuxe, J., Hultdin, M., Roos, G., Pettersson, R. F., & Cao, Y. (2003) · The FASEB Journal · doi:10.1096/fj.02-0599fje · Cited by 49 · see citing works
Superoxide Anions and Endothelial Cell Proliferation in Normoglycemia and Hyperglycemia
Zanetti, M., Zwacka, R. M., Engelhardt, J. F., Katušić, Z. S., & O’Brien, T. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.2.195 · Cited by 48 · see citing works
Xaymardan, M., Zheng, J., Duignan, I. J., Chin, A. I., Holm, J. M., Ballard, V. L. T., & Edelberg, J. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031639 · Cited by 47 · see citing works
Therapeutic Angiogenesis in Diabetes and Hypercholesterolemia: Influence of Oxidative Stress
Boodhwani, M., & Sellke, F. W. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2439 · Cited by 44 · see citing works
Ahluwalia, A., Narula, J., Jones, M. K., Deng, X., & Tarnawski, A. S. (2010) · PubMed · Cited by 43 · see citing works
Rossiter, H. B., Howlett, R. A., Holcombe, H. H., Entin, P. L., Wagner, H. E., & Wagner, P. D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080663 · Cited by 42 · see citing works
Muscle-targeted deletion of VEGF and exercise capacity in mice
Wagner, P. D., Olfert, I. M., Tang, K., & Breen, E. C. (2005) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2005.09.007 · Cited by 40 · see citing works
Telomere attrition and accumulation of senescent cells in cultured human endothelial cells
Hastings, R., Qureshi, M., Verma, R., Lacy, P. S., & Williams, B. (2004) · Cell Proliferation · doi:10.1111/j.1365-2184.2004.00315.x · Cited by 39 · see citing works
ARF Suppresses Tumor Angiogenesis through Translational Control of VEGFA mRNA
Kawagishi, H., Nakamura, H., Maruyama, M., Mizutani, S., Sugimoto, K., Takagi, M., & Sugimoto, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0368 · Cited by 39 · see citing works
The telomerase tale in vascular aging: regulation by estrogens and nitric oxide signaling
Farsetti, A., Grasselli, A., Bacchetti, S., Gaetano, C., & Capogrossi, M. C. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91360.2008 · Cited by 39 · see citing works
Defects in activation of nitric oxide synthases occur during delayed angiogenesis in aging
Bach, M., Sadoun, E., & Reed, M. J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.10.005 · Cited by 38 · see citing works
Hirooka, Y., Eshima, K., Setoguchi, S., Kishi, T., Egashira, K., & Takeshita, A. (2003) · Hypertension Research · doi:10.1291/hypres.26.953 · Cited by 34 · see citing works
Androgens, angiogenesis and cardiovascular regeneration
Sieveking, D. P., Chow, R., & Ng, M. K. C. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283394e20 · Cited by 32 · see citing works
Matsushita, J., Ishihara, M., Inoue, I., Kawagoe, T., Shimatani, Y., Kurisu, S., Nakama, Y., Maruhashi, T., Kagawa, E., Dai, K., et al. (2009) · Japanese Circulation Journal-english Edition · Cited by 31 · see citing works
Stimulation of Coronary Collateral Growth by Granulocyte Stimulating Factor
Carrao, A. C. R., Chilian, W. M., Yun, J. S., Kolz, C. L., Ročić, P., Lehmann, K. E., van den Wijngaard, J. P. H. M., van Horssen, P., Spaan, J. A. E., Ohanyan, V. A., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.186445 · Cited by 27 · see citing works
Dai, J., Zhu, X., Yöder, M. C., Wu, Y., & Colman, R. W. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.222430 · Cited by 26 · see citing works
Leosco, D., Rengo, G., Iaccarino, G., Sanzari, E., Golino, L., Lisa, G. D., Zincarelli, C., Fortunato, F., Ciccarelli, M., Cimini, V., et al. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.5.471 · Cited by 25 · see citing works
Harnessing Hormonal Signaling for Cardioprotection
Ballard, V. L. T., & Edelberg, J. M. (2005) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2005.51.re6 · Cited by 16 · see citing works
Senescence and its bypass in the vascular endothelium
Deborah, A. F. (2005) · Frontiers in bioscience · doi:10.2741/1588 · Cited by 13 · see citing works
