Microvascular oxygen pressures in muscles comprised of different fiber types: Impact of dietary nitrate supplementation

Ferguson, Scott K.; Holdsworth, Clark T.; Wright, Jennifer L.; Fees, Alex J.; Allen, Jason D.; Jones, Andrew M.; Musch, Timothy I.; Poole, David C.

doi:10.1016/j.niox.2014.09.157

Cited by 120Cardiovascular and exercise physiologyNitric Oxide and Endothelin EffectsExercise and Physiological Responses

Microvascular oxygen pressures in muscles comprised of different fiber types: Impact of dietary nitrate supplementation

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Ferguson, Scott K., Holdsworth, Clark T., Wright, Jennifer L., Fees, Alex J., Allen, Jason D., Jones, Andrew M., Musch, Timothy I., Poole, David C.·2015·Nitric Oxide

DOI 10.1016/j.niox.2014.09.157PMC PMC4383717

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Abstract

Nitrate (NO3(-)) supplementation via beetroot juice (BR) preferentially improves vascular conductance and O2 delivery to contracting skeletal muscles comprised predominantly of type IIb + d/x (i.e. highly glycolytic) fibers following its reduction to nitrite and nitric oxide (NO). To address the mechanistic basis for NO3(-) to improve metabolic control we tested the hypothesis that BR supplementation would elevate microvascular PO2 (PO2mv) in fast twitch but not slow twitch muscle. Twelve young adult male Sprague-Dawley rats were administered BR ([NO3(-)] 1 mmol/kg/day, n = 6) or water (control, n = 6) for 5 days. PO2mv (phosphorescence quenching) was measured at rest and during 180 s of electrically-induced 1-Hz twitch contractions (6-8 V) of the soleus (9% type IIb +d/x) and mixed portion of the gastrocnemius (MG, 91% type IIb + d/x) muscles. In the MG, but not the soleus, BR elevated contracting steady state PO2mv by ~43% (control: 14 ± 1, BR: 19 ± 2 mmHg (P < 0.05)). This higher PO2mv represents a greater blood-myocyte O2 driving force during muscle contractions thus providing a potential mechanism by which NO3(-) supplementation via BR improves metabolic control in fast twitch muscle. Recruitment of higher order type II muscle fibers is thought to play a role in the development of the VO2 slow component which is inextricably linked to the fatigue process. These data therefore provide a putative mechanism for the BR-induced improvements in high-intensity exercise performance seen in humans.

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Dietary nitrate may specifically enhance the physiological responses of type II, and not type I, muscle fibers to exercise.
“Given that dietary NO 3 -may specifically enhance the physiological responses of type II, and not type I, muscle fibers to exercise (42,43,53,64)”
From Dietary Nitrate and Physical Performance (2018) · cites this paper as [43]

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Coggan, A. R., Broadstreet, S. R., Mikhalkova, D., Bole, I., Leibowitz, J. L., Kadkhodayan, A., Park, S., Thomas, D. P., Thies, D., & Peterson, L. R. (2018) · Physiological Reports · doi:10.14814/phy2.13575 · Cited by 66 · see citing works
Effect of Beetroot Juice Supplementation on Mood, Perceived Exertion, and Performance During a 30-Second Wingate Test
Jodra, P., Domínguez, R., Sánchez-Oliver, A. J., Veiga-Herreros, P., & Bailey, S. J. (2019) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2019-0149 · Cited by 65 · see citing works
A Single Dose of Dietary Nitrate Increases Maximal Knee Extensor Angular Velocity and Power in Healthy Older Men and Women
Coggan, A. R., Hoffman, R. L., Gray, D. A., Moorthi, R. N., Thomas, D. P., Leibowitz, J. L., Thies, D., & Peterson, L. R. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz156 · Cited by 59 · see citing works
Acute ingestion of dietary nitrate increases muscle blood flow via local vasodilation during handgrip exercise in young adults
Richards, J. C., Racine, M. L., Hearon, C. M., Kunkel, M. J., Luckasen, G. J., Larson, D. G., Allen, J. D., & Dinenno, F. A. (2018) · Physiological Reports · doi:10.14814/phy2.13572 · Cited by 58 · see citing works
Self-citation
On the mechanism by which dietary nitrate improves human skeletal muscle function
Affourtit, C., Bailey, S. J., Jones, A. M., Smallwood, M. J., & Winyard, P. G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00211 · Cited by 58 · see citing works
Self-citation
Can elite athletes benefit from dietary nitrate supplementation?
