Cited by 292Angiogenesis and VEGF in CancerNitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Effects of aging on angiogenesis

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Lähteenvuo, Johanna, Rosenzweig, Anthony·2012·Circulation Research

Abstract

Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse sequelae in the elderly. Angiogenesis is both an essential adaptive response to physiological stress and an endogenous repair mechanism after ischemic injury. In addition, induction of angiogenesis is a promising therapeutic approach for ischemic diseases. For these reasons, understanding the basis of age-related impairment of angiogenesis and endothelial function has important implications for understanding and managing cardiovascular disease. In this review, we discuss the molecular mechanisms that contribute to impaired angiogenesis in the elderly and potential therapeutic approaches to improving vascular function and angiogenesis in aging patients.

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Crossref · 10.1161/circresaha.111.246116

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  • Endothelial cell senescence directly compromises the endothelial barrier through disruption of cellular proliferation, permeability, and motility, possibly contributing to endothelial erosion and intra-plaque haemorrhage.

    “Endothelial cell senescence directly compromised the endothelial barrier through disruption of cellular proliferation, permeability, and motility,112–114 possibly contributing to endothelial erosion and intra-plaque haemorrhage.”

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Authors
Lähteenvuo, J., & Rosenzweig, A.
Affiliations
Beth Israel Deaconess Medical Center (US)
Venue
Circulation Research
Published
2012-04-27
Volume
110
Issue
9
Pages
1252-1264
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
OpenAlex
W2049206418
Cited by
292
References
171
Citations by year
2026: 13 · 2025: 25 · 2024: 28 · 2023: 34 · 2022: 32 · 2021: 31 · 2020: 23 · 2019: 21 · 2018: 18 · 2017: 15 · 2016: 16 · 2015: 10 · 2014: 12 · 2013: 11 · 2012: 3
FWCI
1.05
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Circulation Research
Funders
  • Fondation Leducq
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL110733)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
aging, angiogenesis, endothelial dysfunction, cardiovascular disease, ischemic injury, vascular repair, therapeutic angiogenesis, elderly patients
MeSH terms
Age Factors, Aging, Animals, Cardiovascular Diseases, Humans, Nitric Oxide, Risk Factors, Signal Transduction, Cellular Senescence, Oxidative Stress, Neovascularization, Physiologic, Angiogenic Proteins, Cyclin-Dependent Kinase Inhibitor Proteins

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