VEGF‐D△N△C mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits
Roy, H., Bhardwaj, S., Babu, M., Lähteenvuo, J., & Ylä‐Herttuala, S. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02285.x · Cited by 11 · see citing works
Self-citationPostmenopausal hormone therapy and the risk of cardiovascular disease
Bittner, V. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560903066829 · Cited by 10 · see citing works
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Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919 · see citing works
Aging and age‐related diseases: from mechanisms to therapeutic strategies
Li, Z., Zhang, Z., Ren, Y., Wang, Y., Fang, J., Yue, H., Ma, S., & Guan, F. (2021) · Biogerontology · doi:10.1007/s10522-021-09910-5 · Cited by 668 · see citing works
The Aging Cardiovascular System
Paneni, F., Diaz Cañestro, C., Libby, P., Lüscher, T. F., & Camici, G. G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.064 · Cited by 618 · see citing works
Mechanisms and consequences of endothelial cell senescence
Bloom, S. I., Islam, M. T., Lesniewski, L. A., & Donato, A. J. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00739-0 · Cited by 512 · see citing works
Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases
Kane, A. E., & Sinclair, D. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312498 · Cited by 490 · see citing works
Endothelial dysfunction and angiogenesis impairment in the ageing vasculature
Ungvari, Z. I., Tarantini, S., Kiss, T., Wren, J. D., Giles, C. B., Griffin, C. T., Murfee, W. L., Pacher, P., & Csiszár, A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0030-z · Cited by 478 · see citing works
Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke
Hu, X., Silva, T. M. D., Chen, J., & Faraci, F. M. (2017) · Circulation Research · doi:10.1161/circresaha.116.308427 · Cited by 444 · see citing works
Stem Cells in Wound Healing: The Future of Regenerative Medicine? A Mini-Review
Duscher, D., Barrera, J. A., Wong, V., Maan, Z. N., Whittam, A. J., Januszyk, M., & Gurtner, G. C. (2015) · Gerontology · doi:10.1159/000381877 · Cited by 325 · see citing works
Cai, W., Zhang, K., Li, P., Zhu, L., Xu, J., Yang, B., Hu, X., Lu, Z., & Chen, J. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.006 · Cited by 288 · see citing works
Endothelium and Its Alterations in Cardiovascular Diseases: Life Style Intervention
Favero, G., Paganelli, C., Buffoli, B., Rodella, L. F., & Rezzani, R. (2014) · BioMed Research International · doi:10.1155/2014/801896 · Cited by 251 · see citing works
Han, Y., & Kim, S. Y. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00906-w · Cited by 201 · see citing works
Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
Stojanović, S. D., Fiedler, J., Bauersachs, J., Thum, T., & Sedding, D. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz919 · Cited by 188 · see citing works
Gene expression hallmarks of cellular ageing
Frenk, S., & Houseley, J. M. (2018) · Biogerontology · doi:10.1007/s10522-018-9750-z · Cited by 180 · see citing works
Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity
Trim, W. V., Turner, J. E., & Thompson, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00169 · Cited by 167 · see citing works
Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia
Wang, F., Cao, Y., Ma, L., Pei, H., Rausch, W., & Li, H. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00376 · Cited by 160 · see citing works
Proton Pump Inhibitors Accelerate Endothelial Senescence
Yepuri, G., Sukhovershin, R. A., Nazari‐Shafti, T. Z., Petrascheck, M., Ghebre, Y. T., & Cooke, J. P. (2016) · Circulation Research · doi:10.1161/circresaha.116.308807 · Cited by 156 · see citing works
Kiss, T., Balasubramanian, P., Valcarcel‐Ares, M. N., Tarantini, S., Yabluchanskiy, A., Csípő, T., Lipécz, Á., Reglődi, D., Zhang, X. A., Bari, F., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00074-2 · Cited by 134 · see citing works