Jonvik, K. L., Nyakayiru, J., van Loon, L. J. C., & Verdijk, L. B. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00232.2015 · Cited by 55 · see citing works
Influence of dietary nitrate supplementation on physiological and muscle metabolic adaptations to sprint interval training
Thompson, C., Wylie, L. J., Blackwell, J. R., Fulford, J., Black, M. I., Kelly, J., McDonagh, S. T. J., Carter, J., Bailey, S. J., Vanhatalo, A., et al. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00909.2016 · Cited by 51 · see citing works
Self-citation
Dietary nitrate supplementation enhances high-intensity running performance in moderate normobaric hypoxia, independent of aerobic fitness
Shannon, O. M., Duckworth, L., Barlow, M. J., Woods, D., Lara, J., Siervo, M., & O'Hara, J. P. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.08.001 · Cited by 51 · see citing works
Incubation with sodium nitrite attenuates fatigue development in intact single mouse fibres at physiological
Bailey, S. J., Gandra, P. G., Jones, A. M., Hogan, M. C., & Nogueira, L. (2019) · The Journal of Physiology · doi:10.1113/jp278494 · Cited by 51 · see citing works
Self-citation
Dietary nitrate supplementation in cardiovascular health: an ergogenic aid or exercise therapeutic?
Woessner, M. N., McIlvenna, L. C., Ortiz de Zevallos, J., Neil, C. J., & Allen, J. D. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00414.2017 · Cited by 50 · see citing works
Self-citation
Chronic high-dose beetroot juice supplementation improves time trial performance of well-trained cyclists in normoxia and hypoxia
Rokkedal-Lausch, T., Franch, J., Poulsen, M. K., Thomsen, L. P., Weitzberg, E., Kamavuako, E. N., Karbing, D. S., & Larsen, R. G. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.01.011 · Cited by 46 · see citing works
Dietary nitrate supplementation: impact on skeletal muscle vascular control in exercising rats with chronic heart failure
Ferguson, S. K., Holdsworth, C. T., Colburn, T. D., Wright, J. L., Craig, J. C., Fees, A. J., JONES, A. M., Allen, J. D., Musch, T. I., & Poole, D. C. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00014.2016 · Cited by 45 · see citing works
Self-citation
Effects of Beetroot Juice Ingestion on Physical Performance in Highly Competitive Tennis Players
López‐Samanes, Á., Pérez‐López, A., Moreno-Pérez, V., Nakamura, F. Y., Acebes-Sánchez, J., Quintana-Milla, I., Sánchez-Oliver, A. J., Moreno‐Pérez, D., Fernández-Elías, V. E., & Domínguez, R. (2020) · Nutrients · doi:10.3390/nu12020584 · Cited by 43 · see citing works
Edward F. Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction
Poole, D. C. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00013.2019 · Cited by 43 · see citing works
Self-citation
Time course of human skeletal muscle nitrate and nitrite concentration changes following dietary nitrate ingestion
Kadach, S., Piknova, B., Black, M. I., Park, J. W., Wylie, L. J., Stoyanov, Z., Thomas, S. M., McMahon, N. F., Vanhatalo, A., Schechter, A. N., et al. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.01.003 · Cited by 42 · see citing works
Self-citation
“Beet-ing” the Mountain: A Review of the Physiological and Performance Effects of Dietary Nitrate Supplementation at Simulated and Terrestrial Altitude
Shannon, O. M., McGawley, K., Nybäck, L., Duckworth, L. C., Barlow, M., Woods, D. R., Siervo, M., & O'Hara, J. P. (2017) · Sports Medicine · doi:10.1007/s40279-017-0744-9 · Cited by 40 · see citing works
Prior exercise speeds pulmonary oxygen uptake kinetics and increases critical power during supine but not upright cycling
Goulding, R. P., Roche, D. M., & Marwood, S. (2017) · Experimental Physiology · doi:10.1113/ep086304 · Cited by 39 · see citing works
Dietary nitrate and population health: a narrative review of the translational potential of existing laboratory studies
