The DOI matches its Crossref record; 172 of the 172 references it cites were found in a registry or an index.
Effects of Aging on Angiogenesis
Open accessAbstract
Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse sequelae in the elderly. Angiogenesis is both an essential adaptive response to physiological stress and an endogenous repair mechanism after ischemic injury. In addition, induction of angiogenesis is a promising therapeutic approach for ischemic diseases. For these reasons, understanding the basis of age-related impairment of angiogenesis and endothelial function has important implications for understanding and managing cardiovascular disease. In this review, we discuss the molecular mechanisms that contribute to impaired angiogenesis in the elderly and potential therapeutic approaches to improving vascular function and angiogenesis in aging patients.
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“Endothelial cell senescence directly compromised the endothelial barrier through disruption of cellular proliferation, permeability, and motility,112–114 possibly contributing to endothelial erosion and intra-plaque haemorrhage.”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [112]
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The Aging Cardiovascular System
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Metadata
- Authors
- Lähteenvuo, J., & Rosenzweig, A.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- ORCID
- Rosenzweig, Anthony
- Venue
- Circulation Research
- Published
- 2012-04-27
- Volume
- 110
- Issue
- 9
- Pages
- 1252-1264
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC4101916
- OpenAlex
- W2049206418
- Cited by
- 292
- References
- 171
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 28 · 2023: 34 · 2022: 32 · 2021: 31 · 2020: 23 · 2019: 21 · 2018: 18 · 2017: 15 · 2016: 16 · 2015: 10 · 2014: 12 · 2013: 11 · 2012: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Circulation Research
- Funders
- Fondation Leducq
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL110733)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- aging, angiogenesis, endothelial dysfunction, cardiovascular disease, ischemic injury, vascular repair, therapeutic angiogenesis, elderly patients
- MeSH terms
- Age Factors, Aging, Animals, Cardiovascular Diseases, Humans, Nitric Oxide, Risk Factors, Signal Transduction, Cellular Senescence, Oxidative Stress, Neovascularization, Physiologic, Angiogenic Proteins, Cyclin-Dependent Kinase Inhibitor Proteins
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