Moyamoya Disease and Spectrums of RNF213 Vasculopathy
Bang, O. Y., Chung, J., Kim, D. H., Won, H., Yeon, J. Y., Ki, C., Shin, H. J., Kim, J. S., Hong, S., Kim, D., et al. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00743-6 · Cited by 115 · see citing works
Dragneva, G., Korpisalo, P., & Ylä‐Herttuala, S. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010413 · Cited by 100 · see citing works
The Molecular Adaptive Responses of Skeletal Muscle to High-Intensity Exercise/Training and Hypoxia
Li, J., Li, Y., ATAKAN, M. M., Kuang, J., Hu, Y., Bishop, D. J., & Yan, X. (2020) · Antioxidants · doi:10.3390/antiox9080656 · Cited by 97 · see citing works
Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide
Altaany, Z., Moccia, F., Munaron, L., Mancardi, D., & Wang, R. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140706142930 · Cited by 86 · see citing works
Impaired angiogenesis in ageing: the central role of the extracellular matrix
Xiao, P., Zhang, Y., Zeng, Y., Yang, D., Mo, J., Zheng, Z., Wang, J., Zhang, Y., Zhou, Z., Zhong, X., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04315-z · Cited by 79 · see citing works
Laggner, M., Gugerell, A., Bachmann, C., Hofbauer, H., Vorstandlechner, V., Seibold, M., Lechner, G. G., Peterbauer, A., Madlener, S., Demyanets, S., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1524-2 · Cited by 79 · see citing works
Aging in blood vessels. Medicinal agents FOR systemic arterial hypertension in the elderly
Rubio-Ruiz, M. E., Pérez-Torres, I., Soto, M. E., Pastelı́n, G., & Guarner‐Lans, V. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.001 · Cited by 78 · see citing works
Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels
Bogorad, M. I., DeStefano, J. G., Linville, R. M., Wong, A. D., & Searson, P. C. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19855875 · Cited by 72 · see citing works
Angiogenesis, Cancer, and Vascular Aging
Moriya, J., & Minamino, T. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00065 · Cited by 74 · see citing works
Goswami, A. G., Basu, S., Huda, F., Pant, J., Kar, A. G., Banerjee, T., & Shukla, V. K. (2022) · Growth Factors · doi:10.1080/08977194.2022.2074843 · Cited by 77 · see citing works
Kiss, T., Tarantini, S., Csípő, T., Balasubramanian, P., Nyúl‐Tóth, Á., Yabluchanskiy, A., Wren, J. D., Garman, L., Huffman, D. M., Csiszár, A., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00180-6 · Cited by 73 · see citing works
Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics
Fu, Q., Duan, R., Sun, Y., & Li, Q. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102352 · Cited by 73 · see citing works
Weigel, R., Schilling, L., & Krauss, J. K. (2022) · GeroScience · doi:10.1007/s11357-022-00570-y · Cited by 70 · see citing works
Secretome of Senescent Adipose-Derived Mesenchymal Stem Cells Negatively Regulates Angiogenesis
Ratushnyy, A. Y., Ездакова, М. И., & Buravkova, L. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051802 · Cited by 68 · see citing works
Joshkon, A., Heim, X., Dubrou, C., Bachelier, R., Traboulsi, W., Stalin, J., Fayyad‐Kazan, H., Badran, B. M., Foucault‐Bertaud, A., Leroyer, A. S., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8120633 · Cited by 68 · see citing works
Hadri, K. E., Smith, R., Duplus, E., & Amri, C. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010077 · Cited by 70 · see citing works
Jiang, Y., Li, L., Ma, J., Zhang, L., Niu, F., Feng, T., & Li, C. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.02.009 · Cited by 67 · see citing works
Mechanical regulation of signal transduction in angiogenesis
Flournoy, J., Ashkanani, S., & Chen, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.933474 · Cited by 63 · see citing works
Berkmann, J. C., Herrera, A., Ellinghaus, A., Schlundt, C., Schell, H., Lippens, E., Duda, G. N., Tsitsilonis, S., & Schmidt‐Bleek, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072513 · Cited by 60 · see citing works