Shannon, O. M., Easton, C., Shepherd, A. I., Siervo, M., Bailey, S. J., & Clifford, T. (2021) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-021-00292-2 · Cited by 40 · see citing works
The Effect of Beetroot Ingestion on High-Intensity Interval Training: A Systematic Review and Meta-Analysis
Wong, T. H., Sim, A., & Burns, S. F. (2021) · Nutrients · doi:10.3390/nu13113674 · Cited by 38 · see citing works
Physical activity-induced remodeling of vasculature in skeletal muscle: role in treatment of type 2 diabetes
Laughlin, M. H. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00789.2015 · Cited by 33 · see citing works
Effect of beetroot juice supplementation on 10-km performance in recreational runners
de Castro, T. F., Manoel, F. D. A., Figueiredo, D. H., Figueiredo, D. H., & Machado, F. A. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0277 · Cited by 33 · see citing works
Beetroot Juice Does Not Enhance Supramaximal Intermittent Exercise Performance in Elite Endurance Athletes
Pawlak‐Chaouch, M., Boissière, J., Munyaneza, D., Gamelin, F.-X., Cuvelier, G., Berthoin, S., & Aucouturier, J. (2019) · Journal of the American College of Nutrition · doi:10.1080/07315724.2019.1601601 · Cited by 33 · see citing works
Peripheral and pulmonary effects of inorganic nitrite during exercise in heart failure with preserved ejection fraction
Reddy, Y. N. V., Stewart, G. M., Obokata, M., Koepp, K. E., & Borlaug, B. A. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2093 · Cited by 33 · see citing works
Discrete physiological effects of beetroot juice and potassium nitrate supplementation following 4-wk sprint interval training
Thompson, C., Vanhatalo, A., Kadach, S., Wylie, L. J., Fulford, J., Ferguson, S. K., Blackwell, J. R., Bailey, S. J., & Jones, A. M. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00047.2018 · Cited by 32 · see citing works
Self-citation
Effects of Citrulline Malate and Beetroot Juice Supplementation on Blood Flow, Energy Metabolism, and Performance During Maximum Effort Leg Extension Exercise
Trexler, E. T., Keith, D. S., Schwartz, T. A., Ryan, E. D., Stoner, L. R., Persky, A. M., & Smith‐Ryan, A. E. (2019) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003286 · Cited by 33 · see citing works
Beetroot juice ingestion during prolonged moderate-intensity exercise attenuates progressive rise in O2 uptake
Tan, R., Wylie, L. J., Thompson, C., Blackwell, J. R., Bailey, S. J., Vanhatalo, A., & JONES, A. M. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01006.2017 · Cited by 31 · see citing works
Self-citation
Transcapillary PO2 gradients in contracting muscles across the fibre type and oxidative continuum
Colburn, T. D., Hirai, D. M., Craig, J. C., Ferguson, S. K., Weber, R. E., Schulze, K. M., Behnke, B. J., Musch, T. I., & Poole, D. C. (2020) · The Journal of Physiology · doi:10.1113/jp279608 · Cited by 29 · see citing works
Self-citation
Effects of Beetroot Juice Supplementation on Cognitive Function, Aerobic and Anaerobic Performances of Trained Male Taekwondo Athletes: A Pilot Study
Miraftabi, H., Avazpoor, Z., Berjisian, E., Sarshin, A., Rezaei, S., Domínguez, R., Reale, R., Franchini, É., Samanipour, M. H., Koozehchian, M., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph181910202 · Cited by 29 · see citing works
The Effects of Multi-Day vs. Single Pre-exercise Nitrate Supplement Dosing on Simulated Cycling Time Trial Performance and Skeletal Muscle Oxygenation
Jo, E., Fischer, M., Auslander, A. T., Beigarten, A., Daggy, B. P., Hansen, K., Kessler, L., Osmond, A. D., Wang, H., & Wes, R. (2017) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001958 · Cited by 27 · see citing works
Differential vascular reactivity responses acutely following ingestion of a nitrate rich red spinach extract
Haun, C. T., Kephart, W. C., Holland, A. M., Mobley, C. B., McCloskey, A. E., Shake, J. J., Pascoe, D. D., Roberts, M. D., & Martin, J. S. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3478-8 · Cited by 26 · see citing works
