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Cited by 625MicroRNA in disease regulationRNA Interference and Gene DeliveryCancer-related molecular mechanisms research

Development of microRNA therapeutics is coming of age

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van Rooij, Eva, Kauppinen, Sakari·2014·EMBO Molecular Medicine
DOI 10.15252/emmm.201100899PMC PMC4119351
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Abstract

MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA‐based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.

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  • Pharmacological modulations of disease-associated miRNAs appeared to be well tolerated with promising outcomes in animal models and human patients.

    “Pharmacological modulations of disease-associated miRNAs appeared to be well tolerated with promising outcomes in animal models and human patients (van Rooij and Kauppinen, 2014).”

    From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as van Rooij and Kauppinen, 2014

  • Several miRNAs and antisense oligonucleotides (ASOs) are currently under investigation in clinical trials for various diseases.

    “Several miRNAs and antisense oligonucleotides (ASOs) are currently under investigation in clinical trials for various diseases (Kanasty et al., 2013;van Rooij and Kauppinen, 2014;Gaudet et al., 2015).”

    From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as van Rooij and Kauppinen, 2014

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Cited by

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Authors
van Rooij, E., & Kauppinen, S.
Affiliations
Aalborg University Hospital (DK)
Corresponding author
Kauppinen, Sakari
ORCID
Kauppinen, Sakari
Venue
EMBO Molecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2014-06-16
Volume
6
Issue
7
Pages
851-864
ISSN
  • 1757-4676 (ISSN-L)
  • 1757-4684
DOI
10.15252/emmm.201100899
PMC
PMC4119351
OpenAlex
W2122290210
Cited by
625
References
13
Citations by year
2026: 27 · 2025: 30 · 2024: 38 · 2023: 35 · 2022: 46 · 2021: 39 · 2020: 51 · 2019: 63 · 2018: 61 · 2017: 75 · 2016: 77 · 2015: 62 · 2014: 21
FWCI
7.78
Type
journal article
Language
en
Open access
Licence
Locations
  • EMBO Molecular Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion, cc-by)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion, cc-by)
Funders
  • Lundbeckfonden (R151-2013-14476)
  • Novo Nordisk Fonden (NNF13OC0006395, NNF14SA0011351)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
miRNA-based therapy, microRNA regulation, cancer therapy, cardiovascular disease, hepatitis C virus, antiviral therapy, gene expression regulation
MeSH terms
Animals, Cardiovascular Diseases, Gene Expression Regulation, Hepatitis C, Humans, Neoplasms, Genetic Therapy, Hepacivirus, Oligonucleotides, Antisense, MicroRNAs

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