Successful aging: insights from proteome analyses of healthy centenarians
Santos‐Lozano, A., Valenzuela, P. L., Llavero, F., Lista, S., Carrera‐Bastos, P., Hampel, H. J., Pareja-Galeano, H., Gálvez, B. G., López, J. A., Vázquez, J., et al. (2020) · Aging · doi:10.18632/aging.102826 · Cited by 56 · see citing works
Endothelial nitric oxide synthase, vascular integrity and human exceptional longevity
Puca, A. A., Carrizzo, A., Ferrario, A., Villa, F., & Vecchione, C. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-26 · Cited by 57 · see citing works
Function, Role, and Clinical Application of MicroRNAs in Vascular Aging
Lin, X., Zhan, J., Wang, Y., Tan, P., Chen, Y., Deng, H., & Liu, Y. (2016) · BioMed Research International · doi:10.1155/2016/6021394 · Cited by 59 · see citing works
Growth Differentiation Factor 11 Promotes Neurovascular Recovery After Stroke in Mice
Lu, L., Bai, X., Cao, Y., Luo, H., Yang, X., Kang, L., Shi, M.-J., Fan, W., & Zhao, B. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00205 · Cited by 57 · see citing works
Toya, T., Ahmad, A., Attia, Z. I., Cohen, M. S., Ӧzcan, I., Noseworthy, P. A., López-Jiménez, F. A., Kapa, S., Lerman, L. O., Friedman, P. A., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.018656 · Cited by 57 · see citing works
Blood–Brain Barrier Transporters: Opportunities for Therapeutic Development in Ischemic Stroke
Nilles, K. L., Williams, E. I., Betterton, R. D., Davis, T. P., & Ronaldson, P. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031898 · Cited by 56 · see citing works
The role of TGFβ1 and LRG1 in cardiac remodelling and heart failure
Song, W., & Wang, X. (2015) · Biophysical Reviews · doi:10.1007/s12551-014-0158-y · Cited by 57 · see citing works
El‐Khattouti, A., Hassan, M., & Gómez, C. R. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00158 · Cited by 56 · see citing works
l-Leucine and NO-mediated cardiovascular function
Yang, Y., Wu, Z., Meininger, C. J., & Wu, G. (2014) · Amino Acids · doi:10.1007/s00726-014-1904-y · Cited by 52 · see citing works
Molecular pathways of arterial aging
Paneni, F., Costantino, S., & Cosentino, F. (2014) · Clinical Science · doi:10.1042/cs20140302 · Cited by 52 · see citing works
New insights into RhoA/Rho-kinase signaling: a key regulator of vascular contraction
Nunes, K. P., & Webb, R. C. (2020) · Small GTPases · doi:10.1080/21541248.2020.1822721 · Cited by 51 · see citing works
Potential of Polyphenols to Restore SIRT1 and NAD+ Metabolism in Renal Disease
Tovar‐Palacio, C., Noriega, L. G., & Mercado, A. (2022) · Nutrients · doi:10.3390/nu14030653 · Cited by 51 · see citing works
Banga, A., Mohanka, M. R., Mullins, J., Bollineni, S., Kaza, V., Ring, S., Bajona, P., Peltz, M., Wait, M. A., & Torres, F. (2016) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2016.07.020 · Cited by 51 · see citing works
Exosomes for angiogenesis induction in ischemic disorders
Moeinabadi‐Bidgoli, K., Rezaee, M., Hossein‐Khannazer, N., Babajani, A., Aghdaei, H. A., Arki, M. K., Afaghi, S., Niknejad, H., & Vosough, M. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17689 · Cited by 49 · see citing works
Understanding angiogenesis during aging: opportunities for discoveries and new models
Hodges, N. A., Suarez‐Martinez, A. D., & Murfee, W. L. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00112.2018 · Cited by 50 · see citing works
Kiss, T., Nyúl‐Tóth, Á., Gulej, R., Tarantini, S., Csípő, T., Mukli, P., Ungvari, A., Balasubramanian, P., Yabluchanskiy, A., Benyó, Z., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00519-1 · Cited by 48 · see citing works
Moccia, F. D., Dragoni, S., Cinelli, M., Montagnani, S., Amato, B., Rosti, V., Guerra, G., & Tanzi, F. (2013) · BMC Surgery · doi:10.1186/1471-2482-13-s2-s46 · Cited by 49 · see citing works
Endostatin and kidney fibrosis in aging: a case for antagonistic pleiotropy?