Skeletal Muscle Vascular Control During Exercise
Ferguson, S. K., Glean, A. A., Holdsworth, C. T., Wright, J. L., Fees, A. J., Colburn, T. D., Stäbler, T., Allen, J. D., JONES, A. M., Musch, T. I., et al. (2015) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248415599061 · Cited by 25 · see citing works
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Impact of Acute Dietary Nitrate Supplementation during Exercise in Hypertensive Women
Caldwell, J. T., Sutterfield, S. L., Post, H. K., Craig, J. C., Baumfalk, D. R., Copp, S. W., & Ade, C. J. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001857 · Cited by 25 · see citing works
Effects of nitrite infusion on skeletal muscle vascular control during exercise in rats with chronic heart failure
Glean, A. A., Ferguson, S. K., Holdsworth, C. T., Colburn, T. D., Wright, J. L., Fees, A. J., Hageman, K. S., Poole, D. C., & Musch, T. I. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00421.2015 · Cited by 24 · see citing works
Self-citation
Whole beetroot consumption reduces systolic blood pressure and modulates diversity and composition of the gut microbiota in older participants
Capper, T. E., Houghton, D., Stewart, C. J., Blain, A. P., McMahon, N. F., Siervo, M., West, D. J., & Stevenson, E. (2020) · NFS Journal · doi:10.1016/j.nfs.2020.08.001 · Cited by 24 · see citing works
Effect of dietary nitrate ingestion on muscular performance: a systematic review and meta-analysis of randomized controlled trials
Álvares, T. S., de Oliveira, G. V., Volino‐Souza, M., Conte‐Júnior, C. A., & Murias, J. M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1884040 · Cited by 26 · see citing works
Influence of muscle oxygenation and nitrate-rich beetroot juice supplementation on O2 uptake kinetics and exercise tolerance
Cocksedge, S. P., Breese, B. C., Morgan, P. T., Nogueira, L., Thompson, C., Wylie, L. J., JONES, A. M., & Bailey, S. J. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.03.007 · Cited by 23 · see citing works
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Acute ingestion of beetroot juice does not improve short-duration repeated sprint running performance in male team sport athletes
Reynolds, C. M. E., Evans, M., Halpenny, C., Hughes, C., Jordan, S., Quinn, A., Hone, M., & Egan, B. (2020) · Journal of Sports Sciences · doi:10.1080/02640414.2020.1770409 · Cited by 22 · see citing works
Control of rat muscle nitrate levels after perturbation of steady state dietary nitrate intake
Park, J. W., Thomas, S. M., Schechter, A. N., & Piknova, B. (2021) · Nitric Oxide · doi:10.1016/j.niox.2021.03.003 · Cited by 22 · see citing works
Effects of inorganic nitrate supplementation on cardiovascular function and exercise tolerance in heart failure
Ferguson, S. K., Woessner, M. N., Holmes, M. J., Belbis, M. D., Carlström, M., Weitzberg, E., Allen, J. D., & Hirai, D. M. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00780.2020 · Cited by 21 · see citing works
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Sex differences in the effects of inorganic nitrate supplementation on exercise economy and endurance capacity in healthy young adults
de Zevallos, J. O., Hogwood, A. C., Kruse, K., Guzman, J. D., Buckley, M., WELTMAN, A. L., & Allen, J. D. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00220.2023 · Cited by 20 · see citing works
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Effect of acute nitrate and citrulline supplementation on muscle microvascular response to ischemia–reperfusion in healthy humans
Roux‐Mallouf, T. L., Vibert, F., Doutreleau, S., & Vergès, S. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0081 · Cited by 20 · see citing works
Supplementary Nitric Oxide Donors and Exercise as Potential Means to Improve Vascular Health in People with Type 1 Diabetes: Yes to NO?
