Cited by 292Angiogenesis and VEGF in CancerNitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

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Effects of Aging on Angiogenesis

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Lähteenvuo, Johanna, Rosenzweig, Anthony·2012·Circulation Research

DOI 10.1161/circresaha.111.246116PMC PMC4101916

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Abstract

Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse sequelae in the elderly. Angiogenesis is both an essential adaptive response to physiological stress and an endogenous repair mechanism after ischemic injury. In addition, induction of angiogenesis is a promising therapeutic approach for ischemic diseases. For these reasons, understanding the basis of age-related impairment of angiogenesis and endothelial function has important implications for understanding and managing cardiovascular disease. In this review, we discuss the molecular mechanisms that contribute to impaired angiogenesis in the elderly and potential therapeutic approaches to improving vascular function and angiogenesis in aging patients.

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Authors: Lähteenvuo, J., & Rosenzweig, A.
Affiliations: Beth Israel Deaconess Medical Center (US)
ORCID: Rosenzweig, Anthony
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-04-27
Volume: 110
Issue: 9
Pages: 1252-1264
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.111.246116
PMC: PMC4101916
OpenAlex: W2049206418
Cited by: 292
References: 171
Citations by year: 2026: 13 · 2025: 25 · 2024: 28 · 2023: 34 · 2022: 32 · 2021: 31 · 2020: 23 · 2019: 21 · 2018: 18 · 2017: 15 · 2016: 16 · 2015: 10 · 2014: 12 · 2013: 11 · 2012: 3
FWCI: 1.05
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Circulation Research
Funders: Fondation Leducq
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL110733)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: aging, angiogenesis, endothelial dysfunction, cardiovascular disease, ischemic injury, vascular repair, therapeutic angiogenesis, elderly patients
MeSH terms: Age Factors, Aging, Animals, Cardiovascular Diseases, Humans, Nitric Oxide, Risk Factors, Signal Transduction, Cellular Senescence, Oxidative Stress, Neovascularization, Physiologic, Angiogenic Proteins, Cyclin-Dependent Kinase Inhibitor Proteins

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