Lin, C. H. S., Chen, J., Ziman, B. D., Marshall, S. A., Maizel, J., & Goligorsky, M. S. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00064.2014 · Cited by 47 · see citing works
CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis
Ghimire, K., Li, Y., Chiba, T., Julovi, S. M., Li, J. S. Y., Ross, M. A., Straub, A. C., O’Connell, P. J., Rüegg, C., Pagano, P. J., et al. (2020) · Cells · doi:10.3390/cells9071695 · Cited by 47 · see citing works
Mechanisms and Consequences of Injury and Repair in Older Organ Transplants
Slegtenhorst, B. R., Dor, F. J. M. F., Elkhal, A., Biefer, H. R. C., Yang, X., Edtinger, K., Quante, M., Chong, A. S., & Tullius, S. G. (2014) · Transplantation · doi:10.1097/tp.0000000000000072 · Cited by 45 · see citing works
He, L., Kernogitski, Y., Culminskaya, I. V., Loika, Y., Arbeev, K. G., Loiko, E., Bagley, O., Duan, M., Yashkin, A. P., Ukraintseva, S. V., et al. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00179 · Cited by 45 · see citing works
Interstitial pericytes decrease in aged mouse kidneys
Stefańska, A., Eng, D. G., Kaverina, N. V., Duffield, J. S., Pippin, J. W., Rabinovitch, P. S., & Shankland, S. J. (2015) · Aging · doi:10.18632/aging.100756 · Cited by 44 · see citing works
Mammoto, T., Torisawa, Y.-S., Muyleart, M., Hendee, K., Anugwom, C., Gutterman, D., & Mammoto, A. (2019) · Aging · doi:10.18632/aging.102236 · Cited by 43 · see citing works
The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs
Costanzo, L., Soto, B., Meier, R., & Geraghty, P. M. (2022) · Pulmonary Medicine · doi:10.1155/2022/3632764 · Cited by 43 · see citing works
Epigenetics and cardiovascular regenerative medicine in the elderly
Costantino, S., Camici, G. G., Mohammed, S. A., Volpe, M., Lüscher, T. F., & Paneni, F. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.09.188 · Cited by 43 · see citing works
Adipose tissue macrophages in aging-associated adipose tissue function
Lu, B., Huang, L., Cao, J., Li, L., Wu, W., Chen, X., & Ding, C. (2021) · The Journal of Physiological Sciences · doi:10.1186/s12576-021-00820-2 · Cited by 42 · see citing works
Bernardo-Castro, S., Sousa, J. A., Martins, E., Donato, H., Nunes, C., d’Almeida, O. C., Castelo-Branco, M. S., Abrunhosa, A., Ferreira, L., & Sargento‐Freitas, J. (2023) · International Journal of Stroke · doi:10.1177/17474930231166306 · Cited by 42 · see citing works
Aging Impairs VEGF-Mediated, Androgen-Dependent Regulation of Angiogenesis
Lecce, L., Lam, Y. T., Lindsay, L. A., Yuen, S. C. G., Simpson, P. J. L., Handelsman, D. J., & Ng, M. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1405 · Cited by 41 · see citing works
Angiogenesis: focusing on the effects of exercise in aging and cancer
Kwak, S.-E., Lee, J., Zhang, D., & Song, W. J. (2018) · Physical Activity and Nutrition · doi:10.20463/jenb.2018.0020 · Cited by 37 · see citing works
Brandt, M. M., Cheng, C., Merkus, D., Duncker, D. J., & Sorop, O. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.771960 · Cited by 37 · see citing works
Valli, A., Harris, A. L., & Kessler, B. M. (2015) · Aging · doi:10.18632/aging.100782 · Cited by 37 · see citing works
González‐King, H., Gonçalves‐Rodrigues, P., Albery, T., Tangruksa, B., Gurrapu, R., da Silva, A. M., Musa, G., Kardasz, D., Liu, K., Kull, B., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12445 · Cited by 36 · see citing works
Li, Y., Kračun, D., Dustin, C. M., Massry, M. E., Yuan, S. S., Goossen, C., DeVallance, E., Sahoo, S., Hilaire, C. S., Gurkar, A. U., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015666118 · Cited by 36 · see citing works
Mesenchymal Stem/Stromal Cells for Therapeutic Angiogenesis
Yusoff, F. M., & Higashi, Y. (2023) · Cells · doi:10.3390/cells12172162 · Cited by 35 · see citing works