McCarthy, O. M., Moser, O., Eckstein, M. L., Bain, S. C., Pitt, J. P., & Bracken, R. M. (2019) · Nutrients · doi:10.3390/nu11071571 · Cited by 19 · see citing works
Critical Power
Craig, J. C., Vanhatalo, A., Burnley, M., JONES, A. M., & Poole, D. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814593-7.00008-6 · Cited by 18 · see citing works
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Skeletal muscle as a reservoir for nitrate and nitrite: The role of xanthine oxidase reductase (XOR)
de Zevallos, J. O., Woessner, M. N., & Kelley, E. E. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.10.004 · Cited by 19 · see citing works
Influence of Beetroot Juice Ingestion on Neuromuscular Performance on Semi-Professional Female Rugby Players: A Randomized, Double-Blind, Placebo-Controlled Study
López‐Samanes, Á., Ramos-Álvarez, J. J., Miguel‐Tobal, F., Gaos, S., Jiménez, P. J., Arranz-Muñoz, R., Domínguez, R., & Montoya, J. J. (2022) · Foods · doi:10.3390/foods11223614 · Cited by 19 · see citing works
Acute dietary nitrate supplementation does not attenuate oxidative stress or the hemodynamic response during submaximal exercise in hypobaric hypoxia
Carriker, C. R., Rombach, P., Stevens, B. M., Vaughan, R. A., & Gibson, A. L. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0813 · Cited by 18 · see citing works
Effects of Beetroot Juice on Physical Performance in Professional Athletes and Healthy Individuals: An Umbrella Review
Tian, C., Jiang, Q., Han, M., Guo, L., Huang, R., Zhao, L., & Mao, S. (2025) · Nutrients · doi:10.3390/nu17121958 · Cited by 16 · see citing works
Effects of chronic beetroot juice supplementation on maximum oxygen uptake, velocity associated with maximum oxygen uptake, and peak velocity in recreational runners: a double-blinded, randomized and crossover study
de Castro, T. F., Manoel, F. D. A., Figueiredo, D. H., Figueiredo, D. H., & Machado, F. A. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04094-w · Cited by 17 · see citing works
Dietary nitrate supplementation opposes the elevated diaphragm blood flow in chronic heart failure during submaximal exercise
Smith, J. R., Ferguson, S. K., Hageman, K. S., Harms, C. A., Poole, D. C., & Musch, T. I. (2017) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2017.09.017 · Cited by 16 · see citing works
Self-citation
The acute effects of exercise intensity and inorganic nitrate supplementation on vascular health in females after menopause
Hogwood, A. C., de Zevallos, J. O., Weeldreyer, N. R., Clark, J. R., Mazzella, V., Cain, L., Myaing, D., Love, K. M., WELTMAN, A. L., & Allen, J. D. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00559.2023 · Cited by 14 · see citing works
Self-citation
The effect of dietary nitrate on exercise capacity in chronic kidney disease: a randomized controlled pilot study
Ramick, M. G., Kirkman, D. L., Stock, J. M., Muth, B. J., Farquhar, W. B., Chirinos, J. A., Doulias, P.-T., Ischiropoulos, H., & Edwards, D. G. (2021) · Nitric Oxide · doi:10.1016/j.niox.2020.10.002 · Cited by 14 · see citing works
The effects of inorganic nitrate supplementation on exercise economy and endurance capacity across the menstrual cycle
Hogwood, A. C., de Zevallos, J. O., Kruse, K., Guzman, J. C. D., Buckley, M., WELTMAN, A. L., & Allen, J. D. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00221.2023 · Cited by 14 · see citing works
Self-citation
Dietary nitrate supplementation increases diaphragm peak power in old mice
Kumar, R. A., Kelley, R. C., Hahn, D., & Ferreira, L. F. (2020) · The Journal of Physiology · doi:10.1113/jp280027 · Cited by 12 · see citing works
The effects of nitrate ingestion on high-intensity endurance time-trial performance: A systematic review and meta-analysis
Wong, T. H., Sim, A., & Burns, S. F. (2022) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2022.06.004 · Cited by 11 · see citing works
The effect of nitric oxide synthase inhibition with and without inhibition of prostaglandins on blood flow in different human skeletal muscles
HEINONEN, I. H. A., Saltin, B., Hellsten, Y., & Kalliokoski, K. K. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3604-2 · Cited by 11 · see citing works
