The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
miR-15 Family Regulates Postnatal Mitotic Arrest of Cardiomyocytes
Open accessAbstract
Rationale: Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal development, which significantly limits the capacity of the adult mammalian heart to regenerate after injury. The regulatory mechanisms that govern cardiomyocyte cell cycle withdrawal and binucleation are poorly understood. Objective: Given the potential of microRNAs (miRNAs) to influence large gene networks and modify complex developmental and disease phenotypes, we searched for miRNAs that were regulated during the postnatal switch to terminal differentiation. Methods and Results: Microarray analysis revealed subsets of miRNAs that were upregulated or downregulated in cardiac ventricles from mice at 1 and 10 days of age (P1 and P10). Interestingly, miR-195 (a member of the miR-15 family) was the most highly upregulated miRNA during this period, with expression levels almost 6-fold higher in P10 ventricles relative to P1. Precocious overexpression of miR-195 in the embryonic heart was associated with ventricular hypoplasia and ventricular septal defects in β-myosin heavy chain–miR-195 transgenic mice. Using global gene profiling and argonaute-2 immunoprecipitation approaches, we showed that miR-195 regulates the expression of a number of cell cycle genes, including checkpoint kinase 1 (Chek1), which we identified as a highly conserved direct target of miR-195. Finally, we demonstrated that knockdown of the miR-15 family in neonatal mice with locked nucleic acid–modified anti-miRNAs was associated with an increased number of mitotic cardiomyocytes and derepression of Chek1. Conclusions: These findings suggest that upregulation of the miR-15 family during the neonatal period may be an important regulatory mechanism governing cardiomyocyte cell cycle withdrawal and binucleation.
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Transient Regenerative Potential of the Neonatal Mouse Heart
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Self-citationDysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
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Self-citationArgonaute HITS-CLIP decodes microRNA–mRNA interaction maps
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Self-citationDysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2
Zhao, Y., Ransom, J. F., Li, A., Vedantham, V., von Drehle, M., Muth, A. N., Tsuchihashi, T., McManus, M. T., Schwartz, R. J., & Srivastava, D. (2007) · Cell · doi:10.1016/j.cell.2007.03.030 · Cited by 1,429
Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
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Self-citationModulation of microRNA processing by p53
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Kikuchi, K., Holdway, J. E., Werdich, A. A., Anderson, R. M., Fang, Y., Egnaczyk, G. F., Evans, T., MacRae, C. A., Stainier, D. Y. R., & Poss, K. D. (2010) · Nature · doi:10.1038/nature08804 · Cited by 1,054
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Self-citationFunctional screening identifies miRNAs inducing cardiac regeneration
Eulalio, A., Mano, M., Ferro, M. D., Zentilin, L., Sinagra, G., Zacchigna, S., & Giacca, M. (2012) · Nature · doi:10.1038/nature11739 · Cited by 1,029
Hippo pathway effector Yap promotes cardiac regeneration
Xin, M., Kim, Y., Sutherland, L. B., Murakami, M., Qi, X., McAnally, J., Porrello, E. R., Mahmoud, A. I., Tan, W., Shelton, J. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313192110 · Cited by 895
Self-citationRegulation of neonatal and adult mammalian heart regeneration by the miR-15 family
Porrello, E. R., Mahmoud, A. I., Simpson, E., Johnson, B. A., Grinsfelder, D., Canseco, D., Mammen, P. P., Rothermel, B. A., Olson, E. N., & Sadek, H. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208863110 · Cited by 746
Self-citationDevelopment of microRNA therapeutics is coming of age
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Metadata
- Authors
- Porrello, E. R., Johnson, B. A., Aurora, A. B., Simpson, E., Nam, Y.-J., Matkovich, S. J., Dorn, G. W., van Rooij, E., & Olson, E. N.
- Venue
- Circulation Research
- Published
- 2011-09-02
- Volume
- 109
- Issue
- 6
- Pages
- 670-679
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2107696376
- Cited by
- 444
- References
- 42
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Porrello, E. R., Johnson, B. A., Aurora, A. B., Simpson, E., Nam, Y.-J., Matkovich, S. J., Dorn, G. W., van Rooij, E., & Olson, E. N. (2011). miR-15 Family Regulates Postnatal Mitotic Arrest of Cardiomyocytes. Circulation Research. https://doi.org/10.1161/circresaha.111.248880
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