Molecular aspects of the cardioprotective effect of exercise in the elderly
Rengo, G., Parisi, V., Femminella, G. D., Pagano, G., de Lucia, C., Cannavò, A., Liccardo, D., Giallauria, F., Scala, O., Zincarelli, C., et al. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0117-7 · Cited by 35 · see citing works
Muscle weakness during aging: a deficiency state involving declining angiogenesis
Ambrose, C. T. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.03.005 · Cited by 36 · see citing works
Comparing Aging and Fitness Effects on Brain Anatomy
Fletcher, M. A., Low, K. A., Boyd, R., Zimmerman, B., Gordon, B. A., Tan, C. H., Schneider‐Garces, N., Sutton, B. P., Gratton, G., & Fabiani, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00286 · Cited by 33 · see citing works
Wang, G., Han, B., Zhang, R., Liu, Q., Wang, X., Huang, X., Liu, D., Qiao, W., Yang, M., Luo, X., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.758792 · Cited by 33 · see citing works
MW Laschke, C. G., Laschke, M. W., Gräßer, C., Kleer, S., Scheuer, C., Eglin, D., Alini, M., & Menger, M. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a20 · Cited by 33 · see citing works
Song, B. X., Azhar, L., Koo, G. K., Marzolini, S., Gallagher, D., Swardfager, W., Chen, C. C., Ba, J., Herrmann, N., & Lanctôt, K. L. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.12.004 · Cited by 33 · see citing works
Schwartzman, J. D., McCall, M., Ghattas, Y. S., Pugazhendhi, A. S., Wei, F., Ngo, C., Ruiz, J., Seal, S., & Coathup, M. J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122683 · Cited by 32 · see citing works
Forearm ischemia decreases endothelial colony-forming cell angiogenic potential
Mauge, L., Sabatier, F., Boutouyrie, P., d’Audigier, C., Peyrard, S., Bozec, E., Blanchard, A., Azizi, M., Dizier, B., Dignat‐George, F., et al. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2013.09.007 · Cited by 31 · see citing works
Martín-Pardillos, A., Sosa, C., & Sorribas, V. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs313 · Cited by 30 · see citing works
Gete, Y. G., Koblan, L. W., Mao, X., Trappio, M., Mahadik, B. P., Fisher, J. P., Liu, D. R., & Cao, K. (2021) · Aging Cell · doi:10.1111/acel.13388 · Cited by 29 · see citing works
Aziz, T. A., Nadeem, A. A., Sarwar, A., Perveen, I., Hussain, N., Khan, A. A., Daudzai, Z., Cui, H., & Lin, L. (2023) · Biomedicines · doi:10.3390/biomedicines11020354 · Cited by 30 · see citing works
Endothelial Senescence and Its Impact on Angiogenesis in Alzheimer’s Disease
Georgieva, I., Tchekalarova, J. D., Iliev, D. B., & Tzoneva, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411344 · Cited by 29 · see citing works
Rao, S., He, Z., Wang, Z., Yin, H., Hu, X., Tan, Y., Wan, T., Zhu, H., Luo, Y., Wang, X., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.009 · Cited by 29 · see citing works
MicroRNA-21 (miR-21) in breast cancer: From apoptosis dysregulation to therapeutic opportunities
Syed, R. U., Banu, H., Alshammrani, A., Alshammari, M. D., Satheesh Kumar, G., Kadimpati, K. K., Khalifa, A. A. S., Aboshouk, N. A. M., Almarir, A. M., Hussain, A., et al. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155572 · Cited by 29 · see citing works
Paneni, F., Costantino, S., Kränkel, N., Cosentino, F., & Lüscher, T. F. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw073 · Cited by 29 · see citing works
Izzicupo, P., D’Amico, M. A., Blasio, A. D., Napolitano, G., Nakamura, F. Y., Baldassarre, A. D., & Ghinassi, B. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00363 · Cited by 29 · see citing works
Zhao, Y. G., Xie, Y., & Liu, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.949074 · Cited by 29 · see citing works
The endothelium in lung fibrosis: a core signaling hub in disease pathogenesis?