Effects of Beetroot-Based Supplements on Muscular Endurance and Strength in Healthy Male Individuals: A Systematic Review and Meta-Analysis
Evangelista, J. F., Meirelles, C., Aguiar, G. S., Alves, R., & Matsuura, C. (2023) · Journal of the American Nutrition Association · doi:10.1080/27697061.2023.2211318 · Cited by 11 · see citing works
Dietary nitrate does not acutely enhance skeletal muscle blood flow and vasodilation in the lower limbs of older adults during single-limb exercise
Hughes, W. E., Kruse, N. T., Ueda, K., Feider, A. J., Hanada, S., Bock, J. M., & Casey, D. P. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04368-8 · Cited by 10 · see citing works
Vascular ATP‐sensitive K + channels support maximal aerobic capacity and critical speed via convective and diffusive O 2 transport
Colburn, T. D., Weber, R. E., Hageman, K. S., Caldwell, J. T., Schulze, K. M., Ade, C. J., Behnke, B. J., Poole, D. C., & Musch, T. I. (2020) · The Journal of Physiology · doi:10.1113/jp280232 · Cited by 10 · see citing works
Self-citation
High dose Nitrate ingestion does not improve 40 km cycling time trial performance in trained cyclists
Mosher, S. L., Gough, L. A., Deb, S., Saunders, B., Mc Naughton, L. R., Brown, D. R., & Sparks, S. A. (2020) · Research in Sports Medicine · doi:10.1080/15438627.2019.1586707 · Cited by 9 · see citing works
Effect of acute nitrate ingestion on VO2 response at different exercise intensity domains
Ghiarone, T., Ataide‐Silva, T., Bertuzzi, R., McConell, G. K., & Lima‐Silva, A. E. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0198 · Cited by 10 · see citing works
Consuming Beetroot Juice Improves Slalom Performance and Reduces Muscle Soreness in Alpine Skiers under Hypoxic Conditions
Ahmadpour, A., Fashi, M., & Hemmatinafar, M. (2024) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2024.104408 · Cited by 8 · see citing works
Preworkout dietary nitrate magnifies training-induced benefits to physical function in late postmenopausal women: a randomized pilot study
Carter, S. J., Blechschmid, T. H., Baranauskas, M. N., Long, E. B., Gruber, A. H., Raglin, J. S., Lim, K. J., & Coggan, A. R. (2024) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00150.2024 · Cited by 8 · see citing works
Effects of low and high dietary nitrate intake on human saliva, plasma and skeletal muscle nitrate and nitrite concentrations and their functional consequences
Black, M. I., Wylie, L. J., Kadach, S., Piknova, B., Park, J. W., Stoyanov, Z., L’Heureux, J. E., Schechter, A. N., Vanhatalo, A., & JONES, A. M. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.282 · Cited by 9 · see citing works
Self-citation
Type 2 diabetes-related sarcopenia: role of nitric oxide
Bahadoran, Z., Mirmiran, P., & Ghasemi, A. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00883-z · Cited by 8 · see citing works
Effects of Acute Beetroot Juice Ingestion on Reactive Agility Performance
Rogers, R. R., Davis, A. M., Rice, A. E., & Ballmann, C. G. (2022) · Oxygen · doi:10.3390/oxygen2040037 · Cited by 8 · see citing works
A Single Dose of Beetroot Juice not Enhance Performance during Intervallic Swimming Efforts
Moreno-Heredero, B., Morencos, E., Morais, J. E., Barbosa, T. M., & Veiga, S. (2024) · Journal of Sports Science and Medicine · doi:10.52082/jssm.2024.228 · Cited by 7 · see citing works
Cardiovascular Function
Saghiv, M. S., & Sagiv, M. S. (2020) · Springer eBooks · doi:10.1007/978-3-030-48806-2_6 · Cited by 8 · see citing works
Nutritional Intervention and Ergogenic Aids in Sport Performance and Recovery
Varillas‐Delgado, D. (2025) · Nutrients · doi:10.3390/nu17172806 · Cited by 6 · see citing works
Multiple-day high-dose beetroot juice supplementation does not improve pulmonary or muscle deoxygenation kinetics of well-trained cyclists in normoxia and hypoxia
Rokkedal-Lausch, T., Franch, J., Poulsen, M. K., Thomsen, L. P., Weitzberg, E., Kamavuako, E. N., Karbing, D. S., & Larsen, R. G. (2021) · Nitric Oxide · doi:10.1016/j.niox.2021.03.006 · Cited by 6 · see citing works
Role of nitric oxide in convective and diffusive skeletal muscle microvascular oxygen kinetics