Fließer, E., Lins, T., Berg, J. L., Kolb, M. R. J., & Kwapiszewska, G. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00097.2023 · Cited by 29 · see citing works
Therapeutic potential of nitric oxide in vascular aging due to the promotion of angiogenesis
Zhang, J., Li, C., Zhang, Y., Wu, J., & Huang, Z. (2023) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14248 · Cited by 28 · see citing works
Qi, L., Hong, S., Zhao, T., Yan, J., Ge, W., Wang, J., Fang, X., Jiang, W., Shen, S. G., & Zhang, L. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401275 · Cited by 28 · see citing works
Cell non-autonomous regulation of cerebrovascular aging processes by the somatotropic axis
Bickel, M. A., Csík, B., Gulej, R., Ungvari, A., Nyúl‐Tóth, Á., & Conley, S. M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1087053 · Cited by 28 · see citing works
Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction
Hansen, C. E., Vacondio, D., van der Molen, L., Jüttner, A. A., Fung, W. K., Karsten, M., van het Hof, B., Fontijn, R. D., Kooij, G., Witte, M. E., et al. (2025) · Cell Death & Disease · doi:10.1038/s41419-024-07306-0 · Cited by 27 · see citing works
UNC5B Promotes Vascular Endothelial Cell Senescence via the ROS‐Mediated P53 Pathway
Yang, Z. L., Li, H., Luo, P., Yan, D., Yang, N., Zhang, Y., Huang, Y., Liu, Y., Zhang, L., Yan, J., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5546711 · Cited by 27 · see citing works
Palmer, A., Epton, S., Crawley, E., Straface, M., Gammon, L., Edgar, M. M., Xu, Y., Elahi, S., Chin‐Aleong, J., Martin, J. E., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.747067 · Cited by 27 · see citing works
Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia
Callahan, C. M., Apostolova, L. G., Gao, S., Risacher, S. L., Case, J., Saykin, A. J., Lane, K. A., Swinford, C. G., & Yöder, M. C. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191293 · Cited by 26 · see citing works
Díaz‐Flores, L., Gutiérrez, R., García, M. P., González‐Gómez, M., Díaz-Flores, L., Carrasco, J. L., Madrid, J. F., & Bello, A. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169010 · Cited by 26 · see citing works
Gallego, I., Villate-Beitia, I., del Burgo, L. S., Puras, G., & Pedraz, J. L. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000418 · Cited by 25 · see citing works
Duan, C., Hu, J., Zhao, J., Sheng, X., Li, C., Qin, T., He, R., Dai, G., Cao, Y. B., & Lü, H. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.360245 · Cited by 24 · see citing works
Vascular ageing in hypertension: Focus on mitochondria
Forte, M., Stanzione, R., Cotugno, M., Bianchi, F., Marchitti, S., & Rubattu, S. D. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111267 · Cited by 26 · see citing works
Pourheydar, B., Biabanghard, A., Azari, R., Khalaji, N., & Chodari, L. (2020) · Journal of Cardiovascular and Thoracic Research · doi:10.34172/jcvtr.2020.21 · Cited by 24 · see citing works
- Authors
- Lähteenvuo, J., & Rosenzweig, A.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- ORCID
- Rosenzweig, Anthony
- Venue
- Circulation Research
- Published
- 2012-04-27
- Volume
- 110
- Issue
- 9
- Pages
- 1252-1264
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC4101916
- OpenAlex
- W2049206418
- Cited by
- 292
- References
- 171
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 28 · 2023: 34 · 2022: 32 · 2021: 31 · 2020: 23 · 2019: 21 · 2018: 18 · 2017: 15 · 2016: 16 · 2015: 10 · 2014: 12 · 2013: 11 · 2012: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Circulation Research
- Funders
- Fondation Leducq
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL110733)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- aging, angiogenesis, endothelial dysfunction, cardiovascular disease, ischemic injury, vascular repair, therapeutic angiogenesis, elderly patients
- MeSH terms
- Age Factors, Aging, Animals, Cardiovascular Diseases, Humans, Nitric Oxide, Risk Factors, Signal Transduction, Cellular Senescence, Oxidative Stress, Neovascularization, Physiologic, Angiogenic Proteins, Cyclin-Dependent Kinase Inhibitor Proteins
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