Poole, D. C., Ferguson, S. K., Musch, T. I., & Porcelli, S. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.01.005 · Cited by 6 · see citing works
Self-citation
Acute beetroot juice supplementation enhances short duration high-intensity exercise performance and influences muscle oxygenation in football players
Eroğlu, M. N., Köse, B., Kolayiş, İ. E., & Haberal, B. (2026) · Scientific Reports · doi:10.1038/s41598-026-37514-x · Cited by 5 · see citing works
The effects of inorganic nitrate supplementation on muscular power and endurance across the menstrual cycle
Hogwood, A. C., de Zevallos, J. O., Kruse, K., Buckley, M., Guzman, J. C. D., Lempke, A. F. D., WELTMAN, A. L., & Allen, J. D. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00323.2024 · Cited by 5 · see citing works
Self-citation
Effect of acute nitrite infusion on contractile economy and metabolism in isolated skeletal muscle in situ during hypoxia
Porcelli, S., Rasica, L., Ferguson, B. S., Kavazis, A. N., McDonald, J. R., Hogan, M. C., Grassi, B., & Gladden, L. B. (2020) · The Journal of Physiology · doi:10.1113/jp279789 · Cited by 5 · see citing works
Eight weeks of nitrate-rich beetroot extract supplementation on fasting nitrate and nitrite levels and skeletal muscle contractile properties in postmenopausal women: Results of a randomized, placebo-controlled, and parallel trial
Ramos, O. J. F., Pinheiro, V. D. S., & Álvares, T. S. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.06.026 · Cited by 4 · see citing works
The Effects of Beetroot Juice Supplementation on Balance Performance of Wrestlers
Tatlıcı, A., Lima, Y., Yılmaz, S., Ekin, A., Okut, S., & Ceviz, E. (2021) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs211572234 · Cited by 5 · see citing works
Intracellular oxygen tension limits muscle contraction‐induced change in muscle oxygen consumption under hypoxic conditions during Hb‐free perfusion
Takakura, H., Ojino, M., Jue, T., Yamada, T., Furuichi, Y., Hashimoto, T., Iwase, S., & Masuda, K. (2017) · Physiological Reports · doi:10.14814/phy2.13112 · Cited by 4 · see citing works
Nitrite lowers the oxygen cost of ATP supply in cultured skeletal muscle cells by stimulating the rate of glycolytic ATP synthesis
Wynne, A. G., & Affourtit, C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266905 · Cited by 5 · see citing works
Effect of beetroot supplementation on 10 km time trial performance of distance runners
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Authors: Ferguson, S. K., Holdsworth, C. T., Wright, J. L., Fees, A. J., Allen, J. D., Jones, A. M., Musch, T. I., & Poole, D. C.
Affiliations: Kansas State University (US)
Duke University (US)
University of Exeter (GB)
Corresponding author: Poole, David C.
ORCID: Ferguson, Scott K.
Holdsworth, Clark T.
Allen, Jason D.
Jones, Andrew M.
Musch, Timothy I.
Poole, David C.
Venue: Nitric Oxide
Publisher: Elsevier BV
Published: 2015-08
Volume: 48
Pages: 38-43
ISSN: 1089-8603 (ISSN-L)
DOI: 10.1016/j.niox.2014.09.157
PMC: PMC4383717
OpenAlex: W2071356846
Cited by: 120
References: 61
Citations by year: 2026: 5 · 2025: 5 · 2024: 9 · 2023: 5 · 2022: 11 · 2021: 11 · 2020: 16 · 2019: 11 · 2018: 12 · 2017: 15 · 2016: 9 · 2015: 11
FWCI: 25.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Nitric Oxide (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Kansas State University
American Heart Association Midwest Affiliate (10GRNT4350011)
NIH (HL-108328)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: nitrate supplementation, beetroot juice, skeletal muscle fiber types, fast-twitch muscle, slow-twitch muscle, soleus muscle, gastrocnemius, nitrite, muscle contraction, VO2 slow component, exercise fatigue, high-intensity exercise performance
MeSH terms: Animals, Male, Muscle Contraction, Nitrates, Oxygen, Rats, Sprague-Dawley, Muscle, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Dietary Supplements

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Microvascular oxygen pressures in muscles comprised of different fiber types: Impact of dietary nitrate supplementation

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